UCSCGeneAnnotation:hg18-10230

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Canonical gene details SOCS6 uc002lkr.1
Other loci: uc010dqq.1
Description: suppressor of cytokine signaling 6
RefSeq Summary (NM_004232): The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq].

(description snapshot 15:39, 26 October 2010 (UTC))
Alternate Gene Symbols: CCDS11998, hCG_16045, NM_004232, NP_004223, Q8WUM3, Q8WUM3_HUMAN, uc002lkr.1

created: Jdcody 15:39, 26 October 2010 (UTC) uc010dqq.1

Losses and gains reported in control human samples; PMID: 17666407. The nt mouse has a 1.6 Mb deletion encompassing 4 genes; Rttn, CD226, Dok6 and Txndc10. The homozygous mouse has a phenotype identical to the Rttn homozygous gene-trap line and is embryonic lethal. Hemizygosity in the mouse does not cause an obvious phenotype. PMID: 17551791

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