Phospholipases PLBD1 and PLBD2: Difference between revisions
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SNPs resulting in amino acid substitions: | SNPs resulting in amino acid substitions: | ||
Q54P [http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs7965471 rs7965471] | Q54P [http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs7965471 rs7965471] | ||
A204V [http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs12231990 rs12231990] | A204V [http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs12231990 rs12231990] | ||
R354C [http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs= | R354C [http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs56935204 rs56935204] | ||
Q521K [http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs17852787 rs17852787] | |||
R524C [http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs12425042 rs12425042] | R524C [http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs12425042 rs12425042] | ||
=== PLBD1 reference sequences === | === PLBD1 reference sequences === | ||
Revision as of 15:06, 25 October 2010
PLBD2 active site
Structural superposition of active sites from five NTN hydrolases showing conserved side chains (*) and relevant main chains (....) (adapted from Fig 6 of Lakomek et al. BMC Struct Biol.2009;9:56:) * (*) * * PLBD2 phospholipase B-like gray 3FGR C249 H266 W269 T330 N432 R463 Cephalosporin acylase pink 1OQZ S170 .... H192 .... N413 R443 Conjugated bile acid hydrolase green 2BJF C2 .... D21 .... N175 R228 Penicillin V acylase yellow 3PVA C1 .... D20 .... N175 R228 Penicillin G acylase orange 1K5S S1 .... Q23 .... N241 R263
SNPs resulting in amino acid substitions: Q54P rs7965471 A204V rs12231990 R354C rs56935204 Q521K rs17852787 R524C rs12425042
PLBD1 reference sequences
>PLBD1_homSap Homo sapiens (human) FLJ22662 PMID: 19019078,20093120 0 MTRGGPGGRPGLPQPPPLLLLLLLLPLLLVTAEPPKPA 1 2 GVYYATAYWMPAEKTVQVKNVMDKNGDAYGFYNNSVKTTGWGILEIRAGYGSQTLSNEIIMFVAGFLEGYLTAP 2 1 HMNDHYTNLYPQLITKPSIMDKVQDFME 2 1 KQDKWTRKNIKEYKTDSFWRHTGYVMAQIDGLYVGAKKRAILEGTK 0 0 PMTLFQIQFLNSVGDLLDLIPSLSPTKNGSLKVFKRWDMGHCSALIK 0 0 VLPGFENILFAHSSWYTYAAMLRIYKHWDFNVIDKDTSSSRLSFSSYP 1 2 GFLESLDDFYILSSGLILLQTTNSVFNKTLLKQVIPETLLSWQRVRVANMMADSGKRWADIFSKYNS 1 2 GTYNNQYMVLDLKKVKLNHSLDKGTLYIVEQIPTYVEYSEQTDVLRK 1 2 GYWPSYNVPFHEKIYNWSGYPLLVQKLGLDYSYDLAPRAKIFRRDQGKVTDTASMKYIMRYN 1 2 NYKKDPYSRGDPCNTICCREDLNSPNPSPGGCYDTK 0 0 VADIYLASQYTSYAISGPTVQGGLPVFRWDRFNKTLHQGMPEVYNFDFITMKPILKLDIK* 0 >PLBD1_braFlo Branchiostoma floridae (lancelet) XM_002595538 0 MEGRACRSCRLHHLSAVFLLFLVTIAA 1 2 GAEIQATAYLQAQGKVQVKLGVLDKQNGDAVATYDDR 2 1 LTENGWGVLNVVSGFGPKKLSDNDIMYLAGYLEGVLTQE 2 1 RIYQHYLNLYGIFFMGKSEDLVGK 0 0 VKKFYTAQDTWVRAQVKQSTDPVMKHLSYILSQYDGLVKGYNDN 0 0 LFPHVSFFQKLDIFAFQLLNGNGDTFDIIPAVNPSSRPDFSNMSRVEIDDWVSAHSHCSALVK 0 0 VLGAYENVYMSHSSWFNYAATMRIYKHYNFNIANPATATRKMSFSSYP 1 2 GYLESLDDFYLMDSGLVMLQTTNNVFNGTLYDLVKPESILAWQRVRTANMLARNGDQWGAIMNVHNS 1 2 GTYNNQYMIIDLNLIELGKTIHDGALYVVEQIPGLVMSADQTDILRA 1 2 GYWPSYNIPFYEKVYNLSGYPEFAKSQGLDYTYQLAPRAKIFRRDAGKVKDMESMKAIMRYN 1 2 DYLHDPYSKGNPCSAICCRKDLAKVGAKPDGCYDTK 0 0 VSDYYLARNLTSFAINGPTLGTGLEPFSWSDKFKISHIGLPKVYNFSFVTMTPAEL* 0
PLBD2 reference sequences
>PLBD2_homSap Homo sapiens (human) PMID: 19706171,19237744,17007843 0 MVGQMYCYPGSHLARALTRALALALVLALLVGPFLSGLAGAIPAPGGRWARDGQVPPASRSRSVLLDVSAGQLLMVDGRHPDAVAWANLTNAIRETG 2 1 WAFLELGTSGQYNDSLQAYAAGVVEAAVSEE 0 0 LIYMHWMNTVVNYCGPFEYEVGYCERLKSFLEANLEWMQEEMESNPDSPYWHQ 0 0 VRLTLLQLKGLEDSYEGRVSFPAGKFTIKPLGFL 2 1 LLQLSGDLEDLELALNKTKIKPSLGSGSCSALIKLLPGQSDLLVAHNTWNNYQHMLRVIKKYWLQFREGPW 1 2 GDYPLVPGNKLVFSSYPGTIFSCDDFYILGSGL 0 0 VTLETTIGNKNPALWKYVRPRGCVLEWVRNIVANRLASDGATWADIFKRFNSGT 2 1 YNNQWMIVDYKAFIPGGPSPGSRVLTILEQIP 2 1 GMVVVADKTSELYQKTYWASYNIP 2 1 SFETVFNASGLQALVAQYGDWFSYDGSPRAQIFRRNQSLVQDMDSMVRLMR 2 1 YNDFLHDPLSLCKACNPQPNGENAISARSDLNPANGSYPFQALRQRSHGGIDVK 0 0 VTSMSLARILSLLAASGPTWDQVPPFQWSTSPFSGLLHMGQPDLWKFAPVKVSWD* 0 >PLBD2_braFlo Branchiostoma floridae (lancelet) XM_002612057 0 MAACRNIFCGRMLSCLLLFSFVFSAVSDGSKLASVRYDEAAKTYQITDKLDPSAAAWANFTDRISSTG 2 1 WSFLTVTTNEKYDDSVQAYAAGLVEGYLTRD LMYNHWLNTVGAAFCSSRSAFCKNLESFLKTNLAWMQEQIQASGDTDDYWHQ 0 0 VKLTLQQLSGLDDGYNDDPRQPSLDINPFGFL 2 1 IFQIGGDMEDLQEALKDKDSHRVLGSGSCSALVKLLPGNADLLVAHDTWDTFQSMLRIIKKYQFPFKLGGKK 1 2 GEDKIPGHTVSFSSYPGVIYSGDDFYITSASL 0 0 VAQETTIGNSNPALWKYVQPQGQVLEWLRNIVANRLANKAMDWATIFKKYNSGT 2 1 YNNQWMIVDYKTFTPNKDLPEKGLLVVLEQLP 2 1 GMVMMDDVTSVLAKQAYWPSYNSP 2 1 YFEKIFNTSGLPAMVEKYGDWFSYEHTPRANIFRRDHGKVTDISSMIKLMR 2 1 YNDFQNDPLSKCDCTPPYSAENAISARSDLNPANGTYPFSALQHRCHGGTDMK 0 0 MTSYSMHESHQMMAVSGPTHDQQQPFQWSTSDYDKQFYHLGHPDLFNFDPIHVIWFDQSDN* 0 >PLBD2_droMel Drosophila melanogaster (fruitfly) U57314 retinal lamina neuron ancestor (lama) PMID: 16077094,8892229 MERPEYDGTYCATALWTKQVGFQIENWKQQNDLVNIPTGVGRICYKDSVYENGWAQIEVETQRTYPDWVQAYAAGMLEGSLTWRNIYNQWSNTISSSCERDESTQKFCGWLRDLLTTNYHRLKRQT EKAENDHYWHQLHLFITQLEGLETGYKRGASRARSDLEEEIPFSDFLLMNAAADIQDLKIYYENYELQNSTEHTEEPRTDQPKNFFLPSATMLTKIVQEEESPQVLQLLFGHSTAGSYSSMLRIQK RYKFHYHFSSKLRSNTVPGVDITFTGYPGILGSTDDFYTIKGRHLHAIVGGVGIKNENLQLWKTVDPKKMVPLVARVMAANRISQNRQTWASAMSRHPFTGAKQWITVDLNKMKVQDNLYNVLEGD DKHDDAPVVLNEKDRTAIQQRHDQLRDMVWIAEQLPGMMTKKDVTQGFLVPGNTSWLANGVPYFKNVLELSGVNYSEDQQLTVADEEELTSLASVDKYLRTHGFRGDLLGSQESIAYGNIDLKLFS YNARLGISDFHAFAGPVFLRFQHTQPRTLEDEGQDGGVPPAASMGDERLSVSIEDADSLAEMELITERRSVRNDMRAIAMRKIGSGPFKWSEMSPVEEGGGHEGHPDEWNFDKVSPKWAW* >PLBD2_acyPis Acyrthosiphon pisum (aphid) XM_001948827 MLSIRCILLSLLFVWALQCSATQKNQTLLAVKTDNNRITIQPKHYSVKDKEIIIGKGKFIDRINSTGWAYLEIRTSQKAKDEDQAYGAGYLEGTLTADLIYSYWFNTAKGYCTDRPNVCQQLK DYMTTNKNWIKSKLNESDPYWYQVGLYYKQLDGLYDGYMRGKSPSTPDLTWDDLYWLNALDDLGDLSIALYPSDISNRVLGSGSCSALIKLMPDNKDILVSHATWSGYETMLRIQKRYSLRFRKS KKSNKLIRGFDMSFSSFPGGIQSGDDFYLISSGLTTMETTIENYNDSLWSNVKPVGQVLEFVRAMVANRLADNPTDWANLFKLHNSGTYNNQWMILNYAAFQPGSPLPPRDVLHVLEQIPGHVMHD DFTGHLINRTYWASYNVPYFPFIFNVSGNYEMEQIYGSWFSYSETPRARIFARDHVKIHCDKCMLHLMRSNNYTRD PESRCDCSPPYSAENAISSRNDLNPANGTYPIRALGHRSHGATDVKVTSSQLFQQLQFKAIAGPTQGSNNSLGPFCWSKSDFNDKVSHLGHPDCFNFKPVLHQWSL* >PLBD2_triAdh Trichoplax adhaerens (trichoplax) XM_002107718 introns largely conserved 0 MAQCGKFLIYFSIFIITLATLCSCQSGSVIYKDGLYTFSKGINKRAASYGTFTDKIASSG 2 1 WTYLDVHTNPQDDDFITAYAAGYVEGILTAKY IYMHWKNTVGDYCKQKSIYCQKLKSFIMKNNQWMATQIKHRPHSIYWYH 0 0 INLTLIQQKGLRDGYHKAMPHKPIDEFSFL 2 1 LIELSGDLESLETALKDEDTHHVLGSGSCSAFIKVLPDNRDLYFAHDTWTGYQTMLRIYKYYELNFSMLPKTN 1 2 VTVPGTRISFSSYPGTILSGDDYYLIGSGL 0 0 ATMETTNGNSNEKLWKYVTPSSVLEWIRTIIANRLTSSGNDWVKIFSKYNSGT 2 1 YNNQ 00 WMILDYKLFAPKRPLNPNTLWVLEQIP 2 1 GKIESADVTNVLKKQGYWASYNVP 2 1 YFSSIFNMSGNQEQAKKYGNWFTHDKCPRALIFKRDQHKVNSMESLMKLMR 2 1 YNDFKHDPLSRCNCTPPYSAENAISARSDLNPADGKYNIGALGHRCHGGTDSK STNYTMFHSGLKSYAIAGPTHEQQPPFRWSTAKFNMTKPLGHPDLFNFTRQLVSWD* 0 >PLBD2_monBre Monosiga brevicollis (choanoflagellate) introns all novel 0 MWSCGAAAAAVVAVVVLASPATATVARFVEQTDVQTTYASVFYVESDDSYVVKTENHPWDGDFEKDE 0 0 AVRIKYTPGYLVAGWDQLHVKSNSAMDDATVAYAAGYGEAQLTAEMIYNYAYNNGYDTFTPNDKLADYLAKNQAFMAASIASNRSDANGYWYHVDLILRQLQGVCDGYNSSD FAKSFPLPCESMLAINLMGDMEDLSDALASSDEWYTEDRFFRATHCSALVKLVGGASSPSDIYISQDTWSSLNSMTRIMKRYDLNFLQ 2 1 AKGADDRIAGSSIVFSSYPGSLYSGDDFYLTSAGMAVIETTIGNSNPELYQYIVPDTVLEWIRNIMANRLASNSQTWYEVYRQFNSGT 1 2 YNNMNMILDYKQFKPQEALQDELLTIVEQIP GTVTKTDVTGYLRNMTYWGS 1 2 YNVAFDQNIRELSGANQAEQLYGPW 2 1 FSYWNTSRALIFAREQKNVSSLEDLKRLMRLNQFKTDPL 2 1 YRGWTNCTPAYTAENVIATRGDLNDP 0 0 NGIYSLSSFGLRNHVATDSKISTFSTYDSNNLNVWAIS 2 1 GPTNGPPPNQPVFNWSTSYYKDTRHRGMPEAFDFDWVNFNWPF* 0 >PLBD2_dicDis Dictyostelium discoideum (slime_mold) AAFI02000019 AF411829 introns both novel 0 MRVIRSLLLLTIAIIGSVLSQSSIDDGYTVFYSQPDNYYVKPGTFSNGVAQAIFSNEMMTTGWSFMSISSSEGLYPNDIIAAGAGYLEGYISQEMIYQNWMNMYNNEYHNVIGSD VENWIQENLQYLQTMIDSAPSNDLYWQNVETVLTQITYMQRGYNQSVIDNGVDASQSLGITEFFLMNMDGDMIDLGPALNLTNGKQVTSPATATSPKQAFKEFMRRTGHCSALIKMTDDLSDLFSGHTTW 2 1 SSYYEMVRMFKVYNLKYLFNGQPPASKVTMFSGYPGTLSSIDDFYLLDTKIVVIETTNGLMNNNLYHLITSESVLSWIRVIVANRLATGGESWCQTFSLYNSGTYNNQ 0 0 WIIVDYNKFIKGYGALDGTLYILEQVPDYVEYGDQTAILRTGYWPSFNIPFYENIYGLTGFNETYAQFGNWFSYQASPRSMIFKRDANNIHSLTQFQAMLRYNNWQNDPFSQGNAGN QISSRFDLVTADDPNNQYLDPDAFGGIDSKVVSADMVAALLVNAQSGPSHDNETPFTWNSQWNQKYTYAGQPTTWNFDWMTMSLQSMKPASPSSDSSSDSTTFN* 0
