Opsin evolution: Peropsin phyloSNPs

Introduction to Peropsin Evolution

PhyloSNPs are defined as single coding residue changes at a site (1) strictly conserved ancestrally over great branch lengths but (2) switching in an ancestral stem to a new residue that in turn is (3) strictly conserved in all descendent extant species. A certain amount of excursion from perfect conservation can be admitted (reduced alphabet, disproportionately attributable to sequencing error) and even low levels of homoplasy (where the ancestral value reoccurs in a later diverging a species or two. Peropsin (or RRH) has just a handful of them at its 337 positions, the number depending on quality cutoff. Most of these occured in the earliest mammals.

PhyloSNPs are thus a special case of synapomorphy adapted to protein molecular evolution. Because they are fixed both before and after the stem event, they greatly enrich for defining characters of the stem clade (and its complement) -- they answer the question, what makes a mammal a mammal.

Interpretation of phyloSNPs is not so easy from bioinformatics alone. In opsins, a great deal of structural and experimental information is availble. For example, a peropsin douple phyloSNP in adacent N.S columns at positions 211-213 might appear to be an ancestral glycosylation site lost in a coordinated way in the post- marsupial stem but before atlantogenata diverged, perhaps suggesting a shift in subcellular location in placental mammals. However, the site in fact is on the cytoplasmic side and consequently cannot have been a glycosylation site to begin with.

PhyloSNPs in vertebrate peropsins

PhyloSNPs

homSap..L.S.S.P.I.G.G.H.T.P.L.G.H
panTro...........................
gorGor...........................
ponPyg...........................
nomLeu...........................
macMul...........................
papHam...........................
calJac...........................
tarSyr......................R...Y
otoGar....................A.R....
micMur......................R....
tupBel..............S.L.A.S.R....
musMus..............-...S...C....
ratNor..............-...S...C....
speTri...........................
dipOrd......................H....
cavPor......................R....
oryCun......................H....
ochPri................Y.....Q...P
canFam......................S....
felCat......................S...R
bosTau......................H...T
turTru......................C....
susScr......................R....
vicVic......................R....
equCab........S.............R....
myoLuc....................T......
pteVam...........................
sorAra........R.........I...R...Q
eriEur......................R....
loxAfr..............A.......H....
proCap......................H....
echTel....................R.H...Q
dasNov............S.........R....
choHof......................H....
monDom........A.....P.N.S...Q....
macEug........A.....Y.N.S...Q....
ornAna....G...A.....R.N.S.T.R....
galGal....G...A.....H.N.S.T.R.A.R
taeGut....G...A.....H.N.S.T.R.A.R
anoCar....G...A.....H.N.S.T.K.A.R
xenTro....G...A.....H.N.S.T.R...R
danRer....G.A.A.M.L.K.N.S.T.R.A.R
takRub..I.G.A.A.M.L.K.N.S.T.R.A.R
tetNig..I.G.A.A.M.L.K.N.S.T.R.A.R
gasAcu..I.G.A.A.M.L.K.N.S.T.R.A.R
oryLat..I.G.A.A.M.L.K.N.S.T.R.A.R
calMil................N.S.T.....R
homSap..L.S.S.P.I.G.G.H.T.P.L.G.H
........x.x.x.x.x.x.x.x.x.x.y.y.y
......................2.2.3.1.1.3
........8.7.7.5.4.4.1.1.1.1.2.0.1
........7.6.5.9.9.8.7.1.3.8.9.3.4
........2.2.2.2.2.2.1.5.5.7.3.3.7

..........................................................................................................1.........1.........1.........1.........1.........1.........1.........1.........1...1
................1.........2.........3.........4.........5.........6.........7.........8.........9.........0.........1.........2.........3.........4.........5.........6.........7.........8...8
.......1234567890123456789012345678901234567890123456789012345678901234567890123456789012345678901234567890123456789012345678901234567890123456789012345678901234567890123456789012345678901234
.......EEEEEEEEEEEEEEEEEEEEEEEEEEMMMMMMMMMMMMMMMMMMMMMMMCCCCCCCCCCCCMMMMMMMMMMMMMMMMMMMMMMMMMMEEEEEEEEEEEEEEMMMMMMMMMMMMMMMMMMMMCCCCCCCCCCCCCCCCCCCMMMMMMMMMMMMMMMMMMMMMMMMEEEEEEEEEEEEEEEEEEEE
..............GGG.......................................................................................S.......................DRY..................................................S.........
.......................y..............................xx.........x...............xx..........x...............y.........................y.......................................................
homSap MLRNNLGNSSDSKNEDGSVFSQTEHNIVATYLIMAGMISIISNIIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQVYAGLNIFFGMASIGLLTVVAVDRYLTICLPDVGRRMTTNTYIGLILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRKNDR
panTro ........................................................................................................................................................................................
gorGor ........G................................................................................................................................................L..............................
ponPyg ....................................I..............................................................................................I....................................................
nomLeu ........................................................................................................................................................................................
macMul ........................................L..........................................................................................I...........M........................................
papHam ........................................L..........................................................................................I...........M........................................
calJac .............................S..........L...............................................................................A..........I......S...IM................V.......................
tarSyr ..K.D...................................L.........V................S...............................I............................R..I.........V.M............S...A...T..................A
otoGar ........N...............................L..............................................H...........I............................R..I.......S...M.....V..........T......................A
micMur                                                  I....................M.......R..I......H..V.M.....V......V...T...G..................A
tupBel ..GSDA....NLG...S.A..........A..LT..V...L...V.....VTH...............F..................H.R....H....I..........................L.R.A.....GSS..AAM.....L......A...A...G..................A
musMus ..SEASD...G.RS.G-....R...SVI.A...V..IT..L..VV.................V.....F..................H......H....I..........V.........M......SC............LSM....................................N..T
ratNor ...DA.D...G.GS.G-...TKS..S.I.A...V..I...L.....................V.....F..................H......H...............V.........L......SC........G...LSMV...............V......................T
speTri                                                                                            
dipOrd .....V....G.R....................T..V...L..L........................L....................R.........I....................I.......H..I..G...R..VTM.......................................T
cavPor ...HS........................A...L..L...L.......................M...L..................H........................................R..I.....SHS.V.M.......................................V
oryCun ......S....F.H...................L......L..L........................F..................H...........I....................M.......H.........R..L.......V..........A......................T
ochPri ...H......EA.V.A.............A...L......L..L........................F..................H...........I....................M.......Q..I......H..F.M................V......................K
canFam ......D..T...................A...T..I...F..L.......................................................I....................M.......S..T..........SM.....L.................................A
felCat ......D......................A...T.                                I....................M.......S.NS..........SM.....L.................................A
bosTau ...........C...N.............A...T..V...L...........F..................................H...........I............................H..A.....A....SM.....T.................................V
turTru ..................T..........A...T.....VL..............................................H...........I............................C.GA..........SM.....F..........V......................V
susScr ..LMD...N................S...A...T......L...V.......H...............A..................H...........I............................R.EA..........SM.......................................V
vicVic ...............Y......A......A...T......L...V.......H..............................................I....................M.......R..A..........SM............SV......G...............Q..V
equCab .............................A..........L.........V.......S..............................R.........I....................L.....T.R..A......S..TSM.....V..........V...N..................A
myoLuc ..K...S....F............................L..V.......T...................................H...........                 ..K...H...SM.......................................V
pteVam ..........N......................I......L.........F................................................                 ..........IM.......................................A
sorAra ..E.RSD...GPTP.G.A.L.R...RL..A...V..V...L..TA.............R.....M...L..................H...R..H......................L........L.R..A..S....S.V..........F.......L.........M.........G..V
eriEur ..E.....G...E................A...V.                                I............................R.HT..S.SA.S..AM.....L..........S...G...............E..G
loxAfr ....S.D.........A.......................L..............................................H.R.....T...I............................H.HI.....S...VSM.........L...L..T......................A
proCap ...............E.............A.....                                I..........S.........I.......H.N.                          
echTel ..K..E.T..G.HS.E......A..R...S...T......L..F..................M........................H.............................A..........H..R.....S...V.M........FL...L.V....................E..A
dasNov .....T.......D......................I...F......S.............T.....................................I..........T.........M.......R..T.....I....SM................A.....................NI
choHof                  .I...L...V................TV....................................I............................H........I....SM.............L.VT......................G
monDom .FK..SVKTLAPEK.GP....PI..K...A...T..V...V..V......V...A...A..T.................................D...I.................A..I.......Q..L.G...SYN.TLM..T..V..F.......V...G..................V
macEug .FQ.DS---LEPEK.SY....P.......A...T..V...P.........V.......A..T.....................................I.................A..I.......Q..L                          
ornAna .R..DSA.LLE.EHH.R.A....D.....A...T..IM..V..V......V.FE....A................G...........H......H....I..........S.................R.AI..K..RSN.TAM..A..M..F...S..LL......S...............A
galGal .HW.DSA...E.DA.AH...T........A...T..V...F...V.....V.......A.........F......G...........H.......T...I..A.........................R..I......RN.AA...A....AV...S..TV...G..S........A......T
taeGut .HW.DSS...E.DD.AH.A.T........A...T..V...F...V.....V.......A.........F......G...........H.......T...I..A.........................R..I......RS.AT...A....AV..SS..TA...............V......V
anoCar .FL.DSA...E.DD.PH.A...A......A...T..V..LL...V.....V.......A.........F......G...........H.......T...I..A.................I.......K.HI.S.L.ATN.TT...A....A....S..VV...............V......T
xenTro .AGTGTV.I..ASS.VH.....S......A...T..V...L.........V.......A.........F......G...........H.......V...I....................I.......R..I...ISGRH.TAM..A....AV..SV..VV..S...................A
danRer .ESGL.NV.AETVYGEK.A.T........A...T..V..LS...V..LM.V.FR....A.........F.....AG...........H.......M...I..A.................I.......R..I.QKL..RS.TL..VA..L.AV..SS...V...G...............N..V
takRub ..KVFSLVNISNEV.GK...T.W......G...I..V..LT...V..LM.V.F.....A..F......F.....AG..........IH......HT...I..A.................I...I...R..I..K..VQS.NL...A..L.AV..SS..VV...A...............Q.NV
tetNig ..KVFSLVN.SNDV.GK.A.T.W......G...T..I..LT...V..LM.V.F.....A..F......F.....AG..........IH......HT...I..A.................I.......R..I..K..VQS.NL..AA..L.AV..SS..VV...A...............Q.NA
gasAcu .DPEVNVTDDVTLYGGK.A.T.L......G...T..V..LF...V..LM.W.F.....A..F......F.....AG..........IH...........I..A.................I.......R..I.QK..MQS.NL...A..L.AV..SS..VV...................Q..A
oryLat .DSAVNVSDAAAPYGGK.A.T.L......G...T..V..LS..VL..LM.V.FR....A..I......F..V..AG..........IH.......T...I..A.................I.......R..L.QK..MQS.NL...A..L.AV..SS...V...G...............Q..V
calMil                                                                                            
homSap MLRNNLGNSSDSKNEDGSVFSQTEHNIVATYLIMAGMISIISNIIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQVYAGLNIFFGMASIGLLTVVAVDRYLTICLPDVGRRMTTNTYIGLILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRKNDR
.......................y..............................xx.........x...............xx..........x...............y.........................y.......................................................

.......1....1.........2.........2.........2.........2.........2.........2.........2.........2.........2.........2.........3........3..........3.........3.......3
.......8....9.........0.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0........1..........2.........3.......3
.......5678901234567890123456789012345678901234567890123456789012345678901234567890123456789012345678901234567890123456789012345678901234567890123456789012345678
.......EEEEMMMMMMMMMMMMMMMMMMMMMMMMCCCCCCCCCCCCCCCCCCCCCCCCCCCCMMMMMMMMMMMMMMMMMMMMMMMMEEEEEEEEMMMMMMMMMMMMMMMMMMMMMMMMMCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC*
.................................ggg......................................................................K......................................................
.................................x.y....................................................................................................y...x....................
homSap SFVSYTMTVIAINFIVPLTVMFYCYYHVTLSIKHHTTSDCTESLNRDWSDQIDVTKMSVIMICMFLVAWSPYSIVCLWASFGDPKKIPPPMAIIAPLFAKSSTFYNPCIYVVANKKFRRAMLAMFKCQTHQTMPVTSILPMDVSQNPLASGRI*
panTro .........................................................................................................................................................*
gorGor ......V.................................................                              .....................................*
ponPyg .........................................................................................................................................................*
nomLeu .................................Y....................................................................................K.......WPN.....G.............T..K.*
macMul ...................................A..........E..........................................................................................................*
papHam ...................................A..........E...............................................................M..........................................*
calJac .......A......................F......................................................N...A..................................L............V....I..........*
tarSyr T......A...................A.Q.....VA.N.V..........V....                              .....F..L....Y.A..A..S...N......T..KN*
otoGar                             .......................L.........S...............................F.........A.A........I.......R..*
micMur ...........V..V...M..........Q...R..ATN............V....................A.........N.E....S.....................I.........F.........A......F..G......P...T*
tupBel .......A...V..V......S...VL.ARA.AG.AA.S.S.HRC....E.V.......L..L.....................QR...A...V.................L......K..C.........A.S...V...AS.PR...PA.V*
musMus .......M..VV................SR.LRLYAA....AH.H...A..A..........L...L............C..N......S.....................A.H....K.........P.LAV.EP.T....MP.SS..PV..*
ratNor .......M..VV................SQ.MRLSAA.N..TH.....AH.A.......M..L...L......V.....C..N......SL....................A......K..F..L...P..A..EP.T.A.G.PHS...PA..*
speTri ...........V.................R.....AA.N..AY........V..........L...................N......S.....................A...R.....F.........A.....V.......S.R.....*
dipOrd                             ...V..L......................E......................................L......A.....................*
cavPor A.................A......L.I.RA.RR.VAG.RPPN.SG.....V.......V..L.....................RR.S.S.....................I.........F...Q.....AV..A......A..S.......*
oryCun ....F..A......V..............Q...Q.RA.....Y........V..........F..........................A.....................A...R.....F.........A.....V..........P..I.*
ochPri ....F..A..MV..V...........Y..Q......A....K.........V..........L.....................Q....S.....................A...RS....F......IP.AK....LS.R....S..S...T*
canFam F...F......V.................R...C....N...Y........V..........F..........................S............................K.IF.........A..G.................N*
felCat ....F.........N..............QT..C.D..N..GY......N.V....                              ..K..F.....ENR.P................T...K*
bosTau .......M.V...................Q.....G.NN...Y........V..........L..........................S.....................I.................T.A.....V.....P....T..KV*
turTru .......M.V........IM.........R.....A..N...Y........V..........L..........................SV..L.................I...................A..ME.......P....T..KV*
susScr .........V.V......I..........Q...S.A..N..AY........V..........L................................................I...................A..LE.T.....P........V*
vicVic .......M.V........I..........R...CRA..N...Y........V..........L...L......................S.....................I...................A..M........P....T...L*
equCab .......A.V...................R.M.R.P..N..QY..T.....V..........F..........................S...............................F........RA...........P..Q......*
myoLuc ....F........................R...CRA..N...Y.....A..V..........F..........................S...............................F...........TTM.F.....P....T....*
pteVam ....F.............A..........R...C....N...Y........V..........F..........................S...............................F......D..S.....V.....P....T....*
sorAra .........V.V..VM.....A......IR.L.C...HSSPGH.DG...S.V.......V..LA..A.........F............S..V............................S..LT.RAQGA..AA.T....AAHS.Q....N*
eriEur ..............M...A..L.......R.M.C..ARS.A.YVHG.....V..........L..........V...............S...M.................L.........F.........A....NT....IP.K-.D.R.N*
loxAfr ..........V...V...A..........R...R..A.N.A.Y........L..........L....................S.....S...............................F.........AE...C....N.......A...*
proCap ......V...MV..V...A........I.....C.AARN.A.P.C......L..........L...M.................T....S.........................................AV...N....T....SS.....*
echTel .........VG...V...A..........QT..RQ.A.NGA.N.H......L....                              .....F.LLQ..PQEARR.......N.....M....L*
dasNov .........V....L...A..L.......R......K.N.S.YF.....N.V..........S.....................E....S..............................IF..L......A...M.....N..E........*
choHof .........VV...V..VA........I.R...RRNS.N.S.Y........V..........L...L......................S............................TI.F..L......AV........N..E........*
monDom ..........T...AM..G.......N.SQKM.QYSP.N.PDHI.....N.VA......V..L...L..................E...A...V.................A........IS..IR.....S..ISNA...N*     
macEug ..............VM..V.......N.S.KM.QY.R.S.P.HI.....N.V..........L...L......V...........E...A.....................A........IS..MR.E...S...SNA..LNLT*    
ornAna ..I........V..A...I.......N.SKAMRQYPA.RVL.N..I...E.V.......V..L...M...........S........S.AV..M............................S.VQ....REITI.DV...NR.RS..TL  
galGal .......S...V..V...........N.SRTM.QY.S.N.L..I.M.....V.......V..V...............S........S.A.....................I........I...VR...R.EITISNA...T..LSA.T.  
taeGut ..I....S...V..V...........N.SRTM.QYAS.N.L..I.I.....V.......V..I...............S........S.A.....................I........I...VR...R.EITINNA...S...SA.T.QNS*
anoCar .......S...V..VI..S.......N.SKTM.YYMRNS.L.NI.I.....V.......V..I...L...........S........S.A...V.................I...R....I...IR...R.EITINNV...S...STI.  
xenTro .......S.V.V..V...M.......N.SRTM.GYGSRSSLGGI.A.....T......MV..V...............S.....R....A.....................I........I.S.VQ.KSR.EVTLDNHF..N...ST.TT* 
danRer ..........TV...I..S.......N.SATV.RFKA.N.LD.I.M.....M..........V...A.................Q...A........L.............I........IIG.IR...R.RVTINNQ...MA.SV..NP* 
takRub ..I....A..GV..ML..F.......N.SVTVNRCK..N.LDDI.IE..E.M......LV..I......................A..A......................I........IIG.IR...R.Q.TINTEI..TT..QTATQ* 
tetNig ..I....A..SV...L..F.......N.SVTV.QYKANN.LDNI.IE..E.M......IV..I......................T.SA......................IT.....Q.IIG.IR...R.QITINTDI..TA..QT.TQ* 
gasAcu ..I....A...V..VL..SA......N.SATV.RYKA.N.LD.A.I.....M......IV..I......................T..A......................I........IIG.VR...R.RITIN.QV..TT..Q..TQ* 
oryLat .......A...V..V...........N.SATV.RYKA.N.LD.I.I.....M......IV..V..........M...........T..A......................I........IIG.IR...R.RITISTQV..TI..Q..TQ* 
calMil L..........V..V...S...F...N.SKTMSRFIS.PSP.NI.L.....L.......V..V...L...............N..L...A.....................I......K.IM..IC..NR.EITINHT...TI.RV..TE* 
homSap SFVSYTMTVIAINFIVPLTVMFYCYYHVTLSIKHHTTSDCTESLNRDWSDQIDVTKMSVIMICMFLVAWSPYSIVCLWASFGDPKKIPPPMAIIAPLFAKSSTFYNPCIYVVANKKFRRAMLAMFKCQTHQTMPVTSILPMDVSQNPLASGRI*
.................................x.y....................................................................................................y...x....................

A Curated Set of 48 vertebrate Peropsin Opsins

The sequences below represent all that are available as of March 2008. A few sequences such as chondrichthyes are incomplete. Note the main reference sequence collection contains additional deuterostome and even some lophotrochozoan peropsins.

>homSap Homo sapiens (human)
0 MLRNNLGNSSDSKNEDGSVFSQTEHNIVATYLIMA 1
2 GMISIISNIIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQ 0
0 VYAGLNIFFGMASIGLLTVVAVDRYLTICLPDV 1
2 GRRMTTNTYIGLILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRKNDR 2
1 SFVSYTMTVIAINFIVPLTVMFYCYYHVTLSIKHHTTSDCTESLNRDWSDQIDVTK 0
0 MSVIMICMFLVAWSPYSIVCLWASFGDPKKIPPPMAIIAPLFAKSSTFYNPCIYVVANKK 2
1 FRRAMLAMFKCQTHQTMPVTSILPMDVSQNPLASGRI* 0

>panTro Pan troglodytes (chimp)
0 MLRNNLGNSSDSKNEDGSVFSQTEHNIVATYLIMA 1
2 GMISIISNIIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQ 0
0 VYAGLNIFFGMASIGLLTVVAVDRYLTICLPDV 1
2 GRRMTTNTYIGLILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRKNDR 2
1 SFVSYTMTVIAINFIVPLTVMFYCYYHVTLSIKHHTTSDCTESLNRDWSDQIDVTK 0
0 MSVIMICMFLVAWSPYSIVCLWASFGDPKKIPPPMAIIAPLFAKSSTFYNPCIYVVANKK 2
1 FRRAMLAMFKCQTHQTMPVTSILPMDVSQNPLASGRI* 0

>gorGor Gorilla gorilla (gorilla)
0 MLRNNLGNGSDSKNEDGSVFSQTEHNIVATYLIMA 1
2 GMISIISNIIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQ 0
0 VYAGLNIFFGMASIGLLTVVAVDRYLTICLPDV 1
2 GRRMTTNTYIGLILGAWINGLLWALMPIIGWASYAPDPTGATCTINWRKNDR 2
1 SFVSYTVTVIAINFIVPLTVMFYCYYHVTLSIKHHTTSDCTESLNRDWSDQIDVTK 0
0 2
1 FRRAMLAMFKCQTHQTMPVTSILPMDVSQNPLASGRI* 0

>ponPyg Pongo pygmaeus (orang_abelii)
0 MLRNNLGNSSDSKNEDGSVFSQTEHNIVATYLIMA 1
2 GIISIISNIIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQ 0
0 VYAGLNIFFGMASIGLLTVVAVDRYLTICLPDI 1
2 GRRMTTNTYIGLILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRKNDR 2
1 SFVSYTMTVIAINFIVPLTVMFYCYYHVTLSIKHHTTSDCTESLNRDWSDQIDVTK 0
0 MSVIMICMFLVAWSPYSIVCLWASFGDPKKIPPPMAIIAPLFAKSSTFYNPCIYVVANKK 2
1 FRRAMLAMFKCQTHQTMPVTSILPMDVSQNPLASGRI* 0

>nomLeu Nomascus leucogenys (gibbon)
0 MLRNNLGNSSDSKNEDGSVFSQTEHNIVATYLIMA 1
2 GMISIISNIIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQ 0
0 VYAGLNIFFGMASIGLLTVVAVDRYLTICLPDV 1
2 GRRMTTNTYIGLILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRKNDR 2
1 SFVSYTMTVIAINFIVPLTVMFYCYYHVTLSIKYHTTSDCTESLNRDWSDQIDVTK 0
0 MSVIMICMFLVAWSPYSIVCLWASFGDPKKIPPPMAIIAPLFAKSSTFYNPCIYVVANKK 2
1 FRKAMLAMFKWPNHQTMPGTSILPMDVSQNPLTSGKI* 0

>macMul Macaca mulatta (rhesus)
0 MLRNNLGNSSDSKNEDGSVFSQTEHNIVATYLIMA 1
2 GMISILSNIIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQ 0
0 VYAGLNIFFGMASIGLLTVVAVDRYLTICLPDI 1
2 GRRMTTNTYIGMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRKNDR 2
1 SFVSYTMTVIAINFIVPLTVMFYCYYHVTLSIKHHATSDCTESLNREWSDQIDVTK 0
0 MSVIMICMFLVAWSPYSIVCLWASFGDPKKIPPPMAIIAPLFAKSSTFYNPCIYVVANKK 2
1 FRRAMLAMFKCQTHQTMPVTSILPMDVSQNPLASGRI* 0

>papHam Papio hamadryas (baboon)
0 MLRNNLGNSSDSKNEDGSVFSQTEHNIVATYLIMA 1
2 GMISILSNIIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQ 0
0 VYAGLNIFFGMASIGLLTVVAVDRYLTICLPDI 1
2 GRRMTTNTYIGMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRKNDR 2
1 SFVSYTMTVIAINFIVPLTVMFYCYYHVTLSIKHHATSDCTESLNREWSDQIDVTK 0
0 MSVIMICMFLVAWSPYSIVCLWASFGDPKKIPPPMAIIAPLFAKSSTFYNPCIYMVANKK 2
1 FRRAMLAMFKCQTHQTMPVTSILPMDVSQNPLASGRI* 0

>calJac Callithrix jacchus (marmoset)
0 MLRNNLGNSSDSKNEDGSVFSQTEHNIVASYLIMA 1
2 GMISILSNIIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQ 0
0 VYAGLNIFFGMASIGLLTVVAADRYLTICLPDI 1
2 GRRMTTSTYIIMILGAWINGLFWALMPIVGWASYAPDPTGATCTINWRKNDR 2
1 SFVSYTMAVIAINFIVPLTVMFYCYYHVTLFIKHHTTSDCTESLNRDWSDQIDVTK 0
0 MSVIMICMFLVAWSPYSIVCLWASFGDPKNIPPAMAIIAPLFAKSSTFYNPCIYVVANKK 2
1 FRRAMLAMLKCQTHQTMPVTSVLPMDISQNPLASGRI* 0

>tarSyr Tarsius syrichta (tarsier)
0 MLKNDLGNSSDSKNEDGSVFSQTEHNIVATYLIMA 1
2 GMISILSNIIVLGIFVKYKELRTPTNAIIINLSVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQ 0
0 IYAGLNIFFGMASIGLLTVVAVDRYLTICRPDI 1
2 GRRMTTNTYVGMILGAWINGLFWASMPIAGWATYAPDPTGATCTINWRKNDA 2
1 TFVSYTMAVIAINFIVPLTVMFYCYYHATQSIKHHVASNCVESLNRDWSDQVDVTK 0
0 2
1 FRRAMFAMLKCQTYQAMPATSSLPMNVSQNPLTSGKN* 0

>otoGar Otolemur garnettii (bushbaby)
0 MLRNNLGNNSDSKNEDGSVFSQTEHNIVATYLIMA 1
2 GMISILSNIIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLHGSWKFGYAGCQ 0
0 IYAGLNIFFGMASIGLLTVVAVDRYLTICRPDI 1
2 GRRMTTNSYIGMILGAWVNGLFWALMPITGWASYAPDPTGATCTINWRKNDA 2
1 SFVSYTMTVIAVNFVVPLMVMFYCYYHVTQSIKRHTATNCTESLNRDWSDQVDVTK 0
0 MSVIMICMFLVAWSPYSIVCLWALFGDPKKIPPSMAIIAPLFAKSSTFYNPCIYVVANKK 2
1 FRRAMFAMFKCQTHQAMAVTSILPMDISQNPLASRRI* 0

>micMur Microcebus murinus (mouse_lemur)
0 1
2 0
0 IYAGLNIFFGMASIGLLTVVAMDRYLTICRPDI 1
2 GRRMTTHTYVGMILGAWVNGLFWAVMPITGWAGYAPDPTGATCTINWRKNDA 2
1 0
0 MSVIMICMFLVAWSPYAIVCLWASFGNPEKIPPSMAIIAPLFAKSSTFYNPCIYVIANKK 2
1 FRRAMFAMFKCQTHQAMPVTSIFPMGVSQNPLPSGRT* 0

>tupBel Tupaia belangeri (treeshrew)
0 MLGSDAGNSSNLGNEDSSAFSQTEHNIVAAYLLTA 1
2 GVISILSNIVVLGIFVTHKELRTPTNAIIINLAFTDIGVSSIGYPMSAASDLHGRWKFGHAGCQ 0
0 IYAGLNIFFGMASIGLLTVVAVDRYLTLCRPAV 1
2 GRRMGSSTYAAMILGAWLNGLFWAAMPIAGWAGYAPDPTGATCTINWRKNDA 2
1 SFVSYTMAVIAVNFVVPLTVMSYCYVLVARAIAGHAASSCSEHRCRDWSEQVDVTK 0
0 MSVLMILMFLVAWSPYSIVCLWASFGDPQRIPPAMAIVAPLFAKSSTFYNPCIYVLANKK 2
1 FRKAMCAMFKCQTHQAMSVTSVLPMASSPRPLAPARV* 0

>musMus Mus musculus (mouse)
0 MLSEASDNSSGSRSE-GSVFSRTEHSVIAAYLIVA 1
2 GITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQ 0
0 IYAGLNIFFGMVSIGLLTVVAMDRYLTISCPDV 1
2 GRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDT 2
1 SFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDWADQADVTK 0
0 MSVIMILMFLLAWSPYSIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKK 2
1 FRKAMLAMFKCQPHLAVPEPSTLPMDMPQSSLAPVRI* 0

>ratNor Rattus norvegicus (rat)
0 MLRDALDNSSGSGSE-GSVFTKSEHSIIAAYLIVA 1
2 GIISILSNIIVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQ 0
0 VYAGLNIFFGMVSIGLLTVVALDRYLTISCPDV 1
2 GRRMTGNTYLSMVLGAWINGLFWALMPIVGWASYAPDPTGATCTINWRKNDT 2
1 SFVSYTMMVIVVNFIVPLTVMFYCYYHVSQSMRLSAASNCTTHLNRDWAHQADVTK 0
0 MSVMMILMFLLAWSPYSVVCLWACFGNPKKIPPSLAIIAPLFAKSSTFYNPCIYVAANKK 2
1 FRKAMFAMLKCQPHQAMPEPSTLAMGVPHSPLAPARI* 0

>speTri Spermophilus tridecemlineatus (ground_squirrel)
0 1
2 0
0 1
2 2
1 SFVSYTMTVIAVNFIVPLTVMFYCYYHVTRSIKHHAASNCTAYLNRDWSDQVDVTK 0
0 MSVIMILMFLVAWSPYSIVCLWASFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAANKR 2
1 FRRAMFAMFKCQTHQAMPVTSVLPMDVSQSPRASGRI* 0

>dipOrd Dipodomys ordii (kangaroo_rat)
0 MLRNNVGNSSGSRNEDGSVFSQTEHNIVATYLITA 1
2 GVISILSNLIVLGIFIKYKELRTPTNAIIINLALTDIGVSSIGYPMSAASDLYGRWKFGYAGCQ 0
0 IYAGLNIFFGMASIGLLTVVAIDRYLTICHPDI 1
2 GRGMTTRTYVTMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRKNDT 2
1 0
0 MSVVMILMFLVAWSPYSIVCLWASFGDPKEIPPPMAIIAPLFAKSSTFYNPCIYVVANKK 2
1 FRRAMLAMLKCQTHQAMPVTSILPMDVSQNPLASGRI* 0

>cavPor Cavia porcellus (guinea_pig)
0 MLRHSLGNSSDSKNEDGSVFSQTEHNIVAAYLILA 1
2 GLISILSNIIVLGIFIKYKELRTPTNAIIMNLALTDIGVSSIGYPMSAASDLHGSWKFGYAGCQ 0
0 VYAGLNIFFGMASIGLLTVVAVDRYLTICRPDI 1
2 GRRMTSHSYVGMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRKNDV 2
1 AFVSYTMTVIAINFIVPLAVMFYCYLHITRAIRRHVAGDRPPNLSGDWSDQVDVTK 0
0 MSVVMILMFLVAWSPYSIVCLWASFGDPRRISPSMAIIAPLFAKSSTFYNPCIYVIANKK 2
1 FRRAMFAMFQCQTHQAVPVASILPMDASQSPLASGRI* 0

>oryCun Oryctolagus cuniculus (rabbit)
0 MLRNNLSNSSDFKHEDGSVFSQTEHNIVATYLILA 1
2 GMISILSNLIVLGIFIKYKELRTPTNAIIINLAFTDIGVSSIGYPMSAASDLHGSWKFGYAGCQ 0
0 IYAGLNIFFGMASIGLLTVVAMDRYLTICHPDV 1
2 GRRMTTRTYLGLILGAWVNGLFWALMPIAGWASYAPDPTGATCTINWRKNDT 2
1 SFVSFTMAVIAINFVVPLTVMFYCYYHVTQSIKQHRASDCTEYLNRDWSDQVDVTK 0
0 MSVIMIFMFLVAWSPYSIVCLWASFGDPKKIPPAMAIIAPLFAKSSTFYNPCIYVAANKR 2
1 FRRAMFAMFKCQTHQAMPVTSVLPMDVSQNPLPSGII* 0

>ochPri Ochotona princeps (pika)
0 MLRHNLGNSSEAKVEAGSVFSQTEHNIVAAYLILA 1
2 GMISILSNLIVLGIFIKYKELRTPTNAIIINLAFTDIGVSSIGYPMSAASDLHGSWKFGYAGCQ 0
0 IYAGLNIFFGMASIGLLTVVAMDRYLTICQPDI 1
2 GRRMTTHTYFGMILGAWINGLFWALMPIVGWASYAPDPTGATCTINWRKNDK 2
1 SFVSFTMAVIMVNFVVPLTVMFYCYYYVTQSIKHHTASDCTKSLNRDWSDQVDVTK 0
0 MSVIMILMFLVAWSPYSIVCLWASFGDPQKIPPSMAIIAPLFAKSSTFYNPCIYVAANKR 2
1 SRRAMFAMFKCQIPQAKPVTSLSPRDVSQSPLSSGRT* 0

>canFam Canis familiaris (dog)
0 MLRNNLDNSTDSKNEDGSVFSQTEHNIVAAYLITA 1
2 GIISIFSNLIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQ 0
0 IYAGLNIFFGMASIGLLTVVAMDRYLTICSPDT 1
2 GRRMTTNTYISMILGAWLNGLFWALMPIIGWASYAPDPTGATCTINWRKNDA 2
1 FFVSFTMTVIAVNFIVPLTVMFYCYYHVTRSIKCHTTSNCTEYLNRDWSDQVDVTK 0
0 MSVIMIFMFLVAWSPYSIVCLWASFGDPKKIPPSMAIIAPLFAKSSTFYNPCIYVVANKK 2
1 FRKAIFAMFKCQTHQAMPGTSILPMDVSQNPLASGRN* 0

>felCat Felis catus (cat)
0 MLRNNLDNSSDSKNEDGSVFSQTEHNIVAAYLITA 1
2 0
0 IYAGLNIFFGMASIGLLTVVAMDRYLTICSPNS 1
2 GRRMTTNTYISMILGAWLNGLFWALMPIIGWASYAPDPTGATCTINWRKNDA 2
1 SFVSFTMTVIAINFNVPLTVMFYCYYHVTQTIKCHDTSNCTGYLNRDWSNQVDVTK 0
0 2
1 FRKAMFAMFKCENRQPMPVTSILPMDVSQNPLTSGRK* 0

>bosTau Bos taurus (cow)
0 MLRNNLGNSSDCKNENGSVFSQTEHNIVAAYLITA 1
2 GVISILSNIIVLGIFIKFKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLHGSWKFGYAGCQ 0
0 IYAGLNIFFGMASIGLLTVVAVDRYLTICHPDA 1
2 GRRMTANTYISMILGAWTNGLFWALMPIIGWASYAPDPTGATCTINWRKNDV 2
1 SFVSYTMMVVAINFIVPLTVMFYCYYHVTQSIKHHGTNNCTEYLNRDWSDQVDVTK 0
0 MSVIMILMFLVAWSPYSIVCLWASFGDPKKIPPSMAIIAPLFAKSSTFYNPCIYVIANKK 2
1 FRRAMLAMFKCQTTQAMPVTSVLPMDVPQNPLTSGKV* 0

>turTru Tursiops truncatus (dolphin)
0 MLRNNLGNSSDSKNEDGSTFSQTEHNIVAAYLITA 1
2 GMISVLSNIIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLHGSWKFGYAGCQ 0
0 IYAGLNIFFGMASIGLLTVVAVDRYLTICCPGA 1
2 GRRMTTNTYISMILGAWFNGLFWALMPIVGWASYAPDPTGATCTINWRKNDV 2
1 SFVSYTMMVVAINFIVPLIMMFYCYYHVTRSIKHHATSNCTEYLNRDWSDQVDVTK 0
0 MSVIMILMFLVAWSPYSIVCLWASFGDPKKIPPSVAILAPLFAKSSTFYNPCIYVIANKK 2
1 FRRAMLAMFKCQTHQAMPMESILPMDVPQNPLTSGKV* 0

>susScr Sus scrofa (pig)
0 MLMDLGNNSDSKNEDGSVFSQTEHSIVAAYLITA 1
2 GMISILSNIVVLGIFIKHKELRTPTNAIIINLAATDIGVSSIGYPMSAASDLHGSWKFGYAGCQ 0
0 IYAGLNIFFGMASIGLLTVVAVDRYLTICRPEA 1
2 GRRMTTNTYISMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRKNDV 2
1 SFVSYTMTVVAVNFIVPLIVMFYCYYHVTQSIKSHATSNCTAYLNRDWSDQVDVTK 0
0 MSVIMILMFLVAWSPYSIVCLWASFGDPKKIPPPMAIIAPLFAKSSTFYNPCIYVIANKK 2
1 FRRAMLAMFKCQTHQAMPLESTLPMDVPQNPLASGRV* 0

>vicVic Vicugna vicugna (vicugna)
0 MLRNNLGNSSDSKNEYGSVFSQAEHNIVAAYLITA 1
2 LRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQ 0
0 IYAGLNIFFGMASIGLLTVVAMDRYLTICRPDA 1
2 GRRMTTNTYISMILGAWINGLFWASVPIIGWAGYAPDPTGATCTINWRQNDV 2
1 SFVSYTMMVVAINFIVPLIVMFYCYYHVTRSIKCRATSNCTEYLNRDWSDQVDVTK 0
0 MSVIMILMFLLAWSPYSIVCLWASFGDPKKIPPSMAIIAPLFAKSSTFYNPCIYVIANKK 2
1 FRRAMLAMFKCQTHQAMPMTSILPMDVPQNPLTSGRL* 0

>equCab Equus caballus (horse)
0 MLRNNLGNSSDSKNEDGSVFSQTEHNIVAAYLIMA 1
2 GMISILSNIIVLGIFVKYKELRTSTNAIIINLAVTDIGVSSIGYPMSAASDLYGRWKFGYAGCQ 0
0 IYAGLNIFFGMASIGLLTVVALDRYLTTCRPDA 1
2 GRRMTTSTYTSMILGAWVNGLFWALMPIVGWANYAPDPTGATCTINWRKNDA 2
1 SFVSYTMAVVAINFIVPLTVMFYCYYHVTRSMKRHPTSNCTQYLNTDWSDQVDVTK 0
0 MSVIMIFMFLVAWSPYSIVCLWASFGDPKKIPPSMAIIAPLFAKSSTFYNPCIYVVANKK 2
1 FRRAMFAMFKCQTHRAMPVTSILPMDVPQNQLASGRI* 0

>myoLuc Myotis lucifugus (microbat)
0 MLKNNLSNSSDFKNEDGSVFSQTEHNIVATYLIMA 1
2 GMISILSNVIVLGIFITYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLHGSWKFGYAGCQ 0
0 1
2 GRKMTTHTYISMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRKNDV 2
1 SFVSFTMTVIAINFIVPLTVMFYCYYHVTRSIKCRATSNCTEYLNRDWADQVDVTK 0
0 MSVIMIFMFLVAWSPYSIVCLWASFGDPKKIPPSMAIIAPLFAKSSTFYNPCIYVVANKK 2
1 FRRAMFAMFKCQTHQTMTTMSFLPMDVPQNPLTSGRI* 0

>pteVam Pteropus vampyrus (macrobat)
0 MLRNNLGNSSNSKNEDGSVFSQTEHNIVATYLIIA 1
2 GMISILSNIIVLGIFFKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQ 0
0 1
2 GRRMTTNTYIIMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRKNDA 2
1 SFVSFTMTVIAINFIVPLAVMFYCYYHVTRSIKCHTTSNCTEYLNRDWSDQVDVTK 0
0 MSVIMIFMFLVAWSPYSIVCLWASFGDPKKIPPSMAIIAPLFAKSSTFYNPCIYVVANKK 2
1 FRRAMFAMFKCQDHQSMPVTSVLPMDVPQNPLTSGRI* 0

>sorAra Sorex araneus (shrew)
0 MLENRSDNSSGPTPEGGAVLSRTEHRLVAAYLIVA 1
2 GVISILSNTAVLGIFIKYKELRTRTNAIIMNLALTDIGVSSIGYPMSAASDLHGSWRFGHAGCQ 0
0 VYAGLNIFFGMASIGLLTLVAVDRYLTLCRPDA 1
2 GRSMTTNSYVGLILGAWINGFFWALMPILGWASYAPDPMGATCTINWRGNDV 2
1 SFVSYTMTVVAVNFVMPLTVMAYCYYHVIRSL-----HSSPGHLDGDWSSQVDVTK 0
0 MSVVMILAFLAAWSPYSIVCFWASFGDPKKIPPSMAVIAPLFAKSSTFYNPCIYVVANKK 2
1 FRRAMSAMLTCRAQGAMPAASTLPMDAAHSPQASGRN* 0

>eriEur Erinaceus europaeus (hedgehog)
0 MLENNLGNGSDSENEDGSVFSQTEHNIVAAYLIVA 1
2 0
0 IYAGLNIFFGMASIGLLTVVAVDRYLTICRPHT 1
2 GRSMSANSYIAMILGAWLNGLFWALMPISGWAGYAPDPTGATCTINWRENDG 2
1 SFVSYTMTVIAINFMVPLAVMLYCYYHVTRSMKCHTARSCAEYVHGDWSDQVDVTK 0
0 MSVIMILMFLVAWSPYSVVCLWASFGDPKKIPPSMAIMAPLFAKSSTFYNPCIYVLANKK 2
1 FRRAMFAMFKCQTHQAMPVTNTLPMDIPQK* 0LDSRRN* 0

>loxAfr Loxodonta africana (elephant)
0 MLRNSLDNSSDSKNEDASVFSQTEHNIVATYLIMA 1
2 GMISILSNIIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLHGRWKFGYTGCQ 0
0 IYAGLNIFFGMASIGLLTVVAVDRYLTICHPHI 1
2 GRRMTSNTYVSMILGAWINGLLWALLPITGWASYAPDPTGATCTINWRKNDA 2
1 SFVSYTMTVIVINFVVPLAVMFYCYYHVTRSIKRHTASNCAEYLNRDWSDQLDVTK 0
0 MSVIMILMFLVAWSPYSIVCLWASFGDSKKIPPSMAIIAPLFAKSSTFYNPCIYVVANKK 2
1 FRRAMFAMFKCQTHQAEPVTCILPMNVSQNPLAAGRI* 0

>proCap Procavia capensis (hyrax)
0 MLRNNLGNSSDSKNEEGSVFSQTEHNIVAAYLIMA 1
2 0
0 IYAGLNIFFGMSSIGLLTVVAIDRYLTICHPNV 1
2 2
1 SFVSYTVTVIMVNFVVPLAVMFYCYYHITLSIKCHAARNCAEPLCRDWSDQLDVTK 0
0 MSVIMILMFLMAWSPYSIVCLWASFGDPTKIPPSMAIIAPLFAKSSTFYNPCIYVVANKK 2
1 FRRAMLAMFKCQTHQAVPVTNILPMTVSQNSSASGRI* 0

>echTel Echinops telfairi (tenrec)
0 MLKNNEGTSSGSHSEEGSVFSQAEHRIVASYLITA 1
2 GMISILSNFIVLGIFIKYKELRTPTNAMIINLAVTDIGVSSIGYPMSAASDLHGSWKFGYAGCQ 0
0 VYAGLNIFFGMASIGLLTAVAVDRYLTICHPDR 1
2 GRRMTSNTYVGMILGAWINGFLWALLPVIGWASYAPDPTGATCTINWRENDA 2
1 SFVSYTMTVVGINFVVPLAVMFYCYYHVTQTIKRQTASNGAENLHRDWSDQLDVTK 0
0 2
1 FRRAMFALLQCQPQEARRVTSILPMNVSQNPMASGRL* 0

>dasNov Dasypus novemcinctus (armadillo)
0 MLRNNTGNSSDSKDEDGSVFSQTEHNIVATYLIMA 1
2 GIISIFSNIIVLSIFIKYKELRTPTNTIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQ 0
0 IYAGLNIFFGMTSIGLLTVVAMDRYLTICRPDT 1
2 GRRMTINTYISMILGAWINGLFWALMPIAGWASYAPDPTGATCTINWRKNNI 2
1 SFVSYTMTVVAINFLVPLAVMLYCYYHVTRSIKHHTKSNCSEYFNRDWSNQVDVTK 0
0 MSVIMISMFLVAWSPYSIVCLWASFGDPEKIPPSMAIIAPLFAKSSTFYNPCIYVVANKK 2
1 FRRAIFAMLKCQTHQAMPVMSILPMNVSENPLASGRI* 0

>choHof Choloepus hoffmanni (sloth)
0 1
2 GIISILSNIVVLGIFIKYKELRTPTNTVIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQ 0
0 IYAGLNIFFGMASIGLLTVVAVDRYLTICHPDV 1
2 GRRMTINTYISMILGAWINGLFWALLPVTGWASYAPDPTGATCTINWRKNDG 2
1 SFVSYTMTVVVINFVVPVAVMFYCYYHITRSIKRRNSSNCSEYLNRDWSDQVDVTK 0
0 MSVIMILMFLLAWSPYSIVCLWASFGDPKKIPPSMAIIAPLFAKSSTFYNPCIYVVANKK 2
1 FRTIMFAMLKCQTHQAVPVTSILPMNVSENPLASGRI* 0

>macEug Macropus eugenii (wallaby)
0 MFQNDSLEPEKESYSVFSPTEHNIVAAYLITA 1
2 GVISIPSNIIVLGIFVKYKELRTATNTIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQ 0
0 IYAGLNIFFGMASIGLLTAVAIDRYLTICQPDL 1
2 2
1 SFVSYTMTVIAINFVMPLVVMFYCYYNVSLKMKQYTRSSCPEHINRDWSNQVDVTK 0
0 MSVIMILMFLLAWSPYSVVCLWASFGDPKEIPPAMAIIAPLFAKSSTFYNPCIYVAANKK 2
1 FRRAISAMMRCETHQSMPVSNALPLNLT* 0

>monDom Monodelphis domestica (opossum)
0 MFKNNSVKTLAPEKEGPSVFSPIEHKIVAAYLITA 1
2 GVISIVSNVIVLGIFVKYKALRTATNTIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYDGCQ 0
0 IYAGLNIFFGMASIGLLTAVAIDRYLTICQPDL 1
2 GGRMTSYNYTLMILTAWVNGFFWALMPIVGWAGYAPDPTGATCTINWRKNDV 2
1 SFVSYTMTVITINFAMPLGVMFYCYYNVSQKMKQYSPSNCPDHINRDWSNQVAVTK 0
0 MSVVMILMFLLAWSPYSIVCLWASFGDPKEIPPAMAIVAPLFAKSSTFYNPCIYVAANKK 2
1 FRRAISAMIRCQTHQSMPISNALPMN* 0

>ornAna Ornithorhynchus anatinus (platypus)
0 MRRNDSANLLESEHHDRSAFSQTDHNIVAAYLITA 1
2 GIMSIVSNVIVLGIFVKFEELRTATNAIIINLAVTDIGVSGIGYPMSAASDLHGSWKFGHAGCQ 0
0 IYAGLNIFFGMSSIGLLTVVAVDRYLTICRPAI 1
2 GRKMTRSNYTAMILAAWMNGFFWASMPLLGWASYASDPTGATCTINWRKNDA 2
1 SFISYTMTVIAVNFAVPLIVMFYCYYNVSKAMRQYPASRVLENLNIDWSEQVDVTK 0
0 MSVVMILMFLMAWSPYSIVCLWSSFGDPKKISPAVAIMAPLFAKSSTFYNPCIYVVANKK 2
1 FRRAMLSMVQCQTHREITITDVLPMNRSRSPLTL* 0

>galGal Gallus gallus (chicken)
0 MHWNDSANSSESDAEAHSVFTQTEHNIVAAYLITA 1
2 GVISIFSNIVVLGIFVKYKELRTATNAIIINLAFTDIGVSGIGYPMSAASDLHGSWKFGYTGCQ 0
0 IYAALNIFFGMASIGLLTVVAVDRYLTICRPDI 1
2 GRRMTTRNYAALILAAWINAVFWASMPTVGWAGYASDPTGATCTANWRKNDV 2
1 SFVSYTMSVIAVNFVVPLTVMFYCYYNVSRTMKQYTSSNCLESINMDWSDQVDVTK 0
0 MSVVMIVMFLVAWSPYSIVCLWSSFGDPKKISPAMAIIAPLFAKSSTFYNPCIYVIANKK 2
1 FRRAILAMVRCQTRQEITISNALPMTVSLSALTS* 0

>taeGut Taeniopygia guttata (finch)
0 MHWNDSSNSSESDDEAHSAFTQTEHNIVAAYLITA 1
2 GVISIFSNIVVLGIFVKYKELRTATNAIIINLAFTDIGVSGIGYPMSAASDLHGSWKFGYTGCQ 0
0 IYAALNIFFGMASIGLLTVVAVDRYLTICRPDI 1
2 GRRMTTRSYATLILAAWINAVFWSSMPTAGWASYAPDPTGATCTVNWRKNDA 2
1 SFISYTMSVIAVNFVVPLTVMFYCYYNVSRTMKQYASSNCLESINIDWSDQVDVTK 0
0 MSVVMIIMFLVAWSPYSIVCLWSSFGDPKKISPAMAIIAPLFAKSSTFYNPCIYVIANKK 2
1 FRRAILAMVRCQTRQEITINNALPMSVSQSALTSQNSSHLPA* 0

>anoCar Anolis carolinensis (lizard)
0 MFLNDSANSSESDDEPHSAFSQAEHNIVAAYLITA 1
2 GVISLLSNIVVLGIFVKYKELRTATNAIIINLAFTDIGVSGIGYPMSAASDLHGSWKFGYTGCQ 0
0 IYAALNIFFGMASIGLLTVVAIDRYLTICKPHI 1
2 GSRLTATNYTTLILAAWINALFWASMPVVGWASYAPDPTGATCTVNWRKNDT 2
1 SFVSYTMSVIAVNFVIPLSVMFYCYYNVSKTMKYYMRNSCLENINIDWSDQVDVTK 0
0 MSVVMIIMFLLAWSPYSIVCLWSSFGDPKKISPAMAIVAPLFAKSSTFYNPCIYVIANKR 2
1 FRRAILAMIRCQTRQEITINNVLPMSVSQSTIA* 0

>xenTro Xenopus tropicalis (frog)
0 METLAEVSTLLPAGTGTVNISDASSEVHSVFSQSEHNIVAAYLITA 1
2 GVISILSNIIVLGIFVKYKELRTATNAIIINLAFTDIGVSGIGYPMSAASDLHGSWKFGYVGCQ 0
0 IYAGLNIFFGMASIGLLTVVAIDRYLTICRPDI 1
2 GRRISGRHYTAMILAAWINAVFWSVMPVVGWSSYAPDPTGATCTINWRKNDV 2
1 SFVSYTMSVVAVNFVVPLMVMFYCYYNVSRTMKGYGSRSSLGGINADWSDQTDVTK 0
0 MSMVMIVMFLVAWSPYSIVCLWSSFGDPRKIPPAMAIIAPLFAKSSTFYNPCIYVIANKK 2
1 FRRAILSMVQCKSRQEVTLDNHFPMNVSQSTLTT* 0

>danRer Danio rerio (zebrafish)
0 MESGLLNVSAETVYGEKSAFTQTEHNIVAAYLITA 1
2 GVISLSSNIVVLLMFVKFRELRTATNAIIINLAFTDIGVAGIGYPMSAASDLHGSWKFGYMGCQ 0
0 IYAALNIFFGMASIGLLTVVAIDRYLTICRPDI 1
2 GQKLTTRSYTLLIVAAWLNAVFWSSMPIVGWAGYAPDPTGATCTINWRNNDT 2
1 SFVSYTMTVITVNFIIPLSVMFYCYYNVSATVKRFKASNCLDSINMDWSDQMDVTK 0
0 MSVIMIVMFLAAWSPYSIVCLWASFGDPQKIPAPMAIIAPLLAKSSTFYNPCIYVIANKK 2
1 FRRAIIGMIRCQTRQRVTINNQLPMMASSVPLNP* 0

>takRub Takifugu rubripes (fugu)
0 MKVFSLVNISNEVEGKSVFTQWEHNIVAGYLIIA 1
2 GVISLTSNIVVLLMFVKFKELRTATNFIIINLAFTDIGVAGIGYPMSAASDIHGSWKFGHTGCQ 0
0 IYAALNIFFGMASIGLLTVVAIDRYITICRPDI 1
2 GRKMTVQSYNLLILAAWLNAVFWSSMPVVGWAAYAPDPTGATCTINWRQNNA 2
1 SFISYTMAVIGVNFMLPLFVMFYCYYNVSVTVNRCKTSNCLDDINIEWSEQMDVTK 0
0 MSLVMIIMFLVAWSPYSIVCLWASFGDPKAIPAPMAIIAPLFAKSSTFYNPCIYVIANKK 2
1 FRRAIIGMIRCQTRQQMTINTEIPMTTSQQTATQ* 0

>tetNig Tetraodon nigroviridis (pufferfish)
0 MKSVNSSNDVEGKSAFTQWEHNIVAGYLITA 1
2 GIISLTSNIVVLLMFVKFKELRTATNFIIINLAFTDIGVAGIGYPMSAASDIHGSWKFGHTGCQ 0
0 IYAALNIFFGMASIGLLTVVAIDRYLTICRPDI 1
2 GRKMTVQSYNLLIAAAWLNAVFWSSMPVVGWAAYAPDPTGATCTINWRQNNV 2
1 SFISYTMAVISVNFILPLFVMFYCYYNVSVTVKQYKANNCLDNINIEWSEQMDVTK 0
0 MSIVMIIMFLVAWSPYSIVCLWASFGDPKTISAPMAIIAPLFAKSSTFYNPCIYVITNKK 2
1 FRQAIIGMIRCQTRQQITINTDIPMTASQQTLTQ* 0

>gasAcu Gasterosteus aculeatus (stickleback)
0 MGIDPEVNVTDDVTLYGGKSAFTQLEHNIVAGYLITA 1
2 GVISLFSNIVVLLMFWKFKELRTATNFIIINLAFTDIGVAGIGYPMSAASDIHGSWKFGYAGCQ 0
0 IYAALNIFFGMASIGLLTVVAIDRYLTICRPDI 1
2 GQKMTMQSYNLLILAAWLNAVFWSSMPVVGWASYAPDPTGATCTINWRQNDV 2
1 SFISYTMAVIAVNFVLPLSAMFYCYYNVSATVKRYKASNCLDSANIDWSDQMDVTK 0
0 MSIVMIIMFLVAWSPYSIVCLWASFGDPKTIPAPMAIIAPLFAKSSTFYNPCIYVIANKK 2
1 FRRAIIGMVRCQTRQRITINSQVPMTTSQQPLTQ* 0

>oryLat Oryzias latipes (medaka)
0 DSAVNVSDAAAPYGGKSAFTQLEHNIVAGYLITA 1
2 GVISLSSNVLVLLMFVKFRELRTATNIIIINLAFTDVGVAGIGYPMSAASDIHGSWKFGYTGCQ 0
0 IYAALNIFFGMASIGLLTVVAIDRYLTICRPDL 1
2 GQKMTMQSYNLLILAAWLNAVFWSSMPIVGWAGYAPDPTGATCTINWRQNDA 2
1 SFVSYTMAVIAVNFVVPLTVMFYCYYNVSATVKRYKASNCLDSINIDWSDQMDVTK 0
0 MSIVMIVMFLVAWSPYSMVCLWASFGDPKTIPAPMAIIAPLFAKSSTFYNPCIYVIANKK 2
1 FRRAIIGMIRCQTRQRITISTQVPMTISQQPLTQ* 0

>calMil Callorhinchus milii (elephantfish)
0 1
2 0
0 1
2 2
1 LFVSYTMTVIAVNFVVPLSVMFFCYYNVSKTMSRFISSPSPENINLDWSDQLDVTK 0
0 MSVVMIVMFLLAWSPYSIVCLWASFGNPKLIPPAMAIIAPLFAKSSTFYNPCIYVIANKK 2
1 FRKAIMAMICCQNRQEITINHTLPMTISRVPLTE* 0