PRDM11: giant missing exon: Difference between revisions

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(Created page with "=== PRDM11 reference sequences === The reference sequence for the human gene PRDM11 is wrong in two respects: translating a segment of 5'UTR and running out into a stop codon ra...")
 
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=== PRDM11 reference sequences ===
=== PRDM11 reference sequences ===


The reference sequence for the human gene PRDM11 is wrong in two respects: translating a segment of 5'UTR and running out into a stop codon rather than splicing to the large terminal exon:
The reference sequence for the human gene PRDM11 appears to be wrong in two respects: translating a segment of 5'UTR and running out into a stop codon rather than splicing to the large terminal exon. This gene model is not pursued further here for lack of comparative genomics and because the omitted exon contains two domains presumably vital to a role for PRDM11 in regulation of gene transcription.


  >PRDM11_homSap Homo sapiens (human) original refSeq 511 aa <font color=magenta>model not supported</font> <font color=#00CC66>PhosS</font> <font color=blue>3RAY coverage</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font>
  >PRDM11_homSap Homo sapiens (human) original refSeq 511 aa <font color=magenta>model not supported</font> <font color=#00CC66>PhosS</font> <font color=blue>3RAY coverage</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font>
Line 12: Line 12:
  2 GEKRLQREKSEQVLDNPEDLRGPIHLSVLRQGK</font>SPYKRGFDEGDVHPQAKKKKIDLIFKDVLEASLESAKVEAHQLALSTSLVIRKVPKYQDDAYSQCATTMTHGVQNIGQTQGEGDWKVPQGVSKEPGQLEDEEEEPSSFKADSPAEASLASDPHELPTTSFCPNCIRLKKKVRELQAELDMLKSGKLPEPPVLPPQVLELPEFSDP<font color=magenta>AGKLVWMRLLSEGRVRSGLCGG* 0</font>
  2 GEKRLQREKSEQVLDNPEDLRGPIHLSVLRQGK</font>SPYKRGFDEGDVHPQAKKKKIDLIFKDVLEASLESAKVEAHQLALSTSLVIRKVPKYQDDAYSQCATTMTHGVQNIGQTQGEGDWKVPQGVSKEPGQLEDEEEEPSSFKADSPAEASLASDPHELPTTSFCPNCIRLKKKVRELQAELDMLKSGKLPEPPVLPPQVLELPEFSDP<font color=magenta>AGKLVWMRLLSEGRVRSGLCGG* 0</font>


The sequences below use a gene model of human PRDM11 consistent with transcript data and vertebrate comparative genomics. The coding regions consists of seven exons and 1233 total amino acids, including the second largest exon in the entire proteome (722 amino acids). An early serine is post-translationally modified to phosphoserine (according to its UniProt entry [http://www.uniprot.org/uniprot/Q9NQV5 Q9NQV5]). There are four domains conserved in all species: an early zinc knuckle, a PR(SET) methylation domain, a ZNF_TTF transcription factor zinc finger and a distal hATC dimerization domain. All species containing the gene have these four domains and the same introns. However, it cannot be traced back earlier than rayfinned fish.
The sequences below use a gene model of human PRDM11 consistent with transcript data and vertebrate comparative genomics. The coding regions consists of seven exons and 1233 total amino acids, including the second largest exon in the entire proteome (722 amino acids). An early serine is post-translationally modified to phosphoserine (according to its UniProt entry [http://www.uniprot.org/uniprot/Q9NQV5 Q9NQV5]). There are four domains conserved in all species: an early zinc knuckle, a PR(SET) methylation domain, a ZNF_TTF transcription factor zinc finger and a distal hATC dimerization domain. All species containing the gene have these four domains and the same introns. While much older than PRDM7/9, PRDM11 cannot be traced back earlier than rayfinned fish and may have arisen in stem bony vertebrates though chondrichthyian data is admittedly meagre. Fish sequences are showing major signs of divergence in early exons and are also highly variable in the sixth exon. The PR(SET) domain of PRDM11 is the most closely related such domain found in non-mammalian amniotes (which lack and never had PRDM7/9).
   
   
  >PRDM11_homSap Homo sapiens (human) corrected 511+722 aa <font color=blue>3RAY coverage</font> <font color=#00CC66>PhosS</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font> no early zinc finger or terminal array syn PFM8 related ZNF 862
  >PRDM11_homSap Homo sapiens (human) corrected 511+722 aa <font color=#00CC66>PhosS</font> <font color=blue>3RAY coverage</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font> no early zinc finger or terminal array syn PFM8 related ZNF 862
  0 MTENMKECLAQTNAAVGDMVTVVKTEVC<font color=#00CC66>S</font>PLRDQEYGQPC 2
  0 MTENMKECLAQTNAAVGDMVTVVKTEVC<font color=#00CC66>S</font>PLRDQEYGQPC 2
  1 SRRPD<font color=blue>SSAMEVEPKKLKGKRDLIVPKSFQQVDF</font><font color=#FFBB66>W 1
  1 SRRPD<font color=blue>SSAMEVEPKKLKGKRDLIVPKSFQQVDF</font><font color=#FFBB66>W 1
Line 28: Line 28:
  IIQVLKVLPTSTACCEKGRNALQRVRKNHRSRLTLEQLSDLLTIAVN</font>GPPITNFDAKRALDSWFEEKSGNSYALSAEVLSRMSALEQKPALQTMDHGTEFYPDI* 0
  IIQVLKVLPTSTACCEKGRNALQRVRKNHRSRLTLEQLSDLLTIAVN</font>GPPITNFDAKRALDSWFEEKSGNSYALSAEVLSRMSALEQKPALQTMDHGTEFYPDI* 0
   
   
  >PRDM11_musMus Mus musculus (mouse) blat <font color=blue>3RAY coverage</font> <font color=#00CC66>PhosS</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>  
  >PRDM11_musMus Mus musculus (mouse) blat <font color=#00CC66>PhosS</font> <font color=blue>3RAY coverage</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>  
  0 MTENMKECLAHTKAAVGDMVTVVKTEVCSPLRDQEYGQPC 2
  0 MTENMKECLAHTKAAVGDMVTVVKTEVCSPLRDQEYGQPC 2
  1 SRRLEPSSMEVEPKKLKGKRDLIVTKSFQQVDFW 1
  1 SRRLEPSSMEVEPKKLKGKRDLIVTKSFQQVDFW 1
Line 42: Line 42:
  IIQVLKVLPTSTACCEKGRSALQRVRKNHRSRLTLEQLSDLLTIAVNGPPIANFDAKRALDSWFEEKSGNSYTLSAEVLSRMSALEQKPMLHVVDHGSEFYPDM* 0
  IIQVLKVLPTSTACCEKGRSALQRVRKNHRSRLTLEQLSDLLTIAVNGPPIANFDAKRALDSWFEEKSGNSYTLSAEVLSRMSALEQKPMLHVVDHGSEFYPDM* 0
   
   
  >PRDM11_canFam Canis familiaris (dog) blat <font color=blue>3RAY coverage</font> <font color=#00CC66>PhosS</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>
  >PRDM11_canFam Canis familiaris (dog) blat <font color=#00CC66>PhosS</font> <font color=blue>3RAY coverage</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>
  0 MTENMKECLAQTKAAVGDMVTVVKTEVYSPLRDQEYGQPC 2
  0 MTENMKECLAQTKAAVGDMVTVVKTEVYSPLRDQEYGQPC 2
  1 SRRPDPSTMEVEPKKLKGKRELIMPKSFQQVDFW 1
  1 SRRPDPSTMEVEPKKLKGKRELIMPKSFQQVDFW 1
Line 56: Line 56:
  IIQVLKVLPTSTACCEKGRNALQRVRKNHRSRLTLEQLSDLLTIAVNGPPIANFDAKRALDSWFEEKSGNSYALSAEVLSRMSALEQKPVLQTVDHGSEFYPDI* 0
  IIQVLKVLPTSTACCEKGRNALQRVRKNHRSRLTLEQLSDLLTIAVNGPPIANFDAKRALDSWFEEKSGNSYALSAEVLSRMSALEQKPVLQTVDHGSEFYPDI* 0
   
   
  >PRDM11_loxAfr Loxodonta africana (elephant) blat <font color=blue>3RAY coverage</font> <font color=#00CC66>PhosS</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>
  >PRDM11_loxAfr Loxodonta africana (elephant) blat <font color=#00CC66>PhosS</font> <font color=blue>3RAY coverage</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>
  0 MTENMKECLAKTKAAVGDMVPVVKTEVCSPLHDQEYGQPC 2
  0 MTENMKECLAKTKAAVGDMVPVVKTEVCSPLHDQEYGQPC 2
  1 SRRPDPSAMDVEPKKLKGKRDLIMPKSFQQVDFW 1
  1 SRRPDPSAMDVEPKKLKGKRDLIMPKSFQQVDFW 1
Line 70: Line 70:
  IIQILKVLPTSTVCCEKGRNALQRVRKNHRSRLTLEQLSDLLTIAVNGPPIANFDAKRALDSWFEEKSGHSYTLSAEVLSRMSALEQKPVLQAIDHGTEFYPDI* 0
  IIQILKVLPTSTVCCEKGRNALQRVRKNHRSRLTLEQLSDLLTIAVNGPPIANFDAKRALDSWFEEKSGHSYTLSAEVLSRMSALEQKPVLQAIDHGTEFYPDI* 0
   
   
  >PRDM11_monDom Monodelphis domestica (opossum) blat <font color=blue>3RAY coverage</font> <font color=#00CC66>PhosS</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>
  >PRDM11_monDom Monodelphis domestica (opossum) blat <font color=#00CC66>PhosS</font> <font color=blue>3RAY coverage</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>
  0 MTENLKACLAHTQASMGEMVTVKTEVCSPRRDQEYGQPW 2
  0 MTENLKACLAHTQASMGEMVTVKTEVCSPRRDQEYGQPW 2
  1 SGRPDPPSMEVEPKKPKGKRELIMTKSFQQVDFW 1
  1 SGRPDPPSMEVEPKKPKGKRELIMTKSFQQVDFW 1
Line 84: Line 84:
  IQILKVLPTSTACCEKGRVALQRVRKNNRSRLTLEQLSDLLTIAVNGPPIANFDAKRALDSWFEEKSGNSYTLSAEVLSRMSALDQKPMLPTMDHGSEFYSDL* 0
  IQILKVLPTSTACCEKGRVALQRVRKNNRSRLTLEQLSDLLTIAVNGPPIANFDAKRALDSWFEEKSGNSYTLSAEVLSRMSALDQKPMLPTMDHGSEFYSDL* 0
   
   
  >PRDM11_ornAna Ornithorhynchus anatinus (platypus) blat <font color=blue>3RAY coverage</font> <font color=#00CC66>PhosS</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>
  >PRDM11_ornAna Ornithorhynchus anatinus (platypus) blat <font color=#00CC66>PhosS</font> <font color=blue>3RAY coverage</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>
  0 MTENLKDCLAQTQASMGEMVTV KTEVCSPHRDQEYGQPW 2
  0 MTENLKDCLAQTQASMGEMVTV KTEVCSPHRDQEYGQPW 2
  1 SGRPDPSSMEVEPKKLKGKRDLIMSKSFQQVDFW 1
  1 SGRPDPSSMEVEPKKLKGKRDLIMSKSFQQVDFW 1
Line 98: Line 98:
  VIQILKVLPTSTACCEKGRSALQRVRKNHRSRLTLEQLSDLLTIAVNGPPIAHFDAKRALDSWFEEKSGNSYALSAEVLSRMSSLDQKPMLQSVDHGSEFYPDM* 0
  VIQILKVLPTSTACCEKGRSALQRVRKNHRSRLTLEQLSDLLTIAVNGPPIAHFDAKRALDSWFEEKSGNSYALSAEVLSRMSSLDQKPMLQSVDHGSEFYPDM* 0
   
   
  >PRDM11_allMis Alligator mississippiensis (alligator) scaffold:58581 <font color=blue>3RAY coverage</font> <font color=#00CC66>PhosS</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>  
  >PRDM11_allMis Alligator mississippiensis (alligator) scaffold:58581 <font color=#00CC66>PhosS</font> <font color=blue>3RAY coverage</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>  
  0 MSENLKDCLIQTQTSLGEMVTIKTEACSPHRDQEYGQPC 2
  0 MSENLKDCLIQTQTSLGEMVTIKTEAC<font color=#00CC66>S</font>PHRDQEYGQPC 2
  1 SGRPDPQSMEIEPKKLKGKRDLIMTKSFQQVDFW 1
  1 SGR<font color=blue>PDPQSMEIEPKKLKGKRDLIMTKSFQQVDF</font><font color=#FFBB66>W 1
  2 FCESCQEYFVDECPNHGPPVFVSDTPVPVGIPDRASLTIPPGMEVVKEPNGENDVRCMNEVIPKGHIFGPYEGQISSQDKSAGFFSWL 0
  2 FCESCQEYFVDECPN</font><font color=blue>HGPPVFVSDTPVPVGIPDRASLTIP</font><font color=red>PGMEVVKEPNGENDVRCMNEVIPKGHIFGPYEGQISSQDKSAGFFSWL 0
  0 IVDKNNRYKSIDGTDETKANWMR 2
  0 IVDKNNRYKSIDGTDETKANWMR 2
  1 YVIISREEREQNLMAFQHSERIYFRTCRDIRPGERLRVWYSEDYMKRLHSMSQETINRNLTR 1
  1 YVIISREEREQNLMAFQHSERIYFRTCRDIRPGERLRVWYSEDYMKR</font><font color=blue>LHSMSQETINRNLTR 1
  2 GDKKSQREKSEKNMENQEDMRGPLQLTTLKQGKSPYKRSCEEAESHPQTKKKKIDLIFKDVLEASLESAKLEEHQLTTSTPLSIRKASKYQTEDVFERCGTTIQHSSPNLSRNRSEGEWKVPHSSSFSTAKEMGLLEDEEEEPLSLKADSPTEPSLASTQGNSHEIPTTSFCPNCIRLKKKIRELQAELDMLRSGKLPEQPALAPQVPELQEFSDPT 1
  2 GDKKSQREKSEKNMENQEDMRGPLQLTTLKQGK</font>SPYKRSCEEAESHPQTKKKKIDLIFKDVLEASLESAKLEEHQLTTSTPLSIRKASKYQTEDVFERCGTTIQHSSPNLSRNRSEGEWKVPHSSSFSTAKEMGLLEDEEEEPLSLKADSPTEPSLASTQGNSHEIPTTSFCPNCIRLKKKIRELQAELDMLRSGKLPEQPALAPQVPELQEFSDPT 1
  2 ASESIISVPTIMEDDDQEVDSADESVSNDMIAATDEPSKMSSVTGRRIRRFKQEWLKKFWFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
  2 ASESIISVPTIMEDDDQEVDSADESVSNDMIAATDEPSKMSSVTGR<font color=#990099>RIRRFKQEWLKKFWFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM</font>
  CRNMTLLFNTAYHLALEGRPYYDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFSTTDSYLQALDRAF
  CRNMTLLFNTAYHLALEGRPYYDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFSTTDSYLQALDRAF
  SSLGIRLQDEKPTIGLGVDGANITASLRANLFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPKLMCELRVTAATLCEETEFLGDIRAVKWIIGEQN
  SSLGIRLQDEKPTIGLGVDGANITASLRANLFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPKLMCELRVTAATLCEETEFLGDIRAVKWIIGEQN
  VLNALIKDYLEVVAHLKDVSGQTQRADASAIALALLQFLMDYQSIKLIYFLLDVIAVLSRLAYVFQGEYLLVSQVDDKIEEAIQEISRLADSPGEYLQEFEENFRESFNGIAVKNLRVAE
  VLNALIKDYLEVVAHLKDVSGQTQRADASAIALALLQFLMDYQSIKLIYFLLDVIAVLSRLAYVFQGEYLLVSQVDDKIEEAIQEISRLADSPGEYLQEFEENFRESFNGIAVKNLRVAE
  AKFQSIREKICQKTQVILAQRFDSRSRTFVKACQVFDLAAWPRSTEELMSYGKEDMVQIFEHLETVPSFSREVCREGMDIRGSLLMEWRELKVDYYTKNGFKDLLGHICKYKQRFPLLNK
  AKFQSIREKICQKTQVILAQRFDSRSRTFVKACQVFDLAAWPRSTEELMSYGKEDMVQIFEHLETVPS<font color=brown>FSREVCREGMDIRGSLLMEWRELKVDYYTKNGFKDLLGHICKYKQRFPLLNK
  IVQILKVLPTSSACCEKGRNALQRVRKNNRSRLTLEQLSDLLTIAVNGPAIANFDCKRALDSWFEEKSGNSYALSAEMLSRMSSLDQKPMLQSMDHGSEFYPDI* 0
  IVQILKVLPTSSACCEKGRNALQRVRKNNRSRLTLEQLSDLLTIAVN</font>GPAIANFDCKRALDSWFEEKSGNSYALSAEMLSRMSSLDQKPMLQSMDHGSEFYPDI* 0
   
   
  >PRDM11_galGal Gallus gallus XM_421099 <font color=blue>3RAY coverage</font> <font color=#00CC66>PhosS</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>  
  >PRDM11_galGal Gallus gallus XM_421099 <font color=#00CC66>PhosS</font> <font color=blue>3RAY coverage</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>  
  0 MSENLKDCLNQTQASLGEMVTIKTEACSPHRDQEYGQPC 2
  0 MSENLKDCLNQTQASLGEMVTIKTEACSPHRDQEYGQPC 2
  1 SGRLDPQSMDVEPKKLKGKRDLIMTKSFQQVDFW 1
  1 SGRLDPQSMDVEPKKLKGKRDLIMTKSFQQVDFW 1
Line 126: Line 126:
  IVQILKVLPTSSACCEKGRNALQRVRKNNRSRLTLEQLSDLLTIAVNGPPIANFDCKRALDSWFEEKSGNSYALSAEMLSRMSSLDQKPMLQSVDHGSEFYPDI* 0
  IVQILKVLPTSSACCEKGRNALQRVRKNNRSRLTLEQLSDLLTIAVNGPPIANFDCKRALDSWFEEKSGNSYALSAEMLSRMSSLDQKPMLQSVDHGSEFYPDI* 0
   
   
  >PRDM11_melGal Meleagris gallopavo (turkey) blat/XM_003206406 <font color=blue>3RAY coverage</font> <font color=#00CC66>PhosS</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>  
  >PRDM11_melGal Meleagris gallopavo (turkey) blat/XM_003206406 <font color=#00CC66>PhosS</font> <font color=blue>3RAY coverage</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>  
  0 MSENLKDCLNQTQASLGEMVTIKTEACSPHQDQEYGQPC 2
  0 MSENLKDCLNQTQASLGEMVTIKTEACSPHQDQEYGQPC 2
  1 SGRPDPQSMDVEPKKLKGKRDLIMTKSFQQVDFW 1
  1 SGRPDPQSMDVEPKKLKGKRDLIMTKSFQQVDFW 1
Line 140: Line 140:
  IVQILKVLPTSSACCEKGRNALQRVRKNNRSrlTLEQLSDLLTIAVNGPPIANFDCKRALDSWFEEKSGNSYALSAEMLSRMSSLDQKPMLQSVDHGSEFYPDi* 0
  IVQILKVLPTSSACCEKGRNALQRVRKNNRSrlTLEQLSDLLTIAVNGPPIANFDCKRALDSWFEEKSGNSYALSAEMLSRMSSLDQKPMLQSVDHGSEFYPDi* 0
   
   
  >PRDM11_anaPla Anas platyrhynchos (duck) blast/HQ902403 <font color=blue>3RAY coverage</font> <font color=#00CC66>PhosS</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>  
  >PRDM11_anaPla Anas platyrhynchos (duck) blast/HQ902403 <font color=#00CC66>PhosS</font> <font color=blue>3RAY coverage</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>  
  0 MSENLKDCLNQTQASLGEMVTIKTEACSPHRDQEYGQPc 2
  0 MSENLKDCLNQTQASLGEMVTIKTEACSPHRDQEYGQPc 2
  1 SGRPDPQSMDVEPKKLKGKRDLIVTKSFQQVDFW 1
  1 SGRPDPQSMDVEPKKLKGKRDLIVTKSFQQVDFW 1
Line 154: Line 154:
  IVQILKVLPTSSACCEKGRNALQRVRKNNRSRLTLEQLSDLLTIAVNGPPIANFDCKRALDSWFEEKSGNSYALSAEMLSRMSSLDQKPMLQSMDHGSEFYPDI* 0
  IVQILKVLPTSSACCEKGRNALQRVRKNNRSRLTLEQLSDLLTIAVNGPPIANFDCKRALDSWFEEKSGNSYALSAEMLSRMSSLDQKPMLQSMDHGSEFYPDI* 0
   
   
  >PRDM11_taeGut Taeniopygia guttata (finch) XM_002199814 <font color=blue>3RAY coverage</font> <font color=#00CC66>PhosS</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>  
  >PRDM11_taeGut Taeniopygia guttata (finch) XM_002199814 <font color=#00CC66>PhosS</font> <font color=blue>3RAY coverage</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>  
  0 MSENLRDCLIQTQASLREMVTIKTEACSPHRDQEYGQPC 2
  0 MSENLRDCLIQTQASLREMVTIKTEACSPHRDQEYGQPC 2
  1 SGRPDPQSMEMEPKKLKGKRDVIMTKSFQQVDFW 1
  1 SGRPDPQSMEMEPKKLKGKRDVIMTKSFQQVDFW 1
Line 168: Line 168:
  IVQILKVLPTSSACCEKGRSALQRVRKNNRSRLTLEQLSDLLTIAVNGPPIANFDCKRALDSWFEEKSGNSYALSAEMLSRMSSLDQKPMLQSMDHGSEFYPDI* 0
  IVQILKVLPTSSACCEKGRSALQRVRKNNRSRLTLEQLSDLLTIAVNGPPIANFDCKRALDSWFEEKSGNSYALSAEMLSRMSSLDQKPMLQSMDHGSEFYPDI* 0
   
   
  >PRDM11_anoCar Anolis carolinensis (lizard) blat/XM_003214639 <font color=blue>3RAY coverage</font> <font color=#00CC66>PhosS</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>  
  >PRDM11_anoCar Anolis carolinensis (lizard) blat/XM_003214639 <font color=#00CC66>PhosS</font> <font color=blue>3RAY coverage</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>  
  0 MSEKLNDCLGEMVTIKTEPCSPCREEEYGQLW 2
  0 MSEKLNDCLGEMVTIKTEPCSPCREEEYGQLW 2
  1 SSRKVDSQSVDVEPKKLKGKQDLIMSKSFQQVDFW 1
  1 SSRKVDSQSVDVEPKKLKGKQDLIMSKSFQQVDFW 1
Line 183: Line 183:
  IIQILKVLPTSTACCEKGRNALQRVRKNNRSRLTLEQLSDLLTIAVNGPPIANFEAKRALDSWFEEKSSNSYALSAEMLSRMSSLDHKPMLQSMDHGSEFYPDI* 0
  IIQILKVLPTSTACCEKGRNALQRVRKNNRSRLTLEQLSDLLTIAVNGPPIANFEAKRALDSWFEEKSSNSYALSAEMLSRMSSLDHKPMLQSMDHGSEFYPDI* 0
   
   
  >PRDM11_xenTro Xenopus tropicalis (frog) blat/CF781198 <font color=blue>3RAY coverage</font> <font color=#00CC66>PhosS</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>  
  >PRDM11_xenTro Xenopus tropicalis (frog) blat/CF781198 <font color=#00CC66>PhosS</font> <font color=blue>3RAY coverage</font> <font color=#FFBB66>knuckle</font> <font color=red>SET</font> <font color=#990099>ZnF_TTF</font> <font color=brown>hATC_dimerization</font>  
  1 MSEISKECRVAFSPSLGDIVRVKREVGSPVEEQGYGHFR 2
  1 MSEISKECRVAFSPSLGDIVRVKREVGSPVEEQGYGHFR 2
  1 SSVGPNSRCLDMEPKRLKEKRESTMSKSLQQVDFW 1
  1 SSVGPNSRCLDMEPKRLKEKRESTMSKSLQQVDFW 1
Line 238: Line 238:
  RIVQVIRVLPSSTACCDKGRGSLQKMCKNNRSRLTLEQMNDLLTVAINGPPIANFDGKRALDSWFEEKSGSSYSLSAEVLNRMSAADQKCVLHSVDVNAEFYPDV* 0
  RIVQVIRVLPSSTACCDKGRGSLQKMCKNNRSRLTLEQMNDLLTVAINGPPIANFDGKRALDSWFEEKSGSSYSLSAEVLNRMSAADQKCVLHSVDVNAEFYPDV* 0


PRDM11 fragmentary sequences from the unrecognized terminal exon were utilized in a Dec 2011 study to determine the topology of the amniote tree, notably to resolve the taxonomic position of turtles (outgroup to crocodillians + birds). Because that study sequenced some rarely studied species such as skink, salamander, caecilian and amphibia, the sequences are reproduced here and supplemented with the appropriate region of the full length sequences PRDM11 above (which were largely not used in the study). The fragment begins within the ZNF_TTF zinc finger and terminates well before the end of the exon.
PRDM11 fragmentary sequences from the unrecognized terminal exon were utilized in a [http://www.ncbi.nlm.nih.gov/pubmed/21680872 Dec 2011 study] by XX Shen et al of informative loci to determine the topology of the amniote tree, resolving the taxonomic position of turtles: outgroup to crocodillians + birds. Because that study sequenced species poorly represented at GenBank such as skink, salamander, caecilian and amphibia, translated sequences are reproduced here and supplemented with the appropriate region of the full length sequences PRDM11 above (which were not all used in the study). The fragment studied begins 16 residues within the ZNF_TTF zinc finger and terminates well before the end of the exon. The difference alignment shows a number of group synapomorphies consistent with turtle placement (though one gene alone does not suffice to reliably determine the species tree).


  >PRDM11_homSap Homo sapiens (human) revised 511+722 aa  
  >PRDM11_homSap Homo sapiens (human) revised 511+722 aa  

Revision as of 19:05, 11 December 2011

PRDM11 reference sequences

The reference sequence for the human gene PRDM11 appears to be wrong in two respects: translating a segment of 5'UTR and running out into a stop codon rather than splicing to the large terminal exon. This gene model is not pursued further here for lack of comparative genomics and because the omitted exon contains two domains presumably vital to a role for PRDM11 in regulation of gene transcription. 

>PRDM11_homSap Homo sapiens (human) original refSeq 511 aa model not supported PhosS 3RAY coverage knuckle SET
0 MLKMAEPIASLMIVECRACLRCSPLFLYQREK 0
0 DRMTENMKECLAQTNAAVGDMVTVVKTEVCSPLRDQEYGQPC 2
1 SRRPDSSAMEVEPKKLKGKRDLIVPKSFQQVDFW 1
2 FCESCQEYFVDECPNHGPPVFVSDTPVPVGIPDRAALTIPQGMEVVKDTSGESDVRCVNEVIPKGHIFGPYEGQISTQDKSAGFFSWL 0
0 IVDKNNRYKSIDGSDETKANWMR 2
1 YVVISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYMKRLHSMSQETIHRNLAR 1
2 GEKRLQREKSEQVLDNPEDLRGPIHLSVLRQGKSPYKRGFDEGDVHPQAKKKKIDLIFKDVLEASLESAKVEAHQLALSTSLVIRKVPKYQDDAYSQCATTMTHGVQNIGQTQGEGDWKVPQGVSKEPGQLEDEEEEPSSFKADSPAEASLASDPHELPTTSFCPNCIRLKKKVRELQAELDMLKSGKLPEPPVLPPQVLELPEFSDPAGKLVWMRLLSEGRVRSGLCGG* 0

The sequences below use a gene model of human PRDM11 consistent with transcript data and vertebrate comparative genomics. The coding regions consists of seven exons and 1233 total amino acids, including the second largest exon in the entire proteome (722 amino acids). An early serine is post-translationally modified to phosphoserine (according to its UniProt entry Q9NQV5). There are four domains conserved in all species: an early zinc knuckle, a PR(SET) methylation domain, a ZNF_TTF transcription factor zinc finger and a distal hATC dimerization domain. All species containing the gene have these four domains and the same introns. While much older than PRDM7/9, PRDM11 cannot be traced back earlier than rayfinned fish and may have arisen in stem bony vertebrates though chondrichthyian data is admittedly meagre. Fish sequences are showing major signs of divergence in early exons and are also highly variable in the sixth exon. The PR(SET) domain of PRDM11 is the most closely related such domain found in non-mammalian amniotes (which lack and never had PRDM7/9). 

>PRDM11_homSap Homo sapiens (human) corrected 511+722 aa  PhosS 3RAY coverage knuckle SET ZnF_TTF hATC_dimerization no early zinc finger or terminal array syn PFM8 related ZNF 862
0 MTENMKECLAQTNAAVGDMVTVVKTEVCSPLRDQEYGQPC 2
1 SRRPDSSAMEVEPKKLKGKRDLIVPKSFQQVDFW 1
2 FCESCQEYFVDECPNHGPPVFVSDTPVPVGIPDRAALTIPQGMEVVKDTSGESDVRCVNEVIPKGHIFGPYEGQISTQDKSAGFFSWL 0
0 IVDKNNRYKSIDGSDETKANWMR 2
1 YVVISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYMKRLHSMSQETIHRNLAR 1
2 GEKRLQREKSEQVLDNPEDLRGPIHLSVLRQGKSPYKRGFDEGDVHPQAKKKKIDLIFKDVLEASLESAKVEAHQLALSTSLVIRKVPKYQDDAYSQCATTMTHGVQNIGQTQGEGDWKVPQGVSKEPGQLEDEEEEPSSFKADSPAEASLASDPHELPTTSFCPNCIRLKKKVRELQAELDMLKSGKLPEPPVLPPQVLELPEFSDPA 1
2 ASESMVSGPAIMEDDDQEVDSADESVSNDMMTATDEPSKMSSATGRRIRRFKQEWLKKFWFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYLDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPCLSVILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFSSTESYLQALDRAF
SALGIRLQDEKPTVGLGVDGANITASLRASMFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRSTAATLCEETEFLGDIRAVRWIIGEQN
VLNALIKDYLEVVAHLKEVSSQTQRADASAIALALLQFLMDYQSIKLIYFLLDVIAVLSRLAYIFQGEYLLVSQVDDKIEEAIQEISRLADSPGEYLQEFEENFRESFNGIAMKNLRVAE
AKFQSIREKICQKTQVILAQRFDSRSRIFVKACQVFDLAAWPRSSEELMSYGKEDMVQIFDHLEAIPTFSRDVCREGLDPRGSLLMEWRELKADYYTKNGFKDLISHICKYKQRFPLLNK
IIQVLKVLPTSTACCEKGRNALQRVRKNHRSRLTLEQLSDLLTIAVNGPPITNFDAKRALDSWFEEKSGNSYALSAEVLSRMSALEQKPALQTMDHGTEFYPDI* 0

>PRDM11_musMus Mus musculus (mouse) blat  PhosS 3RAY coverage knuckle SET ZnF_TTF hATC_dimerization 
0 MTENMKECLAHTKAAVGDMVTVVKTEVCSPLRDQEYGQPC 2
1 SRRLEPSSMEVEPKKLKGKRDLIVTKSFQQVDFW 1
2 FCESCQEYFVDECPNHGPPVFVSDTPVPVGIPDRAALTIPQGMEVVKDAGGESDVRCINEVIPKGHIFGPYEGQISTQDKSAGFFSWL 0
0 IVDKNNRYKSIDGSDETKANWMR 2
1 YVVISREEREQNLLAFQHSERIYFRACRDIRPGERLRVWYSEDYMKRLHSMSQETIHRNLAR 1
2 GEKRLQREKAEQALENPEDLRGPTQFPVLKQGRSPYKRSFDEGDIHPQAKKKKIDLIFKDVLEASLESGNVEARQLALSTSLVIRKVPKYQDDDYGRAALTQGICRTPGEGDWKVPQRVAKELGPLEDEEEEPTSFKADSPAEASLASDPHELPTTSFCPNCIRLKKKVRELQAELDMLKSGKLPEPSLLPPQVLELPEFSDPA 1
2 ASESMVSGPAIMEDDDQEVDSADESVSNDVMTATDEPSKMSSATGRRIRRFKQEWLKKFWFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYLDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPCLSIILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFSSTESYLQALDRAF
AALGIRLQDEKPTVGLGVDGANITASLRASMFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRSTASTLCEETEFLGDIRAVRWIIGEQN
VLNALIKDYLEVVAHLKDVSSQTQRADASAIALALLQFLMDYQSMKLIYFLLDVIAVLSRLAYIFQGEYLLVSQVDDKIEEAIQEISRLADSPGEYLQEFEENFRESFNGIAVKNLRVAE
AKFQSIREKICQKTQVILAQRFDSRSRVFVKACQVFDLAAWPRNSEELLSFGKEDMVQIFDHLEAIPAFSRDVCREGTDPRGSLLMEWRDLKADYYTKNGFKDLLSHICKYKQRFPLLNK
IIQVLKVLPTSTACCEKGRSALQRVRKNHRSRLTLEQLSDLLTIAVNGPPIANFDAKRALDSWFEEKSGNSYTLSAEVLSRMSALEQKPMLHVVDHGSEFYPDM* 0

>PRDM11_canFam Canis familiaris (dog) blat  PhosS 3RAY coverage knuckle SET ZnF_TTF hATC_dimerization
0 MTENMKECLAQTKAAVGDMVTVVKTEVYSPLRDQEYGQPC 2
1 SRRPDPSTMEVEPKKLKGKRELIMPKSFQQVDFW 1
2 FCESCQEYFVDECPNHGPPVFVSDTPVPVGIPDRAALTIPQGMEVVKEASGENDVRCINEVIPKGHIFGPYEGQISTQDKSAGFFSWL 0
0 IVDKNNRYKSIDGSDETKANWMR 2
1 YVVISREEREQNLLAFQHSERIYFRACRDIRPGERLRVWYSEDYMKRLHSMSQETIHHNLAR 1
2 GEKRLQREKSEQALDNPEDLRGPIQLPVLRQGKSPYKRGFDEGDAHPQAKKKKIDLIFKDVLEASLESAKVEAHQLALSTSLVIRKVPKYQDDAYSRCAMTMSHGVQNVSRTQGEGDWKIPQGASKEPGPLEDEEEEPSSFKADSPAEASLASDPHELPTTSFCPNCIRLKKKVRELQAELDMLKSGKLPEPPVLPAQVLELPEFSDPA 1
2 ASESMVSGPAIMEDDDQEVDSADESVSNDMLTAADEPSKMSSATGRRIRRFKQEWLKKFWFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYLDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPCLSIILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFSSTESYLQALDRAF
SALGIRLQDEKPTVGLGIDGANVTASLRASMFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRSTASTLCEETEFLGDIRAVRWIIGEQN
VLNALIKDYLEVVAHLKDVSSQTQRADASAIALALLQFLMDYQSIKLIYFLLDVIAVLSRLAYVFQGEYLLVSQVDDKIEEAIQEISRLADSPGEYLQEFEENFRESFNGIAMKNLRVAE
AKFQSVREKICQKTQVILAQRFDSRSRIFVKACQVFDLAAWPRSSEELMSYGKEDMVQIFDHLEAIPTFSRDVCREGLDPRGSLLMEWRELKADYYTKNGFKDLIGHICKYKQRFPLLNK
IIQVLKVLPTSTACCEKGRNALQRVRKNHRSRLTLEQLSDLLTIAVNGPPIANFDAKRALDSWFEEKSGNSYALSAEVLSRMSALEQKPVLQTVDHGSEFYPDI* 0

>PRDM11_loxAfr Loxodonta africana (elephant) blat  PhosS 3RAY coverage knuckle SET ZnF_TTF hATC_dimerization
0 MTENMKECLAKTKAAVGDMVPVVKTEVCSPLHDQEYGQPC 2
1 SRRPDPSAMDVEPKKLKGKRDLIMPKSFQQVDFW 1
2 FCESCQEYFVDECPNHGPPVFVSDTPVPVGIPDRAALTIPQGMEVVKEASGENDVRCISEVIPKGHIFGPYEGQISTQDKSAGFFSWL 0
0 IVDKNNRYKSVDGSDETKANWMR 2
1 YVVISREEREQNLLAFQHSERIYFRVCRDIRPGERLRVWYSQDYMKRLHSMSQETIHRNLAR 1
2 GEKRLQREKSEQALDNPEDLRGSIQLPVLRQGKSPYKRGFDEGDLHPQAKKKKIDLIFKDVLEASLESAKVEAHQLALSTSLVIRKVPKYQDDTYSRCATTMSHGVQNVSRTQGEGDWKIPQGASKEPGPTEDEEEEPSSFKADSPAEASLASDPHELPTTSFCPNCIRLKKKVRELQAELDMLKSGKLPEPPVLPAQVLELPEFSDPA 1
2 ASESMVSGPAIMEDDDQEVDSADESVSNDIMTATDEPSKMSSATGRRIRRFKQEWLKKFWFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYLDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPCLSIILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFSGTESYLQALDRAF
STLGIRLQDEKPTVGLGVDGANITASLRASMFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRSTASTLCEETEFLGDIRAVKWIIGEQN
VLNALIKDYLEVVAHLKDISSQTQRADASAIALALLQFLMDYQSIKLIYFLLDVIAVLSRLAYVFQGEYLLVSQVDDKIEEAIQEISRLADSPGEYLQEFEENFRESFNGIAMKNLRVAE
AKFQSIREKICQKTQVILAQRFDSRSRIFVKACQVFDLAAWPRSSEELVSYGKEDMVQIFDHLEAIPTFSRDVCREGLDPRGSLLMEWRELKADYYTKNGFKDLISHVGKYKQRFPLLNK
IIQILKVLPTSTVCCEKGRNALQRVRKNHRSRLTLEQLSDLLTIAVNGPPIANFDAKRALDSWFEEKSGHSYTLSAEVLSRMSALEQKPVLQAIDHGTEFYPDI* 0

>PRDM11_monDom Monodelphis domestica (opossum) blat  PhosS 3RAY coverage knuckle SET ZnF_TTF hATC_dimerization
0 MTENLKACLAHTQASMGEMVTVKTEVCSPRRDQEYGQPW 2
1 SGRPDPPSMEVEPKKPKGKRELIMTKSFQQVDFW 1
2 FCESCQEYFVDECPNHGPPVFVSDTPVPMGIPDRAALTIPPGMEVVKEASGQSDVRCMNEVIPKGHIFGPYEGQISTQDKSAGFFSWL 0
0 IVDKNNHYKSIDGTDETKANWMR 2
1 YVVISREEREQNLMAFQHSEKIYFRVCRDIRPGERLRVWYSEDYMKRLHSMSQETIQRNLTR 1
2 GDKKLQREKPEKALDHQEDLRGPLQLTVLRHGKSAYKRGFDEVDAHPPPKKKKIDLIFKDVLEASLETSKIEEHPLAPGTPLVLRKAPKFHTEDVYDQCGMAISHGPQDLSRNQGEKEWKAPQGASYGPSKDTSLLEDEEEEPSSFKADSPAEASLASDLHELPTTSFCPNCIRLKKKIRELQAELDMLKSGKLPEPPLLPPQVPELPEFSDPT 1
2 ASESVVSVPTMLEDDDQEVDSADESVSNEMITATDEPSKMSSATGRRIRRFKQEWLKKFWFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYFDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDILADTVAVYVQYTSSDGPPATEFLSLQELGFSTTDSYLQALDRAF
SSLGIRLQDEKPTIGLGVDGANITASLRASMFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRLTASTLCEETEFLGDIRAVRWIIGEQN
VLNALIKDYLEVVAHLKDVSGQTQRADASAIALALLQFLMDYQSIKLIYFLLDVIAVLSRLAYIFQGEYLLVSQVDDKIEEAIQEISRLADSPGEYLQEFEENFRESFNGVAVKNLRVAE
AKFQSIREKICQKTQVILAQRFDSRSRTFVKACQVFDLAAWPRSTEELMSYGKEDMIQIFDHLETIPSFSREICREGMDPRGSLLMEWRELKADYYTKNGFKDLISHICKYKQRFPLLNKI
IQILKVLPTSTACCEKGRVALQRVRKNNRSRLTLEQLSDLLTIAVNGPPIANFDAKRALDSWFEEKSGNSYTLSAEVLSRMSALDQKPMLPTMDHGSEFYSDL* 0

>PRDM11_ornAna Ornithorhynchus anatinus (platypus) blat  PhosS 3RAY coverage knuckle SET ZnF_TTF hATC_dimerization
0 MTENLKDCLAQTQASMGEMVTV KTEVCSPHRDQEYGQPW 2
1 SGRPDPSSMEVEPKKLKGKRDLIMSKSFQQVDFW 1
2 FCESCQEYFVDECPNHGPPVFVSDTPVPVGIPDRAALTIPPGIEVVKEASGENDVRCMNEVIPKGHIFGPYEGQISTQDKSAGFFSWL 0
0 IVDKNNRYKSIDGTDETKANWMR 2
1 YIVISREEREQNLLAFQHSERIYFRVCRDIRPGERLRVWYSEDYMKRLHSMSQETIHRNLTR 1
2 GEKKLLREKTDKAPESQEDLRGPLQLTVLKQGKSPYKRSCDEGDAHPQTKKKKIDLIFKDVLEASLESAKIDEHQLATSTPLAFKKMPKFQAEDVFERCGAILPHGTQSFGRTHSEGDWKLGHGTPYGPSKEKGLLEEDQGEPSPIKVDSPTEASLTGDSQELPTTSFCPNCIRLKKKIRELQAELDMLKSGQLPEPPLVPPQVPELPEFSDPA 1
2 ASESLVSIPTILEDDDPEVDSADESVSNDMIAATDEPSKMSSATGRRIRRFKQEWLKKFWFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYLDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFSTTDSYLQALDRAF
AALGVRLQDEKPTVGLGVDGANVTASLRAGMFMTVRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRLTAATLCEETEFLGDIRAVRWIIGEQN
VLNALIKDYLEVVAHLKDVSGQTQRADASAIALALLQFLMDYQSIKLIYFLLDVIAVLSRLAYVFQGEYLLVSQVDDKIEEAIQEISRLADSPGEYLQEFEENFRESFNGVAVKNLRVAE
AKFQSIREKICQKAQVILAQRFDSRSRTFVKACQVFDLAAWPRSSEELVSYGREDMVQILEHLEAIPSFSREVCREGADPRGALLTEWRELKADYYTKNGFKDLIGHVGKYKQRFPLLNK
VIQILKVLPTSTACCEKGRSALQRVRKNHRSRLTLEQLSDLLTIAVNGPPIAHFDAKRALDSWFEEKSGNSYALSAEVLSRMSSLDQKPMLQSVDHGSEFYPDM* 0

>PRDM11_allMis Alligator mississippiensis (alligator) scaffold:58581 PhosS 3RAY coverage knuckle SET ZnF_TTF hATC_dimerization 
0 MSENLKDCLIQTQTSLGEMVTIKTEACSPHRDQEYGQPC 2
1 SGRPDPQSMEIEPKKLKGKRDLIMTKSFQQVDFW 1
2 FCESCQEYFVDECPNHGPPVFVSDTPVPVGIPDRASLTIPPGMEVVKEPNGENDVRCMNEVIPKGHIFGPYEGQISSQDKSAGFFSWL 0
0 IVDKNNRYKSIDGTDETKANWMR 2
1 YVIISREEREQNLMAFQHSERIYFRTCRDIRPGERLRVWYSEDYMKRLHSMSQETINRNLTR 1
2 GDKKSQREKSEKNMENQEDMRGPLQLTTLKQGKSPYKRSCEEAESHPQTKKKKIDLIFKDVLEASLESAKLEEHQLTTSTPLSIRKASKYQTEDVFERCGTTIQHSSPNLSRNRSEGEWKVPHSSSFSTAKEMGLLEDEEEEPLSLKADSPTEPSLASTQGNSHEIPTTSFCPNCIRLKKKIRELQAELDMLRSGKLPEQPALAPQVPELQEFSDPT 1
2 ASESIISVPTIMEDDDQEVDSADESVSNDMIAATDEPSKMSSVTGRRIRRFKQEWLKKFWFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYYDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFSTTDSYLQALDRAF
SSLGIRLQDEKPTIGLGVDGANITASLRANLFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPKLMCELRVTAATLCEETEFLGDIRAVKWIIGEQN
VLNALIKDYLEVVAHLKDVSGQTQRADASAIALALLQFLMDYQSIKLIYFLLDVIAVLSRLAYVFQGEYLLVSQVDDKIEEAIQEISRLADSPGEYLQEFEENFRESFNGIAVKNLRVAE
AKFQSIREKICQKTQVILAQRFDSRSRTFVKACQVFDLAAWPRSTEELMSYGKEDMVQIFEHLETVPSFSREVCREGMDIRGSLLMEWRELKVDYYTKNGFKDLLGHICKYKQRFPLLNK
IVQILKVLPTSSACCEKGRNALQRVRKNNRSRLTLEQLSDLLTIAVNGPAIANFDCKRALDSWFEEKSGNSYALSAEMLSRMSSLDQKPMLQSMDHGSEFYPDI* 0

>PRDM11_galGal Gallus gallus XM_421099  PhosS 3RAY coverage knuckle SET ZnF_TTF hATC_dimerization 
0 MSENLKDCLNQTQASLGEMVTIKTEACSPHRDQEYGQPC 2
1 SGRLDPQSMDVEPKKLKGKRDLIMTKSFQQVDFW 1
2 FCESCQEYFVDECPNHGPPVFVSDTPVPVGIPDRAALTIPPGIEVVKEPSGENDVRCMNEVIPKGHIFGPYEGQISSQDKSAGFFSWL 0
0 IVDKNNRYKSIDGTDETKANWMR 2
1 YVIISREEREQNLMAFQHSERIYFRACRDIRPGEKLRVWYSEDYMKRLHSMSQETINRNLTT 1
2 GDKKLQKEKSEKNADNQEDTRAPLHFTTLKQGKSPYKRSYDEGESHPQTKKKKIDLIFKDVLEASLESAKFEEKQLATSTPLSTRATSKYQAEEIFERCSSAMQHGSLNLSRNRSEEEWKAPHGSSFSSAKEVGVLEDEEEEPLSLKADSPTELSLASAEGNSHEIPTTSFCPNCIRLKKKIRELQAELDMLRSGKLPEPPVLPPQVPELQEFSDPT 1
2 ASESIISVPTIMEDDDQEVDSADESVSNEMIAATDEPSKMSSATGRRIRRFKQEWLKKFWFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYYDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDVLADTVAVYVQYTSSDGPPATEFLSLQELGFSTTDSYLQALDRAF
SSLGIRLQDEKPTIGLGVDGANITASLRANLFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRVTASTLCEETEFLGDIRAVKWIIGEQN
VLNALIKDYLEVVAHLKDVSGQTQRADASAIALALLQFLMDYQSIKLIYFLLDVIAVLSRLAYVFQGEYLLVSQVDDKIEEAIQEISRLADSPGEYLQEFEENFRESFNGIAVKNLRVAE
AKFQSIREKICQKTQVILAQRFDSRSRTFVKACQVFDLAAWPRSTDELMSYGKEDMVQIFEHLETVPSFSREVCREGMDTQGSLLMEWRELKVDYYTKNGFKDLLSHICKYKQRFPLLNK
IVQILKVLPTSSACCEKGRNALQRVRKNNRSRLTLEQLSDLLTIAVNGPPIANFDCKRALDSWFEEKSGNSYALSAEMLSRMSSLDQKPMLQSVDHGSEFYPDI* 0

>PRDM11_melGal Meleagris gallopavo (turkey) blat/XM_003206406  PhosS 3RAY coverage knuckle SET ZnF_TTF hATC_dimerization 
0 MSENLKDCLNQTQASLGEMVTIKTEACSPHQDQEYGQPC 2
1 SGRPDPQSMDVEPKKLKGKRDLIMTKSFQQVDFW 1
2 FCESCQEYFVDECPNHGPPVFVSDTPVPVGIPDRAALTIPPGIEVVKEPSGENDVRCMNEVIPKGHIFGPYEGQISSQDKSAGFFSWL 0
0 IVDKNNRYKSIDGTDETKANWMR 2
1 YVIISREEREQNLMAFQHSERIYFRACRDIRPGEKLRVWYSEDYMKRLHSMSQETINRNLTT 1
2 GDKKLQKEKSEKNTDNQEDTRGPLQFTMLKQGKSPYKRSYDEGESHPQTKKKKIDLIFKDVLEASLESAKFEEKQLATSTPLSTRATSKYQAEEIFERCSGAMQHLSRNRSEEEWKAPHGSSLSSAKEVGVLEDEEEEPLSLKADSPTELSLASAEGNSHEIPTTSFCPNCIRLKKKIRELQAELDMLRSGKLPEPSVLPPQVPELQEFSDPT 1
2 ASESIISVPTIMEDDDQEVDSADESVSNEMIAATDEPSKMSSATGRRIRRFKQEWLKKFWFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYYDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDVLADTVAVYVQYTSSDGPPATEFLSLQELGFSTTDSYLQALDRAF
SSLGIRLQDEKPTIGLGVDGANITASLRANLFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRVTASTLCEETEFLGDIRAVKWIIGEQN
VLNALIKDYLEVVAHLKDVSGQTQRADASAIALALLQFLMDYQSIKLIYFLLDVIAVLSRLAYVFQGEYLLVSQVDDKIEEAIQEISRLADSPGEYLQEFEENFRESFNGIAVKNLRVAE
AKFQSIREKICQKTQVILAQRFDSRSRTFVKACQVFDLAAWPRSTDELMSYGKEDMVQIFEHLETVPSFSREVCREGMDTQGSLLMEWRELKVDYYTKNGFKDLLSHICKYKQRFPLLNK
IVQILKVLPTSSACCEKGRNALQRVRKNNRSrlTLEQLSDLLTIAVNGPPIANFDCKRALDSWFEEKSGNSYALSAEMLSRMSSLDQKPMLQSVDHGSEFYPDi* 0

>PRDM11_anaPla Anas platyrhynchos (duck) blast/HQ902403  PhosS 3RAY coverage knuckle SET ZnF_TTF hATC_dimerization 
0 MSENLKDCLNQTQASLGEMVTIKTEACSPHRDQEYGQPc 2
1 SGRPDPQSMDVEPKKLKGKRDLIVTKSFQQVDFW 1
2 FCESCQEYFVDECPNHGPPVFVSDTPVPVGIPDRAALTIPPGMEVVKEPSGENDVRCMNEVIPKGHIFGPYEGQISSQDKSAGFFSWL 0
0 IVDKNNRYKSIDGTDETKANWMR 2
1 YVIISREEREQNLMAFQHSERIYFRACRDIRPGEKLRVWYSEDYMKRLHSMSQETINRNLTR 1
2 GDKRLQREKSEKNVENQEDMRGPLQLTTLKQGKSPYKRSCDEGESHPQTKKKKIDLIFKDVLEASLESAKFEENQLATSTPLSIRTASKYQAEDIFERCGTAMQHGSLNLSRNRSEEEWKIPHGSSFSSAKEVGILDDDEEEPLSLKADSPTELSLASAQGNSHEIPTTSFCPNCIRLKKKIRELQAELDMLRSGKLPEPPELPPQVPELQEFSDPT 1
2 ASESIISVPTIMEDDDQEVDSADESVSNDMIAATDEPSKMSSATGRRIRRFKQEWLKKFWFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYYDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDVLADTVAVYVQYTSSDGPPATEFLSLQELGFSTTDSYLQALDRAF
SSLGIRLQDEKPTIGLGVDGANITASLRANLFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRVTAATLCEETEFLGDIRAVKWIIGEQN
VLNALIKDYLEVVAHLKDVSGQTQRADASAIALALLQFLMDYQSIKLIYFLLDVIAVLSRLAYVFQGEYLLVSQVDDKIEEAIQEISRLADSPGEYLQEFEENFRESFNGIAVKNLRVAE
AKFQSIREKICQKTQVILAQRFDSRSRTFVKACQVFDLAAWPRSTDELMSYGKEDMVQIFEHLETVPSFSREVCREGMDTRGSLLMEWRELKVDYYTKNGFKDLLSHICKYKQRFPLLNK
IVQILKVLPTSSACCEKGRNALQRVRKNNRSRLTLEQLSDLLTIAVNGPPIANFDCKRALDSWFEEKSGNSYALSAEMLSRMSSLDQKPMLQSMDHGSEFYPDI* 0

>PRDM11_taeGut Taeniopygia guttata (finch) XM_002199814  PhosS 3RAY coverage knuckle SET ZnF_TTF hATC_dimerization 
0 MSENLRDCLIQTQASLREMVTIKTEACSPHRDQEYGQPC 2
1 SGRPDPQSMEMEPKKLKGKRDVIMTKSFQQVDFW 1
2 FCESCQEYFVDECPNHGPPVFVSDTPVPVGIPDRAALTIPPGMEVVKEPSGENDVRCMNEVIPKGHIFGPYEGQISSQDRSAGFFSWL 0
0 IVDKNNRYKSIDGTDETKANWMR 2
1 YVIISREEREQNLMAFQHSERIYFRACRDIHPGEKLRVWYSEDYMKRLHSMSQETMNRSFTS 1
2 GDKMLQNENSEKNVENQEDARGALQFTTLKQGKSPYKRSCDEGESHPQTKKKKIDLIFKDVLEASLESAKFEENQLATSTPLSLRRASKYQAEDIFEQCGNAMQRSSLSLSRNQSESEWRVPHSSSFISAKEMSILEDEEEEPLSLKADSPTELSLASAQGNSHEIPSTSFCPNCIRLKKKIRELQAELDMLRSGKLPEAPVLPPQVPELQEFSDPT 1
2 ASESIISVPTIMEDDDQEVDSADESVSNDMIAATDEPSKMSSATGRRIRRFKQEWLKKFWFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYYDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFSTTDSYLQALDRAF
SSLGIRLQDEKPTIGLGVDGANITASLRANLFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRVTAATLCEETEFLGDIRAVKWIIGEQN
VLNALIKDYLEVVAHLKDVSGQTQRADASAIALALLQFLMDYQSIKLIYFLLDVIAVLSRLAYVFQGEYLLVSQVDDKIEEAIQEISRLADSPGEYLQEFEENFRESFNGIAVKNLRVAE
AKFQSIREKICQKTQVILAQRFDSRSRTFVKACQVFDLAAWPRSTDELMSYGKEDMVQIFEHLETVPSFSREVCREGMDTRGSLLMEWRELKVDYYTKNGFKDLLSHICKYKQRFPLLNK
IVQILKVLPTSSACCEKGRSALQRVRKNNRSRLTLEQLSDLLTIAVNGPPIANFDCKRALDSWFEEKSGNSYALSAEMLSRMSSLDQKPMLQSMDHGSEFYPDI* 0

>PRDM11_anoCar Anolis carolinensis (lizard) blat/XM_003214639  PhosS 3RAY coverage knuckle SET ZnF_TTF hATC_dimerization 
0 MSEKLNDCLGEMVTIKTEPCSPCREEEYGQLW 2
1 SSRKVDSQSVDVEPKKLKGKQDLIMSKSFQQVDFW 1
2 FCESCQEYFVDECPNHGPPMFLSDAPVPIGIPDRAALTVPPGMEVVKEANGERDVRCVGEIIPKGRIYGPYEGKLSSQDKSAGFFSWL 0
0 IVDKNNRYKSIDGTDETTSNWMR 2
1 YVAISREEREQNLMAFQHSERIYFRTCRDIRPGERLRVWYSEDYMKRLHSMSQETINRNLTR 1
2 GDKKSLRERSERNTENQMEMLYPLELTISKQGKSPYKRCSEEGVSQPQAKKKKIDLIFKDVLEASLESTKMEEHKVTRNSAPSTRKSSRFREQDASESCGTGMQHNSPTHSGSRN
EDEWKVPHGPSFSVSKETGLLEDEGEEPLSFKLNSPTDLTLAPIDDEALGLPTTSLCPNCIRLKKKIRELQAELNMLRSGKLVEPPLLPPQVPEYQAFSYPT 1
2 ASETIMSVPTIMEDDDQEVDSADESVSNDMITATDEPSKMSAVTRRIRRFKQEWLKKFWFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYRLRMHPEKTEEM
CRNMTLLFNTAYHLAMEGRPYCDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERVRQSPFLSIILDGQSDDLLADTVAVYVQYISSDGPPATEFLSLQELGFSATDSYIQALDRAF
SSLGIRLQDERPSVGLGIDGANITASLRANMYMTIRKTLPWLLCLPLMIHKPHLEVLDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRVTAATLCEETEFLGDIRAVKWIIGEQN
VLNALIKDYLEVVAHLKDVSGQTQRADASAIALALLQFLMDYQSIKLIYFLLDVIAVLSRLAFIFQGEYLLVSQVDDKIEEAIQEISRLADSPGEYLQEFEENFRESFNGVAVKNLRVAE
AKFQSIREKICQKTQVILAQRFEPRTRAFVKACQVFDLAMWPRSAEELMSYGREDMVQIFDHLEAVPTFSTDIIREGMDTRGSLLMEWRELKVDYYTKNGFKDLISHICKYRQRFPLLNK
IIQILKVLPTSTACCEKGRNALQRVRKNNRSRLTLEQLSDLLTIAVNGPPIANFEAKRALDSWFEEKSSNSYALSAEMLSRMSSLDHKPMLQSMDHGSEFYPDI* 0

>PRDM11_xenTro Xenopus tropicalis (frog) blat/CF781198  PhosS 3RAY coverage knuckle SET ZnF_TTF hATC_dimerization 
1 MSEISKECRVAFSPSLGDIVRVKREVGSPVEEQGYGHFR 2
1 SSVGPNSRCLDMEPKRLKEKRESTMSKSLQQVDFW 1
2 FCESCQEYFVDECPSHGPPILVPDTLVPIGMPERAALSVPCGIEVVKDSSGESEVRCVNEVIPKGHMFGPYEGQICSQDKSSGFFSWL 0
0 IVDNNNRYKSIDGTDEAYANWMR 2
1 YVVISREEREQNLMAFQHSEKIYFRTCRDIQPGEKLRVWYSEDYMKRLHSMSQETINRNLTQ 1
2 GDKRLLRENNERLLENQEDVKGTFPLATLKQGKSLYKRSCEEVDLHPQTKKKKIDLIFKDVLEASLETARIDEYHLVTSSPLSGQKKNPKYLYENHGDRCRMNRQCSSPQNQIRNMRDWKAKHVSASGLNRQASFPEDEVEDHSSVKAESPTESSAIGNVDEIPTTSFCPNCIRLKKKIRELQAELEMLRSEKMAETSQMTNQINEIPEFADAS 1
2 APEGVAIATTMIDDDEQEVDSADESVSNDMMAATDEPSKMSAGSGRRIRRFKQEWLKKFWFLRYSSTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLAMEGRPYYDFRPLAELLRKCELRVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSEDLLADTVAVYVQYTSSDGPPATEFLSLQELGLPTTESYLQGIDRAF
SALGIRLQDERPTVGLGVDGANITAGLRANLYMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRLTAATLCEETEFLGDIRAVKWIIGEQN
VLNALIKDYLEVVAHLKDVSGQTQRADTSAIALALLQFLMDYQSIKLIYFLLDVIAVLSRLAYVFQGEYLLVSQVDEKVEEAIQEISRLTDSPGEYLQEFEENFRESFNGIALKNLRVAE
AKFQSIREKICQKTQVTLAQRFDSRSRMFVKACQVFDLSTWPRTTEELINYGEEDMLQIYELLETIPNFLHDLGREVADTRGNLLMEWRELKADYCTKNGFKDLIGHICKYKQRFLFLNK
IVQILKVLPTSTACCEKGRNALQRLRKNNRSRLTLDQMSDLLAIAVNGAPIANFDAKRALDSWFEEKSGNSYSLSAEMLSKMSSLDQKPLLQPMEHGSEYYQDI* 0

>PRDM11_latCha Latimeria chalumnae (coelocanth) AFYH01005054 3RAY coverage knuckle SET ZnF_TTF hATC_dimerization
1 2
1 STGAAETPRIEGEPKRTKGKLETIMAKTLQQVDFW 1
2 FCEECQEHFVVECPTHGPPVFTMDTPVPVGMPERAALTAPPGIHIVKGSNGEIDVECVDEVVQKGRIFGPYEGQITTQDKSAGFFSWL 0
0 IVDKNNRYKSIDGTDETKANWMR 2
1 YVVISRDEREQNLLAFQHSEKIYFRASRNLHPGERLRVWYSDEYMKRLHSMSQETIDRNLTA 1
2 GNLKLQRENSEEGWDAQENLRGMLLKQGKSSYKRGNDEAESHQQPKRKKIDLIFKDVLEASLESSKLEGNSLATSSPLPLKKPIKFQLEDVLQKPEYYYKHVSQLLGRGEVEWKSHQKSGCSLPDNEDSDRIKEESPDEVPGNSTEEDPEDVPTTSFCPNCIRLKKKIRELQEELDRLRSGQPPASPQLPQVQELLEPPG 
2 VQEAHPSVSLMEDDDQEVDSADESVSNDMIAASDETSKITVGASRRIRRFKQEWLKKFWFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTVLFNTAYHLALEGRPYLDFRPLSDLLRKCELKVVDQYMNEGDCQILIHHIARALQEDLIERIRQSPFLSVILDGQTDDILADTVAVYIQYTTSDGPPATEFLSLQELGCVTTDSYVQAVDRAF
AVFGLRLQDQRNVVGLGVDGTCLTAGLRANLFMTIRKTLPWLLCLPFMVHKPHLEVLDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRVTAATLCEETEFLGDIRAVKWIIGEQN
VLNALIKDYLEVVAHLKDVSGQTQRADAAAIALALLQFLMDYQSIKLIYFLLDVIAVLSRLAFVFQGEYLLVCQVDDKIEEAIQEISRLSDSPGEYLMEFEENFRESFNGIALKNLRVAE
AKFQSIREKICQKTQVILAQRFDNRSRPFIKACQMLDIATWPRSTDDLKNFGEEEIMVIYEQLELVPTFAREVCREGTDNRGSLVMEWRELKADFYSKNGFKDLIGHICKYRQRFPILNR
VLQILKVLPSSAACCEKGRSALQRIRKNNRSRLTLDQLNDLLTIAINGPSIANFDAKRALDSWFEEKSGNSYALSAEVLNRMSADQKPMLQGMDFVSDFYPDI* 0

>PRDM11_danRef Danio rerio (zebrafish) blat/EB776339/EB946706/BX088562/XM_688756 3RAY coverage knuckle SET ZnF_TTF hATC_dimerization
0 MADSSTNPDHSSMEAEGECSTS 2
1 ASNEKSAEEPNKRLKVEHERYSSFW 1
2 FCEECKKYYLEDCPTHGPPVFVPDTPVVSGVPNRAALTAPSGIEVRRNGDKVDVYCMDEKIPKGALFGPYKGQIMASDKPSGPYSWM 0
0 IVDKDSKYKFIDGSDEATANWMR 2
1 FIHITSDESEQNLSAFQHGDQIYFRVCHRLKVGEKLGVWYSSEYMKRLQSVSRDSIDHNLDT 1
2 GVKSEDQEEPKGPVLRSAMHGRRTLSKHGSDEAENQPQAKKKKIDLIFKDVLEASLEANQSQNNPLNSTLSFPRARTNVCQVFCHPDAESKESVFTSGLVSMDHHEIGFDGKCIKMENTEEDEALTSEGPSTSFCPNCVRLKRRIRELEAELHRLRGQGHAEVKPVPASEMLAGEDHR 1
2 DTMTPIPAALEEDDQDVDSADESISADLLVAADESSKLSVGSGRRIRRFKQEWLKKFWFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMMTLLNAAYHLALEGRPFSDLRPLAELLKKCDLKVVDQYMNENDCQILIQHISRAFKEDLAEKIRLSPFLSIIMDGQNDDLLADMVAVYVQFTTTDGLPATEFLSLQRLCGGNVEGYLQAVDRAF
GVLGLRLQDMLVVGLGIDGSNISSSLRANLYVAIRKTIPWVLCLPVMIHRPHLEVLDAISGKELSCLEDLENNLKQLLSFYRYSPRLMAELRSSAPTLSEETEFLGDIRAVRWIIGEPN
VLNALIKDYLEVVAHLKTISNQTQRGDAAAIALSLLQFLLDYQSVKLIYFLLDVIAVFSRLAFIFQGDYLLVSQVDAKIEDAIHEIGQLVDSPGEYLQEFEDNFRESFNGVDLKNLRVAE
SKFQSIREKICQQSQCILAQRFEPRSRTVVQACQVLDLASWPINRDDLGAYGEEEILVIFDHLETIPSSGRERSIERTDARGSLVVEWRDLKADYCSVNGFKEVVSHIFRYKQRYPLLN
HILQIVRVLPTSTTCCDKGRGSLQKVRRNSRSRLTLDQINDLLTLAVNGPPIGSFDGKRALDSWFEEKSGNSISLSTEVLSRMSTTEQKSVLHNMDMNAEYYPDV* 0

>PRDM11_oreNil Oreochromis niloticus (tilapia) XM_003458287 first exons uncertain
0 MASENCRQIASCLQIEAEKAWRRSEPGRALC 1
2 fCEECQDCFHKECPSHGPPLFIQDTHAAPGTANRAALTVPSGLEVFSEEDEVDVRCVDAIYPKGALFGPYEGELVSKDRSSGFFSWI 0
0 IVDVNNTYQSIDGSDETKANWMR 2
1 YVRTSSEESDRNLTAFQHGKNIYFRVCRALVAGEKLRVWYSDDYIRRLHCVSQESIDRNLDT 1
2 GPGKDFKSRCLQSALQGKLSKQLSEESDGQPPAKRKKIDLIFKDVLEASLEESGKFRSRSGQPSEYKVPALVSRFDSSETGFGIPNLKVEEKEEEENQNTEKPSTSFCPNCVKLKRRILELEEELSRLRGEQRDAAASATSEQTQPQRDQAPPHPEQGPIEDFQ 1
2 GMEPLTPTQVVLDEDDQDVDSADESIAADLVISPEDSSKLSSGGGRRIRRFKQEWLKKFWFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CKNMMLLFNAAYHLALEGRPFSDLRSLAELLKKCELKVVDQYMNEGDCQILIHHIARAVKEDLAEKMRLSPFLSVIMDAQNDDLFSDMVAVYVQFVTNEGSPNTEFLSLQRLTVANVDGYLQVMDRAF
GVLGLRFQDLLVVGLGVDGTNISSGMRANLYIAVQKTFPWILCLPIMIHRPHLEVLDAISGKELSCLEDLENNLKQLLSFYRYSPRMMAELRSTAPTLSEETEFLGDIRAIRWIIGEPN
VLNALIKDYLEVVAHLKEISSQTQRADAAAIALTLLQFLMDYQSVKLIYFLLDIIAILSRLAFTFQGEYLLVSQVEAKIEEAIQEIGQLVDCPGEYLQEFEENFRESFNGVALKNLRVAE
SKFQSIREKICNRSQSILSQRLDLQSRSFAKACKVLDLSTWPSNHEDLQAYGDEEIKIIFNHLESIPTAAQEGSQTEARGSLVVEWKDLKADYYSMNGFKEVIGHICRYKQRFPLLN
RIVQVIRVLPSSTACCDKGRGSLQKMCKNNRSRLTLEQMNDLLTVAINGPPIANFDGKRALDSWFEEKSGSSYSLSAEVLNRMSAADQKCVLHSVDVNAEFYPDV* 0

PRDM11 fragmentary sequences from the unrecognized terminal exon were utilized in a Dec 2011 study by XX Shen et al of informative loci to determine the topology of the amniote tree, resolving the taxonomic position of turtles: outgroup to crocodillians + birds. Because that study sequenced species poorly represented at GenBank such as skink, salamander, caecilian and amphibia, translated sequences are reproduced here and supplemented with the appropriate region of the full length sequences PRDM11 above (which were not all used in the study). The fragment studied begins 16 residues within the ZNF_TTF zinc finger and terminates well before the end of the exon. The difference alignment shows a number of group synapomorphies consistent with turtle placement (though one gene alone does not suffice to reliably determine the species tree). 

>PRDM11_homSap Homo sapiens (human) revised 511+722 aa 
WFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYLDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPCLSVILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFSSTESYLQALDRAF
SALGIRLQDEKPTVGLGVDGANITASLRASMFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRSTAATLCEETEFLGDIRAVRW

>PRDM11_musMus Mus musculus (mouse) blat 
WFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYLDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPCLSIILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFSSTESYLQALDRAF
AALGIRLQDEKPTVGLGVDGANITASLRASMFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRSTASTLCEETEFLGDIRAVRW

>PRDM11_canFam Canis familiaris (dog) blat 
WFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYLDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPCLSIILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFSSTESYLQALDRAF
SALGIRLQDEKPTVGLGIDGANVTASLRASMFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRSTASTLCEETEFLGDIRAVRW

>PRDM11_loxAfr Loxodonta africana (elephant) blat 
WFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYLDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPCLSIILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFSGTESYLQALDRAF
STLGIRLQDEKPTVGLGVDGANITASLRASMFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRSTASTLCEETEFLGDIRAVKW

>PRDM11_monDom Monodelphis domestica (opossum) blat 
WFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYFDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDILADTVAVYVQYTSSDGPPATEFLSLQELGFSTTDSYLQALDRAF
SSLGIRLQDEKPTIGLGVDGANITASLRASMFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRLTASTLCEETEFLGDIRAVR

>PRDM11_ornAna Ornithorhynchus anatinus (platypus) blat 
WFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYLDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFSTTDSYLQALDRAF
AALGVRLQDEKPTVGLGVDGANVTASLRAGMFMTVRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRLTAATLCEETEFLGDIRAVRW

>PRDM11_galGal Gallus gallus XM_421099 
WFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYYDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDVLADTVAVYVQYTSSDGPPATEFLSLQELGFSTTDSYLQALDRAF
SSLGIRLQDEKPTIGLGVDGANITASLRANLFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRVTASTLCEETEFLGDIRAVKW

>PRDM11_melGal Meleagris gallopavo (turkey) blat/XM_003206406 
WFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYYDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDVLADTVAVYVQYTSSDGPPATEFLSLQELGFSTTDSYLQALDRAF
SSLGIRLQDEKPTIGLGVDGANITASLRANLFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRVTASTLCEETEFLGDIRAVKW

>PRDM11_anaPla Anas platyrhynchos (duck) blast/HQ902403 
WFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYYDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDVLADTVAVYVQYTSSDGPPATEFLSLQELGFSTTDSYLQALDRAF
SSLGIRLQDEKPTIGLGVDGANITASLRANLFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRVTAATLCEETEFLGDIRAVKW

>PRDM11_taeGut Taeniopygia guttata (finch) XM_002199814 
WFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYYDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFSTTDSYLQALDRAF
SSLGIRLQDEKPTIGLGVDGANITASLRANLFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRVTAATLCEETEFLGDIRAVKW

>PRDM11_strCam Struthio camelus (ostrich) HQ902400 frag ZnF_TTF
WFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYYDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFSTTDSYLQALDRAF
SSLGIRLQDEKPTIGLGVDGANITASLRANLFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRVTAATLCEETEFLGDIRAVKW

>PRDM11_allMis Alligator mississippiensis (alligator) scaffold:58581 
WFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYYDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFSTTDSYLQALDRAF
SSLGIRLQDEKPTIGLGVDGANITASLRANLFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPKLMCELRVTAATLCEETEFLGDIRAVKW

>PRDM11_allSin Alligator sinensis (alligator) HQ902411 frag ZnF_TTF
WFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYYDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFSTTDSYLQALDRAFSSLGIRLQDEKPT
IGLGVDGANITASLRADLFMTIRKALPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPKLMCELRVTAATLCEETEFLGDIRAVKW

>PRDM11_croSia Crocodylus siamensis (crocodile) HQ902406 frag ZnF_TTF
WFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYYDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFSTTDSYLQALDRAFSSLGIRLQDEKP
TIGLGVDGANITASLRANLFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPKLMCELRVTAATLCEETEFLGDIRAVKW

>PRDM11_carIns Carettochelys insculpta (turtle) HQ902407 frag ZnF_TTF
WFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYFDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFCTTDSYLQALDRAFSSLGIRLQDEKPT
IGLGVDGANITASLRANLFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRVTAATLCEETEFLGDIRAVKW

>PRDM11_podUni Podocnemis unifilis (turtle) HQ902402 frag ZnF_TTF
WFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYFDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFCTTDSYLQALDRAFSSLGIRLQDEKPT
IGLGVDGANITASLRANLFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRVTAATLCEETEFLGDIRAVKW

>PRDM11_traScr Trachemys scripta (turtle) HQ902399 frag ZnF_TTF
WFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYFDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFCTTDSYLQALDRAFSSLGIRLQDEKP
TIGLGVDGANITASLRANLFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRVTAATLCEETEFLGDIRAVKW

>PRDM11_pelSin Pelodiscus sinensis (turtle) HQ902412 frag ZnF_TTF
WFLQYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYFDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARSLREDLVERIRQSPFLSIILDGQSDDWLADTVAVYVQYTSSDGPPATEFLSLQELGFCTTDSYLQALDRAFSSLGIRLQDEKPT
IGLGVDGANITASLRANLFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRVTAATLCEETEFLGDIRAVKW

>PRDM11_anoCar Anolis carolinensis (lizard) blat/XM_003214639 
WFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYRLRMHPEKTEEM
CRNMTLLFNTAYHLAMEGRPYCDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERVRQSPFLSIILDGQSDDLLADTVAVYVQYISSDGPPATEFLSLQELGFSATDSYIQALDRAF
SSLGIRLQDERPSVGLGIDGANITASLRANMYMTIRKTLPWLLCLPLMIHKPHLEVLDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRVTAATLCEETEFLGDIRAVKW

>PRDM11_hemBow Hemidactylus bowringii (gecko) HQ902409 frag ZnF_TTF
WFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYRLRMHPEKTEEM
CRNMTLLFNTAYHLAMEGRPYCDFRSLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDLLADTVAVYVQYISSDGPPATEFLSLQELGFSTADSYIQALDRAFSSLGIRLQDEKPS
VGLGMDGANITASLRANMYMTIRKTLPWLLCLPLMVHKPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRVTAATLCEETEFLGDIRAVKW

>PRDM11_sciRee Scincella reevesii (skink) HQ902404 frag ZnF_TTF
WFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYRLRMHPEKTEEM
CRNMTLLFNTAYHLAMEGRPYCEFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERVRQSPFLSIILDGQSDDLLADTVAVYVQYISSDGPPATEFLSLQELGFSTTDSYIQALDRAFSSLGIRLQDEKPS
VGLGIDGANITASLRANMYMTIRKTLPWLLCLPLMVHKPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRVTAATLCEETEFLGDIRAVKW

>PRDM11_dibBou Dibamus bourreti (skink) HQ902405 frag ZnF_TTF
WFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYRLRMHPEKTEEM
CRNMTLLFNTAYHLAMEGRPYCDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSDDLLADTVAVYVQYISSDGPPATEFLSLQELGFSATDSYIQALDRAFSSLGIRLQDEKPT
VGLGVDGANITASLRASMYMTIRKTLPWLLCLPLMVHKPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRVTAATLCEETEFLGDIRAVKW

>PRDM11_najAtr Naja atra (cobra) HQ902408 frag ZnF_TTF
WFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYRLRMHPEKTEEM
CRNMTLLFNTAYHLAIEGRPYCDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLIERVRQSPFLSIILDGQSDDLLADTVAVYVQYVSCDGPPATEFLSLQELGFSTTDSYVQALDRAFSSLGMRLQDEKPS
VGLGIDGANITASLRANIYMTIRKTLPWLLCLPLMVHKPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRVTAATLCEETEFLGDIRAIKW

>PRDM11_batYen Batrachuperus yenyuanensis (salamander) HQ902410 frag ZnF_TTF
WFLRYSSTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRSMTLLLNTAYHLAVEGRPYYDFRPLAELLRKCELRVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSEYLLADTVAVYVQYTSNDGPPATEFLSLQELGVPTTESYLQAIDRAFSALGIRLQDEKPT
VGLGVDGFNITAGLRANMYMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRVTAATLCEETEFLGDIRGVRW

>PRDM11_ichBan Ichthyophis bannanicus (caecilian amphibian) HQ902398 frag ZnF_TTF
WFLRYSSTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLALEGRPYFDFRPLAELLRKCELRVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSEDLIADTVAVYVQYTSCDGPPATEFLSLQEIGLSTAESYLQGIDRAFSALGIRLQDEKPT
VGLGIDGANITAGLRANMYMTIRKTLPWLLCLPFMVYRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRTTASTLCEETEFLGDIRAVRW

>PRDM11_xenTro Xenopus tropicalis (frog) blat/CF781198 
WFLRYSSTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLAMEGRPYYDFRPLAELLRKCELRVVDQYMNEGDCQILIHHIARALREDLVERIRQSPFLSIILDGQSEDLLADTVAVYVQYTSSDGPPATEFLSLQELGLPTTESYLQGIDRAF
SALGIRLQDERPTVGLGVDGANITAGLRANLYMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRLTAATLCEETEFLGDIRAVKW

>PRDM11_ranNig Rana nigromaculata (dark-spotted frog) HQ902401 frag ZnF_TTF
WFLRYSSTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEM
CRNMTLLFNTAYHLAMEGRPYYDFRPLAELLRKCELRVVDQYMNEGDCQILIHHIARALREDLIERIRQSPFLSIILDGQSEDLLADTVAVYVQYTSNDGPPATEFLSLQELALPTTESYLQGIDRAFSALGIRLQDERPS
VGLGIDGVNITAGLRANLYMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRLTAATLCEETEFLGDIRAVKW
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