Immunogenomics papers: Difference between revisions
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* [http://www.jimmunol.org/content/184/12/6986.long Boyd 2010 J of Immunol, Collins lab, Stanford] | |||
** sequenced IGH with BIOMED2 primers of 12 people | |||
** describe variation | |||
* [http://stm.sciencemag.org/content/1/12/12ra23 Boyd et al, Fire lab, Stanford] | * [http://stm.sciencemag.org/content/1/12/12ra23 Boyd et al, Fire lab, Stanford] | ||
** sequenced IGH-locus with BIOMED2 primers | ** sequenced IGH-locus with BIOMED2 primers | ||
Revision as of 18:57, 3 August 2011
- Boyd 2010 J of Immunol, Collins lab, Stanford
- sequenced IGH with BIOMED2 primers of 12 people
- describe variation
- Boyd et al, Fire lab, Stanford
- sequenced IGH-locus with BIOMED2 primers
- Tomlinson 1996
- Sanger sequencing of <1000 IGH sequences
- compare germline mutations (=IMGT) versus somatic mutations
- In parts of antibody where there is little germline variation, there is lots of somatic mutations, and the inverse
- Glanville 2009, Pons lab, Pfizer
- Zemlin 2003
- CDR3 composition is very different between human and mouse
