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| * B-Cells | | * Basic Immunology |
| ** B-Cells recognize non-body stuff, which are called [http://en.wikipedia.org/wiki/Antigen antigen] by either recognizing it with receptors on their cell membrane or by secreting these receptors in the form of antibodies. | | ** [[Basic Immunology Introduction]] |
| ** B-Cell Proteins | | ** [[B-Cells]] |
| *** An [http://en.wikipedia.org/wiki/Antibody Antibody] comes in five different flavors (in placental mammals) IgA, IgD, IgE, IgG, IgM. They all share the same basic structure, but differ in their additions. Somehow we assume that [http://en.wikipedia.org/wiki/Immunoglobulin_G IgG] is the most important, because it is the most common type and we don't know that much about the other types anyways. | | ** [[T-Cells]] |
| *** IgG is one of those antibody types that looks like a Y. The *ends* of the arms of the Y recognize the antigen, the *ends* not the middle part. | | * Immunology databases |
| *** All antibodies, and so IgG are composed of two identical [http://en.wikipedia.org/wiki/Immunoglobulin_heavy_chain Heavy] and two identical [http://en.wikipedia.org/wiki/Immunoglobulin_light_chain Light Chains] | | ** [[IMGT]] |
| *** The two ends of the Y, the part that recognizes the antigen are together called [http://en.wikipedia.org/wiki/Antibody#CDRs.2C_Fv.2C_Fab_and_Fc_Regions Fab]. One Fab comprises a bit of the heavy chain and a bit of the light chain. Not everything touches the antigen, so the most important region in the Fab fragment is called Fv (variable). | | ** [[Vbase2]] |
| *** The Fv can be split into its three main parts, the [complementary determining regions], called CDR1, CDR2 and CDR3. Remember that there is a light and a heavy chain in one Fv, so there are six complementary determining regions in total. | | ** [[IgPdb]] |
| ** B-cell genomes | | ** [[T-cell epitope databases and algorithms]] |
| ** B-cells are one of the very few cells that can do somatic recombination with their genome | | * [[Mapping of High-throughput sequences to immunology databases]] |
| | | ** [[Immunogenomics papers]] |
| ** Somehow we think that the heavy chains are more important than the light chains, and CDR3 more important than CDR1 and CDR2 | | ** [[Software tools]] |
| | | * [[Companies]] |
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| ** The heavy chains are encoded by one of the few loci that can recombine somatically, the [http://en.wikipedia.org/wiki/IGH@ IGH-locus] | |
| ** | |
