Opsin evolution
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Revision as of 19:34, 16 November 2007 by Tomemerald (talk | contribs)
Below is a large set of phylogenetically representative hand-curated opsin sequences that serves as a gene family classifier ... just blast an unknown sequence against the database below (using http://www.proweb.org/proweb/Tools/WU-blast.html) and look for consistent labelling of the top hits.
The set of sequences is not intended to be exhaustive. Rather, if a given clade has many available similar sequences, those with genome assemblies are chosen to represent the group, for example anole is preferred to gecko, and (rightly or wrongly) any experimental results transfered over. This avoids uninformative clutter from near-identical sequences. If the clade reflects a very deep divergence such as lamprey or amphioxus, all available sequences are provided so as to break up long branches. About half the sequences are not available from GenBank but rather are culled from trace archives, genomic contigs, and genome assemblies, typically by blastx against the full (and growing) set of reference sequences. The level of error is very low, declines with time as anomalies are revisited and fixed, but never reaches zero because of problems inherent to experimental data, incomplete assemblies, and sequence manipulation.
The fasta header of each sequence is a miniature database, with fields showing the opsin type, genus, species and common name, accession number or other source, indels, introns, sequence length, lambda max adsorption, and G protein type with which it interacts. These new standardized fasta headers also serve to summarize the collection.
The protein sequences are broken into their constituent exons using genomic information when available. When not available (eg the opsin originated as a cDNA in a species lacking a genome project), the exons are inferred from the phylogenetically closest opsins. The numbers flanking exons, 012, show the phasing of each intron, eg 12 means an overhang of 1 bp at the 3' end of an exon with that fragmentary codon completed by a 2 bp overhang at the beginning of the next exon. Intron position and phasing are generally conserved over great evolutionary distances -- note here lamprey eel has identical intronation of its opsin genes orthologous to human. Cone and rod opsin paralogs are intronated identically in all species with the exception of LWS opsins which have an extra early intron of phase 12. LWS must have acquired this prior to divergence of lamprey.
Syntentic relationships are also shown. The nearest flanking HUGO-named genes are first chosen for the human opsin, two on each side. The strand orientation noted relative to a fixed convention of plus strand for the human opsin. Then each assembly is revisited to determine the extent of conservation of these flanking genes. In the event humans lack the gene, synteny is defined by the nearest diverging species, typically platypus, that has the gene. Sometimes the original synteny is only partly retained (left- or right-synteny). For deeply diverging species such as amphioxus with an assembly, flanking genes there are pushed forward into other species to help define orthologous opsins (blast clustering can be uncertain because of the diminishing percent identity).
Melanopsins, the unexpected rhabdomeric-class Gq-coupled opsin recently found in upper deuterostomes, are readily confused homologically due to various expansions and contractions. Mammals, human through platypus, have a single melanopsin. However chicken, lizard, frog, and teleost fish experienced a multi-gene segmental duplication and the resulting melanopsins were both retained (though diverged substantially). In ray-finned fish, a processed retrogene arose that may be functional in zebrafish though lost in fugu and stickleback. After its whole genome duplication, zebrafish also retained two copies of the original melanopsin. Chondrichthyes also have a second copy of the primary melanopsin but synteny -- which is essential for analysis since intron placement is uninformative in duplications and sequence alignment is too dependent on unknown rates -- is not available in the current contig-level assembly.
Amphioxus also contains two melanopsins from an apparently independent duplication. Flanking gene order today bears no relation to vertebrate gene order. The lamprey situation awaits assembly of its traces or targeted transcript studies. At this time, only a four exon fragmentary melanopsin can be recovered (however with high percent identity, 80%). Possibly orthologs of this melanopsin locus could be tracked into the highly derived tunicates, acorn worm, and sea urchins. The distinctive intron pattern may even allow melanopsin antecedents to be identified in Cnidaria and Protostomia. At this point, the best blastp match to insects stands at 37% with no evident syntenic or intronic support
While clade-specific proliferation of melanopsins -- and implied role subfunctionalization -- confounds the situation for chordates, it really has little impact on the opsin classifier described here. Unknown sequences will readily find their place because of excellent phylogenetic distribution of reference sequences and the inherent distance of melanopsins from the ciliary collection. The main utility at the level of opsin classifier is the ability to identify other rhabdomeric opsins in later deuterostomes should they occur. At the level of alignment, the melanopsis serve as outgroup to ciliary opsins and so help define motifs specific to Gt-coupled signaling and other structure/function issues.
Please do not add or edit sequences at this time -- email me with suggestions. tom @ cyber-dyne. com. After finishing the encephalopsins upgrade, I will update the alignments, fasta headers, rare genomic event sectors (indels and introns), provide some ancestral sequences at the common ancestor to lamprey, and provide a definitive gene tree. Some sections, such as vision in the ancestral mammal will be split off into separate articles.
A dozen very recent publications have shaken our understanding of the evolution of light reception capabilities. After reviewing topics such as ciliary opsin in protostomes, rhabdomeric opsins in deuterostomes, rich opsin repertoires in cnidarians, and other novel opsin classes, I will consider topics such as the origin of image-forming eyes beween amphioxus and lamprey divergences, noting however that our notion of 'eye' is much more nuanced today. The reconstruction of the ur-bilateran eye probably awaits additional cnidarian genomes -- no new ones are being undertaken unfortunately. However the plethora of new arthopod and lophotrochozoan genome assemblies has opened up new avenues of research as the realization grows that fly and nematode are exceedingly derived, with better ancestral characters retained in other species.
Numerous conflicting gene trees have been published for ciliary opsins. Some methodologies have bordered on the preposterous -- thin phylogenetic coverage, dimly related outgroups such as drosophila rhabdomeric opsin, and naive fixed underlying mutational models assumed for maximal likelihood software despite the great diversity of species and many billions of years of branch length. Nonetheless, the resultant trees have only moderate conflict, suggesting that a definitive opsin tree might not be far off.
Rare genomic changes have lately come into vogue as a supplement to traditional maximal likelihood methods, primarily to resolve polytomies (divergence nodes tightly spaced close in time) and otherwise uncertain gene or species tree topologies. The rare genomic changes applicable to opsins include coding indels (deletions and insertions), intron placement (position and phase comparison), synteny (gene order along the chromosome), and gene copy number change (gene gain from retropositional, tandem, segmental, and whole genome duplications; gene loss from pseudogenization or deletion). Results from these methods must be evaluated for their susceptibility to homoplasy (misleading recurrent independent events that mimic a single event) and incomplete penetration in the population level at the time of speciation (lineage sorting).
Among other phylogenetically informative rare genomic events, we'll be looking at a 6 bp amino acid insert, a novel 12 upstream intron in LWS, and post-GWSR introns in rod/cone opsins, all events located between transmembrane helices TM2 and TM3, ie in extracellular loop 2. Their lack of homoplasy can be seen in the massive alignments below.
Because not all cDNA sequences takes place in species having genome projects and not all species having genome projects have cDNAs, existing cDNAs had to be aligned within the heterologous genome project in order to determine their intron placement. As an example, lamprey opsins from Geotria australis and Lethenteron japonicum worked as queries to locate orthologs within the Petromyzon maritimus genome project (which consists solely of 19 million traces as of mid-November 2007).
The first point to be understood in ciliary opsin evolution is jawless fish such as lamprey exhibit a full-blown set of modern rod and cone opsins whereas early deuterostomes such as hemichordates, echinoderms, amphioxus and tunicates genomes totally lack them (Xenoturbella is not available yet) and indeed altogether lack conventional imaging eyes while using protostome-like rhabdomeric opsins with their disjunct signaling system for photorecepton. Of course, characters in extant (living) species should never be confused with ancestral characters at the time of divergence nodes (last common ancestors); conceivably these early diverging deuterostomes have lost opsin genes, perhaps due to a habitat shift to deep water or burrowing habitat.
However the molecular evidence is quite clear that full-blown pentachromatic color vision and most other modern ciliary opsin classes first appeared during the evolutionary stem preceding lamprey divergence. The oldest known fossil lamprey, Priscomyzon, dates at 360 myr to the Devonian. Molecular clocks place lamprey appearance at approximately 430 myr, some 100 million years after Chengjiang and Burgess Shales fossil Lagerstatte formed. Like most soft tissues, eyes seldom leave a good fossil record, though bilateral placement might be reflected in bone orbits.
Hagfish, sister group to lamprey, have imaging eyes but have not been studied; their opsins situation may be derived due to deepwater marine habitat (similarly deepwater coelocanth opsins are adapted to 420 nm). The next-diverging chondrichtyes have inadequate data at GenBank -- only a few rhodopsin genes from skates and dogfish.
This makes even fragments from the partially sequenced elephantfish Callorhyncus milii quite valuable. Those 9 fragments and 3 from the lamprey genome are provided in the data section. The opsin classifier tool can reliably type a fragment from a single mid-sized exon. While full length genes are always preferable, these fragments serve to prove existence of that gene class at the time of a given divergence node. Further, they can validate certain rare genomic events provided the fragment happens to overlap the region of interest.
Despite 6 sequenced opsin mRNAs in the amphioxus Branchiostoma belcheri and an initial assembly in Branchiostoma floridae, no rod/cone opsin can be located there or in earlier diverging deuterostomes with genome projects (3 unicates, 2 urchins, 1 acorn worm). These species may have larval eye spots, ocelli, pigment cells, and related photoreceptors but lack imaging eyes.
The fossil record is unsatisfactory: less than 1 bilateran in 10,000 in Chengjiang and Burgess Shale fossils is even a candidate for deuterostomy. Low numbers of specimens and poor preservation conspire with career pressure and cite-seeking journals to egregiously misinterpret data in the analysis of Hou, discoverer of the Chinese lagerstaette. Myllokunmingia is in the best situation with 500 specimens but Haikouichthys as stem deuterostome, Metaspreggina as post-ediacaran, and Yunnanozoan are all problematic (in the eye of the beholder). While signs of bilaterily disposed eyes are sometimes inferred, it does not follow these were image-forming eyes. Indeed contemporary Branchiostoma and tunicate larva have an eye-spot (ocellus); the genomes contain ciliary opsins clustering to approximately ENCEPH and PPIN -- still a long long road to imaging opsins. Echinoderms and hemichordates genomes have opsins but even more remote. Sea urchin genome encodes at least six opsins, four of these cluster classify to rhabdomeric, ciliary and Go-type. Tube feet are apparently the photosensory organ in adult urchins.
Meanwhile, thousands of high-quality Cambrian arthropod fossils unmistakably show stalked paired eyes. Fossil trilobite eyes are much studied, due to use of calcite as lens crystalin. Imaging eyes of contemporary arthropods and lophotrochozoa are rhabdomeric, utilizing depolarizing Gq-type receptor, phospholipase C, phosphoinositola, diacylglycerol, and transient receptor potential TRP and TRPL channel signaling. However their genomes can also contain ciliary opsins, using hyperpolarizing Gt-type transducins and phosphodiesterase cGMP second-messaging (as well as Go-type gustducin ciliary opsins in other types of photoreceptors).
Vertebrates are just the opposite, having crossed over to a ciliary opsin-based imaging system, while retaining rhabdomeric signaling in melanopsin retinal ganglion cells. Cnidarian opsins are available from Hydra and Nematostella genomes. Hydra expresses a ciliary-type opsin in ectodermal sensory nerve cells whereas Nematostella has opsins classifying between melanopsin and encephalopsin.
It must not be thought that bilaterans invented imaging eyes because earlier diverging cubomedusan jellyfish Carybdea marsupialis has 4 eyestalks each with 6 photoreceptors of 4 types: simple eyespots, pigment cups, complex pigment cups with lenses, and camera-type eyes with a cornea, lens, and retina. This jellyfish tracks, captures, and eats teleost fish. The species very much needs a genome project.
Thus there is no evidence whatsoever -- and every reason to doubt from genomic analysis -- that deuterostomes had imaging eyes during the Cambrian. Despite this, a BBC series, Walking With Monsters, portrayed a school of 25 mm Haikouichthys attacking and wounding an Anomalocaris twenty times their size. It is easy to guess at the scientific advisory panel. This recurrent anthropocentric theme is echoed by fantastic museum imagery of early mammals nimbly predating on dinosaur nests -- dioramas quietly dismantled after Yucatan meteriorite discovery.
Imaging eyes are not essential to survival; even today subterranean mammals such as blind mole rat flourish without them. Discounting ray-finned fish numbers, a very substantial proportion of extant animal species lack imaging eyes 525 myr after the Cambrian. Of 33 animal phyla, a one-third have no specialized organ for detecting light, one-third have light-sensitive organs, and the remaining 6 have imaging eyes (Cnidaria, Mollusca, Annelida, Onychophora, Arthropoda, and Chordata). Thus 82% of animal phyla have survived well over 500 myr without imaging eyes despite the supposedly unrelenting competition/predation from animals with them.
The table below is a tab-delimited database that can be pasted into excel for further analysis. For example, sorting on the second column would show all the opsin sequences available for a fixed species. Sorting on the lambda max absorption column would group the data by color property (when that column is better filled in). The columns show gene name, genus, species, common name, heterotrimeric G protein alpha subunit used in signaling, intron structure, synteny (2 flanking genes on each side of the opsin), indel status, sequence length, lambda max, and comment field.
>RHO1_homSap Homo sapiens (human) Gt 0...2.1.0.0 -MBD4 +IFT122 +H1FOO -PLXND1 indel 349 aa 497 nm rod_rhodopsin RHO >RHO1_monDom Monodelphis domesticus (opossum) Gt 0...2.1.0.0 -MBD4 +IFT122 +H1FOO -PLXND1 indel 349 aa 000 nm rod_rhodopsin >RHO1_ornAna Ornithorhynchus anatinus (platypus) Gt 0...2.1.0.0 - +IFT122 - -PLXND1 indel 354 aa 000 nm rod_rhodopsin >RHO1_galGal Gallus gallus (chicken) Gt 0...2.1.0.0 -MBD4 +IFT122 +H1FOO -PLXND1 indel 352 aa 000 nm rod_rhodopsin RH1 >RHO1_anoCar Anolis carolinensis (lizard) Gt 0...2.1.0.0 -MBD4 +IFT122 - -PLXND1 indel 343 aa 000 nm rod_rhodopsin >RHO1_xenTro Xenopus tropicalis (frog) Gt 0...2.1.0.0 -MBD4 +IFT122 - -PLXND1 indel 355 aa 000 nm rod_rhodopsin >RHO1_neoFor Neoceratodus forsteri (lungfish) Gt 0...2.1.0.0 x x x x indel 355 aa 000 nm 17961206 rod_rhodopsin >RHO1_latCha Latimeria chalumnae (coelacanth) Gt 0...2.1.0.0 x x x x indel 355 aa 478 nm 10339578 rod_rhodopsin >RHO1_takRub Takifugu rubripes (pufferfish) Gt 0...2.1.0.0 -MBD4 +IFT122 - -PLXND1 indel 000 nm rod_rhodopsin >RHO1_leuEri Leucoraja erinacea (skate) Gt 0...2.1.0.0 x x x x indel 355 aa 000 nm rod_rhodopsin >RHO1_calMil Callorhinchus milii (elephantfish) Gt 0...2.1.0.0 x x x x indel 355 aa 000 nm rod_rhodopsin >RHO1_petMar Petromyzon marinus (lamprey) Gt 0...2.1.0.0 x x x x indel 354 aa 000 nm rod_rhodopsin >RHO1_geoAus Geotria australis (lamprey) Gt 0...2.1.0.0 x x x x indel 354 aa 497 nm 17463225 rod_rhodopsin >RHO1_letJap Lethenteron japonicum (lamprey) Gt 0...2.1.0.0 x x x x indel 354 aa 000 nm cone_rhodopsin >RHO2_galGal Gallus gallus (chicken) Gt 0...2.1.0.0 -IHPK3 -LEMD2 -GRM4 +HMGA1 indel 356 aa 000 nm cone_rhodopsin >RHO2_anoCar Anolis carolinensis (lizard) Gt 0...2.1.0.0 -IHPK3 -LEMD2 -GRM4 +HMGA1 indel 356 aa 000 nm cone_rhodopsin >RHO2_gekGek Gekko gekko (gecko) Gt 0...2.1.0.0 x x x x indel 356 aa 000 nm cone_rhodopsin >RHO2_neoFor Neoceratodus forsteri (lungfish) Gt 0...2.1.0.0 x x x x indel 356 aa 000 nm 17961206 cone_rhodopsin >RHO2_latCha Latimeria chalumnae (coelacanth) Gt 0...2.1.0.0 x x x x indel 355 aa 485 nm 10339578 cone_rhodopsin RH2 >RHO2_geoAus Geotria australis (lamprey) Gt 0...2.1.0.0 x x x x indel 355 aa 492 nm 17463225 cone_rhodopsin RhB >SWS2_ornAna Ornithorhynchus anatinus (platypus) Gt 0...2.1.0.0 -IRAK1 -MECP2 - +TKTL1 indel 364 aa 000 nm cone_short2 >SWS2_galGal Gallus gallus (chicken) Gt 0...2.1.0.0 x x x x indel 362 aa 000 nm cone_short2 >SWS2_taeGut Taeniopygia guttata (finch) Gt 0...2.1.0.0 x x x x indel 363 aa 000 nm cone_short2 >SWS2_utaSta Uta stansburiana (lizard) Gt 0...2.1.0.0 x x x x indel 364 aa 000 nm cone_short2 >SWS2_xenTro Xenopus tropicalis (frog) Gt 0...2.1.0.0 -IRAK1 -MECP2 - - indel 363 aa 000 nm cone_short2 >SWS2_neoFor Neoceratodus forsteri (lungfish) Gt 0...2.1.0.0 x x x x indel 364 aa 000 nm 17961206 cone_short2 >SWS2_takRub Takifugu rubripes (pufferfish) Gt 0...2.1.0.0 x x x x indel 351 aa 000 nm genome cone_short2 >SWS2_gasAcu Gasterosteus aculeatus (stickleback) Gt 0.2.2.1.0.0 x x x x indel 359 aa 000 nm genome cone_short2 >SWS2_geoAus Geotria australis (lamprey) Gt 0...2.1.0.0 x x x x indel 362 aa 439 nm 17463225 cone_short2 >SWS1_homSap Homo sapiens (human) Gt 0.2.2.1.0.0 -FAM137A -CALU -NAG6 -FLNC indel 348 aa 000 nm cone_short1 >SWS1_monDom Monodelphis domesticus (opossum) Gt 0...2.1.0.0 -FAM137A -CALU -NAG6 -FLNC indel 347 aa 000 nm cone_short1 >SWS1_galGal Gallus gallus (chicken) Gt 0...2.1.0.0 x x x x indel 348 aa 000 nm cone_short1 >SWS1_taeGut Taeniopygia guttata (finch) Gt 0...2.1.0.0 x x x x indel 347 aa 000 nm cone_short1 >SWS1_anoCar Anolis carolinensis (lizard) Gt 0.2.2.1.0.0 x -CALU x x indel 347 aa 000 nm genome cone_short1 >SWS1_utaSta Uta stansburiana (lizard) Gt 0...2.1.0.0 x x x x indel 348 aa 000 nm cone_short1 >SWS1_xenLae Xenopus laevis (frog) Gt 0...2.1.0.0 - -CALU - - indel 348 aa 000 nm cone_short1 >SWS1_neoFor Neoceratodus forsteri (lungfish) Gt 0...2.1.0.0 x x x x indel 347 aa 000 nm 17961206 cone_short1 >SWS1_danRer Danio rerio (zebrafish) Gt 0...2.1.0.0 - -CALU - - indel 337 aa 000 nm cone_short1 >SWS1_oryLat Oryzias latipes (medaka) Gt 0...2.1.0.0 - - - - indel 336 aa 000 nm cone_short1 >SWS1_geoAus Geotria australis (lamprey) Gt 0...2.1.0.0 x x x x indel 346 aa 359 nm 17463225 cone_short1 >LWS_homSap Homo sapiens (human) Gt 0.2.2.1.0.0 -IRAK1 -MECP2 -TEX28 +TKTL1 indel 364 aa 530 nm cone_long OPN1MW >LWS_monDom Monodelphis domesticus (opossum) Gt 0.2.2.1.0.0 -IRAK1 -MECP2 - +TKTL1 indel 368 aa 000 nm cone_long >LWS_ornAna Ornithorhynchus anatinus (platypus) Gt 0.2.2.1.0.0 -IRAK1 -MECP2 - - indel 365 aa 000 nm cone_long >LWS_galGal Gallus gallus (chicken) Gt 0.2.2.1.0.0 x x x x indel 363 aa 000 nm cone_long >LWS_anoCar Anolis carolinensis (lizard) Gt 0.2.2.1.0.0 - - -TEX28 +TKTL1 indel 370 aa 000 nm cone_long >LWS_xenTro Xenopus tropicalis (frog) Gt 0.2.2.1.0.0 -IRAK1 -MECP2 - - indel 000 nm cone_long >LWS_neoFor Neoceratodus forsteri (lungfish) Gt 0.2.2.1.0.0 x x x x indel 365 aa 000 nm 17961206 cone_long >LWS_takRub Takifugu rubripes (pufferfish) Gt 0...2.1.0.0 x x x x indel 358 aa 000 nm genome >LWS_gasAcu Gasterosteus aculeatus (stickleback) Gt 0.2.2.1.0.0 - - - - indel 358 aa 000 nm genome cone_long >LWS_petMar Petromyzon maritimus (lamprey) Gt 0.2.2.1.0.0 x x x x indel 366 aa 000 nm cone_long >LWS_letJap Lethenteron japonicum (lamprey) Gt 0.2.2.1.0.0 x x x x indel 365 aa 000 nm cone_long >LWS_geoAus Geotria australis (lamprey) Gt 0.2.2.1.0.0 x x x x indel 365 aa 560 nm 17463225 cone_long >PIN_galGal Gallus gallus (chicken) Gt 0...2.2.0.0 indel 352 aa 000 nm pinopsin >PIN_utaSta Uta stansburiana (lizard) Gt 0...2.2.0.0 x x x x indel 359 aa 000 nm pinopsin >PIN_pheMad Phelsuma madagascariensis (gecko) Gt 0...2.2.0.0 x x x x indel 358 aa 000 nm pinopsin >PIN_podSic Podarcis sicula (lizard) Gt 0...2.2.0.0 x x x x indel 354 aa 000 nm pinopsin >PIN_xenTro Xenopus tropicalis (frog) Gt 0...2.2.0.0 indel 346 aa 000 nm pinopsin >PIN_bufJap Bufo japonicus (frog) Gt 0...2.2.0.0 x x x x indel 347 aa 000 nm pinopsin >VAOP_galGal Gallus gallus (chicken) Gt 0...2.1.0.0 +INPP5A -NXK6 +C10orf61 +ALDH18A1 indel 393 aa 000 nm vertebrate_ancient >VAOP_anoCar Anolis carolinensis (lizard) Gt 0...2.1.0.0 +INPP5A -NXK6 +GPR125 +KNDC1 indel 389 aa 000 nm vertebrate_ancient >VAOP_xenTro Xenopus tropicalis (frog) Gt 0...2.1.0.0 - +GSTO2 -C10orf92 - indel 383 aa 000 nm vertebrate_ancient >VAOP_danRer Danio rerio (zebrafish) Gt 0...2.1.0.0 - - - - indel 378 aa 000 nm vertebrate_ancient >VAOP_takRub Takifugu rubripes (teleost) Gt 0...2.1.0.0 +INPP5A -NXK6 - +KNDC1 indel 362 aa 000 nm vertebrate_ancient >VAOP_rutRut Rutilus rutilus (minnow) Gt 0...2.1.0.0 x x x x indel 383 aa 000 nm vertebrate_ancient >VAOP_petMar Petromyzon marinus (lamprey) Gt 0...2.1.0.0 x x x x indel 445 aa 000 nm 9427550 vertebrate_ancient >PPIN_anoCar Anolis carolinensis (lizard) Gt 0...2...0.0 -CPEB2 -CACNA2D3 +SELK +ACTR8 indel 346 aa 000 nm parapinopsin >PPIN_xenTro Xenopus tropicalis (frog) Gt 0...2...0.0 - - +SELK - indel 349 aa 000 nm parapinopsin >PPIN_ictPun Ictalurus punctatus (catfish) Gt 0...2...0.0 x x x x indel 347 aa 000 nm parapinopsin >PPIN_danRer Danio rerio (zebrafish) Gt 0...2...0.0 - - +SELK - indel 338 aa 000 nm parapinopsin >PPIN_oncMyk Oncorhynchus mykiss (trout) Gt 0...2...0.0 x x x x indel 347 aa 000 nm parapinopsin >PPIN_petMar Petromyzon maritimus (lamprey) Gt 0...2...0.0 x x x x indel 344 aa 000 nm parapinopsin >PPIN_letJap Lethenteron japonicum lamprey Gt 0...2...0.0 x x x x indel 344 aa 000 nm parapinopsin >PPINa_cioInt Ciona intestinalis (tunicate) Gt 0...2...0.0 -HOXB1 +HHEX +CUL4A - indel 391 aa 000 nm 11591373 parapinopsin >PPINb_cioInt Ciona intestinalis (tunicate) Gt 0...2...0.0 -TMEM165 +FUT4 - - indel 353 aa 000 nm parapinopsin >PARIE_utaSta Uta stansburiana (lizard) Gd+Go 0...2...0.0 x x x x indel 347 aa 522 nm 16543463 parietopsin >PARIE_anoCar Anolis carolinensis (lizard) Gd+Go 0...2...0.0 +EEA1 -FLJ46688 +BTG1 - indel 347 aa 000 nm 16543463 parietopsin >PARIE_xenTro Xenopus tropicalis (frog) Gd+Go 0...2...0.0 -lum -DCN - - indel 346 aa 000 nm 16543463 parietopsin >PARIE_takRub Takifugu rubripes (teleost) Gd+Go 0...2...0.0 -HSP90B1 +NT5DC2 -KCND3 -FLNC indel 351 aa 000 nm 16543463 parietopsin >PARIE_gasAcu Gasterosteus aculeatus (stickleback) Gd+Go 0...2...0.0 -HSP90B1 +NT5DC2 -KCND3 -FLNC indel 361 aa 000 nm - parietopsin >PARIE_danRer Danio rerio (zebrafish) Gd+Go 0...2...0.0 - +NT5DC2 +FBXL13 - indel 337 aa 000 nm 16543463 parietopsin >ENCEPH_homSap Homo sapiens (human) Gt 0...2...0.0 -EXO1 -WDR64 -KMO +FH indel 403 aa 000 nm parietopsin OPN3 >ENCEPH_monDom Monodelphis domestica (opossum) Gt 0...2...0.0 -EXO1 -WDR64 -KMO +FH indel 411 aa 000 nm encephalopsin OPN3 >ENCEPH_galGal Gallus gallus (chicken) Gt 0...2...0.0 -EXO1 -WDR64 -PIGM +RGS7 indel 396 aa 000 nm encephalopsin OPN3 >ENCEPH_anoCar Anolis carolinensis (lizard) Gt 0...2...0.0 -EXO1 -WDR64 -PIGM +RGS7 indel 408 aa 000 nm encephalopsin OPN3 >ENCEPH_xenTro Xenopus tropicalis (frog) Gt 0...2...0.0 -ASAH3L +RPS6 -ADFP -DENND4C indel 401 aa 000 nm encephalopsin OPN3 >ENCEPH4a_takRub Takifugu rubripes (teleost) Gt 0...2...0.0 -CALD1 +TNK2 -RAB18 +ABI1 indel 403 aa 000 nm encephalopsin TMT >ENCEPH4b_takRub Takifugu rubripes (teleost) Gt 0...2...0.0 indel 407 aa 000 nm encephalopsin OPN3 >ENCEPH_takRub Takifugu rubripes (teleost) Gt 0...2...0.0 - +PTK7 -KMO +IDE indel 000 nm >ENCEPH_tetNig Tetraodon nigroviridis (pufferfish) Gt 0...2...0.0 - - - - indel 388 aa 000 nm encephalopsin OPN3 >ENCEPH_gasAcu Gasterosteus aculeatus (stickleback) Gt 0...2...0.0 +CDC42EP3 -KMO +IDE indel 389 aa 000 nm encephalopsin OPN3 >ENCEPH4_braFlo Branchiostoma floridae (amphioxus) Gt indel 402 aa 000 nm encephalopsin Amphiop4 >ENCEPH4_braBel Branchiostoma belcheri (amphioxus) Gt x x x x indel 401 aa 000 nm encephalopsin Amphiop4 >ENCEPH5_braBel Branchiostoma belcheri (amphioxus) Gt x x x x indel 421 aa 000 nm encephalopsin Amphiop5 >ENCEPH5_braFlo Branchiostoma floridae (amphioxus) Gt indel 409 aa 000 nm encephalopsin >ENCEPH_apiMel Apis mellifera (bee) Gt indel 329 aa 000 nm encephalopsin >ENCEPH1_anoGam Anopheles gambiae (mosquito) Gt indel 461 aa 000 nm encephalopsin >ENCEPH2_anoGam Anopheles gambiae (mosquito) Gt indel 434 aa 000 nm encephalopsin >CILL2_plaDum Platynereis dumerilii (ragworm) Gt x x x x indel 310 aa 000 nm proto_cilliary >CILL1_plaDum Platynereis dumerilii (ragworm) Gt x x x x indel 355 aa 000 nm proto_cilliary >RGR_homSap Homo sapiens (human) ?? PCDH21 LRRC21 GRID1 WAPAL indel 296 aa 000 nm retinal_ganglia RGR >PER_homSap Homo sapiens (human) ?? CFI NOLA1 EGF ELOVL6 indel 338 aa 000 nm peropsin RRH >PERa_braBel Branchiostoma belcheri (amphioxus) ?? x x x x indel 365 aa 000 nm peropsin Amphiop3 >PERb_braBel Branchiostoma belcheri (amphioxus) ?? x x x x indel 522 aa 000 nm peropsin Amphiop2 >PERc_braBel Branchiostoma belcheri (amphioxus) Go x x x x indel 391 aa 000 nm peropsin Amphiop1 >NEUR_homSap Homo sapiens (human) ?? +CD2AP +GPR115 -C6orf138 -MUT indel 355 aa 000 nm neuropsin OPN5 >MEL1_homSap Homo sapiens (human) Gq -GRID1 -WAPAL +LDB3 +BMPR1A indel 479 aa 000 nm melanopsin OPN4 >MEL1_monDom Monodelphis domestica (opossum) Gq -GRID1 -WAPAL +LDB3 +BMPR1A indel 000 nm melanopsin OPN4 >MEL1_galGal Gallus gallus (chicken) Gq -GRID1 -WAPAL +LDB3 +BMPR1A indel 000 nm 16856781 melanopsin OPN4m >MEL1_xenTro Xenopus tropicalis (frog) Gq -GRID1 -WAPAL +LDB3 +BMPR1A indel 596 aa 000 nm 16856781 melanopsin OPN4m >MEL1_danRer Danio rerio (zebrafish) Gq - +USP54 +LDB3 +BMPR1A indel 000 nm melanopsin OPN4m >MEL1D_danRer Danio rerio (zebrafish) Gq - +USP54 +LDB3 +BMPR1A indel 000 nm >MEL1_takRub Takifugu rubripes (teleost) Gq - +USP54 +LDB3 +BMPR1A indel 000 nm melanopsin OPN4m >MEL1_gasAcu Gasterosteus aculeatus (stickleback) Gq - - +LDB3 +BMPR1A indel 000 nm melanopsin OPN4m >MEL1_oryLat Oryzias latipes (medaka) Gq - +USP54 +LDB3 +BMPR1A indel 000 nm melanopsin OPN4m >MEL1_calMil Callorhinchus milii (elephantfish) Gq - - - - indel 000 nm melanopsin OPN4m >MEL1a_braFlo Branchiostoma floridae (amphioxus) Gq - - - - indel 709 aa 000 nm melanopsin Amphi-mop >MEL1a_braBel Branchiostoma belcheri (amphioxus) Gq x x x x indel 707 aa 000 nm melanopsin Amphi-mop >MEL1b_braFlo Branchiostoma floridae (amphioxus) Gq - - - - indel 000 nm >MEL1b_braBel Branchiostoma belcheri (amphioxus) Gq x x x x indel 402 aa 000 nm melanopsin Amphiop6 >MEL2_galGal Gallus gallus (chicken) Gq +GRID2+SMARCAD1 -PGDS -SEC24B +COL25A1 indel 544 aa 000 nm 17977531 melanopsin >MEL2_anoCar Anolis carolinensis (lizard) Gq +GRID2+SMARCAD1 -ATOH1 +PDLIM5 +BMPR1B indel 290 aa 000 nm melanopsin >MEL2_xenLae Xenopus laevis (frog) Gq +SMARCAD1 +PDLIM5 +BMPR1B indel 535 aa 000 nm melanopsin Xmop >MEL2_danRer Danio rerio (zebrafish) Gq - +FLJ39155 +PDLIM5 - indel 000 nm >MEL2_tetNig Tetraodon nigroviridis (pufferfish) Gq - - - +BMPR1B indel 404 aa 000 nm melanopsin >MEL2_gasAcu Gasterosteus aculeatus (stickleback) Gq KNTC2 +FLJ39155 +PDLIM5 +BMPR1B indel 353 aa 000 nm melanopsin >RHAB_plaDum Platynereis dumerilii (polychaete) Gq x x x x indel 383 aa 000 nm rhabdomeric >RHAB1_apiMel Apis mellifera (bee) Gq indel 378 aa 000 nm rhabdomeric Lop1 >RHAB2_apiMel Apis mellifera (bee) Gq indel 386 aa 000 nm rhabdomeric Lop2 >RHAB3_apiMel Apis mellifera (bee) Gq indel 372 aa 000 nm rhabdomeric >RHAB4_apiMel Apis mellifera (bee) Gq indel 378 aa 000 nm rhabdomeric Blop
>RHO1_homSap rhodopsin ciliary all GT-AG chr3:130,730,172 3q22.1 + 6706 5 12 21 00 00 0 MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLG 1 2 GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSR 2 1 YIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKE 0 0 AAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQ 0 0 FRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA* 0 >RHO1_monDom Monodelphis opossum 349 0 MNGTEGPNFYVPFSNKTGTVRSPFEEPQYYLADPWQFSCLAAYMFMLIVLGFPINFLTLYVTIQHKKLRTPLNYILLNLAIADLFMVFGGFTMTLYTSLHGYFVFGPTGCNLEGFFATLG 1 2 GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIIGVAFTWVMALACAFPPLIGWSR 2 1 YIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPLIVIFFCYGQLVFTVKE 0 0 AAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSNFGPIFMTIPAFFAKSSSVYNPVIYIMMNKQ 0 0 FRTCMITTLCCGKNPLGDDEASATASKTETSQVAPA* 0 >RHO1_ornAna rhodopsin rod pigment Ultra20:114,479-118,391 0 MNGTEGQDFYIPMSNKTGVVRSPFEYPQYYLAEPWQYSVLAAYMFMLIMLGFPINFLTLYVTIQHKKLRTPLNYILLNLAFANHFMVLGGFTTTLYTSLHGYFVFGPTGCNIEGFFATLG 1 2 GEIALWSLVVLAIERYIVVCKPMSNFRFGENHAIMGVAFTWIMALACALPPLVGWSR 2 1 YIPEGMQCSCGIDYYTLRPEVNNESFVIYMFVVHFTIPMTIIFFCYGRLVFTVKE 0 0 AAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTVPAFFAKSSAIYNPVIYIMMNKQ 0 0 FRNCMLTTICCGKNPLGDDEASATASKTEQSSVSTSQVSPA* 0 >RHO1_galGal RH1 RDP1 rhodopsin rod galGal+ ornAna+ homSap+ 0 MNGTEGQDFYVPMSNKTGVVRSPFEYPQYYLAEPWKFSALAAYMFMLILLGFPVNFLTLYVTIQHKKLRTPLNYILLNLVVADLFMVFGGFTTTMYTSMNGYFVFGVTGCYIEGFFATLG 1 2 GEIALWSLVVLAVERYVVVCKPMSNFRFGENHAIMGVAFSWIMAMACAAPPLFGWSR 2 1 YIPEGMQCSCGIDYYTLKPEINNESFVIYMFVVHFMIPLAVIFFCYGNLVCTVKE 0 0 AAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTNQGSDFGPIFMTIPAFFAKSSAIYNPVIYIVMNKQ 0 0 FRNCMITTLCCGKNPLGDEDTSAGKTETSSVSTSQVSPA* 0 >RHO1_anoCar Anolis lizard 0 MNGTEGQNFYVPMSNKTGVVRNPFEYPQYYLADPWQFSALAAYMFLLILLGFPINFLTLFVTIQHKKLRTPLNYILLNLAVANLFMVLMGFTTTMYTSMNGYFIFGTVGR 2 2 GEMGLWSLVVLAVERYVVICKPMSNFRFGETHALIGVSCTWIMALACAGPPLLGWSR 2 1 YIPEGMQCSCGVDYYTPTPEVHNESFVIYMFLVHFVTPLTIIFFCYGRLVCTVKA 0 0 AAAQQQESATTQKAEREVTRMVVIMVISFLVCWVPYASVAFYIFTHQGSDFGPVFMTIPAFFAKSSAIYNPVIYILMNKQ 0 0 FRNCMIMTLCCGKNPLGDEDTSAGTKTETSTVSTSQVSPA* 0 >RHO1_xenTro frog 354 0 MNGTEGPNFYIPMSNKTGVVRSPFDYPQYYLAEPWKYSALAAYMFLLILLGFPINFMTLYVTIQHKKLRTPLNYILLNLVFANHFMVLCGFTVTMYTSMHGYFIFGQTGCYIEGFFATLG 1 2 GEMALWSLVVLAIERYVVVCKPMANFRFGENHAIMGVVFTWIMALSCAAPPLFGWSR 2 1 YIPEGMQCSCGVDYYTLKPEVNNESFVVYMFIVHFTIPLCVIFFCYGRLLCTVKE 0 0 AAAQQQESATTQKAEKEVTRMVVMMVIFFLICWVPYAYVAFYIFTHQGSDFGPVFMTVPAFFAKSSAIYNPVIYIVLNKQ 0 0 FRNCLITTLCCGKNPFGDEEGSSAASSKTEASSVSSSQVSPA* 0 >RHO1_neoFor Neoceratodus forsteri (Australian lungfish) 0 MNGTEGPNFYVPMTNKTGVVRSPFEYPQYYLADPWKYSALAAYMFFLILTGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTAMNGYFVFGVVGCNLEGFFATFG 1 2 GIIALWCLVVLAIERYIVVCKPISNFRFGENHAIMGVVFTWIMALACAGPPLFGWSR 2 1 YIPEGMQCSCGIDYYTLKPEVNNESFVIYMFIVHFTIPLIIIFFCYGRLMCTVKE 0 0 AAAQQQESATTQKAEKEVTRMVYIMVISYLVCWLPYASVSFYIFTHQGSDFGPVFMTVPAFFAKTASVYNPVIYILMNKQ 0 0 FRNCMITTLCCGKNPFGDEETTSAGTSKTEASSVSSSQVSPA* 0 >RHO1_latCha Latimeria chalumnae (coelacanth) 0 MNGTEGPNFYVPMSNKTGVVRNPFEYPQYYLADPWKYSALAAYMFFLILVGFPINFLTLFVTIQHKKLRTPLNYILLDLAVADLCMVFGGFFVTMYSSMNGYFVLGPTGCNIEGFFATLG 1 2 GQVALWALVVLAIERYVVVCKPMSNFRFGENHAIMGVIFTWIMALSCAVPPLFGWSR 2 1 YIPEGMQSSCGVDYYTLKPEVNNESFVIYMFVVHFTIPLIVIFFCYGRLVCTVKD 0 0 AAAQQQESATTQKAEKEVTRMVIVMVISFLVCWVPYASVAAYIFFNQGSEFGPVFMTAPSFFAKSASFYNPVIYILLNKQ 0 0 FRNCMITTLCCGKNPFGDEDATSAAGSSKTEASSVSSSSVSPA* 0 >RHO1_takRub Takifugu rubripes (pufferfish) 0 MNGTEGPNFYIPMSNKTGVVRSPFEYPQYYLAEPWKYSLVAAYMLFLIITAFPVNFLTLFVTVKHKKLRTPLNYVLLNLAVADLFMVIGGFTVTLYTALHAYFVLGVTGCNIEGFFATLG 1 2 GEIALWSLVVLAVERYIVVCKPMTNFRFGEKHAIAGLVFTWIMALTCATPPLLGWSR 2 1 YIPEGMQCSCGIDYYTPKPEINNTSFVIYMFILHFSIPLAIIFFCYSRLLCTVRA 0 0 AAALQQESETTQRAEKEVTRMVIVMVISFLVCWVPYASVAWYIFANQGTEFGPVFMTAPAFFAKSAALYNPVIYILLNRQ 0 0 FRNCMITTVCCGKNPFGDDDAATTVSKTQSSSVSSSQVAPA* 0 >RHO1_leuEri Leucoraja erinacea rod opsin 0 MNGTEGENFYVPMSNKTGVVRSPFDYPQYYLGEPWMFSALAAYMFFLILTGLPVNFLTLFVTIQHKKLRQPLNYILLNLAVSDLFMVFGGFTTTIITSMNGYFIFGPAGCNFEGFFATLG 1 2 GEVGLWCLVVLAIERYMVVCKPMANFRFGSQHAIIGVVFTWIMALSCAGPPLVGWSR 2 1 YIPEGLQCSCGVDYYTMKPEVNNESFVIYMFVVHFTIPLIVIFFCYGRLVCTVKE 0 0 AAAQQQESESTQRAEREVTRMVIIMVVAFLICWVPYASVAFYIFINQGCDFTPFFMTVPAFFAKSSAVYNPLIYILMNKQ 0 0 FRNCMITTICLGKNPFEEEESTSASASKTEASSVSSSQVAPA* 0 >RHO1_calMil Callorhinchus milii complete wgs 0 MNGTEGENFYIPMSNKTGVVRSPFEYPQYYLAEPWQFSILAAYMFFLIITCFPVNFLTLYVTFEHKKLRQPLNFILLNLAVADLFMVFGGFFITVYTSLHGYFVFGVTGCNFEGFFATLG 1 2 GEIGLWSLVVLAIERYVVVCKPMSNFRFGTNHAIMGVAFTWVMALACAVPPLMGWSR 2 1 YIPEGLQCSCGVDYYTLKPEINNESFVIYMFVVHFLIPLIIIFFCYGRLVCTVKE 0 0 AAAQQQESESTQRAEREVTRMVIIMVIFFLICWVPYASVAFFIFTNQGSEFGPIFMAVPAFFAKSSALYNPLIYILLNKQ 0 0 FRNCMITTLCCGKNPFEEDESTSAAASKTEASSVSSSQVSPA* 0 >RHO1_petMar lamprey Petromyzon marinus introns from U67123 0 MNGTEGENFYIPFSNKTGLARSPFEYPQYYLAEPWKYSVLAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAVANLFMVLFGFTLTMYSSMNGYFVFGPTMCNFEGFFATLG 1 2 GEMSLWSLVVLAIERYIVICKPMGNFRFGSTHAYMGVAFTWFMALSCAAPPLVGWSR 2 1 YLPEGMQCSCGPDYYTLNPNFNNESFVIYMFLVHFIIPFIVIFFCYGRLLCTVKE 0 0 AAAAQQESASTQKAEKEVTRMVVLMVIGFLVCWVPYASVAFYIFTHQGSDFGATFMTVPAFFAKTSALYNPIIYILMNKQ 0 0 FRNCMITTLCCGKNPLGDEDSGASTSKTEVSSVSTSQVSPA* 0 >RHO1_geoAus lamprey Geotria australis rodRhA introns by homology 0 MNGTEGQNFYIPFSNKTDVARSPFEYPQYYLAEPWKFSALAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAVSNLFMILFGFTTTMYTSMNGYFVFGPTMCSIEGFFATLG 1 2 GEVSLWSLVVLAIERYIVICKPMGNFRFGNTHAIMGVALTWVMALSCAAPPLLGWSR 2 1 YLPEGMQCSCGPDYYTMNPTYNNESFVIYMFIVHFTIPFVIIFFSYGRLLCTVKE 0 0 AAAAQQESASTQKAEKEVTRMVVLMVVGFLVCWVPYASVAFYIFTNQGSDFGATFMTLPAFFAKSSALYNPVIYILMNKQ 0 0 FRNCMITTLCCGKNPLGDDDSGASTSKTEVSSVSTSQVAPA* 0 >RHO1_letJap lamprey Lethenteron japonicum introns by homology 0 MNGTEGDNFYVPFSNKTGLARSPYEYPQYYLAEPWKYSALAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAMANLFMVLFGFTVTMYTSMNGYFVFGPTMCSIEGFFATLG 1 2 GEVALWSLVVLAIERYIVICKPMGNFRFGNTHAIMGVAFTWIMALACAAPPLVGWSR 2 1 YIPEGMQCSCGPDYYTLNPNFNNESYVVYMFVVHFLVPFVIIFFCYGRLLCTVKE 0 0 AAAAQQESASTQKAEKEVTRMVVLMVIGFLVCWVPYASVAFYIFTHQGSDFGATFMTLPAFFAKSSALYNPVIYILMNKQ 0 0 FRNCMITTLCCGKNPLGDDESGASTSKTEVSSVSTSQVSPA* 0 >RHO2_galGal rhodopsin-like cone galGal+ ornAna- homSap- 0 MNGTEGINFYVPMSNKTGVVRSPFEYPQYYLAEPWKYRLVCCYIFFLISTGLPINLLTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFVFGPVGCAVEGFFATLG 1 2 GQVALWSLVVLAIERYIVVCKPMGNFRFSATHAMMGIAFTWVMAFSCAAPPLFGWSR 2 1 YMPEGMQCSCGPDYYTHNPDYHNESYVLYMFVIHFIIPVVVIFFSYGRLICKVRE 0 0 AAAQQQESATTQKAEKEVTRMVILMVLGFMLAWTPYAVVAFWIFTNKGADFTATLMAVPAFFSKSSSLYNPIIYVLMNKQ 0 0 FRNCMITTICCGKNPFGDEDVSSTVSQSKTEVSSVSSSQVSPA* 0 >RHO2_anoCar rhodopsin-like cone anoCar+ HMGA1 GRM4 RHO2 MLN LEMD2 IHPK3 0 MNGTEGINFYVPLSNKTGLVRSPFEYPQYYLAEPWKYKVVCCYIFFLIFTGLPINILTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFIFGPIGCAIEGFFATLG 1 2 GQVALWSLVVLAIERYIVVCKPMGNFRFSATHALMGISFTWFMSFSCAAPPLLGWSR 2 1 YIPEGMQCSCGPDYYTLNPDYHNESYVLYMFGVHFVIPVVVIFFSYGRLICKVRE 0 0 AAAQQQESASTQKAEREVTRMVILMVLGFLLAWTPYAMVAFWIFTNKGVDFSATLMSVPAFFSKSSSLYNPIIYVLMNKQ 0 0 FRNCMITTICCGKNPFGDEDVSSSVSQSKTEVSSVSSSQVSPA* 0 >RHO2_gekGek Gekko gekko 467 Cone visual pigments are present in gecko rod cells 0 MNGTEGINFYVPLSNKTGLVRSPFEYPQYYLADPWKFKVLSFYMFFLIAAGMPLNGLTLFVTFQHKKLRQPLNYILVNLAAANLVTVCCGFTVTFYASWYAYFVFGPIGCAIEGFFATIG 1 2 GQVALWSLVVLAIERYIVICKPMGNFRFSATHAIMGIAFTWFMALACAGPPLFGWSR 2 1 FIPEGMQCSCGPDYYTLNPDFHNESYVIYMFIVHFTVPMVVIFFSYGRLVCKVRE 0 0 AAAQQQESATTQKAEKEVTRMVILMVLGFLLAWTPYAATAIWIFTNRGAAFSVTFMTIPAFFSKSSSIYNPIIYVLLNKQ 0 0 FRNCMVTTICCGKNPFGDEDVSSSVSQSKTEVSSVSSSQVAPA* 0 >RHO2_neoFor Neoceratodus forsteri (Australian lungfish) 0 MNGTEGINFYVPHSNKTGVVRSPFEYPQYYLADPWKYSIVCAYMFFLIITGLPINLLTLVVTFKHKKLRQPLNYILVNLAVADLFMVCFGFTVTFSTAINGYFIFGPRGCAIEGFMATLG 1 2 GEVALWSLVVLAIERYIVVCKPMGNFRFSNNHSIIGIVFTWLAALSCAAPPLFGWSR 2 1 YLPEGMQCSCGPDYYTMNPDYHNESFVIYMFVVHFFIPVIVIFVSYGRLICKVKE 0 0 AAAQQQESASTQKAEREVTRMVILMVIGFMTAWTPYATVAFWIFMNKGAEFGATFMAAPAFFSKSSALYNPIIYVLMNKQ 0 0 FRNCMVTTLCCGKNPFGDDDVSSSVSAGKTEVSSVSSSQVSPA* 0 >RHO2_latCha Latimeria chalumnae (coelacanth) RH2 opsin 0 MNGTEGMNFYVPLSNRTGLVRSPFEYTQYYLAEPWKFSVLCAYMFLLIILGFPINFLTLLVTFKHKKLRQPLNYILVNLAVASLFMVVFGFTVTFYSSLNGYFVLGPMGCAMEGFFATLG 1 2 GQVALWSLVVLAIERYIVVCKPMGNFRFASSHAIMGIAFTWIMALACAAPPLVGWSR 2 1 YIPEGLQCSCGPDYYTLNPDFHNESYVMYLFLVHFLLPIIIIFFTYGRLICKVKE 0 0 AAAQQQESASTQKAEKEVTRMVILMVIGFLTAWVPYASAAFWIFCNRGAEFTATLMTVPAFFSKSSCLFNPIIYVLLNKQ 0 0 FRNCMITTLCCGKNPLGDDDTSSAVSQSKTDVSSVSSSQVSPA* 0 >RHO2_geoAus Geotria australis lamprey rod RhB lamprey 0 MNGTEGANFYIPFHNRTGVVRSPYEYPQYYLADPWMYSAISAYVFTLILIGFPVNFMTLFVTFKLKKLRQPLNFILVNLCVADLLMIMFGFTTTFYTAMNGYFVFGPTGCNIEGFFATLG 1 2 GEVSLWSLVMLAIERYIVVCKPMGNFRFATTHAALGVVFTWVMASACAVPPLVGWSR 2 1 YIPEGMQCSCGPDYYTLNPKYYNESYVIYLFLVHFLLPVTIIFFTYGRLICTVKE 0 0 AAAQQQESASTQKAEREVTRMVIIMVVGFLVCWVPYASFAFYLFMNKGILFSATAMTVPAFFSKSSVLYNPIIYVLLNKQ 0 0 FRTCMVTTLFCGKNPFGEDDSSMVSTSKTEVSSVSSSQVSPS* 0 >SWS2_ornAna platypus blue cone bp 2 gene tandem -FLNB +MECP2 with MWS1 5 usual exons 0 MHKTHRNLQNELPEDFFIPLPLDTDNITSLSPFLVPQTHLGGSGIFMSLAAFMFLLITLGFPINLLTVICTIKYKKLRSHLNYILVNLAVSNMLVVCVGSATAFYSFAHMYFVLGPTACKIEGFAATLG 1 2 GMVSLWSLAVIAFERFLVICKPLGNLSFRGTHAIFGCAATWVFGLAASLPPLFGWSR 2 1 YIPEGLQCSCGPDWYTTNNKWNNESYVIFLFSFCFGVPLSIIIFSYGRLLLTLRA 0 0 VAKQQEQSATTQKAEREVTKMVIVMVLGFLVCWLPYASFSLWVVTNRGQVFDLRMASIPSVFSKASTIYNPIIYVFMNKQ 0 0 FRSCMLKLVFCGKSPFGDEDEISGSSQATQVSSVSSSQVSPA* 0 >SWS2_galGal chicken blue cone pigment galGal- ornAna+ homSap+ 0 MHPPRPTTDLPEDFYIPMALDAPNITALSPFLVPQTHLGSPGLFRAMAAFMFLLIALGVPINTLTIFCTARFRKLRSHLNYILVNLALANLLVILVGSTTACYSFSQMYFALGPTACKIEGFAATLG 1 2 GMVSLWSLAVVAFERFLVICKPLGNFTFRGSHAVLGCVATWVLGFVASAPPLFGWSR 2 1 YIPEGLQCSCGPDWYTTDNKWHNESYVLFLFTFCFGVPLAIIVFSYGRLLITLRA 0 0 VARQQEQSATTQKADREVTKMVVVMVLGFLVCWAPYTAFALWVVTHRGRSFEVGLASIPSVFSKSSTVYNPVIYVLMNKQ 0 0 FRSCMLKLLFCGRSPFGDDEDVSGSSQATQVSSVSSSHVAPA* 0 >SWS2_taeGut Taeniopygia guttata 0 MPKPREMRDELPEDFYIPMSLETPNLTALSPFLVPQTHLGSPGIFKAMAAFMFLLVLLGVPINALTVLCTAKYKKLRSHLNYILVNLAVANLLVVCVGSTTAFYSFSQMYFALGPLACKIEGFTATLG 1 2 GMVSLWSLAVVAFERFLVICKPLGNFTFRGSHAVLGCAITWIFGLIASLPPLFGWSR 2 1 YIPEGLQCSCGPDWYTTDNKWNNESYVIFLFCFCFGFPLTVIVFSYGRLLLTLRA 0 0 VAKQQEQSASTQKAEREVTKMVVVMVLGFLVCWLPYCSFALWVVTHRGHPFDLGLASIPSVFSKASTVYNPIIYVFMNKQ 0 0 FRSCMLKLVFCGRSPFGDEDDVSGSSQATQVSSVSSSQVSPA* 0 >SWS2_utaSta lizard 0 MHNSRPHSRDDLPEDFFIPMPLDVANITTLSPFLVPQTHLGSPALFMGMAAFMFLLIILGVPINVLTIFCTFKYKKLRSHLNYILVNLAVSNLLVVCIGSTTAFYSFAQMYFSLGPTACKIEGFAATLG 1 2 GMVSLWSLAVVAFERFLVICKPLGNFSFRGTHAIIGCIITWVFGLVASLPPLFGWSR 2 1 YIPEGLQCSCGPDWYTTNNKWNNESYVLFLFSFCFGVPLSVIIFSYGRLLLTLRA 0 0 VAKQQEQSATTQKAEREVTKMVVVMVMGFLVCWLPYASFALWVVTHRGEPFDVRLATIPSVFSKASSVYNPVIYVFMNKQ 0 0 FRSCMLKLVFCGKSPFGDEDDVSGSSQTTQVSSVSSSQVSPA* 0 >SWS2_xenTro Xenopus tropicalis 0 MSKGRPDLRMEMPDEFYVPIPLETTNISSLSPFLVPQTHLGTPGIFMSISAFMLFTIIFGFPLNLLTIICTVKYKKLRSHLNYILVNLAVANLIVICFGSTTAFYSFSQMYFSLGTLACKIEGFTATLG 1 2 GIIGLWSLAVVAFERFLVICKPMGNFTFRESHAVLGCILTWVIGLVAAIPPLLGWSR 2 1 YIPEGLQCSCGPDWYTVNNKWNNESYVLFLFCFCFGFPLAIIVFSYGRLLLALHA 0 0 VAKQQEQSATTQKAEREVTRMVIVMVVGFLVCWLPYASFALWAVTHRGELFDLRMSSVPSVFSKASTVYNPFIYIFMNRQ 0 0 FRSCMMKMIFCGKNPLGDDEETSVSGSTQVSSVSSSQIAPS* 0 >SWS2_neoFor Neoceratodus forsteri (Australian lungfish) 0 MHRTKPDPQEDLPDDFYIPVSLNTNNITMLSPFLVPQTHLGSPSVFMVLSVFMFFLLITGIPINVLTIICTFKYKKLRSHLNYILVNLAVANLIVVGFGSTTAFYSFSQMYFAWGPLACKIEGFAATLG 1 2 GMVSLWSLAVVAFERFLVICKPLGNFTFRSTHAIIGCVATWVFGLISSAPPLFGWSR 2 1 YIPEGLQCSCGPDWYTTNNKWNNESYVIFLFCFCFGFPLSVIIFSYGRLLMTLRA 0 0 VAKQQEQSASTQKAEREVTKMVVVMVLGFLVCWLPYTVFSLWVVTHRGESFELALGSIPAVFSKSSTVYNPLIYVFMNKQ 0 0 FRSCMMKLIFCGKSPFGDEDDASSASQSTQVSSVSSSQVAPA* 0 >SWS2_takRub Takifugu rubripes 0 MRGVRQHEFQEDFYIPIPLDVDNITALSPFLVPQDHLGSPAVFYGMSAFMFFLFVAGTGINVLTIACTIQYKKLRSHLNYILVNLAFSNLLVTTVGSFTCFCCFFVRYMIVGPLGCKIEGFAATLG 1 2 GMVSLWSLAVVAFERWLVVCKPLGNFIFKPDHAIVCCIFTWFFALIISAPPLFGWSR 2 1 YIPEGFQCSCGPDWYTTGNKYNNESYVWFIFGFGFAVPLFVIVFCYSQLLVMLKS 0 0 AKAQAESASTQKAEREVTRMVVVMILGFLVCWLPYASFALWVVNNRGTPFDLRLATIPACFSKASTVYNPIIYVVLNKQ 0 0 FRSCMKKMLGMSGGDDEESSSQSVTEVSKVSPS* 0 >SWS2_gasAcu Gasterosteus aculeatus (stickleback) 359 aa 0 MKHGRVPEIPEDFYIPISLDTDNITSLSPFLVPQDHLASKATFYSLAFYMFFILIVGTFINALTVACTVQNKKLRSHLNYILVNLAVSNLLVSGVGAFTAFLSFAARYFVLGTLACKVEGFLATLG 1 2 GMVSLWSLAVIAFERWLVICKPLGNFIFKPDHALVCCAFTWVFALAASAPPLVGWSR 2 1 YIPEGLQCSCGPDWYTTNNKYNNESYVLFLFGFCFAVPFCTICFCYSQLLFTMKMA 0 0 AKAQAESASTQKAEREVTRMVVLMVMGFLVCWMPYASFALWVVNNRGQTFDLRFASIPSVFSKSSAVYNPVIYVLLNKQ 0 0 FRSCMMKMLGMGGGDDEESSTSSVTEVSKVGPA* 0 >SWS2_geoAus Geotria australis lamprey blue-sensitive retinal pigment lamprey 0 MYQGKSTQVDDLPEDFYIPIALNVKNMSELSPFLVPQVHLGDSFIFYGMSAFMLFLVLAGFPLNFLTVFVTIKYKKLRSHLNYILVNLAIANLIVVCCGSTLAFYSFMHKYFILGPLFCKMEGFTATLG 1 2 GMLSLWSLAVLAFERCLVICKPFGNIAFRGTHALIRCGFAWAAAIAASTPPLFGWSR 2 1 YIPEGLQCSCGPDWYTTNNKYNNESYVMFLFIFCFGTPFTIIIVSYSKLILTLRA 0 0 AAAQQQESASTQKAEKEVSRMVVIMVGGFLVCWLPYASLALWIVFNRGSPFDLRLATIPSVFSKASTVYNPVIYIFLNKQ 0 0 FRSCMMKTIFCGKNPLGDDEDATSTTTQVSSVSTSQVAPA* 0 >SWS1_homSap 5 exons all GT-AG Blue opsin chr7:128,199,783-128,203,087 7q32.1 - 3305 5 348 (tritanopia) [MIM:190900]. 0 MRKMSEEEFYLFKNISSVGPWDGPQYHIAPVWAFYLQAAFMGTVFLIGFPLNAMVLVATLRYKKLRQPLNYILVNVSFGGFLLCIFSVFPVFVASCNGYFVFGRHVCALEGFLGTVA 1 2 GLVTGWSLAFLAFERYIVICKPFGNFRFSSKHALTVVLATWTIGIGVSIPPFFGWSR 2 1 FIPEGLQCSCGPDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLLRALKA 0 0 VAAQQQESATTQKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGLDLRLVTIPSFFSKSACIYNPIIYCFMNKQ 0 0 FQACIMKMVCGKAMTDESDTCSSQKTEVSTVSSTQVGPN* 0 >SWS1_monDom Monodelphis domesticus 0 MSGDEEFYLFKNISSVGPWDGPQYHIAPAWAFHFQTVFMGFVFCAGTPLNAVVLVATLRYKKLRQPLNYILVNVSLCGFIFCIFAVFTVFISSSQGYFIFGRHVCAMEAFLGSVA 1 2 GLVTGWSLAFLAFERFIVICKPFGNFRFNSKHAMMVVLATWVIGIGVSIPPFFGWSR 2 1 FIPEGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIMPLFLICFSYSQLLRALRA 0 0 VAAQQQESATTQKAEREVSRMVVMMVGSFCLCYVPYAALAMYMVNNQNHGLDLRLVTIPAFFSKSACVYNPIIYCFMNKQ 0 0 FHACIMEMVCRKPMTDDSDVSSSQKTEVSAVSSSQVGPT* 0 >SWS1_galGal chicken violet cone pigment 0 MSSDDDFYLFTNGSVPGPWDGPQYHIAPPWAFYLQTAFMGIVFAVGTPLNAVVLWVTVRYKRLRQPLNYILVNISASGFVSCVLSVFVVFVASARGYFVFGKRVCELEAFVGTHG 1 2 GLVTGWSLAFLAFERYIVICKPFGNFRFSSRHALLVVVATWLIGVGVGLPPFFGWSR 2 1 YMPEGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIVPLSLIIFSYSQLLSALRA 0 0 VAAQQQESATTQKAEREVSRMVVVMVGSFCLCYVPYAALAMYMVNNRDHGLDLRLVTIPAFFSKSACVYNPIIYCFMNKQ 0 0 FRACIMETVCGKPLTDDSDASTSAQRTEVSSVSSSQVGPT* 0 >SWS1_taeGut Taeniopygia guttata 0 MDEEEFYLFKNQSSVGPWDGPQYHIAPMWAFYLQTIFMGLVFVAGTPLNAIVLIVTIKYKKLRQPLNYILVNISVSGLMCCVFCIFTVFIASSQGYFVFGKHMCAFEGFAGATG 1 2 GLVTGWSLAFLAFERYIVICKPFGNFRFNSRHALLVVAATWIIGVGVAIPPFFGWSR 2 1 YIPEGLQCSCGPDWYTVGTKYKSEYYTWFLFIFCFIVPLSLIIFSYSQLLSALRA 0 0 VAAQQQESATTQKAEREVSRMVVVMVGSFCMCYVPYAALAMYMVNNREHGIDLRLVTIPAFFSKSSCVYNPIIYCFMNKQ 0 0 FRACIMETVCGRPMTDDSEVSSSAQRTEVSSVSSSQVGPS* 0 >SWS1_anoCar Anolis carolinensis (lizard) 0 MSGQEDFYLFENISSVGPWDGPQYHIAPMWAFYFQTAFMGFVFFAGTPLNAIILIVTVKYKKLRQPLNYILVNISFAGFLFCTFSVFTVFMASSQGYFFFGRHVCAMEAFLGSVA 1 2 GLVTGWSLAFLAFERYIVICKPFGNFRFNSRHALLVVAATWIIGVGVAIPPFFGWSR 2 1 YIPEGLQCSCGPDWYTVGTKYKSEYYTWFLFIFCFIVPLTLIIFSYSQLLGALRA 0 0 VAAQQQESATTQKAEREVSRMVVVMVGSFCLCYVPYASLAMYMVNNRDHGLDLRLVTIPAFFSKSSCVYNPIIYCFMNKQ 0 0 FRACILETVCGKPMSDESDVSSSAQKTEVSSVSSSQVSPS* 0 >SWS1_utaSta Uta stansburiana 0 MSGEEDFYLFENISSVGPWDGPQYHIAPMWAFYFQTAFMGFVFFAGTPLNAIILIVTVKYKKLRQPLNYILVNISFAGFLFCVFSVFTVFLASSQGYFFFGRHICALEAFLGSVA 1 2 GLVTGWSLAFLAFERYIVICKPFGNFRFNSKHALLVVAATWFIGIGVSIPPFFGWSR 2 1 FIPEGLQCSCGPDWYTVGTKYKSEYYTWFLFIFCFIVPLTLIIFSYSQLLGALRA 0 0 VAAQQQESATTQKAEREVSRMVVVMVGSFCLCYVPYAALAMYMVNNRDHGIDLRLVTIPAFFSKSACVYNPIIYCFMNKQ 0 0 FRACIMETVCGKPMTDESDVSSSAQKTEVSSVSSSQVSPS* 0 >SWS1_xenLae Xenopus laevis 0 MLEEEDFYLFKNVSNVSPFDGPQYHIAPKWAFTLQAIFMGMVFLIGTPLNFIVLLVTIKYKKLRQPLNYILVNITVGGFLMCIFSIFPVFVSSSQGYFFFGRIACSIDAFVGTLT 1 2 GLVTGWSLAFLAFERYIVICKPMGNFNFSSSHALAVVICTWIIGIVVSVPPFLGWSR 2 1 YMPEGLQCSCGPDWYTVGTKYRSEYYTWFIFIFCFVIPLSLICFSYGRLLGALRA 0 0 VAAQQQESASTQKAEREVSRMVIFMVGSFCLCYVPYAAMAMYMVTNRNHGLDLRLVTIPAFFSKSSCVYNPIIYSFMNKQ 0 0 FRGCIMETVCGRPMSDDSSVSSTSQRTEVSTVSSSQVSPA* 0 >SWS1_neoFor Neoceratodus forsteri (Australian lungfish) 0 MSGEEEFYLFKNISSVGPWDGPQYHIAPKWAFFLQAAFMGFVLFVGTPLNAIVLFVTIKYKKLQQPLNYILVNISLAGFIFCFFGVFAVFIASCQGYFIFGKTVCALEGFTGSVA 1 2 GLVTGWSLAILAFERYLVICKPIGNFRFGSKHSMIAVVAAWVIGVGVSIPPFFGWSR 2 1 YIPEGLQCSCGPDWYTVGTKYKSEYYTWFLFIFCFIIPLFIICFSYSQLLGALRA 0 0 VAAQQQESATTQKAEREVSRMIIVMVGSFCVCYVPYAALAMYMVNNRDHGIDLRLVTIPAFFSKSSFVYNPIIYCFMNKQ 0 0 FRACIMQTVFGKPMTDDSDISSSGKTEVSSVSSSQVNPS* >SWS1_danRer Danio rerio 0 MDAWAVQFGNASKVSPFEGEQYHIAPKWAFYLQAAFMGFVFIVGTPMNGIVLFVTMKYKKLRQPLNYILVNISLAGFIFDTFSVSQVSVCAARGYYSLGYTLCSMEAAMGSIA 1 2 GLVTGWSLAVLAFERYVVICKPFGSFKFGQGQAVGAVVFTWIIGTACATPPFFGWSR 2 1 YIPEGLGTACGPDWYTKSEEYNSESYTYFLLITCFMMPMTIIIFSYSQLLGALRA 0 0 VAAQQAESESTQKAEREVSRMVVVMVGSFVLCYAPYAVTAMYFANSDEPNKDYRLVAIPAFFSKSSSVYNPLIYAFMNKQ 0 0 FNACIMETVFGKKIDESSEVSSKTETSSVSA* 0 >SWS1_oryLat Oryzias latipes 0 MGKYFYLYENISKVGPYDGPQYYLAPTWAFYLQAAFMGFVFFVGTPLNFVVLLATAKYKKLRVPLNYILVNITFAGFIFVTFSVSQVFLASVRGYYFFGQTLCALEAAVGAVA 1 2 GLVTSWSLAVLSFERYLVICKPFGAFKFGSNHALAAVIFTWFMGVGCACPPFFGWSR 2 1 YIPEGLGCSCGPDWYTNCEEFSCASYSKFLLVTCFICPITIIIFSYSQLLGALRA 0 0 VAAQQAESASTQKAEKEVSRMIIVMVASFVTCYGPYALTAQYYAYSQDENKDYRLVTIPAFFSKSSCVYNPLIYAFMNKQ 0 0 FNGCIMEMVFGKKMEEASEVSSKTEVSTDS*0 >SWS1_geoAus Geotria australis lamprey UV-sensitive retinal pigment lamprey 0 MSGDEEFYLFKNISKVGPWDGPQFHIAPKWAFYLQAAFMGFVFICGTPLNAIVLVVTIKYKKLRQPLNYILVNISAAGLVFCLFSISTVFVASMQGYFFLGPTICALEAFFGSLA 1 2 GLVTGWSLAFLAAERYIVICKPFGNFRFGSKHALVAVGLTWMLGLSVALPPFFGWSR 2 1 YIPEGLQCSCGPDWYTVGTKYKSEYYTYFLFVFCFVVPLSIIIFSYGSLLGTLRA 0 0 VAAQQQESASTQKAEREVSRMVIMMVASFCTCYVPYAALAVYMVTNRDHNIDLRFVTVPAFFSKASCVYNPLIYSFMNKQ 0 0 FRACILETVCGKPITDESETSSSRTEVSSVSTTQMIPG* 0 >LWS_homSap OPN1MW NP_000504 length=364 0 MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTR 1 2 GPFEGPNYHIAPRWVYHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFVLGHPMCVLEGYTVSLC 1 2 GITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWAAVWTAPPIFGWSR 2 1 YWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRA 0 0 VAKQQKESESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPFHPLMAALPAFFAKSATIYNPVIYVFMNRQ 0 0 FRNCILQLFGKKVDDGSELSSASKTEVSSVSSVSPA* 0 >LWS_monDom OPN1MW NP_000504 length=364 macEug for last exon 0 MTQAWDPAGFLARRRDVNEDDNDETTRSSLFVYTNSNNTR 1 2 GPFEGPNYHIAPRWVYNLTSLWMVFVVIASIFTNGLVLVATMKFKKLRHPLNWILVNLAVADLGETVIASTISVINQIYGYFILGHPLCVLEGYTVSLC 1 2 GITGLWSLAIISWERWVVVCKPFGNVKFDAKLAMVGIIFSWVWAAVWTAPPLFGWSR 2 1 YWPHGLKTSCGPDVFSGSSDPGVQSYMIVLMATCCIFPLSIILLCYVQVWLAIRA 0 0 VAKQQKESESTQKAEKEVSRMVVVMILAYCFCWGPYTLFACFAAANPGYSFHPLTASLPAYFAKSATIYNPIIYVFMNRQ 0 0 FRTCILQLFGKKVDDGSEVSSTSRTEVSSVSSVAPA* 0 >LWS_ornAna platypus LWS green cone -Ultra401:228,567-238,486 0 MTPAWNSGVYAARRRFEDEEDTTRTSVFVYTNSNNTR 1 2 DPFEGPNYHIAPRWAYNVTSLWMIFVVIASVFTNGLVLVATMKFKKLRHPLNWILVNLAVADLGETLIASTISVINQIFGYFILGHPMCVLEGYTVSLC 1 2 GITGLWSLSIISWERWIVVCKPFGNVKFDAKLAMVGIVFSWVWAAVWTAPPIFGWSR 2 1 YWPHGLKTSCGPDVFSGSSDPGVQSYMIVLMSTCCILPLSIIVLCYLQVWLAIRA 0 0 VAKQQKESESTQKAEKEVSRMVVVMILAYCFCWGPYTIFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ 0 0 FRNCIMQLFGKKVDDGSELSSTSRTEVSSVSSVSPA* 0 >LWS_galGal chicken green iodopsin red cone long-wave-sensitive missing in assembly 0 MAAWEAAFAARRRHEEEDTTRDSVFTYTNSNNTR 1 2 GPFEGPNYHIAPRWVYNLTSLWMIFVVAASVFTNGLVLVATWKFKKLRHPLNWILVNLAVADLGETVIASTISVINQISGYFILGHPMCVVEGYTVSAC 1 2 GITALWSLAIISWERWFVVCKPFGNIKFDGKLAVAGILFSWLWSCAWTAPPIFGWSR 2 1 YWPHGLKTSCGPDVFSGSSDPGVQSYMVVLMVTCCFFPLAIIILCYLQVSLAIRA 0 0 VAAQQKESESTQKAEKEVSRMVVVMIVAYCFCWGPYTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ 0 0 FRNCILQLFGKKVDDGSEVSTSRTEVSSVSNSSVSPA* 0 >LWS_anoCar Anolis 0 MAGTVTEAWDVAVFAARRRNDEDDTTRDSLFTYTNSNNTR 1 2 GPFEGPNYHIAPRWVYNITSVWMIFVVIASIFTNGLVLVATAKFKKLRHPLNWILVNLAIADLGETVIASTISVINQISGYFILGHPMCVLEGYTVSTC 1 2 GISALWSLAVISWERWVVVCKPFGNVKFDAKLAVAGIVFSWVWSAVWTAPPVFGWSR 2 1 YWPHGLKTSCGPDVFSGSDDPGVLSYMIVLMITCCFIPLAVILLCYLQVWLAIRA 0 0 VAAQQKESESTQKAEKEVSRMVVVMIIAYCFCWGPYTVFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ 0 0 FRNCIMQLFGKKVDDGSELSSTSRTEVSSVSNSSVSPA* 0 >LWS_xenTro Xenopus tropicalis (frog) NM_001102861 0 MASHWNEAVFAARRRNDDDDTTRSSVFTYTNSNNTR 1 2 GPFEGPNYHIAPRWVYNISSLWMIFVVLASVFTNGLVLVATLKFKKLRHPLNWILVNMAIADLGETVIASTISVCNQIFGYFVLGHPMCILEGYTVSVC 1 2 GIAALWSLTVIAWERWFVVCKPFGNIKFDGKLAATGIIFSWVWAAGWCAPPIFGWSR 2 1 YWPHGLKTSCGPDVFSGSSDPGVQSYMLVLMITCCIIPLAIIVLCYMHVWLTIRQ 0 0 VAQQQKESESTQKAEREVSRMVVVMIIAYIFCWGPYTFFACFAAFNPGYNFHPLAAAMPAYFAKSATIYNPIIYVFMNRQ 0 0 FRNCIYQLFGKKVDDGSEVSSTSRTEVSSVSNSSVSPA* 0 >LWS_neoFor Neoceratodus forsteri (Australian lungfish) 0 MAEPWDAVLAARRRHQDEETTRSTIFVYTNSNNTR 1 2 GPFEGPNYHIAPRWVYNLTSLWMIFVVFASCFTNGLVLMATYKFKKLRHPLNWILVNLAIADLGETLIASTISVTNQIFGYFILGHPMCMLEGFTVATC 1 2 GITGLWSLTIIAWERWVVVCKPFGNIKFDGKWAAGGIIFSWVWSAFWCAMPLFGWSR 2 1 FWPHGLKTSCGPDVFSGEDKYGTRSFMIALMITCCIIPLGVIILCYIQVWWAIRT 0 0 VAKQQKESESTQKAEKEVSRMVVVMIFAYCFCWGPYTFMACFGAAYPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ 0 0 FRNCIYQLLGKKVDDGSELSSTSKTEVSSVSNSSVSPA* 0 >LWS_takRub Takifugu rubripes (pufferfish) 0 MAEEWGKQSFAARRYHEDTTRGSAFVYTNSNHTR 1 2 DPFEGPNYHIAPRWVYNVATVWMFIVVVLSVFTNGLVLVATAKFKKLRHPLNWILVNLAIADLGETVFASTISVCNQFFGYFILGHPMCVFEGYTVSTC 1 2 GIAALWSLTIISWERWVVVCKPFGNVKFDAKWATGGIVFSWVWAAVWCAPPIFGWSR 2 1 YWPHGLKTSCGPDVFSGSEDPGVQSYMIVLMITCCIIPLAIIILCYLAVWLAIRS 0 0 VAMQQKESESTQKAEKEVSRMVVVMIVAYCVCWGPYTFFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPVIYVFMNRQ 0 0 FRVCIMKLFGKEVDDGSEVSTSKTEVSSVAPA* 0 >LWS_gasAcu Gasterosteus aculeatus 0 MAEEWGKQAFAARRYNEDTTRGSMFVYTNSNNTK 1 2 DPFEGPNYHIAPRWVYNLSTLWMFIVVALSVFTNGLVLVATAKFKKLQHPLNWILVNLAIADLGETVFASTISVCNQFFGYFILGHPMCVFEGYVVSVC 1 2 GITALWSLTIISWERWIVVCKPFGNVKFDAKWATAGIVFSWIWSAVWCAPPIFGWSR 2 1 YWPHGLKTSCGPDVFSGSEDPGVQSYMIVLMITCCLIPLAIIILCYLAVWLAIRA 0 0 VAMQQKESESTQKAERDVSRMVVVMIVAYIVCWGPYTTFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPVIYVFMNRQ 0 0 FRSCIMQLFGKEVDDGSEVSTsKTEVSSVAPA* 0 >LWS_petMar Petromyzon maritimus lamprey traces key to intron 3 position and gapping 0 MTASWQGAMFAARRRQDDEDTTMESLFRYTNENNTK 1 2 DPFEGPNYHIAPRWVFNLTSVWMIIVVVLSLFSNGLVLVATVKFKKLRHPLNWIIVNLAIADILETIFASTISVCNQVYGYFILGHPMCVFEGYVVSTC 1 2 GIAGLWSLAIISWERWMVVCKPFGNIKFDGKIATILIVFSWVWPASWCSLPIFGWSR 2 1 YWPHGLKTSCGPDVFSGSTDPGVQSYMVVLMITCCFLPLSIIILCYLQVWLAIHS 0 0 VAQQQKESETTQKAERDVSRMVVVMILAYVFCWGPYTFFACFAAANPGYSFHPIAAALPAYFAKGATIYNPIIYVFMNRQ 0 0 FRNCILQLFGKKVDDGSEVSSSSRTEVSSVSNSSVSPA* 0 >LWS_letJap lamprey Lethenteron japonicum 0 MTASWHGAVFAARRRNDDEDTTKDSIFRYTNENNTR 1 2 DPFEGPNYHIAPRWMFNLTSVWMIIVVVLSLFTNGLVLVATMKFKKLRHPLNWILVNLAIADILETIFASTISVCNQVFGYFILGHPMCVFEGYVVSTC 1 2 GIAGLWSLAIISWERWMVVCKPFGNIKFDGKIAIILIVFSWVWPACWCSLPIFGWSR 2 1 YWPHGLKTSCGPDVFSGSSDPGVQSYMVVLMVTCCFLPLSVIILCYLQVWLAIHS 0 0 VAQQQKESETTQKAERDVSRMVVVMILAYIFCWGPYTFFACYAAANPGYAFHPLTAALPAYFAKSATIYNPVIYVFMNRQ 0 0 FRNCIMQLFGKKVDDGSEVSSASRTEVSSVSNSSISPA* >LWS_geoAus Geotria australis lamprey red-sensitive retinal pigment 0 MAQSWERAMFAARRRQDEDTTKGDLFRYTNENNTR 1 2 DPFEGPNYHIAPRWMYNLTSFWMIIVVILSLFTNGLVLVATLKFKKLRHPLNWILVNLAIADIGETIFASTVSVVNQIFGYFILGHPLCVFEGFTVSVC 1 2 GITALWSLAIISFERWMVVCKPFGNLKFDGKVAIVLIIFSWAWSAGWCAPPIFGWSR 2 1 YWPHGLKTSCGPDVFSGSTDPGVQSYMVVLMITCCFIPLALIIICYLQVWLAIHT 0 0 VAQQQKESETTQKAERDVSRMVVVMIFAYIFCWGPYTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ 0 0 FRNCIMQLFGKKVDDGSEVSSSARTEVSSVSNSSVSPA* 0 >PIN_galGal pinopsin pineal pigment non-visual homSap- RPH3AL DOC2B PIN TEX14 RAD51C 0 MSSNSSQAPPNGTPGPFDGPQWPYQAPQSTYVGVAVLMGTVVACASVVNGLVIVVSICYKKLRSPLNYILVNLAVADLLVTLCGSSVSLSNNINGFFVFGRRMCELEGFMVSLT 1 2 GIVGLWSLAILALERYVVVCRPLGDFQFQRRHAVSGCAFTWGWALLWSTPPLLGWSSYVPE 1 2 GLRTSCGPNWYTGGSNNNSYILSLFVTCFVLPLSLILFSYTNLLLTLRA 0 0 AAAQQKEADTTQRAEREVTRMVIVMVMAFLLCWLPYSTFALVVATHKGIIIQPVLASLPSYFSKTATVYNPIIYVFMNKQ 0 0 FQSCLLEMLCCGYQPQRTGKASPGTPGPHADVTAAGLRNKVMPAHPV* 0 >PIN_utaSta Uta stansburiana pinopsin missing in Anole genome 0 MVNEWSNATPGPFDGPQWPYLAPRSIYTSVAVLMGLVVVSAAFVNGLVIVVSIQYKKLRSPLNYILVNLAIADLLVTSFGSTLSFANNIYGFFVLGQTACEFEGFMVSLT 1 2 GIVGLWSLAILAFERYLVICKPVGDFRFQQRHAVFGCVFTWMWSLVWTLPPLFGWSSYVPE 1 2 GLRTSCGPNWYTGGSGNNSYIMALFVTCFALPLGMIIFSYASLLLTLRA 0 0 VATQQKEVETTQQAEKEVTRRVIAMVMAFLVCWLPYASFAMVVATNKDLVIQPALASLPSYFSKTATVYNPIIYVFMNKQ 0 0 FRSCLLSTMSCGHRPRGAQETTPAMISIPQGPTSALQGSRNKVTPSASEGSGNEAIPS* 0 >PIN_pheMad Phelsuma madagascariensis gekko 0 MHVQMANASQASLKNGTLSPFDGPQWPHRASRRVYTSLAALMGVVVLSASLANGLVIAVSVRFKRLRSPLNYILVNLATADLLVTFFGSIISFVNNAVGFFVFGKTACRFEGFMVSLT 1 2 GIVGLWSLAILAFERYLVICKPVGDFQFQRRHAVIGCLYTWGWSLIWTVPPLFGWSSYVPE 1 2 GLGTSCGPNWYMGGTNNNSYIVALFVTCFALPLSMILFSYANLLLTLRA 0 0 VAAQQKEQETTQRAEKEVTRMVITMVMAFLVCWLPYATFAMVVATTKDLSIQPGLASLPSYFSKTATVYNPIIYVFMNKQ 0 0 FRSCLLNTVSCGRIPQTMPGTPATTAVRGGFVLTSEGRGNKVASTELHS* 0 >PIN_podSic Podarcis sicula pinopsin mRNA ruin lizard 0 MQASNASWVEVRNRTPGPFEGPQWPYLAPQSTYISVAVLMGLVVISATLVNGLVIVVSVQFKKLRSPLNYVLVNLAVADLLVTFFGSTISFVNNAQGFFIFGQATCEFEGFMVSLT 1 2 GIVGLWSLAILAFERYLVICKPVGDFRFPARHAVLGCAFTWGWSFVWTVPPLLGWSSYVPE 1 2 GLRTSCGPNWYSGGSSNNSYIMTLFVTCFAMPLSTILFSYANLLMTLRT 0 0 VAAQQKEQETTQRAEREVTRMVVAMVAAFLVCWLPYASFAMVVATHKDLAIRPALASLPSYFSKTATVYNPIIYVFMNKQ 0 0 FRSCLLYKMSCGHRALSSQDTTPAGISLPGRLTTSASKGSRNQVSPS* 0 >PIN_xenTro Xenopus tropicalis 0 MRAGNMSAYEAPGPYDGPQWPHLAPRSTFLTVAAVMCMVVILAFFVNGLVIVVTLKYKKLRSPLNYILVNLAIANLLVTIFGSSVSFSNNVVGYFFMGKTMCEFEGFMVSLT 1 2 GIVGLWSLAILAFERYLVICKPMGDFRFQQKHAILGCSFTWVWSFIWTSPPLFGWCSYVPE 1 2 GLRTSCGPNWYTGGTNNNSYIMALFLTCFIMPLSTIIFSYSNLLMALRA 0 0 VAAQQKDSETTQRAEKEVTRMVIAMVLAFLICWLPYASFAVVVAVNKDVVIEPTVASLPSYFSKTATVYNPIIYVFMNKQ 0 0 FRNCLMTLLCCGRSFGDDETSSASGRTDVTSVSEAGGNKVTPA* 0 >PIN_bufJap Bufo japonicus toad classifies somewhat oddly 0 MHSANMSALETPGPFEGPQWPHVAPRSTYLTVAVLMGMVVFLAFFVNGMVIVVSLKYKKLRSPLNYILVNLAVADILVTMFGSTVSFHNNIFGFFTLGKLVCELEGFVVSLT 1 2 GIVGLWSLAILAFERYIVICKPMGDFRFQQRHAVMGCAFTWIWAFLWTSPPLIGWCSYVPE 1 2 GLGTSCGPNWYTGGTNNNSYILALFTTCFMMPLTTIIFSYSNLLLALRA 0 0 VAAQQKESETTQRAEREVTRMVIAMVLAFLICWLPYAVFAIVMASNKNVVIDPTLASMPSYFSKTATVYNPVIYVFMNKQ 0 0 FRDCLTKLLCCGRNPFGEDETSTTSGRTDVTSVSEGGGNKVTPA* 0 >VAOP_galGal Gallus gallus exon 1 genbank error + too short + frameshift INPP5A NKX6 VAOP ALDH18A stubbed in terminal finch 0 MDVFRALGNESLLSNSSGPARWDPFHHPLDSIQPWHFRLVAAVMFVVTSLSLAENLAVILVTFKFKQLRQPVNYVIVNLSVADFLVSLTGGTISFLANLKGYFYMGHWACVLEGFAVTFF 1 2 GIVALWSLALLAFERYIVICRPVGNMRLRGKHAAQGIAFVWTFSFIWTIPPTMGWSSYTTSKIGTTCEPNW 2 1 YSGAYNDRSYIIAFFTTCFIVPLLVILVSYGKLLQKLRK 0 0 VSNTQGRLRTARKPERQVTRMVVVMIIAFLICWMPYAVFSILATAYPSIELDPHLAAIPAFFSKTATVYNPIIYVFMNKQ 0 0 FRMCLIQMFKCSAIETAESNMNPTSERATLTQDKRDSQLSVMAVRSTILKRKTGDEHRADDLWLFRQLQKPKCVPCRAGDGS* 0 >VAOP_anoCar Anole INPP5A NKX6 VAOP new 0 MAGLRREAENDSWLFDPSSSSAPFDPFLQPLDIIEPWNFHLISALMFVVTLFSLSENFTVILVTIKFKQLRQPLNYVIVNLSVADFLVSLIGGTISFSTNLKGYFYMGHWACVLEGFAVTFF 1 2 GIVALWSLALLAFERYVVICRPLGNMRLNGKHAALGVAFVWIFSFIWTVPPTMGWSSYTTSKIGTTCEPNW 2 1 YSGDYNDHTFIITFFTTCFILPLLVILVSYGKLMRKLRK 0 0 VSDTQGRLGTTRKPERQVTGMVVIMILAFLICWSPYAAFSILVTACPSIELDPRLAAIPAFFSKTATVYNPVIYVFMNNQ 0 0 FRKCLVQLFQCSSQETMDANVNPISEKDTLTHTKHCGEMSTVAAHVIVFNPRSEDEQGSCQSFAQLAISENKVYPL* 0 >VAOP_xenTro frog new lost synteny GSTO1 VAOP C10ORF92 0 MPTNVSLLATPENSTVWNPFTGPLKTIEAWNFHLLAALMFVVTSLSIAENFIVILVTAKFKQLRQPLNYIIVNLSVADFLVSVIGGTISIATNSRGYFYLGSWACVLEGFAVTFF 1 2 GIVALWSLSVLAFERYIVICRPLGNLRLQGKHSALAIIFVWVFSFVWTIPPTMGWSSYTTSKIGTTCEPNW 2 1 YSGEMRDHTYIITFLTTCFVFPLLVIFMSYGKLMRKLRK 0 0 VSDTQGRLGSTRKPEKEVTRMVVIMILAFLICWTPYAAFSILITAHPTIDLDPRLAAIPAFFAKTASMYNPIIYVYMNKQ 0 0 FRRCLYQMFNINDPEAKESNLNPTSERGVLTRNNNGGEMLAIATHITSSAVTNREEEKSSSNSFAHIPVSDNKVCPM* >VAOP_danRer Danio rerio vertebrate ancient long opsin assembly missing exon 3 no synteny 0 MEASSAAVNAVSPAEDPFSAPLSSIAPWNYSVLAALMFVVTALSLSENFTVMLVTFRFQQLRQPLNYIIVNLSLADFLVSLTGGSISFLTNYHGYFFLGKWACVLEGFAVTFF 1 2 GIVALWSLAVLAFERFFVICRPLGNIRLRGKHAALGLVFVWSFSFIWTVPPVLGWSSYTVSRIGTTCEPNW 2 1 YSGNFHDHTFIITLFSTCFIFPLGVIIVCYCKLIRKLRK 0 0 VSNTHGRLGNARKPERQVTRMVVVMIVAFMVAWTPYAAFSIIITAHPSMHVDPRLAAIPAFVAKTAAVYNPIIYVFMNKQ 0 0 FRKCLVQLLSCSKVTVVEGNNNQTTERAGMTSGSNTGEMSAIAARVSVPKTEENPGDRSTFSHIPIPENKVCPM* >VAOP_takRub Takifugu rubripes vertebrate ancient opsin 0 MESLSLSVNGVSYTVAAELAPTNDPFTGPINNIAQWNFTILAVLMFVVTSLSLCENFLVMFITFKFKQLRQPLNYIIVNLAIADFLVSLTGGLISFLTNARGYFFLGRWACVLEGFAVTYF 1 2 GIVAMWSLAVLSFERFFVICRPLGNMRLQAKHAAIGLLFVWTFSFVWTFPPVLGWNRYTVSKIGTTCEPDW 2 1 YSNNMTSHSYIITFFSTCFILPLGIIFFCYGKLLRKLRK 0 0 VSHGRLATARKPERQVTRMVVVMIVAFMVAWTPYATFAILVTIHPTIELDPR 0 FRKCLIQHFIGMGVMAESNMNPTSERPGITAESQTGEMSAIAARVPVGATAALHSDGSPTDCGSLAQLPIPENKVCPI* 0 >VAOP_rutRut Rutilus rutilus (roach minnow) vertebrate ancient opsin 0 MELFPVAVNGVSHAEDPFSGPLTFIAPWNYKVLATLMFVVTAASLSENFAVMLVTFRFTQLRKPLNYIIVNLSLADFLVSLTGGTISFLTNYHGYFFLGKWACVLEGFAVTYF 1 2 GIVALWSLAVLAFERFFVICRPLGNIRLRGKHAALGLLFVWTFSFIWTIPPVLGWSSYTVSKIGTTCEPNW 2 1 YSGNFHDHTFIIAFFITCFILPLGVIVVCYCKLIKKLRK 0 0 VSNTHGRLGNARKPERQVTRMVVVMIVAFMVAWTPYAAFSIVVTAHPSIHLDPRLAAAPAFFSKTAAVYNPVIYVFMNKQ 0 0 FRKCLVQLLRCRDVTIIEGNINQTSERQGMTNESHTGEMSTIASRIPKDGSIPEKTQEHPGERRSLAHIPIPENKVCPM* 0 >VAOP_petMar Petromyzon marinus 5 exons validated #123 in traces pineal gland-specific opsin AH006524 0 MDALQESPPSHHSLPSALPSATGGNGTVATMHNPFERPLEGIAPWNFTMLAALMGTITALSLGENFAVIVVTARFRQLRQPLNYVLVNLAAADLLVSAIGGSVSFFTNIKGYFFLGVHACVLEGFAVTYF 1 2 GVVALWSLALLAFERYFVICRPLGNFRLQSKHAVLGLAVVWVFSLACTLPPVLGWSSYRPSMIGTTCEPNW 2 1 YSGELHDHTFILMFFSTCFIFPLAVIFFSYGKLIQKLKK 0 0 ASETQRGLESTRRAEQQVTRMVVVMILAFLVCWMPYATFSIVVTACPTIHLDPLLAAVPAFFSKTATVYNPVIYIFMNKQ 0 0 FRDCFVQVLPCKGLKKVSATQTAGAQDTEHTASVNTQSPGNRHNIALAAGSLRFTGAVAPSPATGVVEPTMSAAGSMGAPPNKSTAPCQQQGQQQQQQGTPIPAITHVQPLLTHSESVSKICPV* 0 >PPIN_anoCar Anoles parapinopsin PPIN syntenic region deleted in chicken 0 MDSLDTNTLSPNASTVRVVLMPRIGYTIIAIIMATSCTLSVILNTAVIAITIKYRQLRQPINYSLVNLAIADLGAALLGGSLNVETNAVGYYNLGRVGCVTEGFAMAFF 1 2 GIVALCTIAVIAVDRAIVIAKPMGTITFTTRKAMIGVAVSWIWSLVWNTPPLFGWGGYQMEGVMTSCAPDWANSDPINVSYIICYFLFCFTIPFITILASYGYLIWTLRQ 0 0 VAKVGLAQRGSTTKAEAQVSRMVIVMVMAFLICWLPYATFALVVVGNPQIYINPIIATIPMYMAKSSTFYNPIIYIFMNKQ 0 0 FRDCLVRCLLCGRNPCASEQTDEDDLEVSTIAPAPSSRRGKVAPV* 0 >PPIN_xenTro Xenopus tropicalis bistable UV pigment lamprey pineal broken contigs ACTR8 SELK PPIN CACNA2D3 genome only last 2 0 MADEALLPPMMNVTNEEMHPGKVLMPRIGYTILALIMAVFCAAALFLNVTVIVVTFKYRQLRHPINYSLVNLAIADLGVTVLGGALTVETNAVGYFNLGRVGCVIEGFAVAFF 1 2 GIAALCTIAVIALDRVFVVCKPMGTLTFTPKQALAGIAASWIWSLIWNTPPLFGWGSYELEGVMTSCAPNWYSADPVNMSYIVCYFSFCFAIPFLIIVGSYGYLMWTLRQ 0 0 VAKLGVAEGGTTSKAEVQVSRMVIVMILAFLVCWLPYAAFAMTVVANPGMHIDPIIATVPMYLTKTSTVYNPIIYIFMNKQ 0 0 FQECVIPFLFCGRNPWAAEKSSSMETSISVTSGTPTKRGQVAPA* 0 >PPIN_ictPun Ictalurus punctatus (channel catfish) parapinopsin index sequence 0 MASIILINFSETDTLHLGSVNDHIMPRIGYTILSIIMALSSTFGIILNMVVIIVTVRYKQLRQPLNYALVNLAVADLGCPVFGGLLTAVTNAMGYFSLGRVGCVLEGFAVAFF 1 2 GIAGLCSVAVIAVDRYMVVCRPLGAVMFQTKHALAGVVFSWVWSFIWNTPPLFGWGSYQLEGVMTSCAPNWYRRDPVNVSYILCYFMLCFALPFATIIFSYMHLLHTLWQ 0 0 VAKLQVADSGSTAKVEVQVARMVVIMVMAFLLTWLPYAAFALTVIIDSNIYINPVIGTIPAYLAKSSTVFNPIIYIFMNRQ 0 0 FRDYALPCLLCGKNPWAAKEGRDSDTNTLTTTVSKNTSVSPL* 0 >PPIN_danRer Danio rerio parapinopsin [not checked wgd or synteny] 0 MESETSTAASGSIAEVMPRMGYTILAVIIGVFSVCGVILNVTVITVTLKYKQLRQPLNFALVNLAVADLGCAVFGGLPTVVTNAMGYFSLGRVGCVLEGFAVAFF 1 2 GIAALCSVAVIALERCMVVCRPVGSISFQTRHAVFGVAVSWLWSFIWNTPPLFGWGRLQLEGVRTSCAPDWYSRDLANVSFIVCYFLLCFALPFSVIVYSYTRLLWTLRQ 0 0 VSRLQVCEGGSAARAEAQVSCMVVVMILAFLLTWLPYASFALCVILIPELYIDPVIATVPMYLTKSSTVFNPIIYIFMNRQ 0 0 FRDRALPFLLCGRNPWAAEAEEEEEETTVSSVSRSTSVSPA* 0 >PPIN_oncMyk Oncorhynchus mykiss 0 MDHQQLLPNLHGNISSSPGSVSEALLSRTGFTILAVIIGVFSVSGVCMNVLVIMVTMRHRKLRQPLNYALVNLAVADLGCALFGGLPTMVTNAMGYFSMGRLGCVLEGFAVAFF 1 2 GIAGLCSVAVIAVDRYVVVCRPMGAVMFQTRHAVGGVVLSWVWSFLWNTPPLFGWGSFELEGVRTSCSPNWYSREPGNMSYIILYFLLCFAIPFSIIMVSYARILFTLHQ 0 0 VSKLKVLEGNSTTRVEIQVVRMVVVMVMAFLLSWLPYAAFALSVILDPSLHINPLIATVPMYLAKSSTVYNPIIYVFMNRQ 0 0 FRDCAVPFLLCGLNPWASEPVGSEADTALSSVSKNPRVSPQ* >PPIN_petMar Petromyzon maritimus lamprey trace-validated introns bistable pineal UV/green 0 MENLTSLDLLPNGEVPLMPRYGFTILAVIMAVFTLASLVLNSTVIIVTLRHRQLRHPLNFSLVNLAVADLGVTVFGASLVVETNAVGYFNLGRVGCVIEGFAVAFF 1 2 GIAALCTIAVIAVDRFVVVCKPLGTLMFTRRHALLGITWAWLWSFVWNTPPLFGWGSYKLEGVRTSCAPDWYSRDPANVSYIVSFFSFCFAIPFLVIVVAYGRLLWTLHQ 0 0 VAKLGMGESGSTAKAEAQVSRMVVVMVVAFLVCWLPYALFAMIVVAKPGVYIDPVIATLPMYLTKTSTVYNPIIYIFMNRQ 0 0 FRDCAVPFLLCGRNPWAEPSSESATTASTSATSVTLASVPGQVSPS* 0 >PPIN_letJap Lethenteron japonicum lamprey AB116380 bistable pineal UV/green aligns perfectly 0 MENLTSLDLLPNGEVPLMPRYGFTILAVIMAVFTIASLVLNSTVVIVTLRHRQLRHPLNFSLVNLAVADLGVTVFGASLVVETNAVGYFNLGRVGCVIEGFAVAFF 1 2 GIAALCTIAVIAVDRFVVVCKPLGTLMFTRRHALLGIAWAWLWSFVWNTPPLFGWGSYELEGVRTSCAPDWYSRDPANVSYITSYFAFCFAIPFLVIVVAYGRLMWTLHQ 0 0 VAKLGMGESGSTAKAEAQVSRMVVVMVVAFLVCWLPYALFAMIVVTKPDVYIDPVIATLPMYLTKTSTVYNPIIYIFMNRQ 0 0 FRDCAVPFLLCGRNPWAEPSSESATAASTSATSVTLASAPGQVSPS* 0 >PPINa_cioInt Ciona intestinalis parapinopsin 8 mostly odd exons 88 +- 200671 202490 1820 opsin1 larval ocellus 0 MNQWLETIMNERKFEIVNSSLQG 2 1 LLKPDSLGMDHDVTPTVDLTDGVPQCKDLNPYVLKGDGWVPQHISRANRSTYSFLCVYMTFVFLLSCSLNILVIVATLKNK 0 0 VLRQPLNYIIVNLAVVDLLSGFVGGFISIAANGAGYFFWGKTMCQIEGYFVSNFGVTGLL 0 0 SIAVMAFERYFVICKPFGPVRFEEKHSIFGIV 0 0 ITWVWSMFWNTPPLIFWDGYDTEGLGTSCAPNWFVKEKRERLFIILYFVFCFVIPLAVIMICYGKLILTLRQ 0 0 IAKESSLSGGTSPEGEVTKMVVVMVTAFVFCWLPYAAFAMYNVVNPEAQ 0 0 IDYALGAAPAFFAKTATIYNPLIYIGLNRQ 0 0 FRDCVVRMIFNGRNPWVDELVGSQVSSTGSQLTAVSSNKVAPA* 0 >PPINb_cioInt Ciona intestinalis 137 +- 67340 71147 3808 new 61% classifies perhaps as PIN jgi gene model wrong both ends 0 MTTAETTTECYEKNPYIRNEMGWVPKHILIAERHIYTILAVYMTFIFLLAVSLNGFVIIATMKNK 0 0 KLRQPLNYIIINLSIADFLSGLVGGFIGMISNSAGYFYFGKTVCILEGYIVSVA 1 2 GVCGLMSISVMAFERYFVVCKPYGPFTLTNTHAAL 1 2 GIGFTWTWSVLWSTPGLIWLDGYVPEGLGTSCAPNWFSKNK 2 1 SERIFIFVYFVFCFFIPLLVIIICYGKIVLFLKQVSLY 0 0 ATRQSSASSNRQADNKVTKMVLVMISAFLICWTPYGVLSLYNAINPDKQ 0 0 LDYGLGAVPVFFAKTANIYNPLIYIGLNKQ 0 0 FRDGVIKMVFRGRNPWAEEMSTQQRQRSTEAGQPIVSNEV* 0 >PARIE_utaSta Uta stansburiana lizard ancestral shift in counterion gusducin and Go 0 MENDSSLATELAEGAIVKPTIFPKAGYGVLAFLMFLNALFSIFNNSLVIAVTLKNPQLRNPINIFILNLSFSDLMMSLCGTTIVIATNYYGYFYLGRKFCIFQGFAVNYF 1 2 GIVSLWSLTILAYERYNVVCQPLGTLQMSTKRGYQLLGFIWVFCLFWAVVPLFGWSSYGPEGVQTSCSIGWEERSWSNYSYLIVYFLSCFFIPVLIIGFSYGNVIRSLHG 0 0 LNKKVEQLGGKSSPEEEFRAVIMVLVMVVAFLICWLPYTVFALIVVFNPALNISPLAATIPTYLSKTSPVYNPIIYIFLNKQ 0 0 FRDCAVEFITCGQVVLTSPEEDISTSAIPVEGKGPCKINQVTPV* 0 >PARIE_anoCar Anole carolinensis KERA DCN BTG1 PARIE EEA1 NUDT4 0 MENESSLVLEGAEGYIVRPTIFPRAGYGVLAFLMFINALFSLFNNFLVIAVTLKNPQLRNPINIFILNLSFSDLMMSICGTTIVIATNYHGYFYLGRRFCIFQGFAVNYF 1 2 GIVSLWSLTILAYERYNVVCQPLGTLQMSTQRAYQLLGFIWVFCLFWAVVPLFGWSSYGPEGVQTSCSIGWEERSWNNYSYLIVYFLSCFFIPVLIIGFSYGNVIRSLHG 0 0 LNKKVEQLGGKSNPEEEFRAVIMVLVMVVAFLICWLPYTLFALTVVFNPALNISPLAATIPTYLSKTSPVYNPIIYIFLNKE 0 0 FRECAVEFITCGKVVLTSPEEDISTSAISDEGIAPCKINQVTPV* 0 >PARIE_xenTro Xenopus tropicalis parietopsin 0 MDGNSTTPGIAVNLTVMPTIFPRSGYSILSFLMFLNAVFSICNNAIVILVTLKHPQLRNPINIFILNLSFSDLMMALCGTTIVVSTNYHGYFYLGKQFCIFQGFAVNYF 1 2 GIVSLWSLTLLAYERYNVVCEPIGALKLSTKRGYQGLVFIWLFCLFWAIAPLFGWSSYGPEGVQTSCSIGWEERSWSNYSYIISYFLTCFIIPVGIIGFSYGSILRSLHQ 0 0 LNRKIEQQGGKTNPREEKRVVIMVLFMVLAFLICWLPYTVFALIVVINPQLYISPLAATLPTYFAKTSPVYNPIIYIFLNKQ 0 0 FRTYAVQCLTCGHINLDSLEEDTESVSAQAENMLTPKTNQVAPA* 0 >PARIE_takRub Takifugu rubripes (teleost) 0 MDSNSTPWSSPPAPLQAEAVTVAPTIFPRVGYSILSFLMFINTVLSVFNNSLAIAVMLKNPSLLQPINIFILSLAVSDLMIGLCGSLVVTITNYHGSFFIGHTACVFQGFAVNYF 1 2 GLVSLCTLTLLAYERYNVVCKPRAGLKLTMRRSIIGLLFVWTFCLFWAVTPLLGWSSYGPEGVQTSCSLAWEERSWNNYSYLILYTLLCFIFPVGVIIYCYCKVLTSMNK 0 0 LNKSVELQGGLSCRRENKHAINMVLAMIIAFFVCWLPYTALSVVVVVDPELHIPPLVATMPMYFAKTSPVYNPIIYFLSNKQ 0 0 FRDATLEVLSCSRYIPHASSRVSINMRSLNRRSVNTHSKVSPL* 0 >PARIE_gasAcu Gasterosteus aculeatus (stickleback) 0 MDSNSTLWSSGSPPPSIHGKMLTITPTIFPRVGYSILSFLMFINTVLTVFNNVLVITVLVRNPSLLQPMNVFILSLAVSDLMIGLCGSLVVTITNYHGSFFIGHTACIFQGFAVNYF 1 2 GLVSLCTLTLLSYERYNVVCRPRNALKLSMRRSIHGLLIVWTFCLFWAVAPLFGWSGYGPEGVQTSCSLAWEERSWSNYSYLVLYTLLCFIVPVAVIIYCYAKVLTSMNT 0 0 LNRSVEVQGGRSSQKENDHAVSMVLAMIIAFFSCWLPYTALSVVVVVDPTLYIPPLVATMPMYFAKTSPVYNPIIYFLSNKQ 0 0 FRDAALEMLSCGRYIAHMPNTVSINMRSLNRRSRLSSLSRNVNSHSKVLPL* 0 >PARIE_danRer Danio rerio 0 MENFAKTELTMMVQPTIFPRVGYSILSYLMFINTTLSVFNNVLVIAVMVKNLHFLNAMTVIIFSLAVSDLLIATCGSAIVTVTNYEGSFFLGDAFCVFQGFAVNYF 1 2 GLVSLCTLTLLAYERYNVVCKPMAGFKLNVGRSCQGLLLVWLYCLFWAVAPLLGWSSYGPEGVQTSCSLGWEERSWRNYSYLILYTLMCFILPTVIITYCYSNVLLTMRK 0 0 INKSIECQGGKNCAEDNEHAVRMVLAMIIAFFICWLPYTAISVLVVVNPEISIPPLIATMPMYFAKTSPVYNPIIYFLTNKR 0 0 FRESSLEVLSCGRYISRETGGPLMGSSMQRGQSRVNPV* 0 >ENCEPH_homSap encephalopsin OPN3 panopsin encephalopsin 1q43 - 47250 4 chr1:239,823,075-239,870,324 402 cone opsin with intron loss 0 MYSGNRSGGHGYWDGGGAAGAEGPAPAGTLSPAPLFSPGTYERLALLLGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFSGSLF 1 2 GIVSIATLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRYILDVHGLGCTVDWKSKDANDSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRM 0 0 LRCVEDLQTIQVIKILKYEKKLAKMCFLMIFTFLVCWMPYIVICFLVVNGHGHLVTPTISIVSYLFAKSNTVYNPVIYVFMIRK 0 0 FRRSLLQLLCLRLLRCQRPAKDLPAAGSEMQIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVDDSDKTNGSKVDVIQVRPL* 0 >ENCEPH_monDom encephalopsin Monodelphis domestica 82% funny business with extra intron, alt splicing 0 MYSDNSSDDGGGGYWGSGRAGGASGTGVTGEPGPEGSPRQAPLFSPGTYELLALLIATIGLLGLCNNLLVLVLYYKFQRLRTPTHLFLVNISFNDLLVSLFGVTFTFVSCLRSGWVWDSVGCAWDGFSNTLF 1 2 GIVSIMTLTVLAYERYNRIVHAKVINFSWAWRAITYIWLYSLVWTGAPLLGWNRYTLEIHGLGCSVDWKSKDPNDSSFVIFLFFGCLMLPVGVMAYCYGHILYAIRM 0 LRCVEELQTIQVIKILRYEKKVAKMCFLMIAIFLFCWMPYAVICLLVANGYGSLVTPTVAIIASLFAKSSTAYNPIIYIFMSRK 0 0 FRRCLLQLLCFRLLKFQQPKKDRPVIRTEKQIRPIVMSQKVGDRPKKKVTFSSSSIIFIITSDETQMIDENDKNSGTKVNVIQVRPL* 0 >ENCEPH_galGal chicken encephalopsin 0 MHSGNGTGATSRPQLAAAGHEVPGERPLFSAGTYELLALLIATIGTLGVCNNLLVLVLYYKFKRLRTPTNLFLVNISLSDLLVSVCGVSLTFMSCLRSRWVWDAAGCVWDGFSNSLF 1 2 GIVSIMTLTVLAYERYIRVVHAKVIDFSWSWRAITYIWLYSLAWTGAPLLGWNRYTLEIHGLGCSMDWKSKDPNDTSFVLLFFLGCLVAPVVIMAYCYGHILYAVRM 0 0 LRCVEDFQTSQVIKLLKYEKKVAKMCFLMISTFLICWMPYAVVSLLVTYGYSNLVTPTVAIIPSFFAKSSTAYNPVIYIFMSRK 0 0 FRQCLLQLLCFRLMRFQRIMKEPSGAGNVKPIRPIVMSQKVGDRPKKKVTFSSSSIIFIIASDDTQQIDDNSKHNGTKVNVIQVKPL* 0 >ENCEPH_anoCar lizard encephalopsin 0 MFSANGTRSGAGSDLEPGPGQQQQQREASEEEERGAGLSPFSAGTYELLALLVAAIGLLGLCNNLLVLVLYAKFKRLRTPTHLFLVNISLSDLLVSLFGVSFTFGSCLRHRWVWDAAGCVWDGFSNSLF 1 2 GIVSIMTLTVLAYERYIRVVHARVIDFSWSWRAITYIWLYSLAWTGAPLLGWNHYTLEIHGLGCSVDWQSKEPSDSSFVLFFFLGCLAAPVGIMAYCYGHILHAIRM 0 0 LRCVEDLQSIQVIKILRYEKKVAKMCFLMVTTFLICWMPYAVVSLLIAYGYGHLITPTVAIIPSFFAKSSTAYNPVIYIFMSRK 0 0 FRRCLVQLFCVQFLRFKRTLKEQPAIESNKPIRPIVMSQKVGDRPKKKVTFSSSSIIFIITSDDTEQIDVSTKCSDTKINVIQVKPL* 0 >ENCEPH_xenTro Xenopus frog encephalopsin called teleost multiple tissue TMT opsin in fish 0 MPVTNGSHNNSISWLHSKDMFTEDTYHFLALIVATVGFLGLVNNLLVLILYCKFKRLQTPTNLLFFNTSLCHFVFSLLAITFTFMSCVRGSWAFSVEMCVFHGFSKNLL 1 2 GIVSFGTLTVVAYERYARVVYGKYVNSSWSKRSITFVWVYSLAWTGFPLIGWNLYTFETHKLDCSFEWTATDPKDTAFVLLFFLACITLPLSIMAYCYGYILYEIQK 0 0 LRSVKNIQNFQEITILDYEIKMAKMCLLMMLTFLIGWMPYTILSLLVTSGYSKFITPTITVMPSLLAIASAAYNPVIHIFTIKK 0 0 FRQCLVQLLPPINFHPPINPPINNFWRLLKNLNGRLAMKKVKPVLGKGRSHNRPEKKVPPINFSSSDFFTRTTSDTGTHGITESTKGKRTNVRLIQVHPL* 0 >ENCEPH4a_takRub Takifugu rubripes length=403 AF402774 multiple tissue opsin organs and cell lines exhibit circadian oscillations in clock gene 0 MIVSNVSLSGCAGVNGAVCAAEGHQAGGSDRSTLTPTGNLVVSVFLGFIGTFGLVNNLLVLVLFCRYKMLRSPINLLLMNISISDLLVCVLGTPFSFAASTQGRWLIGEAGCVWYGFANSLF 1 2 GVVSLISLAVLSFERYSTMMTPTEADPSNYCKVCLGITLSWVYSLVWTVPPLFGWSSYGPEGPGTTCSVNWTAKTTNSISYIICLFVFCLIVPFLVIVFCYGKLLCAIRQ 0 0 VSGINASTSRKREQRVLCMVVIMVICYLLCWLPYGVVALLATFGPPDLVTPEASIIPSVLAKSSTVINPIIYVFMNKQ 0 0 FYRCFLALLCCQDPRSGSSMKSSSKVATKAKGVTPTGQRRTDFLYMVASLGRPAATIPQLGPSFDATNDFTKPPSSDTIKPVVVSLAAHCDG* >ENCEPH4b_takRub Takifugu rubripes length=342 64% +CES1 +ENC 0 MIVCNVSLSCAHCPGEGTAANDAYAQASGSLATPTLSQRGHLVVAVCLGFIGTVGFLSNFLVLALFCRYRALRTPMNLMLVSISASDLLVSVLGTPFSFAASTQGRWLIGRAGCVWYGFVNACL 1 2 GIVSLISLAVLSYERYCTMVSSTIASNRDYRPVLGGICFSWFYSLAWTVPPLLGWSRYGPEGPGTTCSVDWRTQTPNNISYIVCLFTFCLLLPFFVILYSYGKLLHTIRQ 0 0 VRRVSSTVTRRREHRVLVMVVAMVVCYLICWLPYGVTALLATFGPPNLLTPEATITPSLLAKFSTVINPFIYIFMNKQ 0 0 FYRCFRAFLNCSTPKRDSTVRTFTRISLRALRQDQQQKGSALAPSSARPTPNSIHESSLKGSHSTPSNGGAAAAKSPAANRSKPKLILVAHYRE* 0 >ENCEPH_takRub Takifugu rubripes encephalopsin syntenic to mammal 0 MNPANGSRSERSAEQLLFSGDTYRVLAFTIGTIGAFGFCNNFVVLALYCRFKRLRTPTNLLLVNISLSDLLVSLFGINFTFAACVQGRWTWTQATCVWDGFSNSLF 1 2 GIVSIMTLAALAYERYIRVVHAQVVDFPWAWRAIGHIWLYALAWTGAPLLGWNRYTLEIHRLGCSLDWASKDPNDASFILLFLLACFFVPVGIMIYCYGNILYAVQM 0 0 IRSIQDLQTVQIIKILRYEKKVSVMFFLMISCFLLCWTPYAVVSMMVAFGRRSMVSPTMAIIPSFFAKSSTAYNPLIYVFMSRK 0 0 FRHCLLQLLCSRLSWLQRSLKERPLAPVQRPIRPIVMSRPCGKGNRPKKKVTFSSSSIVFIITSDDFGQLDVTSKSGDSADVNAIQVRPL* 0 >ENCEPH_tetNig encephalopsin 0 MSSADDSRSARSGEPSLFAVHTYRLLAAAIGAIGVLGFCNNLAVAALYWRFRRLRTPTNLLLLNISLSDLLVSLLGVNFTFAACVQGRWTWNQATCVWDGFSNSLF 1 2 GIVSIMTLAALAYERYIRVVHAQVVDFPWAWRAIGHIWLYSLAWTGAPLLGWNRYTLEIHRLGCSLDWASKDPNDASFILLFLLACFFVPVGIMIYCYGNILYAVHM 0 0 IRSIQDLQTVQIIKILRYEKKVSVMFFLMISCFLLCWTPYAVVSMMVAFGRKSMVSPTVAIIPSFFAKSSTAYNPVIYVFMSRK 0 0 FRRCLLQLLCSRLSWLQRGLKERPLAPVQRPIRPIVVSRPCGKGTRPKKKVTFSSSSIVFIITSDDFRQLDVTSRAGDSADVNAIQVRPL* 0 >ENCEPH_gasAcu Gasterosteus aculeatus (stickleback) encephalopsin 0 MNPDNGTREERSTDHSIFAVGTYKLLAFAIGTIGVFGFCNNVVVIVLYCKFKRLRTPTNLLVVNISLSDLLVSVIGINFTFVSCIRGGWTWSRATCIWDGFSNSLF 1 2 GIVSIMTLASLAYERYIRVVHAQVVDFPWAWRAIGHIWLYSLVWTGAPLLGWNRYTLEIHRLGCSLDWASKDPNDASFILLFLLACFFVPVGIMIYCYGNILYAVQM 0 0 LRSIQDLQTVQIIKILRYEKKVAVMFLLMISCFLLCWTPYAVVSMMEAFGRKNMVSPTVAIIPSFFAKSSTAYNPLICVFMSRK 0 0 FRRCLMQLLCSRVTCLQCNLKERPLAPVQRPIRPIVVSAACGGGRVRPKKRVTFSSSSIVFIITRNDIRHTDVTSNTRESSEANVFQVRPL* 0 >ENCEPH4_braFlo Branchiostoma floridae Amphiop4 AB050608 Un - 207841137 207851157 10021 new exon12 and 34 + perfect fit +CES1 -ENC -RTF1 0 MALYNNTSSPSQDLLWDAPYSQGHIWDNSSASNSSEDVMDQGKVELQDFSDAGYTAIATCLALI 1 2 GFVGFTNNFVVILLIGCHRQLRTPFNLLLLNMSVADLLVSVCGNTLSFASAVRHRWLWGRPGCVWYGFANSLF 1 2 GIVSLVTLSALAFERYCVVVRSSDMLTYKSSLVVITFIWLYSLLWTSLPLLGWSSYQFEGHN 0 0 VGCSVNWVQHNPDNVSYIVTLMVTCFFVPMVVVCWSYAWIWRTVRM 0 0 SSEAKPECGNSQNAGRLVTTMVVVMIICFLVCWTPYAVMALIVTFGADHLVTPTASVIPSLVAKSSTAYNPIIYVLMNNQ 0 0 FREFLLARLQRVCCRQQAVPRVTPMDDNVHVRLGGEGPSQSQQFLPAGENVENVDMLEYVQENCKPKADSLSTISE* 0 >ENCEPH4_braBel Branchiostoma belcheri Amphiop4 pinopsin encephalopsin introns from braFlo 83% 0 MPLYNTSSGPTQGLPWDTPYSQDPIWNDSSPSNSSEDAVVDQGRGELQDFSDAGYTAIATGLALI 1 2 GLVGSMNNFVVILLIGCHRQLRTPFNLLLLNVSVADLLVSVCGNTLSFASAVQHRWLWGRPGCVWYGFANSLF 1 2 GIVSLVTLSALAFERYCVVVRSSEMLTYKSSLGMIAFIWMYSLLWTSLPLLGWSSYQFEGHS 0 0 VGCSVNWVKHNVNNVSYIITLMVTCFFVPMVVVCWSYACIWRTVRM 0 0 SAEMKSEFGNPQNTGRLVTTMVVVMIVCFLVCWTPYTVMALIVTFGADHLVTPTASVIPSLVAKSSTAYNPIIYVLMNNQ 0 0 FREFLLARLRTFCCRQPRMLRVTPMDDNAHARLVGEGPSHAQQVIPSEENGENVEMRKVQGNQLKADSLSTISE* 0 >ENCEPH5_braBel Branchiostoma belcheri Amphiop5 AB050609 early dup of ENCEPH extra Nfrag in mrna 0 MLGIYNVVNATEYGNNTTFAAWDFKRNGTGGEEEVEFFGYDAVAGVIAIIGVVGFVSNGAVVVLFLKFPQLRTPFNLLLLNMAVADLLVSVCGNTLSFASAVRHRWLWGRPGCVWYGFANHLF 1 2 GLVSLISLAVISFLRYRMVVKPKGPGSSYLTYTKVGLAILFIYLYCLLWTTLPIAGWSSYQLE 0 0 GPKIGCSVAWEEHSWSNTSYIVVLFITCLFAPLLIIVYSYYRLWHKVKQ 0 0 GSRNLPAAMRKSSQKEQKIAMMVIVMITCFMVCWLPYGAMALVVTFGGERLISHTAAVVPSLLAKSSTCYNPVVYFAMNSQ 0 0 FRRYFQDLLCCGRRLFDVSQSVVTGNTAMPRNNSQGFRKDDSDQKQDNGLPKQSEGPMCDHSSNESQMEGSRHNTAASQQWIEMQTIAVVVKAVEVDTSAANEP* 0 >ENCEPH5_braFlo Branchiostoma floridae extra 00 intron chrUn:398,023,923-398,103,839 +ETF1 -ENC -RTF1 0 MLGMHNVMNATDYDNNNATFAAWNFQRNGTTEEEVEFSGFDTVAVVIAAIGIAGFLSNGAVVLLFLKFRQLRTPFNMLLLNMSVADLLVSVCGNTLSFASAVRHRWLWGRPGCVWYGFANHLF 1 2 GLVSLISLAVISYERYRMVVKPKGPGSSYLTYNKVGLAIIFIYLYCLLWTTLPIVGWSSYQLE 0 0 GPKISCSVAWEEHSLSNTSYIVAIFIMCLLLPLLIIIYSYCRLWYKVKK 0 0 GSQNLPPAIRKSSQKEQKIARMVVVMITCFLVCWLPYGAMALVVSFGGESLISPTAAVVPSLLAKSSTCYNPLVYFAMNNQ 0 0 FRRYFQDLLCCGRRLFDASASVNTCNTSAMPRHSPVFQKPDSDQYNGIQKSREPQMRTTGQNAPYRQWIEMQTIAVVVKADEVNNKFGEVKT* 0 >ENCEPH_apiMel Apis mellifera (honey bee) NM_001039968 328 aa ciliary opsin Gt pteropsin clock -ENC -PSMA3 0 MSLNRSTMEHVIYEDQVSPVMYIGAAIALGFIGFFGFTANLLVAIVIVKDAQILWTPVNVILFNLV 0 0 FGDFLVSIFGNPVAMVSAATGGWYWGYKMCLW 2 1 YAWFMSTLGFASIGNLTVMAVERWLLVARPMQALSIR 2 1 HAVILASFVWIYALSLSLPPLFGWGSYGPEAGNVSCSVSWEVHDPVTNSDTYIGFLFVLGLIVPVFTIVSSYAAIVLTLKKVRKRA 1 2 GASGRREAKITKMVALMITAFLLAWSPYAALAIAAQYFN 0 0 AKPSATVAVLPALLAKSSICYNPIIYAGLNNQFSRFLKKIFDARGSRTAVPDSQHTALTALNRQEQRK* 0 >ENCEPH1_anoGam Anopheles gambiae XM_312503 GPROP11 adjacent head-to-head tandem GPROP12 0 MYDVTDAAAINSDHQELMAPWAYNGAAVTLFFIGFFGFFLNIFVIALMYKDVQ 0 0 LWTPMNIILFNLVCSDFSVSIIGNPLTLTSAISHRWLYGKSICVAYGFFMSLL 1 2 GIASITTLTVLSYERFCLISRPFAAQNRSKQGACLAVLFIWSYSFALTSPPLFGWGAYVNEAANI 1 2 SCSVNWESQTANATSYIIFLFIFGLILPLAVIIYSYINIVLEMRK 0 0 NSARVGRVNRAERRVTSMVAVMIVAFMVAWTPYAIFALIEQFGPPELIGPGLAVLPALVAKSSICYNPIIYVGMNTQ FRAAFWRIRRSNGVAGQPDSNNTNNSNRDKESARHTAKEGL ECSLDFCHWTVRGTRVSISSAERNVPAPAARERSGGHSVTGSREESRDRHVTLKTMLSVGPRSPSSVAPVAADCSTTDVPTSGDGSVRIVRQDSELSVIHDGGGGGGGSSSRVLVIKSQKPRSNML* 0 >ENCEPH2_anoGam Anopheles gambiae XM_312502 GPROP12 0 MNDAPNDVAASAVDYEDLMAPWAYNASAVTLFFIGFFGFFLNLFVIALMCKDMQ 0 0 LWTPMNIILFNLVCSDFSVSIIGNPLTLTSAISHRWIFGRTLCVAYGFFMSLL 1 2 GITSITTLTVLSYERYCLISRPFSSRNLTRRGAFLAIFFIWGYSFALTSPPLFGWGAYVQEAANI 1 2 SCSVNWESQTKNATTYIIFLFVFGLVVPLIVIVYSYTNIIVNMRE 0 0 NSARVGRINRAEQRVTSMVAVMIVAFMVAWTPYAIFALIEQFGPPELIGPGLAVLPALVAKSSICYNPIIYVGMNTQ FRAAFSRVRNKGQQAAADQNTTTMQRELTKSSRDMVECSF DFCRKKSRFKISLVKPTAPLAVVDVSSTSHRDKGTSRSPLDQTVLNETNEDVGRERSGGGGGGGAYAGTRFVRPDFELSVINSGKSILIKSKNFRSNLL* 0 >CILL2_plaDum Platynereis dumerilii CT030681 htgs 171779 bp new CILL1 ENCEPH PARIE 44% e-65 393 5 exons 1 missing 0 MDDLGFLGNSSVNYTVPLLQEDPLLLRILYFGPTSYVITAIYLCIVGVIGTLSNGVIMYLYFKDKSLRSPMNLLFVNLAMSDFTVAFFGAMFQFGLTCTRKYMSPGMALCDFYGFITFLG 1 2 GLASEMNLFIISVERYLAVVRPFDVGNLTNRRVIAGG 1 2 VFVWLYSLVFAGGPLVGWSSYRPEGLGTWCSISWQDRSMNTMSYVTAVFLGCYFFPVSIIIFCYFNVWRKVKE 0 0 AADAQGAGTAGKAEKSIFRMSVIMVTCYLTAWTPYAIVCLIASYGPPNGLPIYAEVLPSLFAKSSQVYNPIIYVLMNKP 0 0 0* 0 >CILL1_plaDum Platynereis dumerilii AAV63834 Gt lophotrochozoa ciliary opsin mRNA polychaeta unavailable genomically 0 MDGENLTIPNPVTELMDTPINSTYFQNLNAETDGGNHYIYNAFTATDYNICAAYLFFIACLGVSLNVLVLVLFIKDRKLRSPNNFLYVSLALGDLLVAVFGTAFKFIITARKTLLREEDGFCKWYGFITYLG 1 2 GLAALMTLSVIAFVRCLAVLRLGSFTGLTTRMGVAAMA 1 2 FIWIYSLAFTLAPLLGWNHYIPEGLATWCSIDWLSDETSDKSYVFAIFIFCFLVPVLIIVVSYGLIYDKVRK 0 0 VAKTGGSVAKAEREVLRMTLLMVSLFMLAWSPYAVICMLASFGPKDLLHPVATVIPAMFAKSSTMYNPLIYVFMNKQ 0 0 FRRSLKVLLGMGVEDLNSESERATGGTATNQVAAT* >RGR_homSap 10q23.1 + 14136 7 chr10:85,994,789-86,008,924 295 exons distinct retinal pigment epithelium and Mueller cells 0 MAETSALPTGFGELEVLAVGMVLLVE 1 2 ALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLR 2 1 VSHRRWPYGSDGCQAHGFQGFVTALASICSSAAIAWGRYHHYCT 1 2 RSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDR 2 1 NFTSFLFTMSFFNFAMPLFITITSYSLMEQKLGKSGHLQ 0 0 VNTTLPARTLLLGWGPYAILYLYAVIADVTSISPKLQM 0 0 VPALIAKMVPTINAINYALGNEMVCRGIWQCLSPQKREKDRTK* 0 >PER_homSap peropsin RRH 4q25 7 chr4:110,968,599-110,985,310 337 + 16712 retinal photoisomerase Retinal pigment epithelium 0 MLRNNLGNSSDSKNEDGSVFSQTEHNIVATYLIMA 1 2 GMISIISNIIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQ 0 0 VYAGLNIFFGMASIGLLTVVAVDRYLTICLPDV 1 2 GRRMTTNTYIGLILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRKNDR 2 1 SFVSYTMTVIAINFIVPLTVMFYCYYHVTLSIKHHTTSDCTESLNRDWSDQIDVTK 0 0 MSVIMICMFLVAWSPYSIVCLWASFGDPKKIPPPMAIIAPLFAKSSTFYNPCIYVVANKK 2 1 FRRAMLAMFKCQTHQTMPVTSILPMDVSQNPLASGRI* 0 >PERa_braBel Branchiostoma belcheri Amphiop3 peropsin AB050610 MDIPTETPYGAEEDIGESAGWRWTETDKNGFHKYDHLIVGLYLFVIGIIGTIENGITLATFSKFRSLRSPTTMLLVHLAI ADLGICIFGYPFSGASSLRSHWLFGGVGCQWYGFNGMFFGMANIGLLTCVAVDRYLVICRHDLVDKVNYNTYGVMAALGW LFAAFWAALPLVGWAEYALEPSGTACTINFQKNDSLYISYVTSCFVLGFVVPLAVMAFCYWQASCFVSKVLKGDIAGDLT FPVAANVDWEYQNHFSKMCLAMVAAFVVAWTPYSVLFLFAAFWNPADIPAWLTLLPPLIAKSSALYNPIIYIIANRR FRNAICSMMKGQDPDVEDDEHADEHRVRSIEDNDKEIISMVNLNMTV* >PERb_braBel Branchiostoma belcheri Amphiop2 peropsin RRH AB050607 MIPTNNNTENNDLEWGLEKEHGVSATIMGVYLTIVGLVATVGNATVVLMFIMKWRQLCRKAPNLLVINLAAANLCITIFG YPFSASSGYAHQWLFPDAICTLYGFSCFLLSMVSMHTLCLISAHRYITICRPEHASKLTMNRTVLAVIGTWLYAIAVAVP PLFNIARYTYEPSGLSCTIDFRVTTVADLVYLGSLIVLCYVIHVAVMATCYFKIIRKFSRHRFRQVRDIRTSHQRSFEMG VTMRCILMTLFYLLSWTPYTAVCIWTMVGPPPPVVVSMAAALIAKTHCAFNPILYAFMSEVYRKLVFRTMCPCCFNRISC KFVGTPTGGSKVSANPDIFTVDYNSRDQAVQINKAPSRRFCFVMETSEDLGSDDTGLTGHSGLWRSGAEVEGLGGLQVTQ SPSVSGSELSLSLLDFLPPKPSGRAVSAKLPSPPALNSERATCPESSQQPSDRPATGLRQYQKGDTTRSSVGDLILTEDD VTNLPPASETWGRKKSENPLSYRQTTRRTFGRSRKHSYIVD* >PERc_braBel Branchiostoma belcheri Amphiop1 peropsin RRH AB050606 Go MNASPSSWLSSGEFFTDSPENSSEWPWTDGPTDTTWRHHQSVDSVSYEGYLASAIYITLTGLIAFFGNVITITVFLTEKE FRKKQQNGFVLNLAIADLSVCVFAYPSSAIAGYAGRWVLGDVGCTIYGFLCFTFALVSMVTLCVISIYRYILICKPQYAH LLTHRRTVYVIIGTWLYALVFTVPPLVGVKRYTYEPMQITCSLDWNVQHPGEKAYIAAVLVIVYVLQVLIMCFCYFNIIF KSANLKFAALASEKTKMAAKKDTWKTSVMCLTMVVSFLIAWTPYAVSSTWDILSAEDLPIIATILPSLFAKSSCMMNPII YACCNTK FRQAAVKSFRKLCGMCKQKVPLSTPQVVLAMQRNTEFTSTVEPTGQAFPMRVLPSISATHTAL* >NEUR_homSap neuropsin 6p12.3 chr6:47,857,757-47,902,075 7 354 0 MALNHTALPQDERLPHYLRDGDPFASKLSWEADLVAGFYLTII 1 2 GILSTFGNGYVLYMSSRRKKKLRPAEIMTINLAVCDLGIS 1 2 VVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSY 1 2 GVWLKRKHAYICLAAIWAYASFWTTMPLVGLGDYVPEPFGTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVLEMKLTK 0 0 VAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYK FACCQTGGLKATKKKSLEGFR 2 1 LHTVTTVRKSSAVLEIHEE 0 0 WE* 0 >MEL1_homSap melanopsin rhabdomeric OPN4 10q23.2 + 11903 10 chr10 GLUD1 MMRN2 BMPR1A LDB3 OPN4 WAPAL GRID1 0 MNPPSGPRVPPSPTQEPSCMATPAPPSWWDSSQSSISSLGRLPSISPT 0 0 APGTWAAAWVPLPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2 1 SRSLRTPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGET 1 2 GCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLYALAWSLPPFFGW 1 2 SAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGR 2 1 ALQTFGACKGNGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAG 2 1 YAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYR 2 1 VAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTLTSHTSNLSWISIRRRQESLGSESEV 0 0 GWTHMEAAAVWGAAQQANGRSLYGQGLEDLEAKAPPRPQGHEAETPGK 0 0 TKGLIPSQDPRM* 0 >MEL1_monDom Monodelphis domestica (opossum) BMPR1A LDB3 OPN4 WAPAL GRID1 0 MNPSPMLRGLSCPAQDTNCTKIMASMSEWNNTEEDAYHLVDLPSIAPT 0 0 AVVLPPSSQNIFPTADVPDHAHYTIGATILAVGFTGVLGNLLVIYTFCR 2 1 LRTPANMFIINLAISDFFMSFTQAPVFFASSMYKRWIFGEK 1 2 ACEFYAFCGALFGITSMITLMAIALDRYFVITRPLASIGVISKKKTGFILLGVWLYSLAWSLPPFFGW 1 2 SAYVPEGLLTSCSWDYTTFTPSVRAYTMLLFCFVFFIPLIVIIYCYIFIFRAIQDTNK 2 1 AVHSIGSGESTASPRHCQRMKNEWKMAKIALVVILLYVLSWAPYSTVALVAFAG 2 1 YSHILTPYMNSVPAIIAKASAIHNPIIYAISHPKYR 2 1 MAIAQNFPCLRALLCVRHPRTRSFSSYRFTRRSTMTSQASDISWLPRGRRQLSLGSESEI 0 0 GWNNMEAGTTSLTSRNQQGSCRMDQETMETRELAAIAKAKGRSWETLEK 0 0 TLEEMDDSSLLEVSVDMEQ* 0 >MEL1_galGal OPN4 melanopsin1 BMPR1A LDB3 OPN4 WAPAL GRID1 0 MDLPPRAPT 0 0 KMTVKDVRGAFPTVDVPDHAHYTIGTVILIVGITGTLGNFLVIYAFCR 2 1 SRTLQKPANIFIINLAVSDFLMSITQSPVFFTNSLHKRWIFGEK 1 2 GCELYAFCGALFGITSMITLMVIALDRYFVITKPLASVRVMSKKKALIILVGVWLYSLAWSLPPFFGW 1 2 SAYVPEGLLTSCSWDYMTFTPSVRAYTMLLFCFVFFIPLIAIIYSYVFIFEAIKKANK 2 1 SVQTFGCKHGNRELQKQYHRMKNEWKLAKIALIVILLYVISWSPYSVVALVAFAG 2 1 YSHVLTPFMNSVPAVIAKASAIHNPIIYAITHPKYR 2 1 TAIATYVPCLGFLLRVSPKESRSFSSYPSSRRTTITSQSSETSGLQKGKRRLSSISDSES 0 0 GCTDTETDITSMISRPASSQVSYEMGEDTTQTSDLGGKPKVKSHDSGIFRK 0 0 TVVDADEIPMVEINDTEHSATSTCKTSEKCNVEEIQ 0 0 RSESLSGIGLREGESRHRTSASQIPSIIITYSNVQGVELHSGYSAGFLHPKNKSHKQNKSSNS* 0 >MEL1_xenTro Xenopus tropicalis melanopsin 0 MNYQSVRKGITCPPQDANCSRILESLNSWNNSEVNSYKLVELPPIVTT 0 0 ETPQYEIHHVYPTVDVPDHVHYVVGAVILAVGITGMLGNFLVIYAFCR 2 1 SRSLRSPANMFIINLAITDFLMSVTQAPVFFATSLHKRWIFGEK 1 2 GCELYAFCGALFGITSMITLMVIAVDRYFVITRPLTSIGVMSKKRAVLILSGVWLYSLAWSLPPFFGW 1 2 SAYVPEGLLTSCTWDYMTFTPSVRAYTMLLFCFVFFIPLFIIIYCYIFIFKAIKNTNR 2 1 AVQKIGTDNNKESHKQYQKMKNEWKMAKIALIVILLYVVSWSPYSTVALLAFAG 2 1 YASILTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2 1 MAIAKYIPCLGSLLRVKRRDSRSYSSYPSSRRSTVTSHCSQSSDVGGHPKLKNHLPSVSDSES 0 0 GWTDTEADSSVNSRPASRQVSYEMGKDTTETNDLKSKAKLKSHDSGIFEK 0 0 TSMDADDISLVELGTVDRSSPIM 0 0 ANKHLNGLGQRKGDSFTRRSPSSRIPSIVVTHSNHQGSPAAVRHNSTLPGIKVSNSQDREKELKRQIEKVKQYVPIVTITSDTENSTGGFSNELLPANTS* 0 >MEL1_danRer Danio rerio (zebrafish) Gq XM_695228 +BMPR1A +LDB3 OPN4 +USP54 +CAMK2G 11 exons AY882945 opn4d 0 MMSGAAHSVRKGISCPTQDPNCTRIVESLSAWNDSVMSAYRLVDLPPTTTTTTSVA 0 0 MVEESVYPFPTVDVPDHAHYTIGAVILTVGITGMLGNFLVIYAFSR 2 1 SRTLRTPANLFIINLAITDFLMCATQAPIFFTTSMHKRWIFGEK 1 2 GCELYAFCGALFGICSMITLMVIAVDRYFVITRPLASIGVLSQKRALLILLVAWVYSLGWSLPPFFGW 1 2 SAYVPEGLLTSCTWDYMTFTPSVRAYTMLLFIFVFFIPLIVIIYCYFFIFRSIRTTNE 2 1 AVGKINGDNKRDSMKRFQRLKNEWKMAKIALIVILMYVISWSPYSTVALTAFAG 2 1 YSDFLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2 1 LAIAKYIPCLRLLLCVPKRDLHSFHSSLMSTRRSTVTSQSSDMSGRFRRTSTGKSRLSSASDSES 0 0 GWTDTEADLSSMSSRPASRQVSCDISKDTAEMPDFKPCNSSSFKSKLKSHDSGIFEK 0 0 SSSDVDDVSVAGIIQPDRTLTN 0 0 AGDITDVPISRGAIGRIPSIVITSESSSLLPSVRPTYRISRSNVSTVGTNPARRDSRGGVQQGAAHLSNAAETPESGHIDNHRPQYL* 0 >MEL1d_danRer Danio rerio (zebrafish) frag Gq XM_695228 +BMPR1A +LDB3 OPN4 +USP54 +CAMK2G diff chrom, WGDup 0 QVAMVQDVRHPFPTVDVPDHAHYTIGSVILAVGITGMVGNLLVMYAFCK 2 1 SRSLRTPANMFIINLAVTDFLMCVTQTPIFFTTSLHKRWIFGEK 1 2 GCELYAFCGALFGICSMITLMIIAVDRYFVITRPLASIGVMSRKRALLILSAAWAYSMGWSLPPFFGW 1 2 SGAYVPEGLLTSCSWDYMTFSPSVRAYTMLLFTFVFFIPLFVIIYCYFFIFKAIRETNR 2 1 AVGKINGEGGPRDSIKKIHRMKNEWKMAKIALIVILLYVISWSPYSCVALTAF 2 1 YADMLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2 1 SAIAKYIPCLGVLLCVPRRDRFSSSSFISTRRSTLTSQSSETSSNLHRAGKARLSSVSDSES 0 0 GWTDTEADLSTASSRPASRQVSSEIRKDLCDIKHSSSLRLKVKSRDSGIFDR 0 0 0 0 QNDVSEKADEKRPLVRIPSIIVTSETCPAVLPAGHSSRLIPGAPAVTDS* 0 >MEL1_takRub Takifugu rubripes (teleost) 0 MNFGKSALQPPAQQSVVSCGGGGPEPNCTLRLAVTVMMSVRLAELQLHAST 0 0 LQVAMVRPFPTVDVPDHAHYTIGSVILVIGITGMIGNFLVIYAFCR 2 1 SRSLRTPANMFIINLAVTDLLMCVTQTPIFFTTSMYKRWIFGEK 1 2 GCELYAFCGALFGICSMITLTVIAIDRYFVITRPLTSIGVLSRKRAFVILMTVWIYSLGWSLPPFFGW 1 2 SGAYVPEGLLTSCTWDYMTFSPSVRAYTMLLFIFVFFLPLFIIIYCYFFIFRAIRATNK 2 1 AVGKVNGSVHSHSRRRESVKNFQRLQNEWKMAKIALMVILLYVISWSPYSCVALTAFAG 2 1 YADMLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2 1 LALAKYIPCLGFLLCISPHELQSTSSSFMSLRRSTVTSQTSDISGQFRPQSKPRRSSASDSES 0 0 CLTDTEADLSSMGSRPASRQVSCDISRDTTELPEYKPASSFNSKVKSPDSGIFEK 0 0 TSFDFDASMAASRERSSIPN 0 0 SGEFPEGHVMRRTLARIPSIIITSESSHFLPNGRKASSTTCIANGSDIKVGPR* 0 >MEL1_gasAcu Gasterosteus aculeatus (stickleback) 0 MNAGESELLLPTQQSILPCGDHEPNCPVAQAETLALSAASANGSA 0 0 VQVAMVSRAPHPYPTVDVPDHAHYTIGSVILAIGITGIIGNVLVIYAFSK 2 1 SRSLRTPANMFIINLAITDLLMCVTQAPIFFTTSMHKRWIFGEK 1 2 GCELYAFCGALFGICSMITLTVIALDRYFVITRPLTSIGMMSRRRALLILMGAWTYSLGWSLPPFFGW 1 2 SGAYVPEGLLTSCTWDYMTFTPSVRAYTMLLFIFVFFLPLFIIIYCYFFIFRAIRVTNR 2 1 AVGKMNGSIHSHGSGRDSTKNFHRLQNEWKMAKIALIVILLYVVSWSPYSAVALTAFAG 2 1 YADMLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2 1 IALAKYIPFLGVLLCVPPRELRSASSSFRSTRRSTVTSQTSDVSSQQRRQGSRNSRLSSASDSES 0 0 CLTDTEADGSSVGSRPASRQVSCDIGRDTAELPEFKPSSSFKSKMKSHDSGIFEK 0 0 SYDTDISMAGVSERGSIPN 0 0 QTDFAEGRDRRSTIGRIPSIVITSETSPFLPTGRNGSCNGRPKTANSSHPGAGSG* 0 >MEL1_oryLat Oryzias latipes (medaka) frag 0 LQVAMVPQTFHPFPTVDVPDHAHYTIGSVILAIGITGIIGNFLVIYAFSR 2 1 SRSLRTPANMFIINLAITDLLMCVTQSPIFFTTSMHKRWIFGEK 1 2 GCELYAFCGALFGICSMITLTVIAIDRYFVITRPLTSIGVLSRKRALLILSAAWAYSLGWSLPPFFGW 1 2 SGAYVPEGLLTSCTWDYMTFTPSVRAYTMLLFIFVFFLPLFIIIYCYVFIFRAIRSTNR 2 1 AVGKINGNTRDAVKSFNRLQNEWKMAKIALIVILLYVISWSPYSTVALTAFAG 2 1 YADMLTPYMNSIPAVIAKASAIHNPIIYAITHPKYR 2 1 MALAKYIPGLGVLLCIHPKDLRSASSSFVSTRRSTVTSQSSDISSQLRRQSTFKSRLSSLSDSES 0 0 GLTDTEADLSSLSSRPASRQVSCEISRDTAELPDFKHTSSFKAKLKNNDSGIFEK 0 0 TSFDTVSIGGVSEHNSIPS 0 0 NRDFGDGNVTRATIGRIPSIVVTSEMSPFLPVGRNGSRTNRSKMANSSAGAGPV* 0 >MEL1_calMil Callorhinchus milii (elephantfish) frag 0 ASVTDAQHHHMFPTVDVPDHAHYIIGATILAVGVTGMVGNFLVIYAFLRYH 2 1 SRSLRTPANTFIINLAATDFLMSVTQSPIFFITSIHKRWIFGEK 1 2 GCELYAFCGALFGITSMITLMVIALDRYFVITRPLASIGVLSHRRAGLIILSLWLYSLAWSLPPFFGW 1 2 SGAYVPEGLLTSCTWDYMTFTPSVRAYTMLLFCFVFFIPLGVIIYCYIFIFRAIKSTNK 2 1 KVGGSTNRESQKQHQRMKNEWKMAKIALIVILLFVISWSPYSTVALTAFAG 2 1 YADMLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2 1 MAIAKYVPLLGLLLRVSRRDSRTSGQYYSTRRSTLTSQTSDLSGYPRGKGRLSSASDSES 0 >MEL1a_braFlo Branchiostom floridae AmphiMop 12 exons 709aa +chrUn:47589027-47597447 size 8421 +tandem dup assembly error 0 MTELPSFQPPTNSTEEENAVFPTALTEWISE 0 0 VGNQVGEAALKLLSGEGDGMEVTPTPGCTGNASVCNGTDSGGGVVWDIPPLAHYIVGTAVFCVGCCGMFGNAVVVYSFIK 2 1 SKGLRTPANFFIINLALSDFLMNLTNMPIFAVNSAFQRWLLSDF 1 2 ACELYGFAGGLFGCLSINTLMAISMDRYLVITKPFLVMRIVTKQR 0 0 VMFAILLLWIWSLVWALPPLFGWSAYVPEGF 1 2 GTSCTFDYMTPKLSYHIFTYIIFFTMYFIPMGVIIYCYYNIFATVKSGDKQFGKAVKEMAHEDVKNK 0 0 AQQERQRKNEIKTAKIAFIVITLFLSAWTPYAVVSALGTLGYQDLVTPYLQSIPAVFAKSSAVYNPI 1 2 VYAITHPKFRAAVKKHIPCLSGCLPADEEETKTKTRGATTTASMSMTQTTAPTV 0 0 HDPQASVHSGSSVSVDDSSGVSRQDTMMVK 0 0 VEVDNRMEKAGGGAADTAPKDGTSVPTVSAQIEVRPSGNVNTKAEVIPSPQSAAVAHGASASPVPK 0 0 VAELSSSVSLESAAIPGKIPTPLPSQPIAAPIERHMAAMADDPPPKPRGVATTVNVRRSESGYERSQDSLRKK 0 0 AVSETRSRSFNSTKDHFASERQTSTTLNQPRDMYSGDMVKKTRQSPEKQEYDNPAFDAGIAEIDTDSENETEGSYDMLSVRFQAMAEEPPVETYRKASDMSINLGKASLMLTEAHDETVL* 0 >MEL1a_braBel Branchiostoma belcheri (Japanese lancelet) AB205400 Amphi-mop 0 MTEIPSFQPPINATEVEEENAVFPTALTEWFSE 0 0 VGNQVGEVALKLLSGEGDGMEVTPTPGCTGNGSVCNGTDSGGVVWDIPPLAHYIVGTAVFCIGCCGMFGNAVVVYSFIK 2 1 SKGLRTPANFFIINLALSDFLMNLTNMPIFAVNSAFQRWLLSDF 1 2 ACELYGFAGGLFGCLSINTLMAISMDRYLVITKPFLVMRIVTKQR 0 0 VMFAILLLWIWSLVWALPPLFGWSAYVSEGF 1 2 GTSCTFDYMTPKLSYHIFTYIIFFTMYFIPGGVMIYCYYNIFATVKSGDKQFGKAVKEMAHEDVKNK 0 0 AQQERQRKNEIKTAKIAFIVISLFMSAWTPYAVVSALGTLGYQDLVTPYLQSIPAMFAKSSAVYSPI 1 2 VYAITYPKFREAVKKHIPCLSGCLPASEEETKTKTRGQSSASASMSMTQTTAPV 0 0 HDPQASVDSGSSVSVDDSSGVSRQDTMMVK 0 0 VEVDKRMEKAGGGAADAAPQEGASVSTVSAQIEVRPSGKVTTKADVISTPQTAHGLSASPVPK 0 0 VAELGSSATLESAAIPGKIPTPLPSQPIAAPIERHMAAMADEPPPKPRGVATTVNVRRTESGYDRSQDSQRKK 0 0 VVGDTHRSRSFNTTKDHFASEQPAALIQPKELYSDDTTKKMARQSSEKHEYDNPAFDEGITEVDTDSENETEGSYDMLSVRFQAMAEEPPVETYRKASDLAINLGKASLMLSEAHDETVL* 0 >MEL1b_braBel Branchiostoma floridae Amphiop6 melanopsin approx Gq 0 MSPNLTNTSLLPNRTDRPELSPADVTMQLVFGSMMLVFGLIGVVGNAVALYAFCR 2 1 SRSLRRPKNYLIANLCLTDMVVCLVYSPIIVTRSLSHG 2 1 LPSKESCIVEGFVVGLGSIVSICSLAGIAVERYVTITQPIKSLSILTHRALLGAVSAVWVYAFLLAFPPLVGWGRYVSEESKISCTFDYLSTDDATRAHVIVLVIGAFGLPFS VITYCYVRSFATVRKCTKERKQMSPLAKSDSRSEVKAAVNSFVITTSFCLCWCPYAVVATMGVSGFTVHSHAVFIAALLAKLSVLFNPVAYVLSIP 1 2 NSNVNIESTELTVPYSASRESCLLSRAATERLAGRSPSLTDIVREFGLQQTASHRE >MEL1b_braBel Branchiostoma belcheri Amphiop6 melanopsin AB050611 Gq 0 MSSNLTNVSLVANRTDQTELSPTDVTMQLIFGSMMLVFGLIGVVGNVVALYAFCR 2 1 TRSLRRPKNYVVANLCLTDMFVCLVYCPIVVSRSFSHG 2 1 FPSKESCIVEGFMVGVGSIASICSLAAIAVERYLSVTQPLKSLTILTQRKLLVAVLTVWVYSLLLAFPPLVGWGRYVREETYISCTFDYLSTDDATRAYVITLVMGAFGFPLL TIAYCYIRVFTTARKHAEERKFMSPLKRPESRTEIKTAVTACVITTSFCLCWCPYAVVATLGISGVSVQQQTVFSAALLAKLTVIINPIVYVLSIPNFRKALFAQEREKYASED VVLTSLPGKTRRMKKVERSQSSNSNVVIEVKESSMAYSTSRESCLLSRAATKRLAGKTKSIVDLVDEFGLQETAPHKESLV* >MEL2_galGal melanopsin2 GRID2 SMARCAD1 PGDS MEL2 SEC24B COL25A1 0 MGTQPHSVTKSEIPDHVLYTVGTCVLVIGSIGIIGNLLVLYAFYS 2 1 NKKLRTPQNFFIMNLAVSDFLMSASQAPICFVNSLHREWILGDI 1 2 GCDLYAFCGALFGITSMMTLLAISVDRYLVITKPLRSIQWTSKKRTIQIIAAVWLYSLGW 1 2 SVAPLLGWSSYVPEGLMISCTWDYVTYSPANRSYTMILCCCVFFIPLIIILHCYLFMFLAIRSTGR 2 1 DVQKLGSCSRKSFLSQSMKNEWKLAKIAFVVIIVYVLSWSPYACVTLIAWAG 2 1 RGNTLTPYSKSVPAVIAKASAIYNPIIYAIIHPRYRK 2 1 TIHNAVPCLRFLIRISKNDLLRGSINESSFRTSLSSHQSLAGRTKNTCVSSVSTGEA 0 0 NWSDVELDTVEPAHEKLQPRRSHSFSSSLRQKRDLLPDSYSCSEETEEK 0 0 VSLSSSYLEKVLGRSAFPSSPVALVTSSLRAASLPVGLNSSSASRGAGSDISQMKTEESHNNGGLDSIVSNTVPQIIIIPTSETNLFQEEPEEEETELFHFHDKKNNLLDLEGLSSSTEFLEAVEKFLS* 0 >MEL2_anoCar melanopsin2 frag GRID2 SMARCAD1 MEL2 PDILM5 BMPR1B UNC5B 0 MGPHHRTKVDVPDHVLYTVGSCVLVIGCIGITGNLLVLYAFYS 2 1 NKRLRTPPNYFIMNLAVSDFLMSATQAPICFLNSMHKEWVLGDI 1 2 GCNLYAFCGALFGITSMITLLAISVDRYCVITKPLQSIKRTSKKRTCIIIVFVWLYSLGWSVCPLFGW 1 2 SSYIPEGLMISCTWDYVTYSPANRSYTMMLCCCVFFIPLVIIFHCYIFMFLAIRSTGR 2 1 RKSSISHSIKSEWKLAKIAFVAIVVFVLSWSPYACVTLISWAG 2 1 TLTPYSKSVPAVIAKASAIYNPIIYAIIHPRYRK 2 1 TIRSAVPCLRFLIPISKSDLSTSSMSESSFRASVSSRHSFSYRNKSTYISSISAKET 0 0 TWCDVELDPVESGHKKLQAYRSNSFSAKGVAEEESGLLLRTNNCNVPARKK 0 >MEL2_xenLae Xenopus laevis melanopsin (Xmop) SMARCAD1 0 MDLGKTVEYGTHRQDAIAQIDVPDQVLYTIGSFILIIGSVGIIGNMLVLYAFYR 2 1 NKKLRTAPNYFIINLAISDFLMSATQAPVCFLSSLHREWILGDI 1 2 GCNVYAFCGALFGITSMMTLLAISINRYIVITKPLQSIQWSSKKRTSQIIVLVWMYSLMWSLAPLLGW 1 2 SSYVPEGLRISCTWDYVTSTMSNRSYTMMLCCCVFFIPLIVISHCYLFMFLAIRSTGR 2 1 NVQKLGSYGRQSFLSQSMKNEWKMAKIAFVIIIVFVLSWSPYACVTLIAWAG 2 1 HGKSLTPYSKTVPAVIAKASAIYNPIIYGIIHPKYRE 2 1 TIHKTVPCLRFLIREPKKDIFESSVRGSIYGRQSASRKKNSFISTVSTAET 0 0 VSSHIWDNTPNGHWDRKSLSQTMSNLCSPLLQDPNSSHTLEQTLTWPDDPSPKEILLPSSLKSVTYPIGLESIVKDEHTNNSCVR NHRVDKSGGLDWIINATLPRIVIIPTSESNISETKEEHDNNSEEKSKRTEEEEDFFNFHVDTSLLNLEGLNSSTDLYEVVERFLS* 0 >MEL2_danRer Danio rerio (zebrafish) FLJ39155 PDILM5 0 MEPQRQIYKRLDVPDHVHYIIAFLILIIGTLGVSGNALVMFAFYR 2 1 NKKLRSLPNYFIMNLAVSDFLMAITQSPIFFINCLYKEWMFGEL 1 2 GCKIYAFCGALFGITSMINLLAISIDRYLVITKPLQTIQWNSKRRTGLAILCIWLYSLAWSLAPLIGW 1 2 GSYIPEGLMTSCTWDYVSPSPANKSYTMMLCCFVFFIPLSIILYCYLFMFLSVRQASR 2 1 QKSSFVKQQSMRSEWKLAKIAAVVIVVYVLSWAPYACVTLVAWAG 2 1 LTPYSKTLPAVLAKSSAIYNPFIYAIIHNKYRA 2 1 TLAEKVPGLSCLSRSQKDGLSSSTNSDASAQDSSVSRQSSVSKNRLHSTMVQ* 0 >MEL2_tetNig frag +BMPR1B 0 MEPKDTHITSSFFSKVDVPDHVHYIIAFFVFVIGILGITGNVLVIFAFYS 2 1 NKKLRSLPNYFIVNLAVSDLLMASTQSPIFFINLYKEWMFGET 1 2 ACKMYAFCGALFGITSMINLLAISVDRYVVITKPLQTIRRSSKRRTALAILMVWLYSLAWSLAPLVGW 1 2 GSYIPEGLMTSCTWDYVTYTLANRSYTMMLCCFVFFIPLAIILCCYLLMFLAIRKTSR 2 1 RKSTLIQQKSIRSEWKLAKIAFVVIVVYVLSWSPYACVTLISWAG 2 1 TLTPYSKSVPAVIAKASAIYNPIIYAIIHPRYRK 2 1 TIRSAVPCLRFLIPISKSDLSTSSMSDSSFRSALSCRHSYRSRSTYISSISAKET 0 0 TWCDVELDPVESGHKKLQAYRSNSFSAKGVAEEESGLLLRTNNCNVPARKK 0 >MEL2_gasAcu Gasterosteus aculeatus KNTC2 FLJ39155 PDLIM5 BMPR1B 0 MEPDNAHTQRSFINKVDVPDHAHYIVAVFVVVIGTLGITGNALVMLAVYS 2 1 NKKLRNLPNYFIMNLAVSDFLMAFTQSPIFFINCLYKEWAFGET 1 2 GCKIYAFCGALFGIASMINLLAISIDRYLVITKPLQAIHWGSKRRTTLAILLVWLYSLAWSLAPLVGW 1 2 GSYIPEGLMTSCTWDYVTYTLANRSYTMMLCCFVFFIPLGIILYCYLFMFLAIRKTSR 2 1 RKSTLIKQKSMKSEWKLAKIAFVVIVVYVLSWSPYACVTLISWAG 2 1 ILSPYSKAVPAIIAKASAIYNPFIYAIIHNKYRM 2 1 TLAAKFPCLRFLSPTPRKDTSSSISESSYRDSVISRQSTASRTHFITACPDTVN 0 >RHAB_plaDum Platynereis dumerilii (clam worm) rhabdomeric opsin Gq AJ316544 runs as melanopsin unavailable genomically MSRSEVLVPGSMSLDGLLTTAHPIGNDSIETILHPYWQQFDIENTIPDSWHYAVAAWMTFFGILGVSGNLLVVWTFLKTKSLRTAPNMLLVNLAIGDMAF SAINGFPLLTISSINKRWVWGKLWRELYAFVGGIFGLMSINTLAWIAIDRFYVITNPLGAAQTMTKKRAFIILTIIWANASLWALAPFFGWGAYIPEGFQ TSCTYDYLTQDMNNYTYVLGMYLFGFIFPVAIIFFCYLGIVRAIFAHHAEMMATAKRMGANTGKADADKKSEIQIAKVAAMTIGTFMLSWTPYAVVGVFG MIKPHSEMFIHPLLAEIPVMMAKASARYNPIIYALSHPKFRAEIDKHFPWLLCCCKPKPKAQLPSSTTKGSIASKTEADTSV* >RHAB1_apiMel Apis mellifera long wavelength sensitive opsin 1 (Lop1) NM_001077825 compound eyes MIAVSGPSYEAFSYGGQARFNNQTVVDKVPPDMLHLIDANWYQY PPLNPMWHGILGFVIGMLGFVSVMGNGMVVYIFLSTKSLRTPSNLFVINLAISDFLMM FCMSPPMVINCYYETWVLGPLFCQIYAMLGSLFGCGSIWTMTMIAFDRYNVIVKGLSG KPLSINGALIRIIAIWLFSLGWTIAPMFGWNRYVPEGNMTACGTDYFNRGLLSASYLV CYGIWVYFVPLFLIIYSYWFIIQAVAAHEKNMREQAKKMNVASLRSSENQNTSAECKL AKVALMTISLWFMAWTPYLVINFSGIFNLVKISPLFTIWGSLFAKANAVYNPIVYGIS HPKYRAALFAKFPSLACAAEPSSDAVSTTSGTTTVTDNEKSNA* >RHAB2_apiMel Apis mellifera long wavelength sensitive opsin 2 (Lop2) NM_001077825 ocelli MDTLNITTSFFIEVMPSNISTLTTTGPQFARQLMRFNNQTVVSK VPEEMLHLIDLYWYQFPPLDPLWHKILGLVMIILGIMGWCGNGVVVYVFIMTPSLRTP SNLLVVNLAFSDFIMMGFMCPPMVICCFYETWVLGSLMCDIYAMVGSLCGCASIWTMT AIALDRYNVIVKGMSGTPLTIKRAMLQILGIWLFGLIWTILPLVGWNRYVPEGNMTAC GTDYLSQDWTFKSYILVYSFFVYYTPLFTIIYSYYFIVSAVAAHEKAMKEQAKKMNVT SLRSGDNQNTSAEAKLAKVALTTISLWFMAWTPYLVINYIGIFNRSLITPLFTIWGSL FAKANAIYNPIVYGISHPKYRAALKEKLPFLVCGSTEDQTAATAGDKASEN* >RHAB3_apiMel Apis mellifera UV-sensitive opsin BK005513 MSNDSIHWEARYLPAGPPRLLGWNVPAEELIHIPEHWLVYPEPN PSLHYLLALLYILFTFLALLGNGLVIWIFCAAKSLRTPSNMFVVNLAICDFFMMIKTP IFIYNSFNTGFALGNLGCQIFAVIGSLTGIGAAITNAAIAYDRYSTIARPLDGKLSRG QVILFIVLIWTYTIPWALMPVMGVWGRFVPEGFLTSCSFDYLTDTNEIRIFVATIFTF SYCIPMILIIYYYSQIVSHVVNHEKALREQAKKMNVDSLRSNANTSSQSAEIRIAKAA ITICFLYVLSWTPYGVMSMIGAFGNKALLTPGVTMIPACTCKAVACLDPYVYAISHPK YRLELQKRLPWLELQEKPISDSTSTTTETVNTPPASS* >RHAB4_apiMel Apis mellifera blue-sensitive opsin (Blop) MLLHNKTLAGKALAFIAEEGYVPSMREKFLGWNVPPEYSDLVHP HWRAFPAPGKHFHIGLAIIYSMLLIMSLVGNCCVIWIFSTSKSLRTPSNMFIVSLAIF DIIMAFEMPMLVISSFMERMIGWEIGCDVYSVFGSISGMGQAMTNAAIAFDRYRTISC PIDGRLNSKQAAVIIAFTWFWVTPFTVLPLLKVWGRYTTEGFLTTCSFDFLTDDEDTK VFVTCIFIWAYVIPLIFIILFYSRLLSSIRNHEKMLREQAKKMNVKSLVSNQDKERSA EVRIAKVAFTIFFLFLLAWTPYATVALIGVYGNRELLTPVSTMLPAVFAKTVSCIDPW IYAINHPRYRQELQKRCKWMGIHEPETTSDATSAQTEKIKTDE*
Here are some fragmentary opsins from key evolutionary groups that I recovered from ongoing genome projects
>RHO1_calMil Callorhinchus milii complete wgs cannot find cone opsins 0 MNGTEGENFYIPMSNKTGVVRSPFEYPQYYLAEPWQFSILAAYMFFLIITCFPVNFLTLYVTFEHKKLRQPLNFILLNLAVADLFMVFGGFFITVYTSLHGYFVFGVTGCNFEGFFATLG 1 2 GEIGLWSLVVLAIERYVVVCKPMSNFRFGTNHAIMGVAFTWVMALACAVPPLMGWSR 2 1 YIPEGLQCSCGVDYYTLKPEINNESFVIYMFVVHFLIPLIIIFFCYGRLVCTVKE 0 0 AAAQQQESESTQRAEREVTRMVIIMVIFFLICWVPYASVAFFIFTNQGSEFGPIFMAVPAFFAKSSALYNPLIYILLNKQ 0 0 FRNCMITTLCCGKNPFEEDESTSAAASKTEASSVSSSQVSPA* 0 >LWS_calMil Callorhinchus milii can just barely see novel exon break 01 2 dPFEGPNYHIAPRWAYNLTSVWMVGVVVASVFTNGLVLVATVRFKKLRHPLNWILVNMALADLGETVLASTVSVANQFFGYFILGHPLCVFEGFVVSLC 1 2 GITALWSLTIIAWERWVVVCKPFGNVKFDGKWAAFGIIFSWVWSIGWCLPPVFGWSR 2 1 0 0 AEKEVSRMVVVMVAAFCLCWGPYACFAMFSALNPGYAFHPLVASIPSYFAKSSTIYNPIIYVFMNRQ 0 0 FRNCILQLFGKKVDDGSELSSTSKTDVSSVSNSSVSPA* 0 >PIN_calMil Callorhinchus milii 0 FGSTVSFSNNINGYFVLGETVCQFEGFMVSLT 1 2 GIVGLWSLAILAFERYIVICKPMGDFRFQQKHAVWGCLFTWLWSLFWTLPPLFGWCSYVPE 1 >PPIN_calMil 0 MDPHNRSANLSEGPGLGGGGAVPGWGPSVRAPLSLVMAVISLSSIVLNSLAIAVVLRFQVLQQPLNYALLSLASADLGTAATGGVLSTVCTALGSFVLGRHSCVAEGFF 1 >VAOP_calMil Callorhinchus milii fragment 0 VASTQGRLGVARKPEKQVTRMVIVMILAFLFCWTPYAAFSITVTACPTIKLDPRLAAIPAFFSKTATVYNPIIYVFMNKQ 0 >ENCEPH_calMil Callorhinchus milii 1099306574966 mainstream fragment 0 MNPTNSTEPQEEHLFSPNTYKLLAVIIGTIGIVGFCNNILVLLLYYKFKRLRTPTNLLLVNISVSDLLVSVFGLSFTFVSCTQGRWGWDSAACVWDG >ENCEPH4_calMil Callorhinchus milii like branch4/5 only missing internal intron holdover 0 MLNSSPNSSPSLPLSQVGWTGLSRTGLTVVAVCLGIIMVLGFLNNLLVLVLFCKYKVLRSPMNMLLLNISVSDMLVCICGTPFSFAASVQGRWLVGEQGCKWYGFANSLF 1 0 REHRILLMVISMVTFYLLCWLPYGTVALIGTFGNADLITPTCSVIPSILAKSSTVINPVIYVIMNKQ 0 >ENCEPH5_calMil Callorhinchus milii 1099306574966 fragment AQTREHRILLMVISMVTFYLLCWLPYGTVALIGTFGNADLITPTCSVIPSILAKSSTVINPVIYVIMNKQ 0 >MEL1b_calMil Callorhinchus milii fragment 70% 1 SKSLRTPANMFIINLAISDFFMSATQPPVFFVTSLHKRWIFGEK 2 GCKLYAFCGALFGITSMITLMAISIDRYWVITKPLQSISSTTTKKNTLKVIILVWLYSLAWSLPPLLGW 1 >ENCEPH_squAca Squalus acanthias (spiny dogfish) EB687868 fragment 0 MNAANSTDTREESLFSPGTYQVLAVIIGTIGVVGFCNNLLMLVLYCKFKRLRTPTNLFLVNISISDLLLSVFGVIFTFVSCVKGRWVWDSAACVWDGFSNCLF 1 2 GISSIMSLTVLAYERYIRVVNATAIDFSWAWRAITYIWLYSLAWTGAPLIGWNSYTLELHRLGCSVNWDSRNPSDTSFVLFLFLGCLLCPIGVIAYCYG >ENCEPH_petMar Petromyzon marinus fragment 0 MQSPKQDSLHYAGDTGAKAAPDSAQGNASALGSNFLLHGGDLGEGSTAFSAATFRLLAGVVGTIGVAGFLNNLLLVALFVGFKRLQTPTNLLLVNISLSDLLVSVFGNTLTLVSCVRRRWVWGNGGCVWDGFSNSLF 1 2 GIVSISTLTALSYERYARLIKAQVLDFSWAWRAVTYTWLYSAAWTGAPLLGWSRYVLEKHGLGCSIDWASSNPPDAAFVLFFFLGCLAAPLLVMGFCFGRIALAITQ 0 0 CWSPYAVASLFVASGFEHLVSPPVSIVPSLLAKSNAVCNPLLFLLMSGN 0 >MEL1_petMar lamprey traces frag 80% 1 SKSLRSPANIFIINLAFADFFMSITQTPIFFVTSLHKRWIFGEK 1 2 GCELYAFCGALFGIASMVTLMVIATDRYLVLTRPLASIGAMSKRRAMYITAAVWFYSLAWSLPPFFGW 1 2 AYVPEGLMTSCTWDYVTFTPAVRSYTMLLFCFVFFIPLIVIIFCYVRIFAAIKNTNR 2 1 YADMLTPYMNSVPAIIAKASAIHNPIVYAITHPKYR 2 >PARIE_petMar 0 LNKKIKRVGGHPDPREEMRATVMVLAMVGAFLACWLPYTVLALCVVLAPGTQIPPLVATLPMYFAKTSPMYNPIIYFFLNPQ 0
Here are those sequences aligned to show rare genomic events such as indels and intron gains and losses:
>RHO1_homSap LAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLG GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWS >RHO1_monDom LAAYMFMLIVLGFPINFLTLYVTIQHKKLRTPLNYILLNLAIADLFMVFGGFTMTLYTSLHGYFVFGPTGCNLEGFFATLG GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIIGVAFTWVMALACAFPPLIGWS >RHO1_ornAna LAAYMFMLIMLGFPINFLTLYVTIQHKKLRTPLNYILLNLAFANHFMVLGGFTTTLYTSLHGYFVFGPTGCNIEGFFATLG GEIALWSLVVLAIERYIVVCKPMSNFRFGENHAIMGVAFTWIMALACALPPLVGWS >RHO1_galGal LAAYMFMLILLGFPVNFLTLYVTIQHKKLRTPLNYILLNLVVADLFMVFGGFTTTMYTSMNGYFVFGVTGCYIEGFFATLG GEIALWSLVVLAVERYVVVCKPMSNFRFGENHAIMGVAFSWIMAMACAAPPLFGWS >RHO1_anoCar LAAYMFLLILLGFPINFLTLFVTIQHKKLRTPLNYILLNLAVANLFMVLMGFTTTMYTSMNGYFIFGTVGCNIEGFFATLG GEMGLWSLVVLAVERYVVICKPMSNFRFGETHALIGVSCTWIMALACAGPPLLGWS >RHO1_xenTro LAAYMFLLILLGFPINFMTLYVTIQHKKLRTPLNYILLNLVFANHFMVLCGFTVTMYTSMHGYFIFGQTGCYIEGFFATLG GEMALWSLVVLAIERYVVVCKPMANFRFGENHAIMGVVFTWIMALSCAAPPLFGWS >RHO1_danRer VAAYMFFLIITGFPVNFLTLYVTIEHKKLRTPLNYILLNLAIADLFMVFGGFTTTMYTSLHGYFVFGRLGCNLEGFFATLG GEMGLKSLVVLAIERWMVVCKPVSNFRFGENHAIMGVAFTWVMACSCAVPPLVGWS >RHO1_Raja LAAYMFFLILTGLPVNFLTLFVTIQHKKLRQPLNYILLNLAVSDLFMVFGGFTTTIITSMNGYFIFGPAGCNFEGFFATLG GEVGLWCLVVLAIERYMVVCKPMANFRFGSQHAIIGVVFTWIMALSCAGPPLVGWS >RHO1_lamp1 LAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAVANLFMVLFGFTLTMYSSMNGYFVFGPTMCNFEGFFATLG GEMSLWSLVVLAIERYIVICKPMGNFRFGSTHAYMGVAFTWFMALSCAAPPLVGWS >RHO1_lamp2 LAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAVSNLFMILFGFTTTMYTSMNGYFVFGPTMCSIEGFFATLG GEVSLWSLVVLAIERYIVICKPMGNFRFGNTHAIMGVALTWVMALSCAAPPLLGWS >RHO1_lamp3 LAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAMANLFMVLFGFTVTMYTSMNGYFVFGPTMCSIEGFFATLG GEVALWSLVVLAIERYIVICKPMGNFRFGNTHAIMGVAFTWIMALACAAPPLVGWS >RHO2_galGal VCCYIFFLISTGLPINLLTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFVFGPVGCAVEGFFATLG GQVALWSLVVLAIERYIVVCKPMGNFRFSATHAMMGIAFTWVMAFSCAAPPLFGWS >RHO2_anoCar VCCYIFFLIFTGLPINILTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFIFGPIGCAIEGFFATLG GQVALWSLVVLAIERYIVVCKPMGNFRFSATHALMGISFTWFMSFSCAAPPLLGWS >RHO2_Gekko LSFYMFFLIAAGMPLNGLTLFVTFQHKKLRQPLNYILVNLAAANLVTVCCGFTVTFYASWYAYFVFGPIGCAIEGFFATIG GQVALWSLVVLAIERYIVICKPMGNFRFSATHAIMGIAFTWFMALACAGPPLFGWS >RHO2_Lat LCAYMFLLIILGFPINFLTLLVTFKHKKLRQPLNYILVNLAVASLFMVVFGFTVTFYSSLNGYFVLGPMGCAMEGFFATLG GQVALWSLVVLAIERYIVVCKPMGNFRFASSHAIMGIAFTWIMALACAAPPLVGWS >RHO2_Geo ISAYVFTLILIGFPVNFMTLFVTFKLKKLRQPLNFILVNLCVADLLMIMFGFTTTFYTAMNGYFVFGPTGCNIEGFFATLG GEVSLWSLVMLAIERYIVVCKPMGNFRFATTHAALGVVFTWVMASACAVPPLVGWS >SWS1_homSap QAAFMGTVFLIGFPLNAMVLVATLRYKKLRQPLNYILVNVSFGGFLLCIFSVFPVFVASCNGYFVFGRHVCALEGFLGTVA GLVTGWSLAFLAFERYIVICKPFGNFRFSSKHALTVVLATWTIGIGVSIPPFFGWS >SWS1_macDom QTVFMGFVFCAGTPLNAVVLVATLRYKKLRQPLNYILVNVSLCGFIFCIFAVFTVFISSSQGYFIFGRHVCAMEAFLGSVA GLVTGWSLAFLAFERFIVICKPFGNFRFNSKHAMMVVLATWVIGIGVSIPPFFGWS >SWS1_galGal QTAFMGIVFAVGTPLNAVVLWVTVRYKRLRQPLNYILVNISASGFVSCVLSVFVVFVASARGYFVFGKRVCELEAFVGTHG GLVTGWSLAFLAFERYIVICKPFGNFRFSSRHALLVVVATWLIGVGVGLPPFFGWS >SWS1_Taenio QTIFMGLVFVAGTPLNAIVLIVTIKYKKLRQPLNYILVNISVSGLMCCVFCIFTVFIASSQGYFVFGKHMCAFEGFAGATG GLVTGWSLAFLAFERYIVICKPFGNFRFNSRHALLVVAATWIIGVGVAIPPFFGWS >SWS1_Gekko QTAFMGFVFFVGTPLNAIILFAIVKYKKLRQPLNYILVNISAAGFLFCVVAVFTVFISSSQGYFIFGKHICALEAFLGSLA GLVTGWSLAFLALERYIVICKPFGNFRFSAKHASLVVAATWFIGIGVSIPPYFGWS >SWS1_Utasta QTAFMGFVFFAGTPLNAIILIVTVKYKKLRQPLNYILVNISFAGFLFCVFSVFTVFLASSQGYFFFGRHICALEAFLGSVA GLVTGWSLAFLAFERYIVICKPFGNFRFNSKHALLVVAATWFIGIGVSIPPFFGWS >SWS1_Xenlae QAIFMGMVFLIGTPLNFIVLLVTIKYKKLRQPLNYILVNITVGGFLMCIFSIFPVFVSSSQGYFFFGRIACSIDAFVGTLT GLVTGWSLAFLAFERYIVICKPMGNFNFSSSHALAVVICTWIIGIVVSVPPFLGWS >SWS1_Danio QAAFMGFVFIVGTPMNGIVLFVTMKYKKLRQPLNYILVNISLAGFIFDTFSVSQVSVCAARGYYSLGYTLCSMEAAMGSIA GLVTGWSLAVLAFERYVVICKPFGSFKFGQGQAVGAVVFTWIIGTACATPPFFGWS >SWS1_Oryzia QAAFMGFVFFVGTPLNFVVLLATAKYKKLRVPLNYILVNITFAGFIFVTFSVSQVFLASVRGYYFFGQTLCALEAAVGAVA GLVTSWSLAVLSFERYLVICKPFGAFKFGSNHALAAVIFTWFMGVGCACPPFFGWS >SWS1_Geotri QAAFMGFVFICGTPLNAIVLVVTIKYKKLRQPLNYILVNISAAGLVFCLFSISTVFVASMQGYFFLGPTICALEAFFGSLA GLVTGWSLAFLAAERYIVICKPFGNFRFGSKHALVAVGLTWMLGLSVALPPFFGWS >SWS2_ornAna LAAFMFLLITLGFPINLLTVICTIKYKKLRSHLNYILVNLAVSNMLVVCVGSATAFYSFAHMYFVLGPTACKIEGFAATLG GMVSLWSLAVIAFERFLVICKPLGNLSFRGTHAIFGCAATWVFGLAASLPPLFGWS >SWS2_galGal MAAFMFLLIALGVPINTLTIFCTARFRKLRSHLNYILVNLALANLLVILVGSTTACYSFSQMYFALGPTACKIEGFAATLG GMVSLWSLAVVAFERFLVICKPLGNFTFRGSHAVLGCVATWVLGFVASAPPLFGWS >SWS2_Taenio MAAFMFLLVLLGVPINALTVLCTAKYKKLRSHLNYILVNLAVANLLVVCVGSTTAFYSFSQMYFALGPLACKIEGFTATLG GMVSLWSLAVVAFERFLVICKPLGNFTFRGSHAVLGCAITWIFGLIASLPPLFGWS >SWS2_Utasta MAAFMFLLIILGVPINVLTIFCTFKYKKLRSHLNYILVNLAVSNLLVVCIGSTTAFYSFAQMYFSLGPTACKIEGFAATLG GMVSLWSLAVVAFERFLVICKPLGNFSFRGTHAIIGCIITWVFGLVASLPPLFGWS >SWS2_Xenopu ISAFMLFTIIFGFPLNLLTIICTVKYKKLRSHLNYILVNLAVANLIVICFGSTTAFYSFSQMYFSLGTLACKIEGFTATLG GIIGLWSLAVVAFERFLVICKPMGNFTFRESHAVLGCILTWVIGLVAAIPPLLGWS >SWS2_Danio MSAFMLFLFIAGTAINVLTIVCTIQYKKLRSHLNYILVNLAISNLWVSVFGSSVAFYAFYKKYFVFGPIGCKIEGFTSTIG GMVSLWSLAVVALERWLVICKPLGNFTFKTPHAIAGCILPWCMALAAGLPPLLGWS >SWS2_Takifu MSAFMFFLFVAGTGINVLTIACTIQYKKLRSHLNYILVNLAFSNLLVTTVGSFTCFCCFFVRYMIVGPLGCKIEGFAATLG GMVSLWSLAVVAFERWLVVCKPLGNFIFKPDHAIVCCIFTWFFALIISAPPLFGWS >SWS2_Geotri MSAFMLFLVLAGFPLNFLTVFVTIKYKKLRSHLNYILVNLAIANLIVVCCGSTLAFYSFMHKYFILGPLFCKMEGFTATLG GMLSLWSLAVLAFERCLVICKPFGNIAFRGTHALIRCGFAWAAAIAASTPPLFGWS >LWS_ornAna TSLWMIFVVIASVFTNGLVLVATMKFKKLRHPLNWILVNLAVADLGETLIASTISVINQIFGYFILGHPMCVLEGYTVSLC GITGLWSLSIISWERWIVVCKPFGNVKFDAKLAMVGIVFSWVWAAVWTAPPIFGWS >LWS_galGal TSLWMIFVVAASVFTNGLVLVATWKFKKLRHPLNWILVNLAVADLGETVIASTISVINQISGYFILGHPMCVVEGYTVSAC GITALWSLAIISWERWFVVCKPFGNIKFDGKLAVAGILFSWLWSCAWTAPPIFGWS >LWS_anoCar TSVWMIFVVIASIFTNGLVLVATAKFKKLRHPLNWILVNLAIADLGETVIASTISVINQISGYFILGHPMCVLEGYTVSTC GISALWSLAVISWERWVVVCKPFGNVKFDAKLAVAGIVFSWVWSAVWTAPPVFGWS >LWS_Lithoch ATLWMFVVVVLSVFTNGLVLVATMKFKKLRHPLNWILVNLAIADLGETVFASTISVCNQFFGYFILGHPMCIFEGYVVSVC GIAALWSLTIISWERWIVVCKPFGNVKFDAKWATAGIVFSWVWAAVWCAPPIFGWS >LWS_Gastero STLWMFIVVALSVFTNGLVLVATAKFKKLQHPLNWILVNLAIADLGETVFASTISVCNQFFGYFILGHPMCVFEGYVVSVC GITALWSLTIISWERWIVVCKPFGNVKFDAKWATAGIVFSWIWSAVWCAPPIFGWS >LWS_Petrom TSVWMIIVVVLSLFSNGLVLVATVKFKKLRHPLNWIIVNLAIADILETIFASTISVCNQVYGYFILGHPMCVFEGYVVSTC GIAGLWSLAIISWERWMVVCKPFGNIKFDGKIATILIVFSWVWPASWCSLPIFGWS >LWS_lamprey TSVWMIIVVVLSLFTNGLVLVATMKFKKLRHPLNWILVNLAIADILETIFASTISVCNQVFGYFILGHPMCVFEGYVVSTC GIAGLWSLAIISWERWMVVCKPFGNIKFDGKIAIILIVFSWVWPACWCSLPIFGWS >LWS_Geotria TSFWMIIVVILSLFTNGLVLVATLKFKKLRHPLNWILVNLAIADIGETIFASTVSVVNQIFGYFILGHPLCVFEGFTVSVC GITALWSLAIISFERWMVVCKPFGNLKFDGKVAIVLIIFSWAWSAGWCAPPIFGWS >PIN_galGal VAVLMGTVVACASVVNGLVIVVSICYKKLRSPLNYILVNLAVADLLVTLCGSSVSLSNNINGFFVFGRRMCELEGFMVSLT GIVGLWSLAILALERYVVVCRPLGDFQFQRRHAVSGCAFTWGWALLWSTPPLLGWS >PIN_UtaSta VAVLMGLVVVSAAFVNGLVIVVSIQYKKLRSPLNYILVNLAIADLLVTSFGSTLSFANNIYGFFVLGQTACEFEGFMVSLT GIVGLWSLAILAFERYLVICKPVGDFRFQQRHAVFGCVFTWMWSLVWTLPPLFGWS >PIN_pheMad LAALMGVVVLSASLANGLVIAVSVRFKRLRSPLNYILVNLATADLLVTFFGSIISFVNNAVGFFVFGKTACRFEGFMVSLT GIVGLWSLAILAFERYLVICKPVGDFQFQRRHAVIGCLYTWGWSLIWTVPPLFGWS >PIN_podSic VAVLMGLVVISATLVNGLVIVVSVQFKKLRSPLNYVLVNLAVADLLVTFFGSTISFVNNAQGFFIFGQATCEFEGFMVSLT GIVGLWSLAILAFERYLVICKPVGDFRFPARHAVLGCAFTWGWSFVWTVPPLLGWS >PIN_xenTro VAAVMCMVVILAFFVNGLVIVVTLKYKKLRSPLNYILVNLAIANLLVTIFGSSVSFSNNVVGYFFMGKTMCEFEGFMVSLT GIVGLWSLAILAFERYLVICKPMGDFRFQQKHAILGCSFTWVWSFIWTSPPLFGWC >PIN_bufJap VAVLMGMVVFLAFFVNGMVIVVSLKYKKLRSPLNYILVNLAVADILVTMFGSTVSFHNNIFGFFTLGKLVCELEGFVVSLT GIVGLWSLAILAFERYIVICKPMGDFRFQQRHAVMGCAFTWIWAFLWTSPPLIGWC >VAOP_galGal VAAVMFVVTSLSLAENLAVILVTFKFKQLRQPVNYVIVNLSVADFLVSLTGGTISFLANLKGYFYMGHWACVLEGFAVTFF GIVALWSLALLAFERYIVICRPVGNMRLRGKHAAQGIAFVWTFSFIWTIPPTMGWS >VAOP_anoCar ISALMFVVTLFSLSENFTVILVTIKFKQLRQPLNYVIVNLSVADFLVSLIGGTISFSTNLKGYFYMGHWACVLEGFAVTFF GIVALWSLALLAFERYVVICRPLGNMRLNGKHAALGVAFVWIFSFIWTVPPTMGWS >VAOP_xenTro LAALMFVVTSLSIAENFIVILVTAKFKQLRQPLNYIIVNLSVADFLVSVIGGTISIATNSRGYFYLGSWACVLEGFAVTFF GIVALWSLSVLAFERYIVICRPLGNLRLQGKHSALAIIFVWVFSFVWTIPPTMGWS >VAOP_danRer LAALMFVVTALSLSENFTVMLVTFRFQQLRQPLNYIIVNLSLADFLVSLTGGSISFLTNYHGYFFLGKWACVLEGFAVTFF GIVALWSLAVLAFERFFVICRPLGNIRLRGKHAALGLVFVWSFSFIWTVPPVLGWS >VAOP_rutRut LATLMFVVTAASLSENFAVMLVTFRFTQLRKPLNYIIVNLSLADFLVSLTGGTISFLTNYHGYFFLGKWACVLEGFAVTYF GIVALWSLAVLAFERFFVICRPLGNIRLRGKHAALGLLFVWTFSFIWTIPPVLGWS >VAOP_Petro LAALMGTITALSLGENFAVIVVTARFRQLRQPLNYVLVNLAAADLLVSAIGGSVSFFTNIKGYFFLGVHACVLEGFAVTYF GVVALWSLALLAFERYFVICRPLGNFRLQSKHAVLGLAVVWVFSLACTLPPVLGWS >PPIN_anaCar IAIIMATSCTLSVILNTAVIAITIKYRQLRQPINYSLVNLAIADLGAALLGGSLNVETNAVGYYNLGRVGCVTEGFAMAFF GIVALCTIAVIAVDRAIVIAKPMGTITFTTRKAMIGVAVSWIWSLVWNTPPLFGWG >PPIN_Xenop LALIMAVFCAAALFLNVTVIVVTFKYRQLRHPINYSLVNLAIADLGVTVLGGALTVETNAVGYFNLGRVGCVIEGFAVAFF GIAALCTIAVIALDRVFVVCKPMGTLTFTPKQALAGIAASWIWSLIWNTPPLFGWG >PPIN_Ictal LSIIMALSSTFGIILNMVVIIVTVRYKQLRQPLNYALVNLAVADLGCPVFGGLLTAVTNAMGYFSLGRVGCVLEGFAVAFF GIAGLCSVAVIAVDRYMVVCRPLGAVMFQTKHALAGVVFSWVWSFIWNTPPLFGWG >PPIN_Danio LAVIIGVFSVCGVILNVTVITVTLKYKQLRQPLNFALVNLAVADLGCAVFGGLPTVVTNAMGYFSLGRVGCVLEGFAVAFF GIAALCSVAVIALERCMVVCRPVGSISFQTRHAVFGVAVSWLWSFIWNTPPLFGWG >PPIN_Oncor LAVIIGVFSVSGVCMNVLVIMVTMRHRKLRQPLNYALVNLAVADLGCALFGGLPTMVTNAMGYFSMGRLGCVLEGFAVAFF GIAGLCSVAVIAVDRYVVVCRPMGAVMFQTRHAVGGVVLSWVWSFLWNTPPLFGWG >PPINa_Ciona LCVYMTFVFLLSCSLNILVIVATLKNKVLRQPLNYIIVNLAVVDLLSGFVGGFISIAANGAGYFFWGKTMCQIEGYFVSNF GVTGLLSIAVMAFERYFVICKPFGPVRFEEKHSIFGIVITWVWSMFWNTPPLIFWD >PPINb_Ciona LAVYMTFIFLLAVSLNGFVIIATMKNKKLRQPLNYIIINLSIADFLSGLVGGFIGMISNSAGYFYFGKTVCILEGYIVSVA GVCGLMSISVMAFERYFVVCKPYGPFTLTNTHAALGIGFTWTWSVLWSTPGLIWLD >PPIN_lamp LAVIMAVFTIASLVLNSTVVIVTLRHRQLRHPLNFSLVNLAVADLGVTVFGASLVVETNAVGYFNLGRVGCVIEGFAVAFF GIAALCTIAVIAVDRFVVVCKPLGTLMFTRRHALLGIAWAWLWSFVWNTPPLFGWG >PARIE_Utast LAFLMFLNALFSIFNNSLVIAVTLKNPQLRNPINIFILNLSFSDLMMSLCGTTIVIATNYYGYFYLGRKFCIFQGFAVNYF GIVSLWSLTILA YERYNVV--CQPLGTLQMSTKR GYQLLGFIWVFCLFWAVVPLFGWS >PARIE_Anole LAFLMFINALFSLFNNFLVIAVTLKNPQLRNPINIFILNLSFSDLMMSICGTTIVIATNYHGYFYLGRRFCIFQGFAVNYF GIVSLWSLTILA YERYNVV--CQPLGTLQMSTQR AYQLLGFIWVFCLFWAVVPLFGWS >PARIE_Xenop LSFLMFLNAVFSICNNAIVILVTLKHPQLRNPINIFILNLSFSDLMMALCGTTIVVSTNYHGYFYLGKQFCIFQGFAVNYF GIVSLWSLTLLA YERYNVV--CEPIGALKLSTKR GYQGLVFIWLFCLFWAIAPLFGWS >ENCEPH_braB VAGVIAIIGVVGFVSNGAVVVLFLKFPQLRTPFNLLLLNMAVADLLVSVCGNTLSFASAVRHRWLWGRPGCVWYGFANHLF GLVSLISLAVIS FLRYRMVVKPKGPGSSYLTYTK VGLAILFIYLYCLLWTTLPIAGWS >ENCEPH_homS LALLLGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFSGSLF GIVSIATLTVLA YERYIRVV-----HARVINFSW AWRAITYIWLYSLAWAGAPLLGWN >ENCEPH_monD LALLIATIGLLGLCNNLLVLVLYYKFQRLRTPTHLFLVNISFNDLLVSLFGVTFTFVSCLRSGWVWDSVGCAWDGFSNTLF GIVSIMTLTVLA YERYNRIV-----HAKVINFSW AWRAITYIWLYSLVWTGAPLLGWN >ENCEPH_galG LALLIATIGTLGVCNNLLVLVLYYKFKRLRTPTNLFLVNISLSDLLVSVCGVSLTFMSCLRSRWVWDAAGCVWDGFSNSLF GIVSIMTLTVLA YERYIRVV-----HAKVIDFSW SWRAITYIWLYSLAWTGAPLLGWN >ENCEPH_anoC LALLVAAIGLLGLCNNLLVLVLYAKFKRLRTPTHLFLVNISLSDLLVSLFGVSFTFGSCLRHRWVWDAAGCVWDGFSNSLF GIVSIMTLTVLA YERYIRVV-----HARVIDFSW SWRAITYIWLYSLAWTGAPLLGWN >ENCEPH_xenT LALIVATVGFLGLVNNLLVLILYCKFKRLQTPTNLLFFNTSLCHFVFSLLAITFTFMSCVRGSWAFSVEMCVFHGFSKNLL GIVSFGTLTVVA YERYARVV-----YGKYVNSSW SKRSITFVWVYSLAWTGFPLIGWN >ENCEPH_braB IATGLALIGLVGSMNNFVVILLIGCHRQLRTPFNLLLLNVSVADLLVSVCGNTLSFASAVQHRWLWGRPGCVWYGFANSLF GIVSLVTLSALA FERYCVVV----RSSEMLTYKS SLGMIAFIWMYSLLWTSLPLLGWS >ENCEPH_braF IATCLALIGFVGFTNNFVVILLIGCHRQLRTPFNLLLLNMSVADLLVSVCGNTLSFASAVRHRWLWGRPGCVWYGFANSLF GIVSLVTLSALA FERYCVVV----RSSDMLTYKS SLVVITFIWLYSLLWTSLPLLGWS >ENCEPH2_Api AIALGFIGFFGFTANLLVAIVIVKDAQILWTPVNVILFNLVFGDFLVSIFGNPVAMVSAATGGWYWGYKMCLWYAWFMSTL GFASIGNLTVMA VERWLLVA----RPMQALSIRH AVILASFVWIYALSLSLPPLFGWG >ENCEPH1_Ano AAVTLFFIGFFGFFLNIFVIALMYKDVQLWTPMNIILFNLVCSDFSVSIIGNPLTLTSAISHRWLYGKSICVAYGFFMSLL GIASITTLTVLS YERFCLIS--RPFAAQNRSKQG ACLAVLFIWSYSFALTSPPLFGWG >ENCEPH2_Ano SAVTLFFIGFFGFFLNLFVIALMCKDMQLWTPMNIILFNLVCSDFSVSIIGNPLTLTSAISHRWIFGRTLCVAYGFFMSLL GITSITTLTVLS YERYCLIS--RPFSSRNLTRRG AFLAIFFIWGYSFALTSPPLFGWG >CILL2_Platy AIYLCIVGVIGTLSNGVIMYLYFKDKSLRSPMNLLFVNLAMSDFTVAFFGAMFQFGLTCTRKYMSPGMALCDFYGFITFLG GLASEMNLFIIS VERYLAVV--RPFDVGNLTNRR VIAGGVFVWLYSLVFAGGPLVGWS >CILL1_Platy AAYLFFIACLGVSLNVLVLVLFIKDRKLRSPNNFLYVSLALGDLLVAVFGTAFKFIITARKTLLREEDGFCKWYGFITYLG GLAALMTLSVIA FVR CLAV-LRLGSFTGLTTRM GVAAMAFIWIYSLAFTLAPLLGWN >MEL1_homSap LGTVILLVGLTGMLGNLTVIYTFCRSRSLRTPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGETGCEFYAFCGALF GISSMITLTAIA LDRYLVIT-RPLATFGVASKRR AAFVLLGVWLYALAWSLPPFFGWS >MEL1_smiCra IGATILVVGFTGVLGNLLVIYTFCRSRSLRTPANMFIINLAISDFFMSFTQAPVFFASSLYERWIFGEKGCEFYAFCGALF GITSMITLMVIA LDRYFVIT-RPLASIGMISKKK TGLILLGVWLYSLAWSLPPFFGWS >MEL1_galGal IGTVILIVGITGTLGNFLVIYAFCRSRTLQKPANIFIINLAVSDFLMSITQSPVFFTNSLHKRWIFGEKGCELYAFCGALF GITSMITLMVIA LDRYFVIT-KPLASVRVMSKKK ALIILVGVWLYSLAWSLPPFFGWS >MEL1_xenTro VGAVILAVGITGMLGNFLVIYAFCRSRSLRSPANMFIINLAITDFLMSVTQAPVFFATSLHKRWIFGEKGCELYAFCGALF GITSMITLMVIA VDRYFVIT-RPLTSIGVMSKKR AVLILSGVWLYSLAWSLPPFFGWS >MEL1a_Bran VGTAVFCIGCCGMFGNAVVVYSFIKSKGLRTPANFFIINLALSDFLMNLTNMPIFAVNSAFQRWLLSDFACELYGFAGGLF GCLSINTLMAIS MDRYLVIT-KPFLVMRIVTKQR VMFAILLLWIWSLVWALPPLFGWS >MEL2_anoCar VGSCVLVIGCIGITGNLLVLYAFYSNKRLRTPPNYFIMNLAVSDFLMSATQAPICFLNSMHKEWVLGDIGCNLYAFCGALF GITSMITLLAIS VDRYCVIT-KPLQSIKRTSKKR TCIIIVFVWLYSLGWSVCPLFGWS >MEL2_xenLae IGSFILIIGSVGIIGNMLVLYAFYRNKKLRTAPNYFIINLAISDFLMSATQAPVCFLSSLHREWILGDIGCNVYAFCGALF GITSMMTLLAIS INRYIVIT-KPLQSIQWSSKKR TSQIIVLVWMYSLMWSLAPLLGWS >NEUR_homSap AGFYLTIIGILSTFGNGYVLYMSSRRKKKLRPAEIMTINLAVCDLGISVVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFF GCGSLITMTAVS LDRYLKIC--YLSYGVWLKRKH AYICLAAIWAYASFWTTMPLVGLG >RGR_homSap VLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRVSHRRWPYGSDGCQAHGFQGFVT ALASICSSAAIA WGRYHHYC-----TRSQLAWNS AVSLVLFVWLSSAFWAALPLLGWG >PER_homSap VATYLIMAGMISIISNIIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQVYAGLNIFF GMASIGLLTVVA VDRYLTIC--LPDVGRRMTTNT YIGLILGAWINGLFWALMPIIGWA >PERa_Branc VGLYLFVIGIIGTIENGITLATFSKFRSLRSPTTMLLVHLAIADLGICIFGYPFSGASSLRSHWLFGGVGCQWYGFNGMFF >PPIN2_cioSa LCVFMSFVFVLAVPLNLLVIVATYKNKVLRRPINYIIVNLAVADLTCSVVGGLLGVLNNGAGYYFLGKSVCIFEGYVMSVT >MEL_Platy GIFGLMSINTLA WIAIDRFYVITNPLGAAQTMTKKRAFIILTIIWANASLWALAPFFGWG >MEL1b_Bran IFGSMMLVFGLIGVVGNVVALYAFCRTRSLRRPKNYVVANLCLTDMFVCLVYCPIVVSRSFSHGFPSKESCIVEGFMVGVG - >MEL2_galGal CFVNSLHREWILGDIGCDLYAFCGALFGITSMMTLLAISVDRYLVITKPLRSIQWTSKKRTIQIIAAVWLYSLGWS
amino terminal alignment of imaging opsins:
((((RHO1,RHO2), SWS1),(LWS,SWS2),(PIN,VAOP)
!!! *** !!! ** *** * * *
>RHO1_homSap MNGTEGPNFYVPFSNATGVVRSPFEYPQY-YLAEPWQFSM LAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLG
>RHO1_monDom MNGTEGPNFYVPFSNKTGTVRSPFEEPQY-YLADPWQFSC LAAYMFMLIVLGFPINFLTLYVTIQHKKLRTPLNYILLNLAIADLFMVFGGFTMTLYTSLHGYFVFGPTGCNLEGFFATLG
>RHO1_ornAna MNGTEGQDFYIPMSNKTGVVRSPFEYPQY-YLAEPWQYSV LAAYMFMLIMLGFPINFLTLYVTIQHKKLRTPLNYILLNLAFANHFMVLGGFTTTLYTSLHGYFVFGPTGCNIEGFFATLG
>RHO1_galGal MNGTEGQDFYVPMSNKTGVVRSPFEYPQY-YLAEPWKFSA LAAYMFMLILLGFPVNFLTLYVTIQHKKLRTPLNYILLNLVVADLFMVFGGFTTTMYTSMNGYFVFGVTGCYIEGFFATLG
>RHO1_anoCar MNGTEGQNFYVPMSNKTGVVRNPFEYPQY-YLADPWQFSA LAAYMFLLILLGFPINFLTLFVTIQHKKLRTPLNYILLNLAVANLFMVLMGFTTTMYTSMNGYFIFGTVGCNIEGFFATLG
>RHO1_xenTro MNGTEGPNFYIPMSNKTGVVRSPFDYPQY-YLAEPWKYSA LAAYMFLLILLGFPINFMTLYVTIQHKKLRTPLNYILLNLVFANHFMVLCGFTVTMYTSMHGYFIFGQTGCYIEGFFATLG
>RHO1_danRer MNGTEGPAFYVPMSNATGVVRSPYEYPQY-YLVAPWAYGF VAAYMFFLIITGFPVNFLTLYVTIEHKKLRTPLNYILLNLAIADLFMVFGGFTTTMYTSLHGYFVFGRLGCNLEGFFATLG
>RHO1_Raja MNGTEGENFYVPMSNKTGVVRSPFDYPQY-YLGEPWMFSA LAAYMFFLILTGLPVNFLTLFVTIQHKKLRQPLNYILLNLAVSDLFMVFGGFTTTIITSMNGYFIFGPAGCNFEGFFATLG
>RHO1_lamp1 MNGTEGENFYIPFSNKTGLARSPFEYPQY-YLAEPWKYSV LAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAVANLFMVLFGFTLTMYSSMNGYFVFGPTMCNFEGFFATLG
>RHO1_lamp2 MNGTEGQNFYIPFSNKTDVARSPFEYPQY-YLAEPWKFSA LAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAVSNLFMILFGFTTTMYTSMNGYFVFGPTMCSIEGFFATLG
>RHO1_lamp3 MNGTEGDNFYVPFSNKTGLARSPYEYPQY-YLAEPWKYSA LAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAMANLFMVLFGFTVTMYTSMNGYFVFGPTMCSIEGFFATLG share second glyco, 2aa insert
>RHO2_galGal MNGTEGINFYVPMSNKTGVVRSPFEYPQY-YLAEPWKYRL VCCYIFFLISTGLPINLLTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFVFGPVGCAVEGFFATLG share second glyco, 2aa insert
>RHO2_anoCar MNGTEGINFYVPLSNKTGLVRSPFEYPQY-YLAEPWKYKV VCCYIFFLIFTGLPINILTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFIFGPIGCAIEGFFATLG
>RHO2_Gekko MNGTEGINFYVPLSNKTGLVRSPFEYPQY-YLADPWKFKV LSFYMFFLIAAGMPLNGLTLFVTFQHKKLRQPLNYILVNLAAANLVTVCCGFTVTFYASWYAYFVFGPIGCAIEGFFATIG
>RHO2_Lat MNGTEGMNFYVPLSNRTGLVRSPFEYTQY-YLAEPWKFSV LCAYMFLLIILGFPINFLTLLVTFKHKKLRQPLNYILVNLAVASLFMVVFGFTVTFYSSLNGYFVLGPMGCAMEGFFATLG
>RHO2_Geo MNGTEGANFYIPFHNRTGVVRSPYEYPQY-YLADPWMYSA ISAYVFTLILIGFPVNFMTLFVTFKLKKLRQPLNFILVNLCVADLLMIMFGFTTTFYTAMNGYFVFGPTGCNIEGFFATLG
>SWS1_homSap MRKMS-EEEFYL-FKNIS--SVGPWDGPQY-HIAPVWAFYL QAAFMGTVFLIGFPLNAMVLVATLRYKKLRQPLNYILVNVSFGGFLLCIFSVFPVFVASCNGYFVFGRHVCALEGFLGTVA 2aa indel is above
>SWS1_macDom MSGDEEFYL-FKNIS--SVGPWDGPQY-HIAPAWAFHF QTVFMGFVFCAGTPLNAVVLVATLRYKKLRQPLNYILVNVSLCGFIFCIFAVFTVFISSSQGYFIFGRHVCAMEAFLGSVA
>SWS1_galGal MSSDDDFYL-FTNGS--VPGPWDGPQY-HIAPPWAFYL QTAFMGIVFAVGTPLNAVVLWVTVRYKRLRQPLNYILVNISASGFVSCVLSVFVVFVASARGYFVFGKRVCELEAFVGTHG
>SWS1_Taeniop MD-EEEFYL-FKNQS--SVGPWDGPQY-HIAPMWAFYL QTIFMGLVFVAGTPLNAIVLIVTIKYKKLRQPLNYILVNISVSGLMCCVFCIFTVFIASSQGYFVFGKHMCAFEGFAGATG
>SWS1_Gekko MSGEEDFYL-YANIS--SVGPFDGPQY-HIAPMWAFYF QTAFMGFVFFVGTPLNAIILFAIVKYKKLRQPLNYILVNISAAGFLFCVVAVFTVFISSSQGYFIFGKHICALEAFLGSLA
>SWS1_Utasta MSGEEDFYL-FENIS--SVGPWDGPQY-HIAPMWAFYF QTAFMGFVFFAGTPLNAIILIVTVKYKKLRQPLNYILVNISFAGFLFCVFSVFTVFLASSQGYFFFGRHICALEAFLGSVA
>SWS1_Xenopus MLEEEDFYL-FKNVS--NVSPFDGPQY-HIAPKWAFTL QAIFMGMVFLIGTPLNFIVLLVTIKYKKLRQPLNYILVNITVGGFLMCIFSIFPVFVSSSQGYFFFGRIACSIDAFVGTLT
>SWS1_Danio MD--AWAVQ-FGNAS--KVSPFEGEQY-HIAPKWAFYL QAAFMGFVFIVGTPMNGIVLFVTMKYKKLRQPLNYILVNISLAGFIFDTFSVSQVSVCAARGYYSLGYTLCSMEAAMGSIA
>SWS1_Oryzias MG--KYFYL-YENIS--KVGPYDGPQY-YLAPTWAFYL QAAFMGFVFFVGTPLNFVVLLATAKYKKLRVPLNYILVNITFAGFIFVTFSVSQVFLASVRGYYFFGQTLCALEAAVGAVA
>SWS1_Geotri MSGDEEFYL-FKNIS--KVGPWDGPQF-HIAPKWAFYL QAAFMGFVFICGTPLNAIVLVVTIKYKKLRQPLNYILVNISAAGLVFCLFSISTVFVASMQGYFFLGPTICALEAFFGSLA
>SWS2_ornAna MHKTHRNLQNELPEDFFIPLPLDTDNIT--SLSPFLVPQT-HLGGSGIFMS LAAFMFLLITLGFPINLLTVICTIKYKKLRSHLNYILVNLAVSNMLVVCVGSATAFYSFAHMYFVLGPTACKIEGFAATLG
>SWS2_galGal MH--PPRPTTDLPEDFYIPMALDAPNIT--ALSPFLVPQT-HLGSPGLFRA MAAFMFLLIALGVPINTLTIFCTARFRKLRSHLNYILVNLALANLLVILVGSTTACYSFSQMYFALGPTACKIEGFAATLG
>SWS2_Taenio MPKPREMRDELPEDFYIPMSLETPNLT--ALSPFLVPQT-HLGSPGIFKA MAAFMFLLVLLGVPINALTVLCTAKYKKLRSHLNYILVNLAVANLLVVCVGSTTAFYSFSQMYFALGPLACKIEGFTATLG
>SWS2_Utasta MHNSRPHSRDDLPEDFFIPMPLDVANIT--TLSPFLVPQT-HLGSPALFMG MAAFMFLLIILGVPINVLTIFCTFKYKKLRSHLNYILVNLAVSNLLVVCIGSTTAFYSFAQMYFSLGPTACKIEGFAATLG
>SWS2_Xenopu MSKGRPDLRMEMPDEFYVPIPLETTNIS--SLSPFLVPQT-HLGTPGIFMS ISAFMLFTIIFGFPLNLLTIICTVKYKKLRSHLNYILVNLAVANLIVICFGSTTAFYSFSQMYFSLGTLACKIEGFTATLG
>SWS2_Danio MKQQQQTPELFEDFHMPITLDVSNIS--AYSPFLVPQD-HLGHSGVFMG MSAFMLFLFIAGTAINVLTIVCTIQYKKLRSHLNYILVNLAISNLWVSVFGSSVAFYAFYKKYFVFGPIGCKIEGFTSTIG
>SWS2_Takifu MRGVRQHEFQEDFYIPIPLDVDNIT--ALSPFLVPQD-HLGSPAVFYG MSAFMFFLFVAGTGINVLTIACTIQYKKLRSHLNYILVNLAFSNLLVTTVGSFTCFCCFFVRYMIVGPLGCKIEGFAATLG
>SWS2_Geotri MYQGKSTQVDDLPEDFYIPIALNVKNMS--ELSPFLVPQV-HLGDSFIFYG MSAFMLFLVLAGFPLNFLTVFVTIKYKKLRSHLNYILVNLAIANLIVVCCGSTLAFYSFMHKYFILGPLFCKMEGFTATLG
>LWS_ornAna MTPAWNSGVYAARRRFEDEEDTTRTSVFVYTNSNNT---RDPFEGPNY-HIAPRWAYNV TSLWMIFVVIASVFTNGLVLVATMKFKKLRHPLNWILVNLAVADLGETLIASTISVINQIFGYFILGHPMCVLEGYTVSLC 1 aa indel
>LWS_galGal MAAWEA--AFAARRR-HEEEDTTRDSVFTYTNSNNT---RGPFEGPNY-HIAPRWVYNL TSLWMIFVVAASVFTNGLVLVATWKFKKLRHPLNWILVNLAVADLGETVIASTISVINQISGYFILGHPMCVVEGYTVSAC
>LWS_anoCar MAGTVTEAWDVAVFAARRR-NDEDDTTRDSLFTYTNSNNT---RGPFEGPNY-HIAPRWVYNI TSVWMIFVVIASIFTNGLVLVATAKFKKLRHPLNWILVNLAIADLGETVIASTISVINQISGYFILGHPMCVLEGYTVSTC
>LWS_Lithoch MAEEWGKQSFAARRY---HEDSTRGSAFAYTNSNNT---RDPFEGPNY-HIAPRWIYNL ATLWMFVVVVLSVFTNGLVLVATMKFKKLRHPLNWILVNLAIADLGETVFASTISVCNQFFGYFILGHPMCIFEGYVVSVC
>LWS_Gastero MAEEWGKQAFAARRY---NEDTTRGSMFVYTNSNNT---KDPFEGPNY-HIAPRWVYNL STLWMFIVVALSVFTNGLVLVATAKFKKLQHPLNWILVNLAIADLGETVFASTISVCNQFFGYFILGHPMCVFEGYVVSVC
>LWS_Petrom MTASWQGAMFAARRR-QDDEDTTMESLFRYTNENNT---KDPFEGPNY-HIAPRWVFNL TSVWMIIVVVLSLFSNGLVLVATVKFKKLRHPLNWIIVNLAIADILETIFASTISVCNQVYGYFILGHPMCVFEGYVVSTC
>LWS_lamprey MTASWHGAVFAARRR-NDDEDTTKDSIFRYTNENNT---RDPFEGPNY-HIAPRWMFNL TSVWMIIVVVLSLFTNGLVLVATMKFKKLRHPLNWILVNLAIADILETIFASTISVCNQVFGYFILGHPMCVFEGYVVSTC
>LWS_Geotria MAQSWERAMFAARRR--QDEDTTKGDLFRYTNENNT---RDPFEGPNY-HIAPRWMYNL TSFWMIIVVILSLFTNGLVLVATLKFKKLRHPLNWILVNLAIADIGETIFASTVSVVNQIFGYFILGHPLCVFEGFTVSVC
>PIN_galGal MSSNSSQAPPNGT---PGPFDGPQWPYQAPQSTYVG VAVLMGTVVACASVVNGLVIVVSICYKKLRSPLNYILVNLAVADLLVTLCGSSVSLSNNINGFFVFGRRMCELEGFMVSLT P 1aa insert non-ancestral unless VAOP earlier
>PIN_utaSta MVNEWSNAT---PGPFDGPQWPYLAPRSIYTS VAVLMGLVVVSAAFVNGLVIVVSIQYKKLRSPLNYILVNLAIADLLVTSFGSTLSFANNIYGFFVLGQTACEFEGFMVSLT these opsins are very limited frog to liz/bird
>PIN_pheMad MHVQMANASQASLKNGT---LSPFDGPQWPHRASRRVYTS LAALMGVVVLSASLANGLVIAVSVRFKRLRSPLNYILVNLATADLLVTFFGSIISFVNNAVGFFVFGKTACRFEGFMVSLT
>PIN_podSic MQASNASWVEVRNRT---PGPFEGPQWPYLAPQSTYIS VAVLMGLVVISATLVNGLVIVVSVQFKKLRSPLNYVLVNLAVADLLVTFFGSTISFVNNAQGFFIFGQATCEFEGFMVSLT
>PIN_xenTro MRAGNMSAYEA---PGPYDGPQWPHLAPRSTFLT VAAVMCMVVILAFFVNGLVIVVTLKYKKLRSPLNYILVNLAIANLLVTIFGSSVSFSNNVVGYFFMGKTMCEFEGFMVSLT the glyco is either not homologous or lost in frogs
>PIN_bufJap MHSANMSALET---PGPFEGPQWPHVAPRSTYLT VAVLMGMVVFLAFFVNGMVIVVSLKYKKLRSPLNYILVNLAVADILVTMFGSTVSFHNNIFGFFTLGKLVCELEGFVVSLT
>VAOP_galGal MDVFRALGNESLLSNSSGPARWDPFHHPLD-SIQP-WHFRL VAAVMFVVTSLSLAENLAVILVTFKFKQLRQPVNYVIVNLSVADFLVSLTGGTISFLANLKGYFYMGHWACVLEGFAVTFF no consistent glyco, much older than PIN
>VAOP_anoCar MAGLRREAENDSWLFDPSSSSAPFLQPLD-IIEP-WNFHL ISALMFVVTLFSLSENFTVILVTIKFKQLRQPLNYVIVNLSVADFLVSLIGGTISFSTNLKGYFYMGHWACVLEGFAVTFF losing all the invariant residues almost
>VAOP_xenTro MPTNVSLLATPENSTVWNPFTGPLK-TIEA-WNFHL LAALMFVVTSLSIAENFIVILVTAKFKQLRQPLNYIIVNLSVADFLVSVIGGTISIATNSRGYFYLGSWACVLEGFAVTFF
>VAOP_danRer MEASSAAVNAVSPAEDPFSAPLS-SIAP-WNYSV LAALMFVVTALSLSENFTVMLVTFRFQQLRQPLNYIIVNLSLADFLVSLTGGSISFLTNYHGYFFLGKWACVLEGFAVTFF
>VAOP_rutRut MELFPVAVNGVSHAEDPFSGPLT-FIAP-WNYKV LATLMFVVTAASLSENFAVMLVTFRFTQLRKPLNYIIVNLSLADFLVSLTGGTISFLTNYHGYFFLGKWACVLEGFAVTYF
>VAOP_Petro MDALQESPPSHHSLPSALPSATGGNGTVATMHNPFERPLE-GIAP-WNFTM LAALMGTITALSLGENFAVIVVTARFRQLRQPLNYVLVNLAAADLLVSAIGGSVSFFTNIKGYFFLGVHACVLEGFAVTYF
>PPIN_anaCar MDSLDTNTLSPNASTVRVVLMPRIGYTI IAIIMATSCTLSVILNTAVIAITIKYRQLRQPINYSLVNLAIADLGAALLGGSLNVETNAVGYYNLGRVGCVTEGFAMAFF
>PPIN_Xenop MADEALLPPMMNVTNEEMHPGKVLMPRIGYTI LALIMAVFCAAALFLNVTVIVVTFKYRQLRHPINYSLVNLAIADLGVTVLGGALTVETNAVGYFNLGRVGCVIEGFAVAFF
>PPIN_Ictal MASIILINFSETDTLHLGSVNDHIMPRIGYTI LSIIMALSSTFGIILNMVVIIVTVRYKQLRQPLNYALVNLAVADLGCPVFGGLLTAVTNAMGYFSLGRVGCVLEGFAVAFF
>PPIN_Danio MESETSTAASGSIAE-VMPRMGYTI LAVIIGVFSVCGVILNVTVITVTLKYKQLRQPLNFALVNLAVADLGCAVFGGLPTVVTNAMGYFSLGRVGCVLEGFAVAFF
>PPIN_Oncor MDHQQLLPNLHGNISSSPGSVSEALLSRTGFTI LAVIIGVFSVSGVCMNVLVIMVTMRHRKLRQPLNYALVNLAVADLGCALFGGLPTMVTNAMGYFSMGRLGCVLEGFAVAFF
>PPINa_Ciona MDHDVTPTVDLTDGVPQCKDLNPYVLKGDGWVPQHISRANRSTYSF LCVYMTFVFLLSCSLNILVIVATLKNKVLRQPLNYIIVNLAVVDLLSGFVGGFISIAANGAGYFFWGKTMCQIEGYFVSNF
>PPINb_Ciona MTTAETTTECYEKNPYIRNEMGWVPKHILIAERHIYTILAVYMTFIFL LAVYMTFIFLLAVSLNGFVIIATMKNKKLRQPLNYIIINLSIADFLSGLVGGFIGMISNSAGYFYFGKTVCILEGYIVSVA
>PPIN2_cioSa IPQNYSNGNPYATTDSGWVPEHIEIANRSTYSG LCVFMSFVFVLAVPLNLLVIVATYKNKVLRRPINYIIVNLAVADLTCSVVGGLLGVLNNGAGYYFLGKSVCIFEGYVMSVT
>PPIN_lamp MENLTSLDLLPNGEVPLMPRYGFTI LAVIMAVFTIASLVLNSTVVIVTLRHRQLRHPLNFSLVNLAVADLGVTVFGASLVVETNAVGYFNLGRVGCVIEGFAVAFF
>PARIE_Utast ME-NDSSLATEL--------------------AEGAIVKPTIFPKAG-------YGV LAFLMFLNALFSIFNNSLVIAVTLKNPQLRNPINIFILNLSFSDLMMSLCGTTIVIATNYYGYFYLGRKFCIFQGFAVNYF
>PARIE_Anole ME--NESSLVLE--------------------AEGYIVRPTIFPRAG-------YGV LAFLMFINALFSLFNNFLVIAVTLKNPQLRNPINIFILNLSFSDLMMSICGTTIVIATNYHGYFYLGRRFCIFQGFAVNYF
>PARIE_Xenop MD-GNSTTPGI---------------------AVNLTVMPTIFPRSG-------YSI LSFLMFLNAVFSICNNAIVILVTLKHPQLRNPINIFILNLSFSDLMMALCGTTIVVSTNYHGYFYLGKQFCIFQGFAVNYF
>ENCEPH_braBe EY-GNNTTFAAWDFKRNGTGGEEEVEF-----------------FG-------YDA VAGVIAIIGVVGFVSNGAVVVLFLKFPQLRTPFNLLLLNMAVADLLVSVCGNTLSFASAVRHRWLWGRPGCVWYGFANHLF
>ENCEPH_homS MYSGNRS--------GGHGYWDGGGAAGAEG------PAPAGTLSPAPLFSPGTYER LALLLGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFSGSLF
>ENCEPH_monD MYSDNSS------DDGGGGYWGSGRAGGASGTGVTGEPGPEGSPRQAPLFSPGTYEL LALLIATIGLLGLCNNLLVLVLYYKFQRLRTPTHLFLVNISFNDLLVSLFGVTFTFVSCLRSGWVWDSVGCAWDGFSNTLF
>ENCEPH_galG MHSGNGT---------------------GATSRPQLAAAGHEVPGERPLFSAGTYEL LALLIATIGTLGVCNNLLVLVLYYKFKRLRTPTNLFLVNISLSDLLVSVCGVSLTFMSCLRSRWVWDAAGCVWDGFSNSLF
>ENCEPH_anoC MFSANGT---------RSGAGSDLEPGPGQQQQQREASEEEERGAGLSPFSAGTYEL LALLVAAIGLLGLCNNLLVLVLYAKFKRLRTPTHLFLVNISLSDLLVSLFGVSFTFGSCLRHRWVWDAAGCVWDGFSNSLF
>ENCEPH_xenT MPVTNGS-----------------------------HNNSISWLHSKDMFTEDTYHF LALIVATVGFLGLVNNLLVLILYCKFKRLQTPTNLLFFNTSLCHFVFSLLAITFTFMSCVRGSWAFSVEMCVFHGFSKNLL
>ENCEPH_braB MPLYNTSSGPTQGLPWDTPYSQDPIWNDSSPSNSSEDAVVDQGRGELQDFSDAGYTA IATGLALIGLVGSMNNFVVILLIGCHRQLRTPFNLLLLNVSVADLLVSVCGNTLSFASAVQHRWLWGRPGCVWYGFANSLF
>ENCEPH_braF MALYNNTSSPSQDLLWDAPYSQGHIW-DNSSASNSSEDVMDQGKVELQDFSDAGYTA IATCLALIGFVGFTNNFVVILLIGCHRQLRTPFNLLLLNMSVADLLVSVCGNTLSFASAVRHRWLWGRPGCVWYGFANSLF
>ENCEPH2_Api MEHVIYEDQVSPVMYIGA AIALGFIGFFGFTANLLVAIVIVKDAQILWTPVNVILFNLVFGDFLVSIFGNPVAMVSAATGGWYWGYKMCLWYAWFMSTL
>ENCEPH1_Ano MYDVTDAAAINSDHQELMAPWAYNGA AVTLFFIGFFGFFLNIFVIALMYKDVQ-LWTPMNIILFNLVCSDFSVSIIGNPLTLTSAISHRWLYGKSICVAYGFFMSLL
>ENCEPH2_Ano MNDAPNDVAASAVDYEDLMAPWAYNAS AVTLFFIGFFGFFLNLFVIALMCKDMQ-LWTPMNIILFNLVCSDFSVSIIGNPLTLTSAISHRWIFGRTLCVAYGFFMSLL
>CILL2_Platyr MDDLGFLGNSSVNYTVPLLQEDPLLLRILYFGPTSYVIT AIYLCIVGVIGTLSNGVIMYLYFKDKSLRSPMNLLFVNLAMSDFTVAFFGAMFQFGLTCTRKYMSPGMALCDFYGFITFLG
>CILL1_Platyr MDGENLTIPNPVTELMDTPINSTYFQNLNAETDGGNHYIYNAFTATDYNIC AAYLFFIACLGVSLNVLVLVLFIKDRKLRSPNNFLYVSLALGDLLVAVFGTAFKFIITARKTLLREEDGFCKWYGFITYLG
!!! *** !!! ** *** * * *
>RHO1_homSap MNGTEGPNFYVPFSNATGVVRSPFEYPQY-YLAEPWQFSM LAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLG
Here's the distal alignment of the opsins:
>RHO1_homSap RYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKE AAAQQQESATTQKAEK----EVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQ FRNCMLTTIC CGKNPLG DDEASATVS KTE TSQVAPA
>RHO1_monDom RYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPLIVIFFCYGQLVFTVKE AAAQQQESATTQKAEK----EVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSNFGPIFMTIPAFFAKSSSVYNPVIYIMMNKQ FRTCMITTLC CGKNPLG DDEASATAS KTE TSQVAPA
>RHO1_ornAna RYIPEGMQCSCGIDYYTLRPEVNNESFVIYMFVVHFTIPMTIIFFCYGRLVFTVKE AAAQQQESATTQKAEK----EVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTVPAFFAKSSAIYNPVIYIMMNKQ FRNCMLTTIC CGKNPLG DDEASATAS KTEQSSVSTSQVSPA
>RHO1_galGal RYIPEGMQCSCGIDYYTLKPEINNESFVIYMFVVHFMIPLAVIFFCYGNLVCTVKE AAAQQQESATTQKAEK----EVTRMVIIMVIAFLICWVPYASVAFYIFTNQGSDFGPIFMTIPAFFAKSSAIYNPVIYIVMNKQ FRNCMITTLC CGKNPLG DEDTSAG KTETSSVSTSQVSPA
>RHO1_anoCar RYIPEGMQCSCGVDYYTPTPEVHNESFVIYMFLVHFVTPLTIIFFCYGRLVCTVKA AAAQQQESATTQKAER----EVTRMVVIMVISFLVCWVPYASVAFYIFTHQGSDFGPVFMTIPAFFAKSSAIYNPVIYILMNKQ FRNCMIMTLC CGKNPLG DEDTSAGT KTETSTVSTSQVSPA
>RHO1_xenTro RYIPEGMQCSCGVDYYTLKPEVNNESFVVYMFIVHFTIPLCVIFFCYGRLLCTVKE AAAQQQESATTQKAEK----EVTRMVVMMVIFFLICWVPYAYVAFYIFTHQGSDFGPVFMTVPAFFAKSSAIYNPVIYIVLNKQ FRNCLITTLC CGKNPFG DEEGSSAASS KTEASSVSSSQVSPA
>RHO1_danRer RYIPEGMQCSCGVDYYTRTPGVNNESFVIYMFIVHFFIPLIVIFFCYGRLVCTVKE AARQQQESETTQRAER----EVTRMVIIMVIAFLICWLPYAGVAWYIFTHQGSEFGPVFMTLPAFFAKTSAVYNPCIYICMNKQ FRHCMITTLC CGKNPFE EEEGASTTAS KTEASSVSSSSVSPA
>RHO1_Raja RYIPEGLQCSCGVDYYTMKPEVNNESFVIYMFVVHFTIPLIVIFFCYGRLVCTVKE AAAQQQESESTQRAER----EVTRMVIIMVVAFLICWVPYASVAFYIFINQGCDFTPFFMTVPAFFAKSSAVYNPLIYILMNKQ FRNCMITTIC LGKNPFE EEESTSASAS KTEASSVSSSQVAPA
>RHO1_lamprey1 RYLPEGMQCSCGPDYYTLNPNFNNESFVIYMFLVHFIIPFIVIFFCYGRLLCTVKE AAAAQQESASTQKAEK----EVTRMVVLMVIGFLVCWVPYASVAFYIFTHQGSDFGATFMTVPAFFAKTSALYNPIIYILMNKQ FRNCMITTLC CGKNPLG DEDSGASTS KTEVSSVSTSQVSPA
>RHO1_lamprey2 RYLPEGMQCSCGPDYYTMNPTYNNESFVIYMFIVHFTIPFVIIFFSYGRLLCTVKE AAAAQQESASTQKAEK----EVTRMVVLMVVGFLVCWVPYASVAFYIFTNQGSDFGATFMTLPAFFAKSSALYNPVIYILMNKQ FRNCMITTLC CGKNPLG DDDSGASTS KTEVSSVSTSQVAPA
>RHO1_lamprey3 RYIPEGMQCSCGPDYYTLNPNFNNESYVVYMFVVHFLVPFVIIFFCYGRLLCTVKE AAAAQQESASTQKAEK----EVTRMVVLMVIGFLVCWVPYASVAFYIFTHQGSDFGATFMTLPAFFAKSSALYNPVIYILMNKQ FRNCMITTLC CGKNPLG DDESGASTS KTEVSSVSTSQVSPA
>RHO2_galGal RYMPEGMQCSCGPDYYTHNPDYHNESYVLYMFVIHFIIPVVVIFFSYGRLICKVRE AAAQQQESATTQKAEK----EVTRMVILMVLGFMLAWTPYAVVAFWIFTNKGADFTATLMAVPAFFSKSSSLYNPIIYVLMNKQ FRNCMITTIC CGKNPFG DEDVSSTVSQSKTEVSSVSSSQVSPA
>RHO2_anoCar RYIPEGMQCSCGPDYYTLNPDYHNESYVLYMFGVHFVIPVVVIFFSYGRLICKVRE AAAQQQESASTQKAER----EVTRMVILMVLGFLLAWTPYAMVAFWIFTNKGVDFSATLMSVPAFFSKSSSLYNPIIYVLMNKQ FRNCMITTIC CGKNPFG DEDVSSSVSQSKTEVSSVSSSQVSPA
>RHO2_Gekko RFIPEGMQCSCGPDYYTLNPDFHNESYVIYMFIVHFTVPMVVIFFSYGRLVCKVRE AAAQQQESATTQKAEK----EVTRMVILMVLGFLLAWTPYAATAIWIFTNRGAAFSVTFMTIPAFFSKSSSIYNPIIYVLLNKQ FRNCMVTTIC CGKNPFG DEDVSSSVSQSKTEVSSVSSSQVAPA
>RHO2_Latime RYIPEGLQCSCGPDYYTLNPDFHNESYVMYLFLVHFLLPIIIIFFTYGRLICKVKE AAAQQQESASTQKAEK----EVTRMVILMVIGFLTAWVPYASAAFWIFCNRGAEFTATLMTVPAFFSKSSCLFNPIIYVLLNKQ FRNCMITTLC CGKNPLG DDDTSSAVSQSKTDVSSVSSSQVSPA
>RHO2_Geot RYIPEGMQCSCGPDYYTLNPKYYNESYVIYLFLVHFLLPVTIIFFTYGRLICTVKE AAAQQQESASTQKAER----EVTRMVIIMVVGFLVCWVPYASFAFYLFMNKGILFSATAMTVPAFFSKSSVLYNPIIYVLLNKQ FRTCMVTTLF CGKNPFG EDDSSMVSTS KTEVSSVSSSQVSPS
>SWS1_homSap RFIPEGLQCSCGPDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLLRALKA VAAQQQESATTQKAER----EVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGLDLRLVTIPSFFSKSACIYNPIIYCFMNKQ FQACIMKMV CGKAMTDESDTCSSQ KTEVSTVSSTQVGPN
>SWS1_macDom RFIPEGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIMPLFLICFSYSQLLRALRA VAAQQQESATTQKAER----EVSRMVVMMVGSFCLCYVPYAALAMYMVNNQNHGLDLRLVTIPAFFSKSACVYNPIIYCFMNKQ FHACIMEMV CRKPMTDDSDVSSSQ KTEVSAVSSSQVGPT
>SWS1_galGal RYMPEGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIVPLSLIIFSYSQLLSALRA VAAQQQESATTQKAER----EVSRMVVVMVGSFCLCYVPYAALAMYMVNNRDHGLDLRLVTIPAFFSKSACVYNPIIYCFMNKQ FRACIMETV CGKPLTDDSDASTSAQ RTEVSSVSSSQVGPT
>SWS1_Taeni RYIPEGLQCSCGPDWYTVGTKYKSEYYTWFLFIFCFIVPLSLIIFSYSQLLSALRA VAAQQQESATTQKAER----EVSRMVVVMVGSFCMCYVPYAALAMYMVNNREHGIDLRLVTIPAFFSKSSCVYNPIIYCFMNKQ FRACIMETV CGRPMTDDSEVSSSAQ RTEVSSVSSSQVGPS
>SWS1_Gekko RFIPEGLQCSCGPDWYTVGTKYYSEYYTWFLFVLCFIVPLSIIVFSYSQLLSALRA VAAQQQESATTQKAER----EVSRMVVVMVGSFCLCYVPYAALAMYMVNNRNHGIDLRMVTIPAFFSKSSCVYNPIIYCFMNKQ FRGCILEMV CGKTMAEESEVSSASQ KTEVSSVSSSQVGPS
>SWS1_Uta RFIPEGLQCSCGPDWYTVGTKYKSEYYTWFLFIFCFIVPLTLIIFSYSQLLGALRA VAAQQQESATTQKAER----EVSRMVVVMVGSFCLCYVPYAALAMYMVNNRDHGIDLRLVTIPAFFSKSACVYNPIIYCFMNKQ FRACIMETV CGKPMTDESDVSSSAQ KTEVSSVSSSQVSPS
>SWS1_Xenop RYMPEGLQCSCGPDWYTVGTKYRSEYYTWFIFIFCFVIPLSLICFSYGRLLGALRA VAAQQQESASTQKAER----EVSRMVIFMVGSFCLCYVPYAAMAMYMVTNRNHGLDLRLVTIPAFFSKSSCVYNPIIYSFMNKQ FRGCIMETV CGRPMSDDSSVSSTSQ RTEVSTVSSSQVSPA
>SWS1_Danio RYIPEGLGCSCGPDWYTNCEEFSCASYSKFLLVTCFICPITIIIFSYSQLLGALRA VAAQQAESASTQKAEK----EVSRMIIVMVASFVTCYGPYALTAQYYAYSQDENKDYRLVTIPAFFSKSSCVYNPLIYAFMNKQ FNACIMETV FGKKIDESSEVSS KTETSSVSA
>SWS1_Oryzia RYIPEGLQCSCGPDWYTVGTKYKSEYYTYFLFVFCFVVPLSIIIFSYGSLLGTLRA VAAQQQESASTQKAER----EVSRMVIMMVASFCTCYVPYAALAVYMVTNRDHNIDLRFVTVPAFFSKASCVYNPLIYSFMNKQ FNGCIMEMV FGKKMEEASEVSS KTEVSTDS
>SWS1_Geotri RYIPEGLQCSCGPDWYTVGTKYKSEYYTYFLFVFCFVVPLSIIIFSYGSLLGTLRA VAAQQQESASTQKAER----EVSRMVIMMVASFCTCYVPYAALAVYMVTNRDHNIDLRFVTVPAFFSKASCVYNPLIYSFMNKQ FRACILETV CGKPITDESETSSS RTEVSSVSTTQMIPG
>SWS2_ornAna RYIPEGLQCSCGPDWYTTNNKWNNESYVIFLFSFCFGVPLSIIIFSYGRLLLTLRA VAKQQEQSATTQKAER----EVTKMVIVMVLGFLVCWLPYASFSLWVVTNRGQVFDLRMASIPSVFSKASTIYNPIIYVFMNKQ FRSCMLKLVF CGKSPFGDEDEISGSS QATQVSSVSSSQVSPA
>SWS2_galGal RYIPEGLQCSCGPDWYTTDNKWHNESYVLFLFTFCFGVPLAIIVFSYGRLLITLRA VARQQEQSATTQKADR----EVTKMVVVMVLGFLVCWAPYTAFALWVVTHRGRSFEVGLASIPSVFSKSSTVYNPVIYVLMNKQ FRSCMLKLLF CGRSPFGDDEDVSGSS QATQVSSVSSSHVAPA
>SWS2_Taeni RYIPEGLQCSCGPDWYTTDNKWNNESYVIFLFCFCFGFPLTVIVFSYGRLLLTLRA VAKQQEQSASTQKAER----EVTKMVVVMVLGFLVCWLPYCSFALWVVTHRGHPFDLGLASIPSVFSKASTVYNPIIYVFMNKQ FRSCMLKLVF CGRSPFGDEDDVSGSS QATQVSSVSSSQVSPA
>SWS2_Uta RYIPEGLQCSCGPDWYTTNNKWNNESYVLFLFSFCFGVPLSVIIFSYGRLLLTLRA VAKQQEQSATTQKAER----EVTKMVVVMVMGFLVCWLPYASFALWVVTHRGEPFDVRLATIPSVFSKASSVYNPVIYVFMNKQ FRSCMLKLVF CGKSPFGDEDDVSGSS QTTQVSSVSSSQVSPA
>SWS2_Xeno RYIPEGLQCSCGPDWYTVNNKWNNESYVLFLFCFCFGFPLAIIVFSYGRLLLALHA VAKQQEQSATTQKAER----EVTRMVIVMVVGFLVCWLPYASFALWAVTHRGELFDLRMSSVPSVFSKASTVYNPFIYIFMNRQ FRSCMMKMIF CGKNPLGDDEETSVSG STQVSSVSSSQIAPS
>SWS2_Danio RYIPEGLQCSCGPDWYTTNNKFNNESYVMFLFCFCFAVPFSTIVFCYGQLLITLKL AAKAQADSASTQKAER----EVTKMVVVMVFGFLICWGPYAIFAIWVVSNRGAPFDLRLATIPSCLCKASTVYNPVIYVLMNKQ FRSCMMKMVF NKNIEEDEASSSS QVTQVSSVAPEK
>SWS2_Takif RYIPEGFQCSCGPDWYTTGNKYNNESYVWFIFGFGFAVPLFVIVFCYSQLLVMLKS AAKAQAESASTQKAER----EVTRMVVVMILGFLVCWLPYASFALWVVNNRGTPFDLRLATIPACFSKASTVYNPIIYVVLNKQ FRSCMKKMLG MSGGDDEESSS QSVTEVSKVSPS
>SWS2_Geotria RYIPEGLQCSCGPDWYTTNNKYNNESYVMFLFIFCFGTPFTIIIVSYSKLILTLRA AAAQQQESASTQKAEK----EVSRMVVIMVGGFLVCWLPYASLALWIVFNRGSPFDLRLATIPSVFSKASTVYNPVIYIFLNKQ FRSCMMKTIF CGKNPLGDDEDATSTTT QVSSVSTSQVAPA
>LWS_ornAna RYWPHGLKTSCGPDVFSGSSDPGVQSYMIVLMSTCCILPLSIIVLCYLQVWLAIRA VAKQQKESESTQKAEK----EVSRMVVVMILAYCFCWGPYTIFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ FRNCIMQL FGKKVDDGSELSSTS RTEVSSVSS VSPA
>LWS_galGal RYWPHGLKTSCGPDVFSGSSDPGVQSYMVVLMVTCCFFPLAIIILCYLQVSLAIRA VAAQQKESESTQKAEK----EVSRMVVVMIVAYCFCWGPYTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ FRNCILQL FGKKVDDGSEVSTS RTEVSSVSNSSVSPA
>LWS_anoCar RYWPHGLKTSCGPDVFSGSDDPGVLSYMIVLMITCCFIPLAVILLCYLQVWLAIRA VAAQQKESESTQKAEK----EVSRMVVVMIIAYCFCWGPYTVFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ FRNCIMQL FGKKVDDGSELSSTS RTEVSSVSNSSVSPA
>LWS_Lithoch RYWPHGLKTSCGPDVFSGSEDPGVQSYMIVLMLTCCIFPLAIIILCYLAVWMAIRA VAMQQKESESTQKAER----EVSRMVVVMIVAYCVCWGPYTFFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPIIYVFMNRQ FRTCIMQL FGKQVDDGSEVSTS KTEV SSVAPA
>LWS_Gastero RYWPHGLKTSCGPDVFSGSEDPGVQSYMIVLMITCCLIPLAIIILCYLAVWLAIRA VAMQQKESESTQKAER----DVSRMVVVMIVAYIVCWGPYTTFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPVIYVFMNRQ FRSCIMQL FGKEVDDGSEVSTs KTEV SSVAPA
>LWS_Petromy RYWPHGLKTSCGPDVFSGSTDPGVQSYMVVLMITCCFLPLSIIILCYLQVWLAIHS VAQQQKESETTQKAER----DVSRMVVVMILAYVFCWGPYTFFACFAAANPGYSFHPIAAALPAYFAKGATIYNPIIYVFMNRQ FRNCILQL FGKKVDDGSEVSSSS RTEVSSVSNSSVSPA
>LWS_lamprey RYWPHGLKTSCGPDVFSGSSDPGVQSYMVVLMVTCCFLPLSVIILCYLQVWLAIHS VAQQQKESETTQKAER----DVSRMVVVMILAYIFCWGPYTFFACYAAANPGYAFHPLTAALPAYFAKSATIYNPVIYVFMNRQ FRNCIMQL FGKKVDDGSEVSSAS RTEVSSVSNSSISPA
>LWS_Geotria RYWPHGLKTSCGPDVFSGSTDPGVQSYMVVLMITCCFIPLALIIICYLQVWLAIHT VAQQQKESETTQKAER----DVSRMVVVMIFAYIFCWGPYTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ FRNCIMQL FGKKVDDGSEVSSSA RTEVSSVSNSSVSPA
>PIN_galGal SYVPEGLRTSCGPNWYTGGSNNN--SYILSLFVTCFVLPLSLILFSYTNLLLTLRA AAAQQKEADTTQRAER----EVTRMVIVMVMAFLLCWLPYSTFALVVATHKGIIIQPVLASLPSYFSKTATVYNPIIYVFMNKQ FQSCLLEMLC CGYQPQRTGKASPGTPGPHADVTAAGLRNKVMPAHPV
>PIN_Uta sta SYVPEGLRTSCGPNWYTGGSGNN--SYIMALFVTCFALPLGMIIFSYASLLLTLRA VATQQKEVETTQQAEK----EVTRRVIAMVMAFLVCWLPYASFAMVVATNKDLVIQPALASLPSYFSKTATVYNPIIYVFMNKQ FRSCLLSTMS CGHRPRGAQETTPAMISIPQGPTSALQGSRNKVTPSA
>PIN_Phelsuma SYVPEGLGTSCGPNWYMGGTNNN--SYIVALFVTCFALPLSMILFSYANLLLTLRA VAAQQKEQETTQRAEK----EVTRMVITMVMAFLVCWLPYATFAMVVATTKDLSIQPGLASLPSYFSKTATVYNPIIYVFMNKQ FRSCLLNTVS CGRIPQTMPGTPATTAVRGGFVLTSEGRGNKVASTEL
>PIN_Podarcis SYVPEGLRTSCGPNWYSGGSSNN--SYIMTLFVTCFAMPLSTILFSYANLLMTLRT VAAQQKEQETTQRAER----EVTRMVVAMVAAFLVCWLPYASFAMVVATHKDLAIRPALASLPSYFSKTATVYNPIIYVFMNKQ FRSCLLYKMS CGHRALSSQDTTPAGISLPGRLTTSASKGSRNQVSPS
>PIN_xenTro SYVPEGLRTSCGPNWYTGGTNNN--SYIMALFLTCFIMPLSTIIFSYSNLLMALRA VAAQQKDSETTQRAEK----EVTRMVIAMVLAFLICWLPYASFAVVVAVNKDVVIEPTVASLPSYFSKTATVYNPIIYVFMNKQ FRNCLMTLLC CGRSFGDDETSSASGRTDVTSVSEAGGNKVTPA
>PIN_Bufo SYVPEGLGTSCGPNWYTGGTNNN--SYILALFTTCFMMPLTTIIFSYSNLLLALRA VAAQQKESETTQRAER----EVTRMVIAMVLAFLICWLPYAVFAIVMASNKNVVIDPTLASMPSYFSKTATVYNPVIYVFMNKQ FRDCLTKLLC CGRNPFGEDETSTTSGRTDVTSVSEGGGNKVTPA
>CILL2_Platyn SYRPEGLGTWCSISWQDRSMNTM--SYVTAVFLGCYFFPVSIIIFCYFNVWRKVKE AADAQGAGTAGKAEKS-----IFRMSVIMVTCYLTAWTPYAIVCLIASYGPPNGLPIYAEVLPSLFAKSSQVYNPIIYVLMNKP
>ENCEPH_braBel SYQFEGHSVGCSVNWVKHNVNNV--SYIITLMVTCFFVPMVVVCWSYACIWRTVRM SAEMKSEFGNPQNTGR----LVTTMVVVMIVCFLVCWTPYTVMALIVTFGADHLVTPTASVIPSLVAKSSTAYNPIIYVLMNNQ FREFLLARLRTFCCRQPRMLRVTPMDDNAHARLVGEGPSHAQQVIPSEEN
>ENCEPH_braFlo SYQFEGHNVGCSVNWVQHNPDNV--SYIVTLMVTCFFVPMVVVCWSYAWIWRTVRM SSEAKPECGNSQNAGR----LVTTMVVVMIICFLVCWTPYAVMALIVTFGADHLVTPTASVIPSLVAKSSTAYNPIIYVLMNNQ FREFLLARLQRVCCRQQAVPRVTPMDDNVHVRLGGEGPSQSQQFLPAGEN
>VAOP_galGal SYTTSKIGTTCEPNWYSGAYNDR--SYIIAFFTTCFIVPLLVILVSYGKLLQKLRK VSNTQGRLRTARKPER----QVTRMVVVMIIAFLICWMPYAVFSILATAYPSIELDPHLAAIPAFFSKTATVYNPIIYVFMNKQ FRMCLIQMFK CSAIETAESNMNPTSERATLTQDKRDSQLSVMAVRST
>VAOP_anoCar SYTTSKIGTTCEPNWYSGDYNDH--TFIITFFTTCFILPLLVILVSYGKLMRKLRK VSDTQGRLGTTRKPER----QVTGMVVIMILAFLICWSPYAAFSILVTACPSIELDPRLAAIPAFFSKTATVYNPVIYVFMNNQ FRKCLVQLFQ CSSQETMDANVNPISEKDTLTHTKHCGEMSTVAAHVI
>VAOP_xenTro SYTTSKIGTTCEPNWYSGEMRDH--TYIITFLTTCFVFPLLVIFMSYGKLMRKLRK VSDTQGRLGSTRKPEK----EVTRMVVIMILAFLICWTPYAAFSILITAHPTIDLDPRLAAIPAFFAKTASMYNPIIYVYMNKQ FRRCLYQMFN INDPEAKESNLNPTSERGVLTRNNNGGEMLAIATHIT
>VAOP_Danio SYTVSRIGTTCEPNWYSGNFHDH--TFIITLFSTCFIFPLGVIIVCYCKLIRKLRK VSNTHGRLGNARKPER----QVTRMVVVMIVAFMVAWTPYAAFSIIITAHPSMHVDPRLAAIPAFVAKTAAVYNPIIYVFMNKQ FRKCLVQLLS CSKVTVVEGNNNQTTERAGMTSGSNTGEMSAIAARVS
>VAOP_Ruti SYTVSKIGTTCEPNWYSGNFHDH--TFIIAFFITCFILPLGVIVVCYCKLIKKLRK VSNTHGRLGNARKPER----QVTRMVVVMIVAFMVAWTPYAAFSIVVTAHPSIHLDPRLAAAPAFFSKTAAVYNPVIYVFMNKQ FRKCLVQLLR CRDVTIIEGNINQTSERQGMTNESHTGEMSTIASRIP
>VAOP_Petrom SYRPSMIGTTCEPNWYSGELHDH--TFILMFFSTCFIFPLAVIFFSYGKLIQKLKK ASETQRGLESTRRAEQ----QVTRMVVVMILAFLVCWMPYATFSIVVTACPTIHLDPLLAAVPAFFSKTATVYNPVIYIFMNKQ FRDCFVQVLP CKGLKKVSATQTAGAQDTEHTASVNTQSPGNRHNIAL
>PPIN_anaCar GYQMEGVMTSCAPDWANSDPINV--SYIICYFLFCFTIPFITILASYGYLIWTLRQ VAKVGLAQRGSTTKAEA---QVSRMVIVMVMAFLICWLPYATFALVVVGNPQIYINPIIATIPMYMAKSSTFYNPIIYIFMNKQ FRDCLVRCLL CGRNPCASEQTDEDDLEVSTIAPAPSSRRGKVAPV
>PPIN_Xeno SYELEGVMTSCAPNWYSADPVNM--SYIVCYFSFCFAIPFLIIVGSYGYLMWTLRQ VAKLGVAEGGTTSKAEV---QVSRMVIVMILAFLVCWLPYAAFAMTVVANPGMHIDPIIATVPMYLTKTSTVYNPIIYIFMNKQ FQECVIPFLF CGRNPWAAEKSSSMETSISVTSGTPTKRGQVAPA
>PPIN_Icta SYQLEGVMTSCAPNWYRRDPVNV--SYILCYFMLCFALPFATIIFSYMHLLHTLWQ VAKLQVADSGSTAKVEV---QVARMVVIMVMAFLLTWLPYAAFALTVIIDSNIYINPVIGTIPAYLAKSSTVFNPIIYIFMNRQ FRDYALPCLL CGKNPWAAKEGRDSDTNTLTTTVSKNTSVSPL
>PPIN_Danio RLQLEGVRTSCAPDWYSRDLANV--SFIVCYFLLCFALPFSVIVYSYTRLLWTLRQ VSRLQVCEGGSAARAEA---QVSCMVVVMILAFLLTWLPYASFALCVILIPELYIDPVIATVPMYLTKSSTVFNPIIYIFMNRQ FRDRALPFLL CGRNPWAAEAEEEEEETTVSSVSRSTSVSPA
>PPIN_Oncorhy SFELEGVRTSCSPNWYSREPGNM--SYIILYFLLCFAIPFSIIMVSYARILFTLHQ VSKLKVLEGNSTTRVEI---QVVRMVVVMVMAFLLSWLPYAAFALSVILDPSLHINPLIATVPMYLAKSSTVYNPIIYVFMNRQ FRDCAVPFLL CGLNPWASEPVGSEADTALSSVSKNPRVSPQs
>PPIN_lamp SYELEGVRTSCAPDWYSRDPANV--SYITSYFAFCFAIPFLVIVVAYGRLMWTLHQ VAKLGMGESGSTAKAEA---QVSRMVVVMVVAFLVCWLPYALFAMIVVTKPDVYIDPVIATLPMYLTKTSTVYNPIIYIFMNRQ FRDCAVPFLL CGRNPWAEPSSESATAASTSATSVTLASAPGQVSPS
>PARIE_Uta SYGPEGVQTSCSIGWEERSWSNY--SYLIVYFLSCFFIPVLIIGFSYGNVIRSLHG LNKKVEQLGGKSSPEEEF--RAVIMVLVMVVAFLICWLPYTVFALIVVFNPALNISPLAATIPTYLSKTSPVYNPIIYIFLNKQ FRDCAVEFIT CGQVVLTSPEEDISTSAIPVEGKGPCKINQVTPV
>PARIE_Anole SYGPEGVQTSCSIGWEERSWNNY--SYLIVYFLSCFFIPVLIIGFSYGNVIRSLHG LNKKVEQLGGKSNPEEEF--RAVIMVLVMVVAFLICWLPYTLFALTVVFNPALNISPLAATIPTYLSKTSPVYNPIIYIFLNKE FRECAVEFIT CGKVVLTSPEEDISTSAISDEGIAPCKINQVTPV
>PARIE_Xenop SYGPEGVQTSCSIGWEERSWSNY--SYIISYFLTCFIIPVGIIGFSYGSILRSLHQ LNRKIEQQGGKTNPREEK--RVVIMVLFMVLAFLICWLPYTVFALIVVINPQLYISPLAATLPTYFAKTSPVYNPIIYIFLNKQ FRTYAVQCLT CGHINLDSLEEDTESVSAQAENMLTPKTNQVAPA
>ENCEPH_braBel SYQLEGPKIGCSVAWEEHSWSNT--SYIVVLFITCLFAPLLIIVYSYYRLWHKVKQ GSRNLPAAMRKSSQKEQ---KIAMMVIVMITCFMVCWLPYGAMALVVTFGGERLISHTAAVVPSLLAKSSTCYNPVVYFAMNSQ FRRYFQDLLC CGRRLFDVSQSVVTGNTAMPRNNSQGFRKDDSDQKQD
>ENCEPH_homSap RYILDVHGLGCTVDWKSKDANDS--SFVLFLFLGCLVVPLGVIAHCYGHILYSIRM LRCVEDLQTIQVIKILKYEKKLAKMCFLMIFTFLVCWMPYIVICFLVVNGHGHLVTPTISIVSYLFAKSNTVYNPVIYVFMIRK FRRCLLQLLC FRLLKFQQPKKDRPVIRTEKQIRPIVMSQKVGDRPKKKVT
>ENCEPH_monDom RYTLEIHGLGCSVDWKSKDPNDS--SFVIFLFFGCLMLPVGVMAYCYGHILYAIRM LRCVEELQTIQVIKILRYEKKVAKMCFLMIAIFLFCWMPYAVICLLVANGYGSLVTPTVAIIASLFAKSSTAYNPIIYIFMSRK FRRCLLQLLC FRLLKFQQPKKDRPVIRTEKQIRPIVMSQKVGDRPKKKVT
>ENCEPH_galGal RYTLEIHGLGCSMDWKSKDPNDT--SFVLLFFLGCLVAPVVIMAYCYGHILYAVRM LRCVEDFQTSQVIKLLKYEKKVAKMCFLMISTFLICWMPYAVVSLLVTYGYSNLVTPTVAIIPSFFAKSSTAYNPVIYIFMSRK FRQCLLQLLC FRLMRFQRIMKEPSGAGNVKPIRPIVMSQKVGDRPKKKVT
>ENCEPH_anoCar HYTLEIHGLGCSVDWQSKEPSDS--SFVLFFFLGCLAAPVGIMAYCYGHILHAIRM LRCVEDLQSIQVIKILRYEKKVAKMCFLMVTTFLICWMPYAVVSLLIAYGYGHLITPTVAIIPSFFAKSSTAYNPVIYIFMSRK FRRCLVQLFC VQFLRFKRTLKEQPAIESNKPIRPIVMSQKVGDRPKKKVT
>ENCEPH_xenTro LYTFETHKLDCSFEWTATDPKDT--AFVLLFFLACITLPLSIMAYCYGYILYEIQK LRSVKNIQNFQEITILDYEIKMAKMCLLMMLTFLIGWMPYTILSLLVTSGYSKFITPTITVMPSLLAIASAAYNPVIHIFTIKK FRQCLVQLLP PINFHPPINPPINNFWRLLKNLNGRLAMKKVKPVLGKGRS
>ENCEPH1_Anoph AYVNEAANISCSVNWESQTANAT--SYIIFLFIFGLILPLAVIIYSYINIVLEMRK NSARVGRVNRAERRVT-------SMVAVMIVAFMVAWTPYAIFALIEQFGPPELIGPGLAVLPALVAKSSICYNPIIYVGMNTQ FRAAFWRIRR SNGVAGQPDSNNTNNSNRDKESARHTAKEGL
>ENCEPH2_Anoph AYVQEAANISCSVNWESQTKNAT--TYIIFLFVFGLVVPLIVIVYSYTNIIVNMRE NSARVGRINRAEQRVT-------SMVAVMIVAFMVAWTPYAIFALIEQFGPPELIGPGLAVLPALVAKSSICYNPIIYVGMNTQ FRAAFSRVRN KGQQAAADQNTTTMQRELTKSSRDMVECSF
>ENCEPH2_Apis SYGPEAGNVSCSVSWEVHDPVTNSDTYIGFLFVLGLIVPVFTIVSSYAAIVLTLKK VRKRAGASGRREAKIT-------KMVALMITAFLLAWSPYAALAIAAQYFNAKPSATV-AVLPALLAKSSICYNPIIYAGLNNQ FSRFLKKIFD ARGSRTAVPDSQHTALTALNRQEQRK
>CILL1_Platyn HYIPEGLATWCSIDWLSDETSDK--SYVFAIFIFCFLVPVLIIVVSYGLIYDKVRK VAKTGGSVAKAEREVL-------RMTLLMVSLFMLAWSPYAVICMLASFGPKDLLHPVATVIPAMFAKSSTMYNPLIYVFMNKQ FRRSLKVLLG MGVEDLNSESERATGGTATNQVAAT
>PER_homSap SYAPDPTGATCTINWRKNDRSFV--SYTMTVIAINFIVPLTVMFYCYYHVTLSIKH HTTSDCTESLNRDWSD--QIDVTKMSVIMICMFLVAWSPYSIVCLWASFGDPKKIPPPMAIIAPLFAKSSTFYNPCIYVVANKK FRRAMLAMFK CQTHQTMPVTSILPMDVSQNPLASGRI
>PERa_Bran EYALEPSGTACTINFQKNDSLYI--SYVTSCFVLGFVVPLAVMAFCYWQASCFVSK VLKGDIAGDLTFPVAAN.QNHFSKMCLAMVAAFVVAWTPYSVLFLFAAFWNPADIPAWLTLLPPLIAKSSALYNPIIYIIANRR FRNAICSMMK GQDPDVEDDEHADEHRVRSIEDNDKEIISMVNLNMTV
>PERc_Bran YTYETPMQITCSLDWNVQHPGEK--AYIAAVLVIVYVLQVLIMCFCYFNIIFKSAN LKFAALASEKTKMAAKKDTWKTSVMCLTMVVSFLIAWTPYAVSSTWDILSAE-DLPIIATILPSLFAKSSCMMNPIIYACCNTK FRQAAVKSFR KLCGMCKQKVPLSTPQVVLAMQRNTEFTSTVEPT
>NEUR_homSap DYVPEPFGTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKS SSKEVAHFDSRIHSSHVLEMKLTKVAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYK FACCQTGGLK ATKKKSLEGFRLHTVTTVRKSSAVLEIHEEWE
>MEL_Platy AYIPEGFQTSCTYDYLTQDMNNY--TYVLGMYLFGFIFPVAIIFFCYLGIVRAIFA HHAEMMATAKRMGAN...EIQIAKVAAMTIGTFMLSWTPYAVVGVFGMIKPHSEMFIH.AEIPVMMAKASARYNPIIYALSHPK FRAEIDKHFPWLLCCCKPKPKAQLPSSTTKGSIASKTEADTSV
>MEL1_homSap AYVPEGLLTSCSWDYMSFTPAVR--AYTMLLCCFVFFLPLLIIIYCYIFIFRAIRE TGRALQTFGACKGNG.QSECKMAKIMLLVILLFVLSWAPYSAVALVAFAGYAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPK YRVAIAQHLP CLGVLLGVSRRHSRPYPSYRSTHRSTLTSHTSNL
>PPINa_Ciona YDTEGLGTSCAPNWFVKEKRERL--FIILYFVFCFVIPLAVIMICYGKLILTLRQ IAKESSLSGGTSPEGEVTKMVVVMVTAFVFCWLPYAAFAMYNVVNPEAQ IDYALGAAPAFFAKTATIYNPLIYIGLNRQ FRDCVVRMIF NGRNPWVDELVGSQVSSTGSQLTAVSSNKVAPA
>PPINb_Ciona GYVPEGLGTSCAPNWFSKNKSER--IFIFVYFVFCFFIPLLVIIICYGKIVLFLKQVSLY ATRQSSASSNRQADNKVTKMVLVMISAFLICWTPYGVLSLYNAINPDKQ LDYGLGAVPVFFAKTANIYNPLIYIGLNKQ FRDGVIKMVF RGRNPWAEEMSTQQRQRSTEAGQPIVSNEV
>PPIN2_Ciona SVIWHTPGLFFWNGYEPEGFGTS--CAPNWFSQQKRERIFIFAYFAFCFLTPLTIIFACYLKLILFIRKVSVSKKSMVNEADRRDFEVTRMVFVMIAAFLICWLPYGCLSMYNAIHPD FRDGVIRMLF KGRNPWLDGRNTTSSTSTRAQ
Structural and functional markers along the opsin molecule:
>RHO1_homSap rhodopsin <----------TM1---------> c1 <----------TM2-------> x1 <c--i------TM3---------> c2 <----------TM4--------> x2 <----------TM5------c-> c3
MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKE
AAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA* 0
c3 <----------TM6-------> x3 <--------b-TM7---gprot> helix8 palm cyto tail
